J Curb

Summary

Affiliation: Pacific Health Research Institute
Country: USA

Publications

  1. pmc FOXO3A genotype is strongly associated with human longevity
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 105:13987-92. 2008
  2. ncbi request reprint A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly
    J D Curb
    Pacific Health Research Institute, Honolulu, HI, USA
    J Lipid Res 45:948-53. 2004
  3. ncbi request reprint Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly men
    J David Curb
    Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
    J Am Geriatr Soc 52:1975-80. 2004
  4. ncbi request reprint Performance-based measures of physical function for high-function populations
    J David Curb
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    J Am Geriatr Soc 54:737-42. 2006
  5. ncbi request reprint Are remnant-like particles independent predictors of coronary heart disease incidence? The Honolulu Heart study
    Claudia Imke
    Department of Public Health Sciences and Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arterioscler Thromb Vasc Biol 25:1718-22. 2005
  6. ncbi request reprint High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program
    J David Curb
    Pacific Health Research Institute, Honolulu, HI 96817, USA
    Am J Epidemiol 160:150-7. 2004
  7. ncbi request reprint Siblings of Okinawan centenarians share lifelong mortality advantages
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    J Gerontol A Biol Sci Med Sci 61:345-54. 2006
  8. ncbi request reprint Midlife risk factors and healthy survival in men
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    JAMA 296:2343-50. 2006
  9. ncbi request reprint C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    Expert Rev Neurother 4:507-18. 2004
  10. ncbi request reprint How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    J Gerontol A Biol Sci Med Sci 59:789-95. 2004

