M F McCarty

Summary

Affiliation: Pantox Laboratories
Country: USA

Publications

  1. ncbi Dairy products and insulin resistance
    Mark F McCarty
    JAMA 288:693; author reply 693-4. 2002
  2. ncbi The putative therapeutic value of high-dose selenium in proliferative retinopathies may reflect down-regulation of VEGF production by the hypoxic retina
    M F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:159-61. 2005
  3. ncbi Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 62:993-1002. 2004
  4. ncbi Proposal for a dietary "phytochemical index"
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:813-7. 2004
  5. ncbi Optimizing endothelial nitric oxide activity may slow endothelial aging
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:719-23. 2004
  6. ncbi Should we restrict chloride rather than sodium?
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:138-48. 2004
  7. ncbi Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:709-18. 2004
  8. ncbi Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 63:699-708. 2004
  9. ncbi Concurrent treatment with an ACE inhibitor may amplify the utility of calcium supplementation for control of hypertension
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:818-22. 2004
  10. ncbi Sub-optimal taurine status may promote platelet hyperaggregability in vegetarians
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:426-33. 2004

Collaborators

  • Dusan Miljkovic
  • Natasha Miljkovic

Detail Information

Publications96

  1. ncbi Dairy products and insulin resistance
    Mark F McCarty
    JAMA 288:693; author reply 693-4. 2002
  2. ncbi The putative therapeutic value of high-dose selenium in proliferative retinopathies may reflect down-regulation of VEGF production by the hypoxic retina
    M F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:159-61. 2005
    ..Since selenium is inexpensive and non-toxic in the dose employed by Crary, an effort to replicate his findings is warranted...
  3. ncbi Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 62:993-1002. 2004
    ....
  4. ncbi Proposal for a dietary "phytochemical index"
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:813-7. 2004
    ....
  5. ncbi Optimizing endothelial nitric oxide activity may slow endothelial aging
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:719-23. 2004
    ..The impact of lifelong caloric restriction on endothelial aging requires further study, preferably in primates...
  6. ncbi Should we restrict chloride rather than sodium?
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:138-48. 2004
    ....
  7. ncbi Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:709-18. 2004
    ....
  8. ncbi Vascular endothelium is the organ chiefly responsible for the catabolism of plasma asymmetric dimethylarginine--an explanation for the elevation of plasma ADMA in disorders characterized by endothelial dysfunction
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 63:699-708. 2004
    ..Whether or not ADMA plays an important pathogenic role, it seems likely to emerge as a potent risk factor for adverse vascular events, since it may be viewed as a barometer of endothelial health...
  9. ncbi Concurrent treatment with an ACE inhibitor may amplify the utility of calcium supplementation for control of hypertension
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:818-22. 2004
    ..The imminent availability of safe nutraceutical ACE inhibitors may make it more feasible for the general public to benefit from these therapeutic/preventive possibilities...
  10. ncbi Sub-optimal taurine status may promote platelet hyperaggregability in vegetarians
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:426-33. 2004
    ..Taurine is just one of a number of nutrients found almost solely in animal products--"carninutrients"--which are rational candidates for supplementation in vegans...
  11. ncbi An elevation of triglycerides reflecting decreased triglyceride clearance may not be pathogenic -- relevance to high-carbohydrate diets
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:1065-73. 2004
    ....
  12. ncbi Elevated sympathetic activity may promote insulin resistance syndrome by activating alpha-1 adrenergic receptors on adipocytes
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 29109, USA
    Med Hypotheses 62:830-8. 2004
    ..Taurine and high-dose pyridoxine may represent practical nutritional strategies for moderating elevated sympathetic activity, and exercise training and low-insulin-response diets may be useful in this regard as well...
  13. ncbi Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 56:137-54. 2001
    ..Many of these measures appear suitable for use in cancer prevention...
  14. ncbi A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light - a further advantage of vegan diets
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:543-60. 2003
    ....
  15. ncbi Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:567-73. 2003
    ..People who are insulin resistant can minimize any health risk associated with iron overload by avoiding heme-rich flesh foods and donating blood regularly...
  16. ncbi Iatrogenic lipodystrophy in HIV patients - the need for very-low-fat diets
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:561-6. 2003
    ..Despite perceptions to the contrary, very-low-fat diets can meet with good compliance in well-motivated subjects given appropriate instruction...
  17. ncbi A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:419-25. 2004
