Research Topics
Species | Steve J PandolSummaryCountry: USA Publications
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Publications
Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharidesChristopher E Savard
Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington, USA
BMC Gastroenterol 2:23. 2002..The synthesis and secretion of the tumor necrosis factor-alpha (TNF-alpha) protein by these cells was also measured...- Animal and in vitro models of alcoholic pancreatitis: role of cholecystokininStephen J Pandol
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, California 90073, USA
Pancreas 27:297-300. 2003.... - Ethanol sensitizes NF-kappaB activation in pancreatic acinar cells through effects on protein kinase C-epsilonAkihiko Satoh
VA Greater L A Healthcare System, West L A Healthcare Center, Bldg 258, RM 340, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 291:G432-8. 2006..These results suggest that ethanol enhances the CCK-8-induced NF-kappaB activation at least in part through its effects on PKC-epsilon... - Integrated response to a mealStephen J Pandol
Department of Veterans Affairs, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
JPEN J Parenter Enteral Nutr 32:564-6. 2008..The overall result of the integrated response is assimilation of nutrients and elimination of wastes from the GI tract... - Acute pancreatitisStephen J Pandol
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Curr Opin Gastroenterol 21:538-43. 2005.... - Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paperSteve J Pandol
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
J Gastroenterol Hepatol 21:S109-10. 2006 - Acute pancreatitisStephen J Pandol
VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258 Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Opin Gastroenterol 22:481-6. 2006..This review presents advances in our understanding of the pathobiologic responses of acute pancreatitis from studies using animal models of experimental pancreatitis as well as results of key clinical trials and observations... - Are we studying the correct state of the stellate cell to elucidate mechanisms of chronic pancreatitis?S J Pandol
UCLA Department of Medicine, West Los Angeles VAGLAHS, 11301 Wilshire Blvd, Building 258, Room 340, Los Angeles, CA 90073, USA
Gut 54:744-5. 2005 - A rat model reproducing key pathological responses of alcoholic chronic pancreatitisIlya Gukovsky
UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008..The results indicate that alcohol impairs recovery from acute pancreatitis, suggesting a mechanism by which alcohol sensitizes pancreas to chronic injury... - Curcumin ameliorates ethanol and nonethanol experimental pancreatitisIlya Gukovsky
Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
Am J Physiol Gastrointest Liver Physiol 284:G85-95. 2003..They suggest that curcumin, which is currently in clinical trials for cancer prevention, may be useful for treatment of pancreatitis... - Alcohol and pancreatic cancerVay Liang W Go
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Alcohol 35:205-11. 2005.... - Pathobiology of alcoholic pancreatitisStephen J Pandol
Department of Medicine, University of California, Department of Veterans Affairs, Los Angeles, California, USA
Pancreatology 7:105-14. 2007.... - Acute pancreatitis: bench to the bedsideStephen J Pandol
Department of Medicine, Department of Veterans Affairs and University of California, Los Angeles, California, USA
Gastroenterology 132:1127-51. 2007 - Signal transduction in alcohol-related diseasesMinoti V Apte
Pancreatic Research Group, The University of New South Wales, Sydney, Australia
Alcohol Clin Exp Res 29:1299-1309. 2005 - Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient miceAurelia Lugea
USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
Gastroenterology 131:885-99. 2006..To understand better the role of plg in pancreas recovery following injury, we examined the course of cerulein-induced pancreatitis in plg-deficient and -sufficient mice... - Cell death in pancreatitis: caspases protect from necrotizing pancreatitisOlga A Mareninova
Veterans Affairs Greater Los Angeles Healthcare System and Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90073, USA
J Biol Chem 281:3370-81. 2006..Manipulating these signals to change the pattern of death responses presents a therapeutic strategy for treatment of pancreatitis... - Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitisAnna S Gukovskaya
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and the UCLA, Los Angeles, California 90073, USA
