Bradley Willcox

Summary

Affiliation: Pacific Health Research Institute
Country: USA

Publications

  1. ncbi Linkage disequilibrium of single-nucleotide polymorphism data: how sampling methods affect estimates of linkage disequilibrium
    Qimei He
    Pacific Health Research Institute, 700 Bishop Street, Bishop Tower, Suite 900, Honolulu, Hawaii 96813 USA
    BMC Proc 3:S105. 2009
  2. ncbi FOXO3A genotype is strongly associated with human longevity
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 105:13987-92. 2008
  3. ncbi Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Am J Cardiol 101:75D-86D. 2008
  4. ncbi Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
  5. ncbi Growth-associated proteins and regeneration-induced gene expression in the aging neuron
    Bradley J Willcox
    Gerontology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb 440, Boston, MA 02215, USA
    Mech Ageing Dev 125:513-6. 2004
  6. ncbi Midlife risk factors and healthy survival in men
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    JAMA 296:2343-50. 2006
  7. ncbi C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    Expert Rev Neurother 4:507-18. 2004
  8. ncbi Siblings of Okinawan centenarians share lifelong mortality advantages
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    J Gerontol A Biol Sci Med Sci 61:345-54. 2006
  9. ncbi How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    J Gerontol A Biol Sci Med Sci 59:789-95. 2004
  10. ncbi Are remnant-like particles independent predictors of coronary heart disease incidence? The Honolulu Heart study
    Claudia Imke
    Department of Public Health Sciences and Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arterioscler Thromb Vasc Biol 25:1718-22. 2005

