H-R Berthoud

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Comp Neurol 485:127-42. 2005
  2. ncbi Neurobiology of exercise
    Rod K Dishman
    Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
    Obesity (Silver Spring) 14:345-56. 2006
  3. ncbi Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Physiol Behav 89:517-24. 2006
  4. ncbi Interactions between the "cognitive" and "metabolic" brain in the control of food intake
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Physiol Behav 91:486-98. 2007
  5. ncbi Neurobiology of nutrition and obesity
    Christopher D Morrison
    Neurosignaling Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Nutr Rev 65:517-34. 2007
  6. ncbi Modulation of taste responsiveness and food preference by obesity and weight loss
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA Electronic address
    Physiol Behav 107:527-32. 2012
  7. ncbi Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Ann N Y Acad Sci 1264:36-48. 2012
  8. ncbi Neural and metabolic regulation of macronutrient intake and selection
    Hans Rudolf Berthoud
    Neurobiology of Nutrition, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Proc Nutr Soc 71:390-400. 2012
  9. ncbi Metabolic and hedonic drives in the neural control of appetite: who is the boss?
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Opin Neurobiol 21:888-96. 2011
  10. ncbi Anatomy and function of sensory hepatic nerves
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:827-35. 2004

Research Grants

  1. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2007
  2. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2007
  3. Neural mechanisms controlling food intake and body weight after bariatric surgery
    Hans Rudolf Berthoud; Fiscal Year: 2010
  4. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
  5. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2002
  6. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010