J Biol Chem 277:22595-604. 2002..Protection against necrosis and trypsin activation by caspases can explain why the severity of pancreatitis in experimental models correlates inversely with the extent of apoptosis... - Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitisAnna S Gukovskaya
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Gastroenterology 122:974-84. 2002..Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation... - Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitisMichael Beil
Department of Internal Medicine I, University of Ulm, 89070 Ulm, Germany
Am J Physiol Gastrointest Liver Physiol 282:G450-60. 2002..Thus we propose that the caspase 8-mediated degradation of plectin represents a critical biochemical event during CCK-induced secretory blockade and cell injury... - Ethanol metabolism and transcription factor activation in pancreatic acinar cells in ratsAnna S Gukovskaya
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles 90073, California, USA
Gastroenterology 122:106-18. 2002.... - Tumor necrosis factor-alpha mediates pancreatitis responses in acinar cells via protein kinase C and proline-rich tyrosine kinase 2Akihiko Satoh
Veterans Affairs Greater Los Angeles Health Care System and University of California, 90073, USA
Gastroenterology 129:639-51. 2005..The results provide insights into the mechanisms in pancreatic acinar cells that link tumor necrosis factor alpha to critical processes in acute pancreatitis... - Substance P mediates cerulein-induced pancreatic microcirculatory dysfunction in miceYoshiya Ito
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724 5044, USA
Pancreas 34:138-43. 2007..The present study was conducted to examine the contribution of substance P to the pancreatic microcirculatory dysfunction during acute pancreatitis... - Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitisPatrick P L Lam
Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Traffic 8:605-17. 2007.... - Pancreatitis and calcium signalling: report of an international workshopRobert Sutton
Division of Surgery and Oncology, MRC Group, University of Liverpool, Liverpool, UK
Pancreas 36:e1-14. 2008..The publication of these proceedings is intended to provide a platform for enhancing research and therapeutic development for acute pancreatitis... - Long-term ethanol consumption alters pancreatic gene expression in rats: a possible connection to pancreatic injuryConstanze H Kubisch
Department of Cancer Biology, MD Anderson Cancer Center, University of Texas, Houston, TX 77230-1429, USA
Pancreas 33:68-76. 2006..The identified genes may help explain the relationship between long-term ethanol abuse and pancreatic disease and lead to possible preventative or therapeutic approaches to ethanol-induced pancreatic disease... - Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cellsIlya Gukovsky
Department of Medicine, VA Greater Los Angeles Healthcare Sysytem and University of California, Los Angeles, 90073, USA
Gastroenterology 126:554-66. 2004..We here report that these responses are regulated by phosphatidylinositide 3-kinase (PI3K) gamma... - Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreasAurelia Lugea
University of Southern California University of California Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
Gastroenterology 125:1845-59. 2003..The mechanisms involved in ethanol-induced pancreas fibrosis are poorly understood. Here we show that fatty acid ethyl esters (FAEEs), nonoxidative ethanol metabolites, increase extracellular matrix (ECM) protein levels in pancreas... - Ethanol differentially regulates NF-kappaB activation in pancreatic acinar cells through calcium and protein kinase C pathwaysAnna S Gukovskaya
UCLA VA Greater Los Angeles Healthcare System, West Los Angeles Center, Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 286:G204-13. 2004..These effects may play a role in the ability of ethanol to sensitize pancreas to the inflammatory response and pancreatitis... - A new severe acute necrotizing pancreatitis model induced by L-ornithine in ratsZoltan Rakonczay
First Department of Medicine, University of Szeged, Szeged, Hungary
Crit Care Med 36:2117-27. 2008..We therefore set out to determine whether metabolites of L-arginine (L-ornithine, L-citrulline, and nitric oxide) cause pancreatitis... - The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cellsEdwin C Thrower
Department of Internal Medicine, Section of Digestive Diseases, Veterans Affairs Connecticut Healthcare of West Haven, West Haven, CT 06516, USA
Am J Physiol Gastrointest Liver Physiol 294:G1344-53. 2008..These results indicate that PKC-delta and -epsilon isoforms translocate to specific acinar cell compartments and modulate zymogen activation... - Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cellsRichard Hu
