- Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentinD J Dooley
Department of Neuroscience Therapeutics, Parke Davis Pharmaceutical Research, Division of Warner Lambert Co, Ann Arbor, MI 48105, USA
Neurosci Lett 280:107-10. 2000..The inhibitory effect of gabapentin and related compounds on GLU release may reflect a subtle modulation of VSCC function which normalizes pathological changes in neurotransmitter release...
- Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalinD J Dooley
Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
J Pharmacol Exp Ther 295:1086-93. 2000..This type of modulation of neurotransmitter release may be integral to the clinical pharmacology of these drugs...
- Modulation of K(+)-induced synaptosomal calcium influx by gabapentinW P Meder
Pfizer Global Research and Development, Department of Neuroscience Therapeutics, Ann Arbor, MI 48105, USA
Brain Res 875:157-9. 2000..7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release...