Collaborators

Detail Information

Publications47

  1. ncbi Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Comp Neurol 485:127-42. 2005
    ..The results confirm that hypothalamomedullary orexin projections are involved in a variety of physiological functions, including ingestive behavior and sympathetic outflow...
  2. ncbi Neurobiology of exercise
    Rod K Dishman
    Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
    Obesity (Silver Spring) 14:345-56. 2006
    ....
  3. ncbi Brainstem mechanisms integrating gut-derived satiety signals and descending forebrain information in the control of meal size
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Physiol Behav 89:517-24. 2006
    ..Longer-term downstream effects of ERK activation might involve CREB-mediated gene transcription known to produce plasticity changes in neurocircuitry that could determine inter-meal intervals and the size of future meals...
  4. ncbi Interactions between the "cognitive" and "metabolic" brain in the control of food intake
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Physiol Behav 91:486-98. 2007
    ....
  5. ncbi Neurobiology of nutrition and obesity
    Christopher D Morrison
    Neurosignaling Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Nutr Rev 65:517-34. 2007
    ....
  6. ncbi Modulation of taste responsiveness and food preference by obesity and weight loss
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA Electronic address
    Physiol Behav 107:527-32. 2012
    ..Better understanding would be helpful in designing strategies to promote healthier eating and prevention of obesity and the accompanying chronic disease risks...
  7. ncbi Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Ann N Y Acad Sci 1264:36-48. 2012
    ....
  8. ncbi Neural and metabolic regulation of macronutrient intake and selection
    Hans Rudolf Berthoud
    Neurobiology of Nutrition, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Proc Nutr Soc 71:390-400. 2012
    ..A better understanding of these nutrient-specific neural processes could help design drugs and behavioural strategies that promote healthier eating...
  9. ncbi Metabolic and hedonic drives in the neural control of appetite: who is the boss?
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Opin Neurobiol 21:888-96. 2011
    ....
  10. ncbi Anatomy and function of sensory hepatic nerves
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:827-35. 2004
    ..Great caution is therefore necessary when interpreting functional outcomes of so-called specific hepatic denervation studies...
  11. ncbi Neural control of appetite: cross-talk between homeostatic and non-homeostatic systems
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Appetite 43:315-7. 2004
    ..To find new behavioral and pharmacological treatments of obesity, it will be important to identify the specific pathways that link these externally driven processes with the homeostatic regulatory system...
  12. ncbi Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:197S-200S. 2006
    ....
  13. ncbi Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Histochem Cell Biol 123:147-56. 2005
    ....
  14. ncbi Paying the price for eating ice cream: is excessive GLP-1 signaling in the brain the culprit?
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 149:4765-7. 2008
  15. ncbi The vagus nerve, food intake and obesity
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana, USA
    Regul Pept 149:15-25. 2008
    ....
  16. ncbi Vagal-enteric interface: vagal activation-induced expression of c-Fos and p-CREB in neurons of the upper gastrointestinal tract and pancreas
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Anat Rec 262:29-40. 2001
    ..They represent the first step in the identification of function-specific units of parasympathetic vagal outflow...
  17. ncbi Vagal and hormonal gut-brain communication: from satiation to satisfaction
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Neurogastroenterol Motil 20:64-72. 2008
    ....
  18. ncbi The brain, appetite, and obesity
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Annu Rev Psychol 59:55-92. 2008
    ..The predisposition to develop obesity can theoretically result from any pathological malfunction or lack of adaptation to changing environments of this highly complex system...
  19. ncbi Mind versus metabolism in the control of food intake and energy balance
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Physiol Behav 81:781-93. 2004
    ..While many projections from the hypothalamus contain the various "feeding peptides," the neurochemistry of projections to the hypothalamus has not been well characterized...
  20. ncbi Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Neurogastroenterol Motil 16:28-33. 2004
    ..Whether functional changes have anatomical correlates is not known, but it is likely that they underlie diseases involving visceral hypersensitivity...
  21. ncbi Functional and chemical anatomy of the afferent vagal system
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Auton Neurosci 85:1-17. 2000
    ..Furthermore, these functions are in line with a general defensive character ascribed to the vagal afferent, paraventricular system in lower vertebrates...
  22. ncbi Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Brain Res 915:143-54. 2001
    ..This may indicate a high degree of convergence among sensory signals, or alternatively, the presence of other transmission systems such as peptides referring sensory specificity to second order neurons...
  23. ncbi The lateral hypothalamus as integrator of metabolic and environmental needs: from electrical self-stimulation to opto-genetics
    Hans Rudi Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Physiol Behav 104:29-39. 2011
    ..Exciting new techniques allowing selective stimulation or inhibition of specific neuronal phenotypes will greatly facilitate the functional mapping of both input and output pathways...
  24. ncbi Multiple neural systems controlling food intake and body weight
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Neurosci Biobehav Rev 26:393-428. 2002
    ....
  25. ncbi Video-based spatio-temporal maps for analysis of gastric motility in vitro: effects of vagal stimulation in guinea-pigs
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Neurogastroenterol Motil 14:677-88. 2002
    ....
  26. ncbi "Liking" and "wanting" of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition
