Steve J Pandol

Summary

Country: USA

Publications

  1. pmc Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharides
    Christopher E Savard
    Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington, USA
    BMC Gastroenterol 2:23. 2002
  2. ncbi request reprint Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin
    Stephen J Pandol
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, California 90073, USA
    Pancreas 27:297-300. 2003
  3. ncbi request reprint Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon
    Akihiko Satoh
    VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006
  4. doi request reprint Integrated response to a meal
    Stephen J Pandol
    Department of Veterans Affairs, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    JPEN J Parenter Enteral Nutr 32:564-6. 2008
  5. ncbi request reprint Acute pancreatitis
    Stephen J Pandol
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Opin Gastroenterol 21:538-43. 2005
  6. ncbi request reprint Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper
    Steve J Pandol
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Gastroenterol Hepatol 21:S109-10. 2006
  7. ncbi request reprint Acute pancreatitis
    Stephen J Pandol
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258 Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Opin Gastroenterol 22:481-6. 2006
  8. pmc Are we studying the correct state of the stellate cell to elucidate mechanisms of chronic pancreatitis?
    S J Pandol
    UCLA Department of Medicine, West Los Angeles VAGLAHS, 11301 Wilshire Blvd, Building 258, Room 340, Los Angeles, CA 90073, USA
    Gut 54:744-5. 2005
  9. ncbi request reprint A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
  10. ncbi request reprint Curcumin ameliorates ethanol and nonethanol experimental pancreatitis
    Ilya Gukovsky
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
    Am J Physiol Gastrointest Liver Physiol 284:G85-95. 2003

