Lynne K Garrity-Ryan
Affiliation: Paratek Pharmaceuticals
- Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia modelLynne K Garrity-Ryan
Paratek Pharmaceuticals, Inc, Boston, MA 02111, USA
Infect Immun 78:4683-90. 2010..The MAR family of transcription factors is well conserved, with members playing central roles in pathogenesis across bacterial genera; thus, the inhibitors could have broad applicability...
- N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agentsOak K Kim
Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, Massachusetts 02111, USA
J Med Chem 52:5626-34. 2009..These results demonstrate that N-hydroxybenzimidazole inhibitors, exemplified by 14, 22, and 36, are effective antivirulence agents and have the potential to prevent infections caused by Yersinia spp...
- N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stabilityMark C Grier
Paratek Pharmaceuticals, Inc 75 Kneeland Street, Boston, MA 02111, USA
Bioorg Med Chem Lett 20:3380-3. 2010..aeruginosa was demonstrated in a whole cell assay. Select N-hydroxybenzimidazole inhibitors were stable in an in vitro human liver microsomal assay...
- MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritisPaul Casaz
Paratek Pharmaceuticals, Inc, 75 Kneeland Street, Boston, MA 02111, USA
Microbiology 152:3643-50. 2006..Deletion of soxS or rob alone was more detrimental than the removal of marA. Thus, all three proteins contribute to virulence in vivo...