    Andrew C Shin
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1267-80. 2011
    ....
  27. ncbi Food reward, hyperphagia, and obesity
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1266-77. 2011
    ....
  28. ncbi Neural systems controlling food intake and energy balance in the modern world
    Hans Rudolf Berthoud
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Opin Clin Nutr Metab Care 6:615-20. 2003
    ..Thus, this review is intended to bridge this apparent neural dichotomy and highlight possible ways of interactions between these homeostatic and nonhomeostatic systems...
  29. ncbi Obesity surgery and gut-brain communication
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Physiol Behav 105:106-19. 2011
    ....
  30. ncbi Melanin concentrating hormone innervation of caudal brainstem areas involved in gastrointestinal functions and energy balance
    H Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Neuroscience 135:611-25. 2005
    ..Projections to ventral medullary sites may play a role in the inhibitory effect of melanin-concentrating hormone on energy expenditure...
  31. ncbi Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Neurosci 27:11075-82. 2007
    ....
  32. ncbi Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1436-44. 2003
    ..However, activation of many neurons not expressing these peptides suggests that additional peptides/transmitters in the lateral hypothalamus and accumbens projections to other brain areas might also be involved...
  33. ncbi Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1773-81. 2002
    ..Activation of CART neurons in the ARC (which likely coexpress proopiomelanocortin) could indicate attempts to activate counterregulatory decreases in food intake...
  34. ncbi Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  35. ncbi Vanilloid receptor (VR1) expression in vagal afferent neurons innervating the gastrointestinal tract
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Cell Tissue Res 311:277-87. 2003
    ....
  36. ncbi Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 289:R247-58. 2005
    ....
  37. ncbi Extracellular signal-regulated kinase 1/2 signaling pathway in solitary nucleus mediates cholecystokinin-induced suppression of food intake in rats
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Neurosci 24:10240-7. 2004
    ....
  38. ncbi Behavioral analysis of anorexia produced by hindbrain injections of AMPA receptor antagonist NBQX in rats
    Huiyuan Zheng
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Regul Integr Comp Physiol 282:R147-55. 2002
    ..More localized injections and response measures will be necessary...
  39. ncbi Eating for pleasure or calories
    Huiyuan Zheng
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Opin Pharmacol 7:607-12. 2007
    ..On the other hand, brain areas involved in reward, cognition, and executive control can override metabolic regulation by talking to the hypothalamus...
  40. ncbi Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus
    Gregory M Sutton
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 146:3739-47. 2005
    ..The cAMP-->ERK-->CREB cascade may thus constitute a molecular integrator for converging satiety signals from the gut and adiposity signals from the hypothalamus in the control of meal size and food intake...
  41. ncbi Vagal afferents innervating the gastrointestinal tract and CCKA-receptor immunoreactivity
    Laurel M Patterson
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Anat Rec 266:10-20. 2002
    ....
  42. ncbi Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function
    Zbigniew K Krowicki
    Department of Pharmacology and Center of Excellence for Neuroscience, Louisiana State University Health Sciences Center, New Orleans 70112, USA
    Am J Physiol Gastrointest Liver Physiol 283:G465-72. 2002
    ..These data are consistent with the idea that orexin A stimulates vagal excitatory motor neurons. These are the first data to suggest that orexins in the DMN have potent and long-lasting effects to increase gastric contractility...
  43. ncbi Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys
    Haijun D Sun
    ImClone Systems Inc, 180 Varick St, New York, NY 10014, USA
    Am J Physiol Endocrinol Metab 292:E964-76. 2007
    ..Our data suggest that FGF signaling through FGFR1c may play a physiological role in hypothalamic feeding circuit and that blocking it leads to hypophagia and weight loss...
  44. ncbi Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons
    Niels Vrang
    Rheoscience, 2610 Rødovre, Denmark
    Am J Physiol Regul Integr Comp Physiol 285:R470-8. 2003
    ..The results support the view that the medullary GLP system is involved in appetite control and is activated by stimuli within the behavioral continuum, ranging from satiety to nausea...
  45. ncbi Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons
    Shuxia Wan
    Key Laboratory of Allergy and Immune Related Diseases, Department of Physiology, School of Basic Medical Science, Wuhan University, Wuhan 430071, Hubei, China
    J Neurosci 28:4957-66. 2008
    ....
  46. ncbi Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    Wouter J de Jonge
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Nat Immunol 6:844-51. 2005
    ..We conclude that the vagal anti-inflammatory pathway acts by alpha7 subunit-mediated Jak2-STAT3 activation...
  47. ncbi Neurochemical control and reconfiguration of the medullary network controlling different oromotor behaviors
    Hans-Rudolf Berthoud
    Am J Physiol Regul Integr Comp Physiol 285:R19-20. 2003

Research Grants25

  1. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..framework of how the different psychological processes involved in food reward are neurologically organized, and (3) the development of pharmacological and behavioral therapeutic tools to counteract "common" obesity in a world of plenty ..
  2. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..abstract_text> ..
  3. Neural mechanisms controlling food intake and body weight after bariatric surgery
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..This will result in more optimal surgical procedures, behavioral tips helping patients to cope with different eating habits, and development of new drugs. ..
  4. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  5. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2002
    ....
  6. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..