D L Springer
Affiliation: Pacific Northwest National Laboratory
- Platelet proteome changes associated with diabetes and during platelet storage for transfusionDavid L Springer
Fundamental Science Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland Washington 99352, USA
J Proteome Res 8:2261-72. 2009..These identified differences allow us to formulate new hypotheses and experimentation to improve clinical outcomes by targeting "high risk platelets" that render platelet transfusion less effective or even unsafe...
- Characterization of medium conditioned by irradiated cells using proteome-wide, high-throughput mass spectrometryD L Springer
Pacific Northwest National Laboratory, Richland, WA 99352, USA
Radiat Res 164:651-4. 2005....
- Characterization of plasma membrane proteins from ovarian cancer cells using mass spectrometryDavid L Springer
Biological Sciences Division, Pacific Northwest National Laboratories, Richland, WA 99352, USA
Dis Markers 19:219-28. 2003..Further characterization of plasma membrane proteins will contribute to our understanding of the mechanisms underlying progression of this deadly disease and may lead to new targeted interventions as well as new biomarkers for diagnosis...
- Large-scale proteomic analysis of membrane proteinsMamoun Ahram
Biological Sciences Division, Pacific Northwest National Laboratory, Battelle, PO Box 999, Richland, WA 99352, USA
Expert Rev Proteomics 1:293-302. 2004..Along with technological innovations, advancements in the areas of sample preparation and computational prediction of membrane proteins will lead to exciting discoveries...
- Elevated blood pressure and heart rate in rats exposed to a coal-derived complex organic mixtureL B Sasser
Biology and Chemistry Department, Pacific Northwest Laboratory, Richland, WA 99352
J Appl Toxicol 9:47-52. 1989..These results suggest that the cardiovascular system could be detrimentally affected by exposure to coal-derived complex mixtures and, possibly, to other complex organic mixtures...
- Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometryJ H Miller
Washington State University Tri Cities, Richland, WA, USA
Radiat Res 169:700-6. 2008....
- Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometryJoshua N Adkins
Biological Sciences Department, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
Mol Cell Proteomics 1:947-55. 2002..With this study, we have performed the most extensive analysis of serum proteins to date and laid the foundation for future refinements in the identification of novel protein biomarkers of disease...
- Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modelingK D Thrall
Molecular Biosciences Department, Pacific Northwest National Laboratory, Richland, WA 99352, USA
J Toxicol Environ Health A 60:531-48. 2000..49 mg/h/kg body weight and 0.25 mg/L for Vmax and Km, respectively. Normalizing the rate of metabolism (Vmax/Km) by milligrams liver protein, the rate of metabolism of CCl4 differs across species, with hamster > mouse > rat > human...
- Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomesR C Zangar
Molecular Biosciences Department, Battelle PNNL, Richland, WA, USA
Chem Biol Interact 125:233-43. 2000..At higher CCl(4) levels, CYP3A and possibly other CYP450 forms may contribute to CCl(4) metabolism...
- A proteomic approach to characterize protein sheddingMamoun Ahram
Biological Sciences Division, Battelle, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Proteomics 5:123-31. 2005..These results demonstrate that tandem mass spectrometry can be used to identify shed proteins and to estimate changes in protein abundance...
- The effects of shared peptides on protein quantitation in label-free proteomics by LC/MS/MSShuangshuang Jin
School of Electrical Engineering and Computer Science, Washington State University Tri Cities, 2710 University Drive, Richland, Washington 99352, USA
J Proteome Res 7:164-9. 2008..On the basis of these results, we propose that peptide-sharing closure groups provide a way to include abundance data for shared peptides in quantitative protein profiling by high-throughput mass spectrometry...
- Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteinsDale D Edberg
School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
J Biol Chem 280:8961-73. 2005....