M M Shi
Affiliation: Parke-Davis Pharmaceutical Research
- High-throughput genotyping method for glutathione S-transferase T1 and M1 gene deletions using TaqMan probesM M Shi
Department of Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert Company, Ann Arbor, MI 48105, USA
Res Commun Mol Pathol Pharmacol 103:3-15. 1999..5% and 40.8% for GSTT1 and GSTM1, respectively. This TaqMan genotyping method is rapid, reproducible, and highly sensitive and could be applied toward fully automated large-scale genotyping...
- Technologies for detecting genetic polymorphisms in pharmacogenomicsM M Shi
Genomic Pathology Laboratory, Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
Mol Diagn 4:343-51. 1999..Pharmacogenomics is an emerging scientific discipline examining the genetic basis for individual variations in response to therapeutics...
- High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probesM M Shi
Genomic Pathology Laboratory, Parke Davis Pharmaceutical Research, Warner Lambert Company, Ann Arbor, MI 48105, USA
Mol Pathol 52:295-9. 1999..The aim of this study was to develop a rapid genotyping procedure for epidemiological and clinical research into the potential biological and toxicological implications associated with this genetic polymorphism...
- Pharmacogenetic application in drug development and clinical trialsM M Shi
Genomic Pathology Laboratory, Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan, USA
Drug Metab Dispos 29:591-5. 2001..Pharmacogenetics, thus, impacts all phases of drug development and will fundamentally change the practice of medicine in the near future...