V Poitout

Summary

Affiliation: Pacific Northwest Research Institute
Country: USA

Publications

  1. ncbi request reprint The ins and outs of fatty acids on the pancreatic beta cell
    Vincent Poitout
    Pacific Northwest Research Institute and Department of Medicine, University of Washington, Seattle, WA, USA
    Trends Endocrinol Metab 14:201-3. 2003
  2. ncbi request reprint Gluco-lipotoxicity of the pancreatic beta cell
    V Poitout
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Ann Endocrinol (Paris) 65:37-41. 2004
  3. ncbi request reprint Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity
    Vincent Poitout
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Endocrinology 143:339-42. 2002
  4. ncbi request reprint Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats
    I Briaud
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Horm Metab Res 32:103-6. 2000
  5. ncbi request reprint Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats
    I Briaud
    Pacific Northwest Research Institute, Seattle WA, USA
    Horm Metab Res 32:53-6. 2000
  6. ncbi request reprint Does leptin regulate insulin secretion?
    V Poitout
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Diabetes Metab 24:321-6. 1998
  7. ncbi request reprint Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
    J S Harmon
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 50:2481-6. 2001
  8. ncbi request reprint Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate
    S M Parker
    Pacific Nortwest Research Institute, Seattle, WA 98122, USA
    Metabolism 52:1367-71. 2003
  9. ncbi request reprint Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha)
    Hélène Bihan
    INSERM U 341, Hotel Dieu, Paris, France
    FEBS Lett 579:2284-8. 2005
  10. pmc Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
    Derek K Hagman
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 280:32413-8. 2005

Collaborators

  • G Reach
  • B Portha
  • R Paul Robertson
  • J S Harmon
  • B Staels
  • Thomas L Jetton
  • Shinichi Matsumoto
  • I R Sweet
  • M Guerre-Millo
  • Louis Philipson
  • C J Rhodes
  • S R Murthy Madiraju
  • N Ruderman
  • Marc Prentki
  • Derek K Hagman
  • Martin G Latour
  • Cynthia L Kelpe
  • Susan D Parazzoli
  • Caroline Tremblay
  • Patrick C Moore
  • I Briaud
  • Melkam Kebede
  • Meriem Semache
  • Thierry Alquier
  • Ghislaine Fontes
  • Thomas O Metz
  • Hélène Bihan
  • Li Zhao
  • Maria F Pino
  • Lori B Hays
  • Raphael Roduit
  • Barton Wicksteed
  • Cristina Alarcon
  • S M Parker
  • Kazuro Yaekura
  • Lisa M Johnson
  • Isabelle Briaud
  • C Rouault
  • James A Lausier
  • Violet Roskens
  • Swarup K Chakrabarti
  • Julie Amyot
  • Raghavendra G Mirmira
  • Elizabeth Oseid
  • Daniel C H Lin
  • Jian Luo
  • Jon M Jacobs
  • Richard D Smith
  • Wei Jun Qian
  • David G Camp
  • Marina A Gritsenko
  • Christopher D Green
  • Katrina D Linning
  • Taka Aki Matsuoka
  • Diana Z Ye
  • Roland Stein
  • L Karl Olson
  • Min Guo
  • Christine Rouault
  • Johane Morin
  • Viviane Delghingaro-Augusto
  • Patrick Moore
  • Frédéric Massé
  • Christopher Nolan
  • Annie Barbeau
  • Bernard Massie
  • Ewa Przybykowski
  • Marco A Ugas
  • Denis G Baskin
  • P C Moore
  • L M Johnson
  • Yong Wang
  • Richard Julyan
  • Barton L Wicksteed
  • Scott Sommers
  • Phuong Oanh T Tran

