H Wiley

Summary

Affiliation: Pacific Northwest National Laboratory
Country: USA

Publications

  1. ncbi Receptor downregulation and desensitization enhance the information processing ability of signalling receptors
    Harish Shankaran
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland WA 99352, USA
    BMC Syst Biol 1:48. 2007
  2. ncbi HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells
    Yi Zhang
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99352, USA
    BMC Cell Biol 10:78. 2009
  3. ncbi Regulation of receptor tyrosine kinase signaling by endocytic trafficking
    H S Wiley
    Environmental and Health Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Traffic 2:12-8. 2001
  4. ncbi Computational modeling of the EGF-receptor system: a paradigm for systems biology
    H Steven Wiley
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Trends Cell Biol 13:43-50. 2003
  5. ncbi Should software hold data hostage?
    H Steven Wiley
    Biomolecular Systems Initiative, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Nat Biotechnol 22:1037-8. 2004
  6. ncbi Integrating multiple types of data for signaling research: challenges and opportunities
    H Steven Wiley
    EMSL, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Sci Signal 4:pe9. 2011
  7. ncbi Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques
    G R Holtom
    Pacific North west National Laboratory, PO Box 999, Richland, WA 99352, USA
    Traffic 2:781-8. 2001
  8. ncbi A model of cytokine shedding induced by low doses of gamma radiation
    J H Miller
    Washington State University Tri Cities, Richland, WA 99354, USA
    Radiat Res 163:337-42. 2005

Research Grants

  1. Regulated Ligand Access in Control Receptor Processes
    H Wiley; Fiscal Year: 2004

Collaborators

  • Haluk Resat
  • G R Holtom
  • Harish Shankaran
  • Yi Zhang
  • J H Miller
  • Lee Opresko
  • William B Chrisler
  • S Jin
  • L K Opresko
  • F Zheng

Detail Information

Publications8

  1. ncbi Receptor downregulation and desensitization enhance the information processing ability of signalling receptors
    Harish Shankaran
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland WA 99352, USA
    BMC Syst Biol 1:48. 2007
    ....
  2. ncbi HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells
    Yi Zhang
    Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, WA, 99352, USA
    BMC Cell Biol 10:78. 2009
    ..Using our clone library, we have quantified the receptor activation patterns and systematically tested the validity of the existing hypotheses about the interaction patterns between HER1-3 receptors...
  3. ncbi Regulation of receptor tyrosine kinase signaling by endocytic trafficking
    H S Wiley
    Environmental and Health Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Traffic 2:12-8. 2001
    ..This may act as a mechanism to produce ligand-specific signals. Thus, trafficking could play diverse roles in receptor signaling, depending on the specific cell and tissue type...
  4. ncbi Computational modeling of the EGF-receptor system: a paradigm for systems biology
    H Steven Wiley
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Trends Cell Biol 13:43-50. 2003
    ..The success of EGFR modeling can be a guide to combining models and experiments productively to understand complex biological processes as integrated systems...
  5. ncbi Should software hold data hostage?
    H Steven Wiley
    Biomolecular Systems Initiative, Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Nat Biotechnol 22:1037-8. 2004
  6. ncbi Integrating multiple types of data for signaling research: challenges and opportunities
    H Steven Wiley
    EMSL, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Sci Signal 4:pe9. 2011
    ..However, solving the fundamental issues of data sharing will enable the investigation of entirely new areas of cell signaling research...
  7. ncbi Achieving molecular selectivity in imaging using multiphoton Raman spectroscopy techniques
    G R Holtom
    Pacific North west National Laboratory, PO Box 999, Richland, WA 99352, USA
    Traffic 2:781-8. 2001
    ..A particularly powerful aspect of CARS microscopy is its ability to selectively image deuterated compounds, thus allowing the visualization of molecules, such as lipids, that are chemically indistinguishable from the native species...
  8. ncbi A model of cytokine shedding induced by low doses of gamma radiation
    J H Miller
    Washington State University Tri Cities, Richland, WA 99354, USA
    Radiat Res 163:337-42. 2005
    ....

Research Grants4

  1. Regulated Ligand Access in Control Receptor Processes
    H Wiley; Fiscal Year: 2004
    ..In addition, they should provide some general insights into how other growth factor systems are regulated. ..