Department of Veterans Affairs University of California, Los Angeles Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, Calif 90073, USA
Pancreatology 7:332-40. 2007..The aims of this study were to determine the presence and role of the NADPH oxidase system in mediating alcohol effects on PaSCs with specific emphasis on proliferation... - Role of S-adenosylmethionine in two experimental models of pancreatitisShelly C Lu
Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
FASEB J 17:56-8. 2003..Third, in contrast to the situation in the liver, where absence of MAT1A and decreased hepatic SAM level can lead to spontaneous tissue injury, in the pancreas the roles of SAM and MAT1A appear more complex and remain to be defined... - The pancreatic stellate cell: a star on the rise in pancreatic diseasesM Bishr Omary
Department of Medicine, VA Palo Alto Health Care System, Palo Alto, California 94304, USA
J Clin Invest 117:50-9. 2007..Therefore, understanding the biology of PaSCs offers potential therapeutic targets for the treatment and prevention of these diseases... - Emerging concepts for the mechanism of alcoholic pancreatitis from experimental modelsStephen J Pandol
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258, Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
J Gastroenterol 38:623-8. 2003..These pathologic processes include inflammation, cell death, intrapancreatic digestive enzyme activation, and fibrosis... - Ethanol feeding alters death signaling in the pancreasYan-Ling Wang
USC-UCLA Research Center for Alcohol Liver and Pancreatic Diseases, University of California, Los Angeles, USA
Pancreas 32:351-9. 2006..The decrease in caspase expression and increase in cathepsin B expression indicate that ethanol feeding may prevent apoptosis and promote necrosis of pancreatic tissue with stresses that cause pancreatitis... - PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cellsAkihiko Satoh
Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 287:G582-91. 2004..These findings suggest a key role for the novel PKCs in pancreatitis... - Cell death in pancreatitis: effects of alcoholAnna S Gukovskaya
Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
J Gastroenterol Hepatol 21:S10-3. 2006..This paper reviews the signaling pathways mediating the balance between apoptosis and necrosis in acute pancreatitis, and alcohol's effects on cell death responses in pancreatitis... - Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitisE Vaquero
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 280:G1197-208. 2001..Correlation between localized NF-kappaB activation, cytokine upregulation, and tissue damage suggests a key role for NF-kappaB in the development of the inflammatory response of acute pancreatitis... - Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitisA S Gukovskaya
Department of Veterans Affairs Medical Center, West Los Angeles, California 90073, USA
J Clin Invest 100:1853-62. 1997..The results indicate that pancreatic acinar cells produce, release, and respond to TNFalpha. This cytokine regulates apoptosis in both isolated pancreatic acini and experimental pancreatitis... - Cell death pathways in pancreatitis and pancreatic cancerAnna S Gukovskaya
VA Greater Los Angeles Health Care System and University of California, Los Angeles, CA 90073, USA
Pancreatology 4:567-86. 2004.... - Food-derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosisMichelle Mouria
Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, CA 90073, USA
Int J Cancer 98:761-9. 2002..The results suggest that food-derived polyphenols inhibit pancreatic cancer growth and prevent metastasis by inducing mitochondrial dysfunction, resulting in cytochrome c release, caspase activation and apoptosis... - Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cellsMouad Edderkaoui
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, CA 90073, California, United States
World J Gastroenterol 14:3672-80. 2008..To determine the effect of ellagic acid on apoptosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid... - Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoidPeter Buchler
Department of Surgery, UCLA School of Medicine, University of California and Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095 6904, USA
Pancreas 26:264-73. 2003..The critical need for novel therapeutic approaches to pancreatic cancer treatment is clear. Genistein, a naturally occurring isoflavonoid, is active against certain solid malignancies, but its effect on pancreatic cancer is unknown...