Donald H Chace

Summary

Affiliation: Pediatrix Medical Group
Country: USA

Publications

  1. ncbi request reprint The application of tandem mass spectrometry to neonatal screening for inherited disorders of intermediary metabolism
    Donald H Chace
    Division of BioAnalytical Chemistry and Mass Spectrometry, Neo Gen Screening, Bridgeville, Pennsylvania 15017, USA
    Annu Rev Genomics Hum Genet 3:17-45. 2002
  2. ncbi request reprint Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns
    Donald H Chace
    Pediatrix Screening, PO Box 219, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Clin Chem 49:1797-817. 2003
  3. doi request reprint Rapid metabolic and newborn screening of thyroxine (T4) from dried blood spots by MS/MS
    Donald H Chace
    Pediatrix Analytical, The Pediatrix Center for Research and Education 1301 Concord Terrace Sunrise, FL 33323, United States
    Clin Chim Acta 403:178-83. 2009
  4. doi request reprint Mass spectrometry in newborn and metabolic screening: historical perspective and future directions
    Donald H Chace
    Pediatrix Analytical, Pittsburgh, PA, USA
    J Mass Spectrom 44:163-70. 2009
  5. doi request reprint Improved MS/MS analysis of succinylacetone extracted from dried blood spots when combined with amino acids and acylcarnitine butyl esters
    Donald H Chace
    Pediatrix Analytical, The Center for Research and Education, Pediatrix Medical Group, Inc 1301 Concord Terrace, Sunrise, FL 33323, United States
    Clin Chim Acta 407:6-9. 2009
  6. ncbi request reprint 2005 International Conference on Metabolic Profiling. November 14-15, 2006, NC, USA
    Donald H Chace
    Pediatrix Analytical, Bridgeville, PA 15017, USA
    Expert Rev Mol Diagn 6:135-6. 2006
  7. doi request reprint Potential loss of methionine following extended storage of newborn screening samples prepared for tandem mass spectrometry analysis
    Donald H Chace
    Pediatrix Analytical, The Center for Research and Education, Pediatrix Medical Group, Inc, 1301 Concord Terrace, Sunrise, FL 33323, USA
    Clin Chim Acta 411:1284-6. 2010
  8. ncbi request reprint 2005 Biomarker Discovery Summit: impressions and summary. September 26-28, 2005, PA, USA
    Donald H Chace
    Pediatrix Analytical, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Expert Rev Proteomics 2:837-8. 2005
  9. doi request reprint Tandem mass spectrometric identification of dextrose markers in dried-blood spots from infants receiving total parenteral nutrition
    Donald H Chace
    Pediatrix Analytical, The Pediatrix Center for Research, Education and Quality, Pediatrix Medical Group, Inc 1301 Concord Terrace, Sunrise, FL 33323, USA
    Clin Chim Acta 411:1806-16. 2010
  10. ncbi request reprint A biochemical perspective on the use of tandem mass spectrometry for newborn screening and clinical testing
    Donald H Chace
    Pediatrix Analytical, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Clin Biochem 38:296-309. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The application of tandem mass spectrometry to neonatal screening for inherited disorders of intermediary metabolism
    Donald H Chace
    Division of BioAnalytical Chemistry and Mass Spectrometry, Neo Gen Screening, Bridgeville, Pennsylvania 15017, USA
    Annu Rev Genomics Hum Genet 3:17-45. 2002
    ..It is therefore imperative that the genetics community be familiar with tandem mass spectrometric newborn screening...
  2. ncbi request reprint Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns
    Donald H Chace
    Pediatrix Screening, PO Box 219, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Clin Chem 49:1797-817. 2003
    ....
  3. doi request reprint Rapid metabolic and newborn screening of thyroxine (T4) from dried blood spots by MS/MS
    Donald H Chace
    Pediatrix Analytical, The Pediatrix Center for Research and Education 1301 Concord Terrace Sunrise, FL 33323, United States
    Clin Chim Acta 403:178-83. 2009
    ..Some laboratories measure either total T(4) or TSH as a means of detecting infants with hypothyroidism with a subset that analyzes both total T(4) and TSH as a primary screen or a combination of primary and secondary screens...
  4. doi request reprint Mass spectrometry in newborn and metabolic screening: historical perspective and future directions
    Donald H Chace
    Pediatrix Analytical, Pittsburgh, PA, USA
    J Mass Spectrom 44:163-70. 2009
    ..These features are excellent selectivity and multiple analyte or profile analysis; features recognized in the 1950s and remain true today...
  5. doi request reprint Improved MS/MS analysis of succinylacetone extracted from dried blood spots when combined with amino acids and acylcarnitine butyl esters
    Donald H Chace
    Pediatrix Analytical, The Center for Research and Education, Pediatrix Medical Group, Inc 1301 Concord Terrace, Sunrise, FL 33323, United States
    Clin Chim Acta 407:6-9. 2009
    ..However, butyl esterification techniques may result in contamination of underivatized acylcarnitines by as much as 20%. We have developed a simple wash step to improve the combined analysis of SUAC, AA and AC in DBS by MS/MS...
  6. ncbi request reprint 2005 International Conference on Metabolic Profiling. November 14-15, 2006, NC, USA
    Donald H Chace
    Pediatrix Analytical, Bridgeville, PA 15017, USA
    Expert Rev Mol Diagn 6:135-6. 2006
  7. doi request reprint Potential loss of methionine following extended storage of newborn screening samples prepared for tandem mass spectrometry analysis
    Donald H Chace
    Pediatrix Analytical, The Center for Research and Education, Pediatrix Medical Group, Inc, 1301 Concord Terrace, Sunrise, FL 33323, USA
    Clin Chim Acta 411:1284-6. 2010