    ..Moderate alcohol consumption, the well-tolerated drug pentoxifylline, and 5-lipoxygenase inhibitors--zileuton, boswellic acids, fish oil--may also have potential in this regard...
  18. ncbi Hepatic monitoring of essential amino acid availability may regulate IGF-I activity, thermogenesis, and fatty acid oxidation/synthesis
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 56:220-4. 2001
    ..The fact that vegans ingest diets that tend to be relatively low in certain EAAs may play a key role in their characteristic leanness and their decreased risk for diabetes, coronary disease, and cancer...
  19. ncbi A wholly nutritional 'multifocal angiostatic therapy' for control of disseminated cancer
    M F McCarty
    Pantox Laboratories, San Diego, California 92129, USA
    Med Hypotheses 61:1-15. 2003
    ..Inasmuch as cox-2 is overexpressed in many cancers, and cAMP can boost tumor production of various angiogenic factors as well as autogenous growth factors, adjunctive use of cox-2-specific NSAIDS may be warranted in some cases...
  20. ncbi ACE inhibition may decrease diabetes risk by boosting the impact of bradykinin on adipocytes
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 60:779-83. 2003
    ....
  21. ncbi Does postprandial storage of triglycerides in endothelial cells contribute to the endothelial dysfunction associated with insulin resistance and fatty diets?
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:167-72. 2003
    ....
  22. ncbi Suppression of dolichol synthesis with isoprenoids and statins may potentiate the cancer-retardant efficacy of IGF-I down-regulation
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 56:12-6. 2001
    ..Since dolichol and IGF-I appear to be essential for angiogenesis, these measures may also prove useful for control of pathogenic neovascularization...
  23. ncbi A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, California 92109, USA
    Med Hypotheses 62:62-71. 2004
    ..These safe and relatively inexpensive nutritional strategies for coping with angina deserve far more attention than orthodox medical practice has thus far accorded them...
  24. ncbi Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:854-63. 2005
    ....
  25. ncbi A preliminary fast may potentiate response to a subsequent low-salt, low-fat vegan diet in the management of hypertension - fasting as a strategy for breaking metabolic vicious cycles
    M F McCarty
    Pantox Laboratories, San Diego, California, USA
    Med Hypotheses 60:624-33. 2003
    ....
  26. ncbi The A54T polymorphism of fatty acid-binding protein 2 may entail a reduction in fat-stimulated secretion of GIP that potentiates the adverse impact of fatty diets on insulin sensitivity
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:458-62. 2003
    ..If this thesis proves to be correct, it will help to clarify the importance of appropriate GIP secretion to maintenance of insulin sensitivity in the context of fatty diets...
  27. ncbi Homologous physiological effects of phenformin and chromium picolinate
    M F McCarty
    Nutrition 21, San Diego, CA 92109
    Med Hypotheses 41:316-24. 1993
    ..Safe, appropriate measures for promoting lifelong insulin sensitivity include a low-fat diet, exercise training, and supplemental chromium picolinate...
  28. ncbi Upregulation of lymphocyte apoptosis as a strategy for preventing and treating autoimmune disorders: a role for whole-food vegan diets, fish oil and dopamine agonists
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 57:258-75. 2001
    ....
  29. ncbi The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 56:217-9. 2001
    ..Administration of hydrolyzed chlorophyll may represent the most cost-effective strategy for raising human tissue levels of phytanic acid...
  30. ncbi Androgenic progestins amplify the breast cancer risk associated with hormone replacement therapy by boosting IGF-I activity
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 56:213-6. 2001
    ....
  31. ncbi Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantethine
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 56:314-7. 2001
    ..As a safe and effective compound of natural origin, pantethine merits broader use in the management of hyperlipidemias...
  32. ncbi Hepatothermic therapy of obesity: rationale and an inventory of resources
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 57:324-36. 2001
    ..Initial clinical efforts to evaluate the potential of HT are now in progress...
  33. ncbi Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 75:141-7. 2010
    ....
  34. ncbi PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:535-42. 2003
    ....
  35. ncbi High-dose biotin may down-regulate hepatic expression of acute phase reactants by mimicking the physiological role of nitric oxide
    M F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:417-8. 2003
    ..If this effect is mediated by cGMP, then high-dose biotin--which can directly activate guanylyl cyclase--may have the potential to suppress hepatic production of acute phase proteins...
  36. ncbi Does regular ethanol consumption promote insulin sensitivity and leanness by stimulating AMP-activated protein kinase?
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 57:405-7. 2001
    ....
  37. ncbi Policosanol safely down-regulates HMG-CoA reductase - potential as a component of the Esselstyn regimen
    M F McCarty
    Pantox Laboratories, San Diego 92109, USA
