Research Topics
| Karla ThrallSummaryAffiliation: Pacific Northwest National Laboratory Country: USA Publications
Research Grants
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Detail Information
Publications
A real-time in-vivo method for studying the percutaneous absorption of volatile chemicalsK D Thrall
Molecular Biosciences Department, Pacific Northwest National Laboratory, P O Box 999, Mail Stop P7 59, Richland, WA 99352, USA
Int J Occup Environ Health 6:96-103. 2000..The method was found to be sufficiently sensitive for animal and human dermal studies at low exposure concentrations over small body surface areas, for short periods, using non-steady-state exposure conditions...
A real-time methodology to evaluate the nasal absorption of volatile compounds in anesthetized animalsKarla D Thrall
Biological Monitoring and Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington 99352, USA
Inhal Toxicol 21:531-6. 2009..Similarly, the percent of MeI absorbed in the nasal cavity of the rat ranged from 51 to 71% (average 63 +/- 8)...- Studies supporting the development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide: pharmacokinetics of sodium iodide (NaI) in pregnant rabbitsKarla D Thrall
Biological Monitoring and Modeling Group, Battelle, Pacific Northwest Division, Richland, Washington 99354, USA
Inhal Toxicol 21:519-23. 2009..There was no evidence for preferential accumulation of radioiodide in fetal thyroid tissues... - A liquid chromatographic-mass spectrometric method to evaluate the distribution kinetics of 1,2-diethylbenzene and its metabolite 1,2-diacetylbenzene in the F344 male ratKarla D Thrall
Center for Biological Monitoring and Modeling, Health Effects and Risk Sciences Division, Battelle, Pacific Northwest Division, Richland, Washington 99352, USA
J Toxicol Environ Health A 70:67-72. 2007..Urine concentrations of 1,2-DAB, however, showed the reverse, with peak concentrations observed at 24 h postinjection and only a slight decrease in concentration by 48 h... - Development of a physiologically based pharmacokinetic model for chlorobenzene in F-344 ratsKarla D Thrall
Biological Sciences Division, Pacific Northwest National Laboratory, 902 Battelle Blvd, Mail Stop P7 59, Richland, WA 99352, USA
J Toxicol Environ Health A 67:525-36. 2004..Exhaled breath profiles were evaluated and absorption rates were determined. Development of the chlorobenzene PBPK model in rats is the first step toward future extrapolations to apply to humans... - Evaluation of the dermal bioavailability of aqueous xylene in F344 rats and human volunteersKarla Thrall
Chemical Dosimetry Group, Biological Sciences Division, Battelle, Pacific Northwest Laboratory, Richland, Washington 99352, USA
J Toxicol Environ Health A 66:1267-81. 2003..Rat skin was found to be approximately 12 times more permeable to aqueous o-xylene than human skin. The estimated human and rat aqueous o-xylene K(p) values were 0.005 +/- 0.001 cm/h and 0.058 +/- 0.009 cm/h, respectively... - A real-time method to evaluate the nasal deposition and clearance of acetone in the human volunteerKarla D Thrall
Biological Sciences Division, Battelle, Pacific Northwest Laboratory, Richland, WA 99352, USA
Inhal Toxicol 15:523-38. 2003..Breath-by-breath analyses of [(13)C]acetone concentrations indicate that between 40 and 75% of the compound is absorbed upon inhalation and nearly all of that absorbed is released back into the breath stream during exhalation... - Evaluation of the dermal absorption of aqueous toluene in F344 rats using real-time breath analysis and physiologically based pharmacokinetic modelingKarla D Thrall
Molecular Biosciences Department, Fundamental Science Division, Battelle, Pacific Northwest Laboratory, Richland, Washington 99352, USA
J Toxicol Environ Health A 65:2087-100. 2002..These rat studies using aqueous toluene will form the basis for comparing the dermal bioavailability of toluene in various paint products and may ultimately aid in understanding human health risk under a variety of exposure scenarios... - Route-of-entry and brain tissue partition coefficients for common superfund contaminantsKarla D Thrall
Molecular Biosciences Department, Fundamental Science Division, Battelle, Pacific Northwest Laboratory, Richland, Washington 99352, USA
J Toxicol Environ Health A 65:2075-86. 2002..The similarities of the resulting values suggest that both labor and laboratory resources may be reduced when partition coefficients are determined as chemical mixtures... - Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteersKarla D Thrall
Molecular Biosciences Department, Fundamental Science Division, Battelle, Pacific Northwest Laboratory, Richland, Washington 99352, USA
Toxicol Sci 68:280-7. 2002.... - Design and evaluation of a breath-analysis system for biological monitoring of volatile compoundK D Thrall
Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
AIHAJ 62:28-35. 2001..The results of the field studies illustrate the utility of monitoring workers for exposures throughout the day, particularly when job-specific tasks may indicate a potential for exposure... - Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modelingK D Thrall
Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
J Toxicol Environ Health A 60:531-48. 2000..49 mg/h/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by milligrams liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse > rat > human... - Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humansKarla D Thrall
Battelle, Pacific Northwest Division, Richland, WA 99354 1793, USA
J Long Term Eff Med Implants 18:133-44. 2008..Thus, it is unlikely that D4 would be detected in any tissue within a few weeks of receiving an implant, even if immediately ruptured, under the assumptions used in this model... - Development of a physiologically based pharmacokinetic model for methyl ethyl ketone in F344 ratsKarla D Thrall
Molecular Biosciences Department, Fundamental Science Division, Battelle, Pacific Northwest Laboratory, Richland, Washington 99352, USA
J Toxicol Environ Health A 65:881-96. 2002..Development of a comprehensive PBPK model for MEK in rats is the first step toward future extrapolations to apply to humans... - PBPK modeling of the percutaneous absorption of perchloroethylene from a soil matrix in rats and humansTorka S Poet
Battelle, Pacific Northwest Division, P O Box 999, Richland, Washington 99352, USA
Toxicol Sci 67:17-31. 2002..In real-world situations, percutaneous absorption of PCE is likely to be minimal... - Physiologically based pharmacokinetic modeling of 1,4-Dioxane in rats, mice, and humansLisa M Sweeney
The Sapphire Group, Dayton, Ohio 45431, USA
Toxicol Sci 101:32-50. 2008..Consistent with previous PBPK models, nasal tissues were not specifically included in the model. Use of these models will reduce the uncertainty in future 1,4-dioxane risk assessments...
Research Grants
- DERMATOPHARMACOKINETICS OF PAINT SOLVENTSKarla Thrall; Fiscal Year: 2002....
- Dermatopharmacokinetics: In Vivo Analysis of SolventsKarla Thrall; Fiscal Year: 2005..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..