D J Dooley

Summary

Affiliation: Parke-Davis Pharmaceutical Research
Country: USA

Publications

  1. ncbi request reprint Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin
    D J Dooley
    Department of Neuroscience Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Co, Ann Arbor, MI 48105, USA
    Neurosci Lett 280:107-10. 2000
  2. ncbi request reprint Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin
    D J Dooley
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    J Pharmacol Exp Ther 295:1086-93. 2000
  3. ncbi request reprint Modulation of K(+)-induced synaptosomal calcium influx by gabapentin
    W P Meder
    Pfizer Global Research and Development, Department of Neuroscience Therapeutics, Ann Arbor, MI 48105, USA
    Brain Res 875:157-9. 2000

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin
    D J Dooley
    Department of Neuroscience Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Co, Ann Arbor, MI 48105, USA
    Neurosci Lett 280:107-10. 2000
    ..The inhibitory effect of gabapentin and related compounds on GLU release may reflect a subtle modulation of VSCC function which normalizes pathological changes in neurotransmitter release...
  2. ncbi request reprint Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin
    D J Dooley
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    J Pharmacol Exp Ther 295:1086-93. 2000
    ..This type of modulation of neurotransmitter release may be integral to the clinical pharmacology of these drugs...
  3. ncbi request reprint Modulation of K(+)-induced synaptosomal calcium influx by gabapentin
    W P Meder
    Pfizer Global Research and Development, Department of Neuroscience Therapeutics, Ann Arbor, MI 48105, USA
    Brain Res 875:157-9. 2000
    ..7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release...