Detail Information

Publications63

  1. pmc FOXO3A genotype is strongly associated with human longevity
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Proc Natl Acad Sci U S A 105:13987-92. 2008
    ..Further exploration of the FOXO3A gene, human longevity and other aging phenotypes is warranted in other populations...
  2. ncbi request reprint A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly
    J D Curb
    Pacific Health Research Institute, Honolulu, HI, USA
    J Lipid Res 45:948-53. 2004
    ..These data indicate that HDL-C remains an important risk factor for CHD in the elderly. Whether a CETP mutation offers additional protection against CHD warrants further investigation...
  3. ncbi request reprint Prospective association between low and high total and low-density lipoprotein cholesterol and coronary heart disease in elderly men
    J David Curb
    Honolulu Heart Program, Kuakini Medical Center, Honolulu, Hawaii, USA
    J Am Geriatr Soc 52:1975-80. 2004
    ..To examine the relationship between total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and the incidence of coronary heart disease (CHD) in elderly men...
  4. ncbi request reprint Performance-based measures of physical function for high-function populations
    J David Curb
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    J Am Geriatr Soc 54:737-42. 2006
    ..To improve and broaden the applicability of performance-based measures of function for use in clinical and research settings...
  5. ncbi request reprint Are remnant-like particles independent predictors of coronary heart disease incidence? The Honolulu Heart study
    Claudia Imke
    Department of Public Health Sciences and Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
    Arterioscler Thromb Vasc Biol 25:1718-22. 2005
    ..This is the first long-term prospective investigation of the relationship between remnant-like particles and a cardiovascular disease outcome in healthy men...
  6. ncbi request reprint High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program
    J David Curb
    Pacific Health Research Institute, Honolulu, HI 96817, USA
    Am J Epidemiol 160:150-7. 2004
    ..These findings suggest that HDL cholesterol level is inversely related to the risk of thromboembolic stroke in elderly men. Whether HDL cholesterol alters the effect of other factors on stroke risk in elderly men warrants further study...
  7. ncbi request reprint Siblings of Okinawan centenarians share lifelong mortality advantages
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, Hawaii, USA
    J Gerontol A Biol Sci Med Sci 61:345-54. 2006
    ..58-fold likelihood, and male siblings a 5.43-fold likelihood, versus their birth cohorts, of reaching the age of 90 years. These data support a significant familial component to exceptional human longevity...
  8. ncbi request reprint Midlife risk factors and healthy survival in men
    Bradley J Willcox
    Pacific Health Research Institute, Honolulu, HI 96813, USA
    JAMA 296:2343-50. 2006
    ..Healthy survival has no clear phenotypic definition, and little is known about its attributes, particularly in men...
  9. ncbi request reprint C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    Expert Rev Neurother 4:507-18. 2004
    ..New and increasingly available high-sensitivity assays may make C-reactive protein a standard screening tool for cardiovascular disease...
  10. ncbi request reprint How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, HI 96813, USA
    J Gerontol A Biol Sci Med Sci 59:789-95. 2004
    ..Thus, we observed trends between low energy intake and reduced risk for all-cause mortality in humans until energy intake fell to less than half the group mean, consistent with previous findings in other species...
  11. ncbi request reprint Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
    ..This study lends epidemiologic support for phenotypic benefits of CR in humans and is consistent with the well-known literature on animals with regard to CR phenotypes and healthy aging...
  12. doi request reprint Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Honolulu, HI 96813, USA
    Am J Cardiol 101:75D-86D. 2008
    ..This should help clarify the true potential utility of antioxidants in CVD and may lead to a better understanding of the role of oxidative stress in atherosclerosis...
  13. ncbi request reprint C-reactive protein and the future risk of thromboembolic stroke in healthy men
    J David Curb
    Pacific Health Research Institute, Honolulu, Hawaii 96813, USA
    Circulation 107:2016-20. 2003
    ..Whether associations are altered in the presence of other risk factors is unclear. The purpose of this study was to additionally assess the relation between CRP and TE stroke...
  14. doi request reprint Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure
    Jennifer L Kimbell
    Pacific Health Research Institute, Honolulu, HI 96813, United States
    Diabetes Res Clin Pract 81:231-7. 2008
    ..We searched for associations between common resistin gene variants and factors related to insulin resistance in Asian individuals with high or low blood pressure (BP)...
  15. ncbi request reprint A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men
    Tanya A Koropatnick
    Pacific Health Research Institute, 846 South Hotel St, Suite 301, Honolulu, Hawaii 96813, USA
    J Gerontol A Biol Sci Med Sci 63:1235-40. 2008
    ..In light of this controversy, we examined the relationship among HDL-C, CETP mutations, and longevity phenotypes in the long-lived Japanese-American men of the Honolulu Heart Program (HHP)...
  16. ncbi request reprint Proteinuria and risk for stroke and coronary heart disease during 27 years of follow-up: the Honolulu Heart Program
    James R Madison
    Department of Internal Medicine, University of Hawaii, John A Burns School of Medicine, Honolulu, USA
    Arch Intern Med 166:884-9. 2006
    ..Urinary protein excretion has been linked to coronary heart disease (CHD); the relationship to stroke is less clear. We assessed whether urine dipstick screening for protein predicted stroke and CHD in the Honolulu Heart Program cohort...
  17. ncbi request reprint Bowel movement frequency in late-life and incidental Lewy bodies
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA
    Mov Disord 22:1581-6. 2007
    ..Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes...
  18. ncbi request reprint Venous thrombosis and conjugated equine estrogen in women without a uterus
    J David Curb
    University of Hawaii and Pacific Health Research Institute, Honolulu, USA
    Arch Intern Med 166:772-80. 2006
    ..Clinical trial data on the effects of estrogen alone on VT are limited...