    Med Hypotheses 59:268-79. 2002
    ....
  38. ncbi Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 56:8-11. 2001
    ..Preparation of these compounds from crucifera seeds or sprouts should enable commercial production of supplements that would protect the livers of social drinkers while concurrently reducing risk for carcinogen-induced cancers...
  39. ncbi Modulation of adipocyte lipoprotein lipase expression as a strategy for preventing or treating visceral obesity
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 57:192-200. 2001
    ....
  40. ncbi Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease
    Mark F McCarty
    NutriGuard Research, Encinitas CA 92024, USA
    Med Hypotheses 74:1055-8. 2010
    ....
  41. ncbi IGF-I activity may be a key determinant of stroke risk--a cautionary lesson for vegans
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:323-34. 2003
    ..Nonetheless, vegans have the potential to achieve a truly exceptional 'healthspan' if they face this problem forthrightly by restricting salt intake and taking other practical measures that promote cerebrovascular health...
  42. ncbi Insulin secretion as a determinant of pancreatic cancer risk
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 57:146-50. 2001
    ....
  43. ncbi Mortality from Western cancers rose dramatically among African-Americans during the 20th century: are dietary animal products to blame?
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 57:169-74. 2001
    ....
  44. ncbi Up-regulation of hepatic IGFBP-1 production as a strategy for preventing benign prostatic hyperplasia
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 56:1-4. 2001
    ..A clinical impression that BPH is becoming more common in Japan, and evidence that Japanese making frequent use of meat and dairy products are at increased risk for this disorder, also appear consistent with this view...
  45. ncbi Turning an 'Achilles' Heel' into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:509-11. 2003
    ..Thus, it can be anticipated that many tumors which evolve relative resistance to angiostatic therapy will be selectively susceptible to attack by the iron-loading/artemisinin strategy...
  46. ncbi Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, 811 B Nahant Ct, San Diego, CA 92024, USA
    Med Hypotheses 75:276-81. 2010
    ..Appropriate rodent studies should pave the way for clinical trials with salsalate in patients at vascular risk...
  47. ncbi Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 69:1367-70. 2007
    ..The impact of supplemental gamma-tocopherol on compromised endothelium-dependent vasodilation in various disorders merits examination...
  48. ncbi AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1211-5. 2005
    ..More generally, metformin - or, preferably, better tolerated activators of AMPK - may have considerable potential for promoting vascular health in the large proportion of the adult population afflicted with insulin resistance syndrome...
  49. ncbi Up-regulatory impact of boron on vitamin D function -- does it reflect inhibition of 24-hydroxylase?
    Dusan Miljkovic
    FutureCeuticals Inc, 5080 Shoreham Plaza, San Diego, CA 92122, USA
    Med Hypotheses 63:1054-6. 2004
    ....
  50. ncbi Supplemental arginine and high-dose folate may promote bone health by supporting the activity of endothelial-type nitric oxide synthase in bone
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 64:1030-3. 2005
    ..These considerations suggest that supplementation with arginine as well as high-dose folate might aid maintenance of bone density by helping to preserve optimal NO synthase activity in bone cells...
  51. ncbi The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:394-8. 2005
    ..Thus, a taurine supplemented low-fat vegan diet may be recommended as a strategy for minimizing AGE-mediated complications in diabetics and in patients with renal failure...
  52. ncbi Nutraceutical resources for diabetes prevention--an update
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:151-8. 2005
    ..Nutraceuticals featuring meaningful doses of combinations of these agents would likely have substantial diabetes-preventive efficacy, and presumably could be marketed legally as aids to good glucose tolerance and insulin sensitivity...
  53. ncbi A paradox resolved: the postprandial model of insulin resistance explains why gynoid adiposity appears to be protective
    Mark F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 61:173-6. 2003
    ..The ability of the postprandial model of insulin resistance to rationalize the seeming protection afforded by gynoid obesity constitutes evidence that this model has validity...
  54. ncbi Prospects for glycerol-rescued hypoglycemia as a cancer therapy
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 56:286-9. 2001
    ..Further research along these lines may enable glycerol-rescued hypoglycemia to become a feasible cancer therapy that has particular value as a complement to antiangiogenic measures...
  55. ncbi Concurrent administration of sustained-release bezafibrate may counteract the increased thrombotic risk associated with oral estrogen therapy
    M F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 57:216-20. 2001
    ..These predictions require confirmation in controlled clinical studies. Certain natural hypolipidemic agents may also have potential as adjuvants to oral estrogen, but their effects on hemostasis require further investigation...
