J G Teeguarden
Affiliation: Pacific Northwest National Laboratory
- Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approachJustin G Teeguarden
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, 902 Battelle Boulevard, P7 56, Richland, Washington 99352, USA
Toxicol Sci 85:823-38. 2005....
- A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetryJustin G Teeguarden
Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Inhal Toxicol 20:375-90. 2008..The rat and human acetaldehyde PBPK models developed here can also be used as a bridge between acetaldehyde dose-response and mode-of-action data as well as between similar databases for other acetaldehyde-producing nasal toxicants...
- Pharmacokinetic modeling of manganese in the rat IV: Assessing factors that contribute to brain accumulation during inhalation exposureAndy Nong
Division of Computational Biology Division, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
J Toxicol Environ Health A 71:413-26. 2008..Once validated across test animals, these PBPK models will be useful in tissue-dose based risk assessment with manganese...
- Macrophage responses to silica nanoparticles are highly conserved across particle sizesKatrina M Waters
Environmental Biomarkers Program, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 107:553-69. 2009..However, our results suggest that on an equivalent nominal surface area basis, common biological modes of action are expected for nano- and supranano-sized silica particles...
- Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in miceJustin G Teeguarden
Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 120:123-35. 2011..Two high-sensitivity markers of inflammation, one (S100a9) observed in humans exposed to AB, were found and may be promising biomarkers of human response to SWCNT exposure...
- A multi-route model of nicotine-cotinine pharmacokinetics, pharmacodynamics and brain nicotinic acetylcholine receptor binding in humansJustin G Teeguarden
Battelle, Pacific Northwest Division, 902 Battelle Blvd, Richland, WA 99352, USA
Regul Toxicol Pharmacol 65:12-28. 2013..This framework can be used as a key element of a dosimetry-driven risk assessment strategy for cigarette smoke constituents...
- ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studiesPaul M Hinderliter
Biological Sciences Division, Pacific Northwest National Laboratory, Richland WA 99352, USA
Part Fibre Toxicol 7:36. 2010..Particle transport to cells is calculated by simultaneous solution of Stokes Law (sedimentation) and the Stokes-Einstein equation (diffusion)...
- Derivation of a human equivalent concentration for n-butanol using a physiologically based pharmacokinetic model for n-butyl acetate and metabolites n-butanol and n-butyric acidJ G Teeguarden
Battelle, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 85:429-46. 2005..Human equivalent concentrations of 169 ppm and 1066 ppm n-butanol corresponding to the rat n-butyl acetate NOAELs of 500 and 3000 ppm were derived using the models...
- Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposureJustin G Teeguarden
Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Toxicol Sci 123:48-57. 2011..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
- Submicrometer and nanoscale inorganic particles exploit the actin machinery to be propelled along microvilli-like structures into alveolar cellsGalya Orr
Chemical and Materials Sciences, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
ACS Nano 1:463-75. 2007..The retrograde pathway brings a new mechanism by which positive surface charge supports particle recruitment, and potential subsequent toxicity, by polarized epithelial cells bearing microvilli...
- Pharmacokinetic modeling of manganese. II. Hepatic processing after ingestion and inhalationJustin G Teeguarden
Pacific Northwest National Laboratory, Richland, Washington, USA
J Toxicol Environ Health A 70:1505-14. 2007..These differences in hepatic processing of blood Mn derived from different dose routes need to be accounted for in more complete PK models for Mn that are intended to support human health risk assessments...
- Pharmacokinetic modeling of manganese. III. Physiological approaches accounting for background and tracer kineticsJustin G Teeguarden
Pacific Northwest National Laboratory, Richland, Washington, USA
J Toxicol Environ Health A 70:1515-26. 2007....
- Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalationDavid C Dorman
CIIT at The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA david
Inhal Toxicol 20:245-56. 2008..A model of acetaldehyde pharmacokinetics in the nose was used to derive an inhalation reference concentration (RfC) of 0.4 ppm, based on the no-observed-adverse-effect level (NOAEL) of 50 ppm for the nasal pathology seen in this study...
- Interspecies dose extrapolation for inhaled dimethyl sulfate: a PBPK model-based analysis using nasal cavity N7-methylguanine adductsRamesh Sarangapani
ICF Consulting, Research Triangle Park, North Carolina, USA
Inhal Toxicol 16:593-605. 2004..The model-based interspecies dose comparison, using N7 mG adduct levels in the nasal respiratory tissue as the appropriate dose metrics, predicts a dose rate seven times higher in rats compared to humans...
- Computational modeling of serum-binding proteins and clearance in extrapolations across life stages and species for endocrine active compoundsJustin G Teeguarden
ENVIRON Health Sciences Institute, Ruston, LA 71270, USA
Risk Anal 24:751-70. 2004..The examples illustrate the utility of this approach for integrating available experimental data from in vitro and in vivo studies to estimate the relative potency of these compounds...
- Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetryHarvey J Clewell
ENVIRON Health Sciences Institute, Ruston, Louisiana 71270, USA
Toxicol Sci 79:381-93. 2004..Given the potential for age-dependent pharmacodynamic factors during early life, there may be chemicals and health outcomes for which decreased clearance over a relatively brief period could have a substantial impact on risk...
- Evaluation of the potential impact of age- and gender-specific lung morphology and ventilation rate on the dosimetry of vaporsRamesh Sarangapani
The K S Crump Group, Inc, ICF Consulting, Research Triangle Park, North Carolina, USA
Inhal Toxicol 15:987-1016. 2003....
- Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humansRamesh Sarangapani
The K S Crump Group, Inc, Research Triangle Park, North Carolina, USA
Inhal Toxicol 14:789-834. 2002..Pharmacodynamic factors are also expected to contribute to species sensitivity, potentially augmenting pharmacokinetics-based differences...