Collaborators

Detail Information

Publications43

  1. pmc Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharides
    Christopher E Savard
    Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington, USA
    BMC Gastroenterol 2:23. 2002
    ..The synthesis and secretion of the tumor necrosis factor-alpha (TNF-alpha) protein by these cells was also measured...
  2. ncbi request reprint Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin
    Stephen J Pandol
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, California 90073, USA
    Pancreas 27:297-300. 2003
    ....
  3. ncbi request reprint Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilon
    Akihiko Satoh
    VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006
    ..These results suggest that ethanol enhances the CCK-8-induced NF-kappaB activation at least in part through its effects on PKC-epsilon...
  4. doi request reprint Integrated response to a meal
    Stephen J Pandol
    Department of Veterans Affairs, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    JPEN J Parenter Enteral Nutr 32:564-6. 2008
    ..The overall result of the integrated response is assimilation of nutrients and elimination of wastes from the GI tract...
  5. ncbi request reprint Acute pancreatitis
    Stephen J Pandol
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Curr Opin Gastroenterol 21:538-43. 2005
    ....
  6. ncbi request reprint Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper
    Steve J Pandol
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    J Gastroenterol Hepatol 21:S109-10. 2006
  7. ncbi request reprint Acute pancreatitis
    Stephen J Pandol
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258 Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Opin Gastroenterol 22:481-6. 2006
    ..This review presents advances in our understanding of the pathobiologic responses of acute pancreatitis from studies using animal models of experimental pancreatitis as well as results of key clinical trials and observations...
  8. pmc Are we studying the correct state of the stellate cell to elucidate mechanisms of chronic pancreatitis?
    S J Pandol
    UCLA Department of Medicine, West Los Angeles VAGLAHS, 11301 Wilshire Blvd, Building 258, Room 340, Los Angeles, CA 90073, USA
    Gut 54:744-5. 2005
  9. ncbi request reprint A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
    ..The results indicate that alcohol impairs recovery from acute pancreatitis, suggesting a mechanism by which alcohol sensitizes pancreas to chronic injury...
  10. ncbi request reprint Curcumin ameliorates ethanol and nonethanol experimental pancreatitis
    Ilya Gukovsky
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
    Am J Physiol Gastrointest Liver Physiol 284:G85-95. 2003
    ..They suggest that curcumin, which is currently in clinical trials for cancer prevention, may be useful for treatment of pancreatitis...
  11. ncbi request reprint Alcohol and pancreatic cancer
    Vay Liang W Go
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Alcohol 35:205-11. 2005
    ....
  12. ncbi request reprint Pathobiology of alcoholic pancreatitis
    Stephen J Pandol
    Department of Medicine, University of California, Department of Veterans Affairs, Los Angeles, California, USA
    Pancreatology 7:105-14. 2007
    ....
  13. ncbi request reprint Acute pancreatitis: bench to the bedside
    Stephen J Pandol
    Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
    Gastroenterology 132:1127-51. 2007
  14. ncbi request reprint Signal transduction in alcohol-related diseases
    Minoti V Apte
    Pancreatic Research Group, The University of New South Wales, Sydney, Australia
    Alcohol Clin Exp Res 29:1299-1309. 2005
  15. pmc Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice
    Aurelia Lugea
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
    Gastroenterology 131:885-99. 2006
    ..To understand better the role of plg in pancreas recovery following injury, we examined the course of cerulein-induced pancreatitis in plg-deficient and -sufficient mice...
  16. ncbi request reprint Cell death in pancreatitis: caspases protect from necrotizing pancreatitis
    Olga A Mareninova
    Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90073, USA
    J Biol Chem 281:3370-81. 2006
    ..Manipulating these signals to change the pattern of death responses presents a therapeutic strategy for treatment of pancreatitis...
  17. ncbi request reprint Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
    J Biol Chem 277:22595-604. 2002
    ..Protection against necrosis and trypsin activation by caspases can explain why the severity of pancreatitis in experimental models correlates inversely with the extent of apoptosis...
  18. ncbi request reprint Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 122:974-84. 2002
    ..Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation...
  19. ncbi request reprint Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis
    Michael Beil
    Department of Internal Medicine I, University of Ulm, 89070 Ulm, Germany
    Am J Physiol Gastrointest Liver Physiol 282:G450-60. 2002
    ..Thus we propose that the caspase 8-mediated degradation of plectin represents a critical biochemical event during CCK-induced secretory blockade and cell injury...
  20. ncbi request reprint Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles 90073, California, USA
    Gastroenterology 122:106-18. 2002
    ....
  21. ncbi request reprint Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2
    Akihiko Satoh
    Veterans Affairs Greater Los Angeles Health Care System and University of California, 90073, USA
    Gastroenterology 129:639-51. 2005
    ..We investigated the role for tumor necrosis factor alpha in cytoskeletal responses and the underlying signaling mechanisms in pancreatic acinar cells...
  22. ncbi request reprint Substance P mediates cerulein-induced pancreatic microcirculatory dysfunction in mice
    Yoshiya Ito
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724 5044, USA
    Pancreas 34:138-43. 2007
    ..The present study was conducted to examine the contribution of substance P to the pancreatic microcirculatory dysfunction during acute pancreatitis...
  23. ncbi request reprint Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis
    Patrick P L Lam
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Traffic 8:605-17. 2007
    ....
  24. doi request reprint Pancreatitis and calcium signalling: report of an international workshop
    Robert Sutton
    Division of Surgery and Oncology, MRC Group, University of Liverpool, Liverpool, UK
    Pancreas 36:e1-14. 2008
    ..The publication of these proceedings is intended to provide a platform for enhancing research and therapeutic development for acute pancreatitis...
  25. ncbi request reprint Long-term ethanol consumption alters pancreatic gene expression in rats: a possible connection to pancreatic injury
    Constanze H Kubisch
    Department of Cancer Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77230 1429, USA
    Pancreas 33:68-76. 2006