    ..We report on the stability of labeled and unlabeled Met solutions and their storage in two types of 96 well microtiter plates to illustrate the potential loss of Met following storage of samples prior to MS/MS analysis...
  8. ncbi request reprint 2005 Biomarker Discovery Summit: impressions and summary. September 26-28, 2005, PA, USA
    Donald H Chace
    Pediatrix Analytical, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Expert Rev Proteomics 2:837-8. 2005
  9. doi request reprint Tandem mass spectrometric identification of dextrose markers in dried-blood spots from infants receiving total parenteral nutrition
    Donald H Chace
    Pediatrix Analytical, The Pediatrix Center for Research, Education and Quality, Pediatrix Medical Group, Inc 1301 Concord Terrace, Sunrise, FL 33323, USA
    Clin Chim Acta 411:1806-16. 2010
    ..These markers were closely correlated with the detection of very high multiple amino acid increases in the profiles of newborns administered with TPN and who were ultimately found to be normal and free of inherited metabolic disorders...
  10. ncbi request reprint A biochemical perspective on the use of tandem mass spectrometry for newborn screening and clinical testing
    Donald H Chace
    Pediatrix Analytical, 90 Emerson Lane, Bridgeville, PA 15017, USA
    Clin Biochem 38:296-309. 2005
    ..MS/MS is a powerful tool for accessing the metabolic status of a newborn and can detect both inborn metabolic errors as well as examine the effect of acquired diseases or pharmacologic intervention on intermediary metabolism...
  11. ncbi request reprint Altered metabolism and newborn screening using tandem mass spectrometry: lessons learned from the bench to bedside
    Donald H Chace
    Pediatrix Center for Research, Education and Quality, Pediatrix Medical Group, 1301 Concord Terrace Sunrise, FL 33323, USA
    Curr Pharm Biotechnol 12:965-75. 2011
    ..The use of a highly specific, sensitive and multiplex platform such as MS/MS will continue to grow and experience in the newborn screening application will insure this outcome...
  12. doi request reprint Detection of TPN contamination of dried blood spots used in newborn and metabolic screening and its impact on quantitative measurement of amino acids
    Donald H Chace
    The Pediatrix Center for Research, Education and Quality, Pediatrix Medical Group, Inc, 1301 Concord Terrace, Sunrise, FL 33323, USA
    Clin Chim Acta 412:1385-90. 2011
    ..This study investigates quantitative parameters of dextrose and amino acids in blood samples enriched with different TPN solutions...
  13. doi request reprint Quantification of malonylcarnitine in dried blood spots by use of MS/MS varies by stable isotope internal standard composition
    Donald H Chace
    Pediatrix Analytical, The Center for Research and Education, Pediatrix Medical Group, Inc, 1301 Concord Terrace, Sunrise, FL 33323, United States
    Clin Chim Acta 402:14-8. 2009
    ..Quantitative features were unknown, so that its measurement was an approximation. Synthesis of malonylcarnitine enabled both a study in the analytical characteristics of C3DC and a survey of its measurement in NBS laboratories...
  14. pmc Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth
    Sara F Michaliszyn
    Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 97:E2119-24. 2012
    ..In longitudinal studies of adults, elevated amino acid (AA) concentrations predicted future type 2 diabetes mellitus (T2DM)...
  15. pmc Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation
    Stephanie J Mihalik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:605-11. 2012
    ..We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents...
  16. ncbi request reprint Effects of two different doses of amino acid supplementation on growth and blood amino acid levels in premature neonates admitted to the neonatal intensive care unit: a randomized, controlled trial
    Reese H Clark
    Pediatrix Medical Group, 1301 Concord Terrace, Sunrise, FL 33323 2825, USA
    Pediatrics 120:1286-96. 2007
    ..The goal was to measure the effects of 2 distinct strategies for parenteral nutrition on neonatal growth and blood amino acid profiles...
  17. ncbi request reprint Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectometry
    Donald H Chace
    Neo Gen Screening, Division of BioAnalytical Chemistry and Mass Spectrometry, Bridgeville, PA 15017, USA
    Pediatr Res 53:823-9. 2003
    ....
  18. doi request reprint Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
    Stephanie J Mihalik
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 18:1695-700. 2010
    ..Plasma long-chain AcylCN species are increased in obesity and T2DM, suggesting that more fatty acids can enter mitochondria. In T2DM, many shorter species accumulate, suggesting that they have a generalized complex oxidation defect...
  19. ncbi request reprint Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry after hypoxia-ischemia in newborn rats
    Mark S Wainwright
    Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Stroke 37:524-30. 2006
    ..We used a newborn rat model of hypoxia-ischemia (HI) to test the hypothesis that HI alters acyl-CoA:CoA homeostasis and that this effect can be prevented by treatment with carnitine...
  20. ncbi request reprint Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease
    Stephanie E Reuter
    Centre for Pharmaceutical Research, University of South Australia, North Terrace, Adelaide, SA 5000, Australia
    Ann Clin Biochem 42:387-93. 2005
    ....
  21. ncbi request reprint Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia
    Carla Z Minutti
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:3687-93. 2004
    ..This would prevent unnecessary blood draws, medical evaluations, and stress to families...