Detail Information

Publications30

  1. ncbi request reprint The ins and outs of fatty acids on the pancreatic beta cell
    Vincent Poitout
    Pacific Northwest Research Institute and Department of Medicine, University of Washington, Seattle, WA, USA
    Trends Endocrinol Metab 14:201-3. 2003
  2. ncbi request reprint Gluco-lipotoxicity of the pancreatic beta cell
    V Poitout
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Ann Endocrinol (Paris) 65:37-41. 2004
  3. ncbi request reprint Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity
    Vincent Poitout
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Endocrinology 143:339-42. 2002
    ..We propose that chronic hyperglycemia, independent of hyperlipidemia, is toxic for beta-cell function, whereas chronic hyperlipidemia is deleterious only in the context of concomitant hyperglycemia...
  4. ncbi request reprint Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats
    I Briaud
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Horm Metab Res 32:103-6. 2000
    ..In contrast, no significant effect of glucose was found on insulin mRNA levels in n0-STZ islets. We conclude that insulin gene regulation by glucose is impaired in n0-STZ rat islets...
  5. ncbi request reprint Glucose-induced insulin mRNA accumulation is impaired in islets from neonatal streptozotocin-treated rats
    I Briaud
    Pacific Northwest Research Institute, Seattle WA, USA
    Horm Metab Res 32:53-6. 2000
    ..In contrast, no significant effect of glucose was found on insulin mRNA levels in n0-STZ islets. We conclude that insulin gene regulation by glucose is impaired in n0-STZ rat islets...
  6. ncbi request reprint Does leptin regulate insulin secretion?
    V Poitout
    Pacific Northwest Research Institute, Seattle, WA 98122, USA
    Diabetes Metab 24:321-6. 1998
    ....
  7. ncbi request reprint Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
    J S Harmon
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 50:2481-6. 2001
    ..We conclude that antecedent elevated plasma glucose levels, not plasma lipid levels, are associated with elevated islet TAG content and decreased insulin mRNA levels in ZDF animals...
  8. ncbi request reprint Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate
    S M Parker
    Pacific Nortwest Research Institute, Seattle, WA 98122, USA
    Metabolism 52:1367-71. 2003
    ..Further, 2-bromopalmitate partly inhibited the potentiating effect of palmitate. These results support the concept that FA potentiation of insulin release is mediated by FA-derived signals generated in the esterification pathway...
  9. ncbi request reprint Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARalpha)
    Hélène Bihan
    INSERM U 341, Hotel Dieu, Paris, France
    FEBS Lett 579:2284-8. 2005
    ..As such, islet PPARalpha could contribute to delay the progression of type 2 diabetes...
  10. pmc Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
    Derek K Hagman
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 280:32413-8. 2005
    ..These results demonstrate that prolonged exposure of islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA...
  11. pmc Regulation of the insulin gene by glucose and fatty acids
    Vincent Poitout
    Department of Medicine, University of Montreal, Montreal, QC, Canada
    J Nutr 136:873-6. 2006
    ..Glucotoxicity and lipotoxicity have common targets, which makes their combination particularly harmful to insulin gene expression and beta-cell function in type 2 diabetes...
  12. pmc GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
    Martin G Latour
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC, H1W 4A4 Canada
    Diabetes 56:1087-94. 2007
    ..We conclude that GPR40 contributes approximately half of the full acute insulin secretory response to fatty acids in mice but does not play a role in the mechanisms by which fatty acids chronically impair insulin secretion...
  13. pmc G protein-coupled receptors and insulin secretion: 119 and counting
    S R Murthy Madiraju
    Montreal Diabetes Research Centre, University of Montreal, 2901 Rachel East, Montreal, Quebec, Canada
    Endocrinology 148:2598-600. 2007
  14. pmc Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets
    Derek K Hagman
    DVM, Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC, H1W 4A4, Canada
    Diabetes 57:424-31. 2008
    ..Whether such a phenomenon also occurs in vivo is unknown. Our objective was therefore to ascertain whether chronic nutrient oversupply inhibits insulin gene expression in vivo...
  15. pmc The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
    Melkam Kebede
    Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Diabetes 57:2432-7. 2008
    ..Glucose tolerance, insulin tolerance, and insulin secretion in response to glucose and Intralipid were assessed during the course of the diet period...
  16. ncbi request reprint Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element
