- Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamicsJohn P Harrelson
School of Pharmacy, Pacific University, HPC Ste 451, Hillsboro, Oregon 97123, USA
Biochemistry 47:2978-88. 2008..That is, the accommodation of a second xylene molecule in the active site leads to a decrease in substrate dynamics...
- A comparison of substrate dynamics in human CYP2E1 and CYP2A6John P Harrelson
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
Biochem Biophys Res Commun 352:843-9. 2007..Speculatively, if this explanation is valid, then intramolecular isotope effect experiments should be useful in the mechanistic investigation of P450 cooperativity...
- Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophenJohn P Harrelson
School of Pharmacy, Pacific University Oregon, 222 S E 8th Ave, Ste 451, Hillsboro, OR 97123, USA
Drug Metab Dispos 40:1460-5. 2012..This study reports the first direct evidence of AMAP-derived hydroquinone metabolites bound to human CYP2E1...