Research Grants

  1. Defining the Healthy Aging Phenotype
    Bradley Willcox; Fiscal Year: 2007
  2. Genetics of Longevity in Okinawan-Japanese Centenarians
    Bradley Willcox; Fiscal Year: 2002
  3. Defining the Genetics of Exceptional Human Survival
    Bradley Willcox; Fiscal Year: 2005
  4. Defining the Healthy Aging Phenotype
    Bradley J Willcox; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. ncbi Linkage disequilibrium of single-nucleotide polymorphism data: how sampling methods affect estimates of linkage disequilibrium
    Qimei He
    Pacific Health Research Institute, 700 Bishop Street, Bishop Tower, Suite 900, Honolulu, Hawaii 96813 USA
    BMC Proc 3:S105. 2009
    ..Therefore it may be more suitable for LD analysis than using independent individuals. We must be cautious when comparing the LD estimates from trios, and those from independent individuals...
  2. ncbi FOXO3A genotype is strongly associated with human longevity
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 105:13987-92. 2008
    ..Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations...
  3. ncbi Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Am J Cardiol 101:75D-86D. 2008
    ..This should help clarify the true potential utility of antioxidants in CVD and may lead to a better understanding of the role of oxidative stress in atherosclerosis...
  4. ncbi Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
    ..This study lends epidemiologic support for phenotypic benefits of CR in humans and is consistent with the well-known literature on animals with regard to CR phenotypes and healthy aging...
  5. ncbi Growth-associated proteins and regeneration-induced gene expression in the aging neuron
    Bradley J Willcox
    Gerontology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb 440, Boston, MA 02215, USA
    Mech Ageing Dev 125:513-6. 2004
    ..However, during regeneration, the aging DRG neuron appears capable of inducing alpha(1)-tubulin, NF-L and GAP-43 as well as the young adult...
  6. ncbi Midlife risk factors and healthy survival in men
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    JAMA 296:2343-50. 2006
    ..Healthy survival has no clear phenotypic definition, and little is known about its attributes, particularly in men...
  7. ncbi C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    Expert Rev Neurother 4:507-18. 2004
    ..New and increasingly available high-sensitivity assays may make C-reactive protein a standard screening tool for cardiovascular disease...
  8. ncbi Siblings of Okinawan centenarians share lifelong mortality advantages
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    J Gerontol A Biol Sci Med Sci 61:345-54. 2006
    ..58-fold likelihood, and male siblings a 5.43-fold likelihood, versus their birth cohorts, of reaching the age of 90 years. These data support a significant familial component to exceptional human longevity...
  9. ncbi How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    J Gerontol A Biol Sci Med Sci 59:789-95. 2004
    ..Thus, we observed trends between low energy intake and reduced risk for all-cause mortality in humans until energy intake fell to less than half the group mean, consistent with previous findings in other species...
  10. ncbi Are remnant-like particles independent predictors of coronary heart disease incidence? The Honolulu Heart study
    Claudia Imke
    Department of Public Health Sciences and Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arterioscler Thromb Vasc Biol 25:1718-22. 2005
    ..This is the first long-term prospective investigation of the relationship between remnant-like particles and a cardiovascular disease outcome in healthy men...
  11. ncbi A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men
    Tanya A Koropatnick
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, Hawaii 96813, USA
    J Gerontol A Biol Sci Med Sci 63:1235-40. 2008
    ..In light of this controversy, we examined the relationship among HDL-C, CETP mutations, and longevity phenotypes in the long-lived Japanese-American men of the Honolulu Heart Program (HHP)...
  12. ncbi First autopsy study of an Okinawan centenarian: absence of many age-related diseases
    Adam M Bernstein
    Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Gerontol A Biol Sci Med Sci 59:1195-9. 2004
    ..Her late-life morbidity pattern is contrasted with that of white centenarians...
  13. ncbi They really are that old: a validation study of centenarian prevalence in Okinawa
    D Craig Willcox
    Department of Human Welfare, Okinawa International University, 2 6 1 Ginowan, Ginowan City, Okinawa, Japan
    J Gerontol A Biol Sci Med Sci 63:338-49. 2008
    ..We conclude that the high reported centenarian prevalence in Okinawa is valid and warrants further study for its genetic and environmental correlates...
  14. ncbi Caloric restriction and human longevity: what can we learn from the Okinawans?
    D Craig Willcox
    College of Nursing, Okinawa Prefectural University, 1 24 1 Yogi, Naha, Okinawa 902 0076, Japan
    Biogerontology 7:173-7. 2006
    ..We review the human studies in the context of a special human population, older Okinawans, who appear to have undergone a mild form of prolonged CR for about half their adult lives...
  15. ncbi The cultural context of "successful aging" among older women weavers in a northern Okinawan village: the role of productive activity
    D Craig Willcox
    College of Nursing, Okinawa Prefectural University, 1 24 1, Yogi, Naha City, Okinawa, 902 0076, Japan
    J Cross Cult Gerontol 22:137-65. 2007
    ..Interestingly, "doing basho" may be considered one means to help achieve successful aging in this particular cultural context...
  16. ncbi Aging gracefully: a retrospective analysis of functional status in Okinawan centenarians
    D Craig Willcox
    College of Nursing, Okinawa Prefectural University, Okinawa, Japan
    Am J Geriatr Psychiatry 15:252-6. 2007
    ..This study retrospectively explored the late-life functional status of Okinawan centenarians...
  17. ncbi Coronary artery calcification and total mortality in elderly men
    Robert D Abbott
    Division of Biostatistics and Epidemiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Geriatr Soc 55:1948-54. 2007
    ..To examine the relationship between coronary artery calcification (CAC) and mortality in a sample of elderly men...
  18. ncbi Coronary artery calcification in Japanese men in Japan and Hawaii
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA 22908 0717, USA
    Am J Epidemiol 166:1280-7. 2007
    ..0 (95% confidence interval: 2.2, 7.4). Further studies are needed to identify factors that protect against atherosclerosis in Japanese men in Japan...
  19. ncbi Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study
    Akira Sekikawa
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 52:417-24. 2008
    ..We sought to examine whether marine-derived n-3 fatty acids are associated with less atherosclerosis in Japanese versus white populations in the U.S...
  20. ncbi Disability and depression: investigating a complex relation using physical performance measures
    Masahiko Yanagita
    Fukui Prefectural University, Fukui, Japan
    Am J Geriatr Psychiatry 14:1060-8. 2006
    ..CONCLUSION: These results demonstrate physical performance measures, particularly gait speed, may be important potential correlates of depression in community-dwelling older men...

Research Grants7

  1. Defining the Healthy Aging Phenotype
    Bradley Willcox; Fiscal Year: 2007
    ..abstract_text> ..
  2. Genetics of Longevity in Okinawan-Japanese Centenarians
    Bradley Willcox; Fiscal Year: 2002
    ..abstract_text> ..
  3. Defining the Genetics of Exceptional Human Survival
    Bradley Willcox; Fiscal Year: 2005
    ..abstract_text> ..
  4. Defining the Healthy Aging Phenotype
    Bradley J Willcox; Fiscal Year: 2010
    ..abstract_text> ..