Genomes and Genes
H J Sofia
Affiliation: Pacific Northwest National Laboratory
- BioGraphE: high-performance bionetwork analysis using the Biological Graph EnvironmentGeorge Chin
High Performance Computing Group, Computational Sciences and Mathematics Division, Pacific Northwest National Laboratory, Richland, Washington, USA
BMC Bioinformatics 9:S6. 2008..Yet, as the amount of genomic and bionetwork information rapidly grows, scientists need advanced new computational strategies and tools for dealing with the complexities of the bionetwork analysis and the volume of the data...
- Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methodsH J Sofia
Applied Mathematics, Environmental Molecular Sciences Laboratory EMSL, Pacific Northwest National Laboratory, Richland, WA 99352, USA
Nucleic Acids Res 29:1097-106. 2001..Two functional predictions for unknown proteins are made based on integrating other data types such as motif, domain, operon and biochemical pathway into an organized view of similarity relationships...
- beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation moduleE M Kajkowski
Wyeth Neuroscience, Wyeth Ayerst Research, CN 8000, Princeton, New Jersey 08543 8000, USA
J Biol Chem 276:18748-56. 2001..These findings suggest that BBP is a target of neurotoxic beta-amyloid peptide and provide new insight into the molecular pathophysiology of Alzheimer's disease...