    Maria F Pino
    Department of Physiology, Michigan State University, 3176 Biomedical and Physical Sciences Building, East Lansing, MI 48824, USA
    Mol Endocrinol 19:1343-60. 2005
    ....
  17. pmc Glucolipotoxicity of the pancreatic beta-cell: myth or reality?
    Vincent Poitout
    Montreal Diabetes Research Center, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC, Canada, H1W 4A4
    Biochem Soc Trans 36:901-4. 2008
    ....
  18. ncbi request reprint Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats
    Isabelle Briaud
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Diabetes 51:662-8. 2002
    ..We conclude that hyperlipidemia induced by high-fat feeding affects insulin secretion in islets from hyperglycemic GK rats only, by a mechanism which may involve, at least in part, modulation of UCP-2 expression...
  19. ncbi request reprint Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase
    Cynthia L Kelpe
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    Endocrinology 143:3326-32. 2002
    ..We conclude that a selective increase in TG content impairs glucose-induced insulin secretion, a mechanism likely to mediate, at least in part, the deleterious effects of FA on pancreatic beta-cell function...
  20. ncbi request reprint Insulin secretory deficiency and glucose intolerance in Rab3A null mice
    Kazuro Yaekura
    Pacific Northwest Research Institute and Departments of Pharmacology and Medicine, University of Washington, Seattle, Washington 98122, USA
    J Biol Chem 278:9715-21. 2003
    ..Also, this study indicates, for the first time, that the in vivo insulin secretory dysfunction found in type-2 diabetes can lie solely at the level of defective insulin exocytosis...
  21. ncbi request reprint Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
    Cynthia L Kelpe
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 278:30015-21. 2003
    ..We conclude that prolonged exposure to elevated levels of palmitate affects glucose-stimulated insulin gene expression via transcriptional mechanisms and ceramide synthesis...
  22. ncbi request reprint Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    R Paul Robertson
    Pacific Northwest Research Institute and the Departments of Medicine and Pharmacology, University of Washington, Seattle, Washington 98122, USA
    Diabetes 53:S119-24. 2004
    ....
  23. ncbi request reprint A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
    Raphael Roduit
    Molecular Nutrition Unit, Department of Nutrition, University of Montréal and the Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Diabetes 53:1007-19. 2004
    ..The data show the existence of important links between the metabolic coupling factor malonyl-CoA, the partitioning of fatty acids, and the stimulation of insulin secretion to both fuel and nonfuel stimuli...
  24. ncbi request reprint Beta-cell lipotoxicity: burning fat into heat?
    Vincent Poitout
    Endocrinology 145:3563-5. 2004
  25. pmc Characterization of the human pancreatic islet proteome by two-dimensional LC/MS/MS
    Thomas O Metz
    Biological Science Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, USA
    J Proteome Res 5:3345-54. 2006
    ..The resulting peptide reference library provides a resource for future higher throughput and quantitative studies of islet biology...
  26. ncbi request reprint Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation Protocol
    Shinichi Matsumoto
    Islet and Cell Processing Laboratory ICPL at Puget Sound Blood Center and Northwest Tissue Center, Seattle, WA, USA
    Transplantation 74:1414-9. 2002
    ..In this study, we hypothesized that the two-layer method (TLM) could extend the acceptable preservation period of pancreata before islet isolation and increase islet yields...
  27. pmc Phospholipid hydrolysis and insulin secretion: a step toward solving the Rubik's cube
    Vincent Poitout
    Montreal Diabetes Research Center, CR CHUM, Technopole Angus, 2901 Rachel Est, Montreal, Quebec, Canada
    Am J Physiol Endocrinol Metab 294:E214-6. 2008
  28. ncbi request reprint The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription
    Li Zhao
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:11887-94. 2005
    ..Collectively, these results suggest that MafA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells...
  29. pmc Glucolipotoxicity: fuel excess and beta-cell dysfunction
    Vincent Poitout
    Montreal Diabetes Research Center, CR CHUM, Technopole Angus, 2901 Rachel Est, Montreal, Quebec, Canada H1W 4A4
    Endocr Rev 29:351-66. 2008
    ..Finally, we attempt to define the role of these phenomena in the natural history of beta-cell compensation, decompensation, and failure during the course of type 2 diabetes...
  30. ncbi request reprint Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
    Patrick C Moore
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Diabetes 53:2610-6. 2004
    ....