    ..The mechanisms responsible for this sensitization are unknown. To determine whether alterations in pancreatic gene expression might participate in ethanol-mediated sensitization, we performed gene-profiling analysis...
  26. ncbi request reprint Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells
    Ilya Gukovsky
    Department of Medicine, VA Greater Los Angeles Healthcare Sysytem and University of California, Los Angeles, 90073, USA
    Gastroenterology 126:554-66. 2004
    ..We here report that these responses are regulated by phosphatidylinositide 3-kinase (PI3K) gamma...
  27. ncbi request reprint Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas
    Aurelia Lugea
    University of Southern California University of California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
    Gastroenterology 125:1845-59. 2003
    ..The mechanisms involved in ethanol-induced pancreas fibrosis are poorly understood. Here we show that fatty acid ethyl esters (FAEEs), nonoxidative ethanol metabolites, increase extracellular matrix (ECM) protein levels in pancreas...
  28. ncbi request reprint Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathways
    Anna S Gukovskaya
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 286:G204-13. 2004
    ..These effects may play a role in the ability of ethanol to sensitize pancreas to the inflammatory response and pancreatitis...
  29. doi request reprint A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats
    Zoltan Rakonczay
    First Department of Medicine, University of Szeged, Szeged, Hungary
    Crit Care Med 36:2117-27. 2008
    ..We therefore set out to determine whether metabolites of L-arginine (L-ornithine, L-citrulline, and nitric oxide) cause pancreatitis...
  30. pmc The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells
    Edwin C Thrower
    Department of Internal Medicine, Section of Digestive Diseases, Veterans Affairs Connecticut Healthcare of West Haven, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1344-53. 2008
    ..These results indicate that PKC-delta and -epsilon isoforms translocate to specific acinar cell compartments and modulate zymogen activation...
  31. pmc Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells
    Richard Hu
    Department of Veterans Affairs University of California, Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, Calif 90073, USA
    Pancreatology 7:332-40. 2007
    ..The aims of this study were to determine the presence and role of the NADPH oxidase system in mediating alcohol effects on PaSCs with specific emphasis on proliferation...
  32. ncbi request reprint Role of S-adenosylmethionine in two experimental models of pancreatitis
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
    FASEB J 17:56-8. 2003
    ..Third, in contrast to the situation in the liver, where absence of MAT1A and decreased hepatic SAM level can lead to spontaneous tissue injury, in the pancreas the roles of SAM and MAT1A appear more complex and remain to be defined...
  33. pmc The pancreatic stellate cell: a star on the rise in pancreatic diseases
    M Bishr Omary
    Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Clin Invest 117:50-9. 2007
    ..Therefore, understanding the biology of PaSCs offers potential therapeutic targets for the treatment and prevention of these diseases...
  34. ncbi request reprint Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models
    Stephen J Pandol
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258, Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    J Gastroenterol 38:623-8. 2003
    ..These pathologic processes include inflammation, cell death, intrapancreatic digestive enzyme activation, and fibrosis...
  35. ncbi request reprint Ethanol feeding alters death signaling in the pancreas
    Yan Ling Wang
    USC UCLA Research Center for Alcohol Liver and Pancreatic Diseases, University of California, Los Angeles, USA
    Pancreas 32:351-9. 2006
    ..Alcohol abuse is a major cause of pancreatitis, which is associated with death of parenchymal cells. The goal of this study was to explore the effects of ethanol on cell death pathways in the pancreas...
  36. ncbi request reprint PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells
    Akihiko Satoh
    Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 287:G582-91. 2004
    ..These findings suggest a key role for the novel PKCs in pancreatitis...
  37. ncbi request reprint Cell death in pancreatitis: effects of alcohol
    Anna S Gukovskaya
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Gastroenterol Hepatol 21:S10-3. 2006
    ..This paper reviews the signaling pathways mediating the balance between apoptosis and necrosis in acute pancreatitis, and alcohol's effects on cell death responses in pancreatitis...
  38. ncbi request reprint Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis
    E Vaquero
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 280:G1197-208. 2001
    ..Correlation between localized NF-kappaB activation, cytokine upregulation, and tissue damage suggests a key role for NF-kappaB in the development of the inflammatory response of acute pancreatitis...
  39. pmc Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis
    A S Gukovskaya
    Department of Veterans Affairs Medical Center, West Los Angeles, California 90073, USA
    J Clin Invest 100:1853-62. 1997
    ..The results indicate that pancreatic acinar cells produce, release, and respond to TNFalpha. This cytokine regulates apoptosis in both isolated pancreatic acini and experimental pancreatitis...
  40. ncbi request reprint Cell death pathways in pancreatitis and pancreatic cancer
    Anna S Gukovskaya
    VA Greater Los Angeles Health Care System and University of California, Los Angeles, CA 90073, USA
    Pancreatology 4:567-86. 2004
    ....
  41. ncbi request reprint Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis
    Michelle Mouria
    Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, CA 90073, USA
    Int J Cancer 98:761-9. 2002
    ..The results suggest that food-derived polyphenols inhibit pancreatic cancer growth and prevent metastasis by inducing mitochondrial dysfunction, resulting in cytochrome c release, caspase activation and apoptosis...
  42. pmc Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells
    Mouad Edderkaoui
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, CA 90073, California, United States
    World J Gastroenterol 14:3672-80. 2008
    ..To determine the effect of ellagic acid on apoptosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid...
  43. ncbi request reprint Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid
    Peter Buchler
    Department of Surgery, UCLA School of Medicine, University of California and Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095 6904, USA
    Pancreas 26:264-73. 2003
    ..The critical need for novel therapeutic approaches to pancreatic cancer treatment is clear. Genistein, a naturally occurring isoflavonoid, is active against certain solid malignancies, but its effect on pancreatic cancer is unknown...