  56. ncbi Versatile cytoprotective activity of lipoic acid may reflect its ability to activate signalling intermediates that trigger the heat-shock and phase II responses
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 57:313-7. 2001
    ..This model also predicts that LA should have anticarcinogenic activity...
  57. ncbi Does a vegan diet reduce risk for Parkinson's disease?
    M F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 57:318-23. 2001
    ..Vegan diets could also be helpful to PD patients by promoting vascular health and aiding blood-brain barrier transport of L-dopa...
  58. ncbi Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:1027-9. 2005
    ..Thus, it is postulated that MBG mediates the impact of salt loading on renal calcium retention...
  59. ncbi Chromium picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance
    Mark F McCarty
    NutriGuard Research, 1054 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1220-4. 2005
    ..The impact of chromium picolinate on smoking- or nicotine-induced insulin resistance merits study...
  60. ncbi Adjuvant strategies for prevention of glomerulosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 67:1277-96. 2006
    ..Most of these measures may likewise reduce risk for left ventricular hypertrophy in hypertensives, inasmuch as the signaling mechanisms which mediate this disorder appear similar to those involved in glomerulosclerosis...
  61. ncbi Potential utility of natural polyphenols for reversing fat-induced insulin resistance
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 64:628-35. 2005
    ....
  62. ncbi AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 63:328-33. 2004
    ..Although the impact of metformin on plasma IL-6 levels has not been reported, the possibility that AMPK activation could influence adipocyte secretion of this cytokine also merits scrutiny...
  63. ncbi Supplementary taurine may stabilize atheromatous plaque by antagonizing the activation of metalloproteinases by hypochlorous acid
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe St, San Diego, CA 92109, USA
    Med Hypotheses 63:414-8. 2004
    ....
  64. ncbi A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process
    Mark F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 60:784-92. 2003
    ....
  65. ncbi Insulin's stimulation of endothelial superoxide generation may reflect up-regulation of isoprenyl transferase activity that promotes rac translocation
    Mark F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 58:472-5. 2002
    ..The resulting imbalance of endothelial nitric oxide and superoxide production may be responsible for much of the excess vascular risk associated with this syndrome...
  66. ncbi Targeting multiple signaling pathways as a strategy for managing prostate cancer: multifocal signal modulation therapy
    Mark F McCarty
    NutriGuard Research, Encinitas, California 92024, USA
    Integr Cancer Ther 3:349-80. 2004
    ..When MSMTs fail to raise the spontaneous apoptosis rate sufficiently to achieve tumor stasis or regression, incorporation of appropriate cytotoxic agents into the regimen may improve the clinical outcome...
  67. ncbi Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:1022-6. 2005
    ....
  68. ncbi Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1015-21. 2005
    ..Whether these nutritional measures do indeed influence LVH risk could be examined in prospective studies targeting patients at high risk, such as hypertensives...
  69. ncbi Chronic activation of AMP-activated kinase as a strategy for slowing aging
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:334-9. 2004
    ....
  70. ncbi Does bitter melon contain an activator of AMP-activated kinase?
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 63:340-3. 2004
    ....
  71. ncbi Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist
    Mark F McCarty
    Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA
    Med Hypotheses 64:619-27. 2005
    ..These considerations, however, should not detract from efforts to better inform the public regarding the strong desirability of choosing whole grain products in preference to refined grains...
  72. ncbi Clinical potential of Spirulina as a source of phycocyanobilin
    Mark F McCarty
    NutriGuard Research, Encinitas, CA 92024, USA
    J Med Food 10:566-70. 2007
    ..Such a regimen should be evaluated in clinical syndromes characterized and in part mediated by NADPH oxidase overactivity in affected tissues...
  73. ncbi Dietary saturate/unsaturate ratio as a determinant of adiposity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, United States
    Med Hypotheses 75:14-6. 2010
    ....
  74. ncbi Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:385-7. 2005
    ..These considerations suggest that it may be possible to achieve worthwhile reductions in CRP by avoiding high-insulin-response starchy foods and by ingesting more soluble fiber, in foods or as a meal-time supplement...
  75. ncbi Oster rediscovered--mega-dose folate for symptomatic atherosclerosis
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, United States
    Med Hypotheses 69:325-32. 2007
    ..In light of these new findings, a properly controlled assessment of Oster's mega-dose folate therapy is warranted...
  76. ncbi High mitochondrial redox potential may promote induction and activation of UCP2 in hepatocytes during hepatothermic therapy
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:1216-9. 2005
