D L Springer

Summary

Affiliation: Pacific Northwest National Laboratory
Country: USA

Publications

  1. pmc Platelet proteome changes associated with diabetes and during platelet storage for transfusion
    David L Springer
    Fundamental Science Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland Washington 99352, USA
    J Proteome Res 8:2261-72. 2009
  2. ncbi request reprint Characterization of medium conditioned by irradiated cells using proteome-wide, high-throughput mass spectrometry
    D L Springer
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Radiat Res 164:651-4. 2005
  3. ncbi request reprint Characterization of plasma membrane proteins from ovarian cancer cells using mass spectrometry
    David L Springer
    Biological Sciences Division, Pacific Northwest National Laboratories, Richland, WA 99352, USA
    Dis Markers 19:219-28. 2003
  4. ncbi request reprint Large-scale proteomic analysis of membrane proteins
    Mamoun Ahram
    Biological Sciences Division, Pacific Northwest National Laboratory, Battelle, PO Box 999, Richland, WA 99352, USA
    Expert Rev Proteomics 1:293-302. 2004
  5. ncbi request reprint Elevated blood pressure and heart rate in rats exposed to a coal-derived complex organic mixture
    L B Sasser
    Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, WA 99352
    J Appl Toxicol 9:47-52. 1989
  6. doi request reprint Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry
    J H Miller
    Washington State University Tri Cities, Richland, WA, USA
    Radiat Res 169:700-6. 2008
  7. ncbi request reprint Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry
    Joshua N Adkins
    Biological Sciences Department, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Mol Cell Proteomics 1:947-55. 2002
  8. ncbi request reprint Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modeling
    K D Thrall
    Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Toxicol Environ Health A 60:531-48. 2000
  9. ncbi request reprint Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
    R C Zangar
    Molecular Biosciences Department, Battelle PNNL, Richland, WA, USA
    Chem Biol Interact 125:233-43. 2000
  10. ncbi request reprint A proteomic approach to characterize protein shedding
    Mamoun Ahram
    Biological Sciences Division, Battelle, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Proteomics 5:123-31. 2005

Collaborators

Detail Information

Publications12

  1. pmc Platelet proteome changes associated with diabetes and during platelet storage for transfusion
    David L Springer
    Fundamental Science Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland Washington 99352, USA
    J Proteome Res 8:2261-72. 2009
    ..These identified differences allow us to formulate new hypotheses and experimentation to improve clinical outcomes by targeting "high risk platelets" that render platelet transfusion less effective or even unsafe...
  2. ncbi request reprint Characterization of medium conditioned by irradiated cells using proteome-wide, high-throughput mass spectrometry
    D L Springer
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Radiat Res 164:651-4. 2005
    ....
  3. ncbi request reprint Characterization of plasma membrane proteins from ovarian cancer cells using mass spectrometry
    David L Springer
    Biological Sciences Division, Pacific Northwest National Laboratories, Richland, WA 99352, USA
    Dis Markers 19:219-28. 2003
    ..Further characterization of plasma membrane proteins will contribute to our understanding of the mechanisms underlying progression of this deadly disease and may lead to new targeted interventions as well as new biomarkers for diagnosis...
  4. ncbi request reprint Large-scale proteomic analysis of membrane proteins
    Mamoun Ahram
    Biological Sciences Division, Pacific Northwest National Laboratory, Battelle, PO Box 999, Richland, WA 99352, USA
    Expert Rev Proteomics 1:293-302. 2004
    ..Along with technological innovations, advancements in the areas of sample preparation and computational prediction of membrane proteins will lead to exciting discoveries...
  5. ncbi request reprint Elevated blood pressure and heart rate in rats exposed to a coal-derived complex organic mixture
    L B Sasser
    Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, WA 99352
    J Appl Toxicol 9:47-52. 1989
    ..These results suggest that the cardiovascular system could be detrimentally affected by exposure to coal-derived complex mixtures and, possibly, to other complex organic mixtures...
  6. doi request reprint Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry
    J H Miller
    Washington State University Tri Cities, Richland, WA, USA
    Radiat Res 169:700-6. 2008
    ....
  7. ncbi request reprint Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry
    Joshua N Adkins
    Biological Sciences Department, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Mol Cell Proteomics 1:947-55. 2002
    ..With this study, we have performed the most extensive analysis of serum proteins to date and laid the foundation for future refinements in the identification of novel protein biomarkers of disease...
  8. ncbi request reprint Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modeling
    K D Thrall
    Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Toxicol Environ Health A 60:531-48. 2000
    ..49 mg/h/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by milligrams liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse > rat > human...
  9. ncbi request reprint Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes
    R C Zangar
    Molecular Biosciences Department, Battelle PNNL, Richland, WA, USA
    Chem Biol Interact 125:233-43. 2000
    ..At higher CCl(4) levels, CYP3A and possibly other CYP450 forms may contribute to CCl(4) metabolism...
  10. ncbi request reprint A proteomic approach to characterize protein shedding
    Mamoun Ahram
    Biological Sciences Division, Battelle, Pacific Northwest National Laboratory, Richland, WA 99352, USA
    Proteomics 5:123-31. 2005
    ..These results demonstrate that tandem mass spectrometry can be used to identify shed proteins and to estimate changes in protein abundance...
  11. ncbi request reprint The effects of shared peptides on protein quantitation in label-free proteomics by LC/MS/MS
    Shuangshuang Jin
    School of Electrical Engineering and Computer Science, Washington State University Tri Cities, 2710 University Drive, Richland, Washington 99352, USA
    J Proteome Res 7:164-9. 2008
    ..On the basis of these results, we propose that peptide-sharing closure groups provide a way to include abundance data for shared peptides in quantitative protein profiling by high-throughput mass spectrometry...
  12. ncbi request reprint Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteins
    Dale D Edberg
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    J Biol Chem 280:8961-73. 2005
    ....