G Krishna

Summary

Affiliation: Parke-Davis Pharmaceutical Research
Country: USA

Publications

  1. ncbi Principles and practices of integrating genotoxicity evaluation into routine toxicology studies: a pharmaceutical industry perspective
    G Krishna
    Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Environ Mol Mutagen 32:115-20. 1998
  2. ncbi Historical vehicle and positive control micronucleus data in mice and rats
    G Krishna
    Department of Worldwide Preclinical Safety, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Mutat Res 453:45-50. 2000
  3. ncbi In vivo rodent micronucleus assay: protocol, conduct and data interpretation
    G Krishna
    Department of Worldwide Preclinical Safety, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Mutat Res 455:155-66. 2000
  4. ncbi Use of acridine orange in: flow cytometric assessment of micronuclei induction
    K A Criswell
    Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert, Ann Arbor, MI 48105, USA
    Mutat Res 414:63-75. 1998
  5. ncbi Use of acridine orange in: flow cytometric evaluation of erythropoietic cytotoxicity
    K A Criswell
    Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert, Ann Arbor, MI 48105, USA
    Mutat Res 414:49-61. 1998
  6. ncbi Validation of a flow cytometric acridine orange micronuclei methodology in rats
    K A Criswell
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Mutat Res 528:1-18. 2003

Detail Information

Publications6

  1. ncbi Principles and practices of integrating genotoxicity evaluation into routine toxicology studies: a pharmaceutical industry perspective
    G Krishna
    Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Environ Mol Mutagen 32:115-20. 1998
    ..Based on the experience in our laboratory, integrating micronucleus assessment in routine toxicology testing is promising and should be utilized when practical...
  2. ncbi Historical vehicle and positive control micronucleus data in mice and rats
    G Krishna
    Department of Worldwide Preclinical Safety, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Mutat Res 453:45-50. 2000
    ..These data demonstrate the reproducibility of positive control response in MN assay in our laboratory and support the MN Assay Expert Panel's view that the use of positive control may not be necessary in every study...
  3. ncbi In vivo rodent micronucleus assay: protocol, conduct and data interpretation
    G Krishna
    Department of Worldwide Preclinical Safety, Parke Davis Pharmaceutical Research, Division of Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Mutat Res 455:155-66. 2000
    ..It is expected that such improvements of the protocol will continue to drive the utility of this assay in the product safety assessment...
  4. ncbi Use of acridine orange in: flow cytometric assessment of micronuclei induction
    K A Criswell
    Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert, Ann Arbor, MI 48105, USA
    Mutat Res 414:63-75. 1998
    ..These results support the use of AO-based flow cytometry to provide a rapid and sensitive indicator of micronuclei inducers...
  5. ncbi Use of acridine orange in: flow cytometric evaluation of erythropoietic cytotoxicity
    K A Criswell
    Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert, Ann Arbor, MI 48105, USA
    Mutat Res 414:49-61. 1998
    ..The AO methodology provided a more rapid, statistically-superior, and thorough approach in the assessment of bone marrow and spleen cytotoxicity than the conventional manual method of scoring PCE/NCE ratio alone...
  6. ncbi Validation of a flow cytometric acridine orange micronuclei methodology in rats
    K A Criswell
    Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, MI 48105, USA
    Mutat Res 528:1-18. 2003
    ....