    ..Under these conditions, high mitochondrial redox potential would be expected, and induction of UCP2's uncoupling activity would represent a homeostatically appropriate antioxidant response...
  77. ncbi Estrogen agonists/antagonists may down-regulate growth hormone signaling in hepatocytes--an explanation for their impact on IGF-I, IGFBP-1, and lipoprotein(a)
    Mark F McCarty
    Pantox Laboratories, San Diego, CA 92109, USA
    Med Hypotheses 61:335-9. 2003
    ..Preliminary evidence suggests that flax lignans and perhaps other phytoestrogens may have potential in this regard...
  78. ncbi Favorable impact of a vegan diet with exercise on hemorheology: implications for control of diabetic neuropathy
    Mark F McCarty
    Pantox Laboratories, San Diego, California 92109, USA
    Med Hypotheses 58:476-86. 2002
    ..The vegan diet/exercise strategy represents a safe, 'low-tech' approach to managing diabetes that deserves far greater attention from medical researchers and practitioners...
  79. ncbi An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:636-45. 2005
    ....
  80. ncbi Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:399-407. 2005
    ..Phytanic acid, a branched-chain fatty acid found in omnivore diets, can also activate PPARdelta, and thus should be examined with respect to its impact on mitochondrial biogenesis and insulin sensitivity...
  81. ncbi Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Avenue, Encinitas, CA 92024, USA
    Med Hypotheses 64:380-4. 2005
    ..Future prospective epidemiology should assess whether the estimated acid-base balance of habitual diets - calculated from the ratio of dietary protein and potassium - correlates with risk for insulin resistance syndrome and diabetes...
  82. ncbi Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis
    Mark F McCarty
    Pantox Laboratories, California 92109, USA
    Med Hypotheses 58:491-5. 2002
    ....
  83. ncbi De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome
    Mark F McCarty
    NutriGuard Research, 1051 Hermes Ave, Encinitas, CA 92024, USA
    Med Hypotheses 64:388-93. 2005
    ..g., metformin), which can be expected to lessen tissue DAG synthesis...
  84. ncbi High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Road, San Marcos, CA 92078, USA
    Med Hypotheses 69:12-9. 2007
    ..As a complement to the proven benefits of low-dose aspirin, a supplemental regimen emphasizing these nutrients in appropriate doses may act directly on platelets to further diminish risk for thrombotic episodes...
  85. ncbi Rationale for a novel nutraceutical complex 'K-water': potassium taurine bicarbonate (PTB)
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 67:65-70. 2006
    ....
  86. ncbi Insulin and IGF-I as determinants of low "Western" cancer rates in the rural third world
    Mark F McCarty
    Int J Epidemiol 33:908-10. 2004
  87. ncbi Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 70:170-81. 2008
    ....
  88. ncbi ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 69:974-94. 2007
    ..Phycobilins, algal biliverdin metabolites that are good substrates for biliverdin reductase, may prove to have clinical antioxidant potential comparable to that of bilirubin...
  89. ncbi PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation
    Mark F McCarty
    Oasis of Hope Hospital, Tijuana, Mexico
    Med Hypotheses 70:419-23. 2008
    ....
  90. ncbi Neuroprotective potential of the Bahadori leanness program: a "mini-fast with exercise" strategy
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 68:935-40. 2007
    ..Thus, it is conceivable that BLP will provide a range of health benefits extending beyond those attributable to its favorable impact on body composition...
  91. ncbi Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 67:251-69. 2006
    ..To achieve optimal clinical outcomes, regimens which down-regulate microglial activation could be used in conjunction with complementary measures which address other aspects of excitotoxicity...
  92. ncbi Induction of heat shock proteins may combat insulin resistance
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 66:527-34. 2006
    ..The possible complementarity of bimoclomol and lipoic acid for heat shock protein induction should be assessed, and further efforts to identify well-tolerated agents active in this regard are warranted...
  93. ncbi PKC-mediated modulation of L-type calcium channels may contribute to fat-induced insulin resistance
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, USA
    Med Hypotheses 66:824-31. 2006
    ..A report that chromium picolinate can induce the plasmalemmal Ca2+-ATPase in smooth muscle cells, raises the possibility that modulation of calcium transport might play a role in the insulin-sensitizing efficacy of bioactive chromium...
  94. ncbi Vitamin D, parathyroid hormone, and insulin sensitivity
    Mark F McCarty
    Am J Clin Nutr 80:1451-2; author reply 1452-3. 2004
  95. ncbi Vitamin D status and muscle strength
    Mark F McCarty
    Am J Clin Nutr 76:1454-5; author reply 1455-6. 2002
  96. ncbi Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides
    Mark F McCarty
    Natural Alternatives International, 1185 Linda Vista Dr, San Marcos, CA 92078, United States
    Med Hypotheses 67:682-97. 2006
    ..The impact of these measures on Abeta production in rodent models of AD should be evaluated, with the intent of defining practical strategies for AD prevention...