  19. ncbi request reprint The prevalence and prognosis of a Brugada-type electrocardiogram in a population of middle-aged Japanese-American men with follow-up of three decades
    Hiroki Ito
    John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Am J Med Sci 331:25-9. 2006
    ..There are conflicting data about its prevalence and prognosis. Particularly, population-based studies are lacking in the United States and other countries...
  20. ncbi request reprint Outcomes ascertainment and adjudication methods in the Women's Health Initiative
    J David Curb
    Department of Geriatric Medicine, University of Hawaii, Honolulu, HI 96813, USA
    Ann Epidemiol 13:S122-8. 2003
  21. pmc Cystatin-C, renal function, and incidence of hip fracture in postmenopausal women
    Andrea Z LaCroix
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Am Geriatr Soc 56:1434-41. 2008
    ..To evaluate the association between chronic kidney disease and incident hip fracture using serum cystatin-C as a biomarker of renal function calculated without reference to muscle mass...
  22. ncbi request reprint Caloric restriction and human longevity: what can we learn from the Okinawans?
    D Craig Willcox
    College of Nursing, Okinawa Prefectural University, 1 24 1 Yogi, Naha, Okinawa 902 0076, Japan
    Biogerontology 7:173-7. 2006
    ..We review the human studies in the context of a special human population, older Okinawans, who appear to have undergone a mild form of prolonged CR for about half their adult lives...
  23. ncbi request reprint Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension
    Ming Wei Lin
    Faculty of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan
    Am J Hypertens 19:1118-24. 2006
    ....
  24. doi request reprint Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]
    Katsuyuki Miura
    Department of Health Science, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Hypertension 52:408-14. 2008
    ..42/-0.98 mm Hg (P<0.05 for both) with 2 SD higher intake (4.04% kcal). Dietary linoleic acid intake may contribute to prevention and control of adverse blood pressure levels in general populations...
  25. ncbi request reprint Disability and depression: investigating a complex relation using physical performance measures
    Masahiko Yanagita
    Fukui Prefectural University, Fukui, Japan
    Am J Geriatr Psychiatry 14:1060-8. 2006
    ..The objective of this study was to examine the relation of physical performance measures with depressive symptoms in older men...
  26. pmc Difference in carotid intima-media thickness between Korean and Japanese men
    Jina Choo
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Epidemiol 18:310-5. 2008
    ..We aimed to evaluate levels of carotid intima-media thickness (IMT) and coronary risk factors in Korean and Japanese men in the post-World War II birth cohort...
  27. pmc Linkage and association analyses of type 2 diabetes/impaired glucose metabolism and adiponectin serum levels in Japanese Americans from Hawaii
    Ilija P Kovac
    Department of Psychiatry, McGill University, Alan Memorial Institute, R and T Building, 1033 Pine Avenue West, Montreal H3A 1A1, Quebec, Canada
    Diabetes 56:537-40. 2007
    ..2 cM. The present study was limited by relatively small sample size. Nevertheless, these results corroborate earlier studies, suggesting that further research is warranted in the candidate region approximately 30 cM on chromosome 14...
  28. ncbi request reprint Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study
    Themistocles L Assimes
    Stanford University Medical Center, Division of Cardiovascular Medicine, Stanford, California, USA
    J Hypertens 25:985-92. 2007
    ..An estimate of this proportion has not been reported previously in an East Asian population. The objective of this study was to estimate the heritability of LV mass in Japanese families living in Hawaii...
  29. ncbi request reprint Relation of dietary and other lifestyle traits to difference in serum adiponectin concentration of Japanese in Japan and Hawaii: the INTERLIPID Study
    Yasuyuki Nakamura
    Cardiovascular Epidemiology, Kyoto Women s University, Kyoto, Japan
    Am J Clin Nutr 88:424-30. 2008
    ..In initial analyses, we found significant differences between serum adiponectin in Japanese living in Japan and Hawaii...
  30. ncbi request reprint Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart Program
    Chung Eun Ha
    Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai i, Honolulu 96813, USA
    Hawaii Med J 66:148, 150-2. 2007
    ..However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels...
  31. ncbi request reprint Coronary artery calcification and total mortality in elderly men
    Robert D Abbott
    Division of Biostatistics and Epidemiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Am Geriatr Soc 55:1948-54. 2007
    ..To examine the relationship between coronary artery calcification (CAC) and mortality in a sample of elderly men...
  32. pmc Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study
    Akira Sekikawa
    University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 52:417-24. 2008
    ..We sought to examine whether marine-derived n-3 fatty acids are associated with less atherosclerosis in Japanese versus white populations in the U.S...
  33. ncbi request reprint Dietary factors related to higher plasma fibrinogen levels of Japanese-americans in hawaii compared with Japanese in Japan
    Katsuyuki Miura
    Department of Epidemiology and Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, 920 0293, Japan
    Arterioscler Thromb Vasc Biol 26:1674-9. 2006
    ..We investigated whether dietary factors explain higher plasma fibrinogen levels in Japanese emigrants living a Western lifestyle in Hawaii compared with Japanese in Japan...
  34. ncbi request reprint Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial
    Sylvia Wassertheil-Smoller
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    JAMA 289:2673-84. 2003
    ..The Women's Health Initiative (WHI) trial of estrogen plus progestin was stopped early because of adverse effects, including an increased risk of stroke in the estrogen plus progestin group...
  35. ncbi request reprint The American Diabetes Association and World Health Organization classifications for diabetes: their impact on diabetes prevalence and total and cardiovascular disease mortality in elderly Japanese-American men
    Beatriz L Rodriguez
    Division of Clinical Epidemiology and the Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii at Manoa, Hawaii
    Diabetes Care 25:951-5. 2002
    ....
  36. ncbi request reprint Age-related changes in risk factor effects on the incidence of thromboembolic and hemorrhagic stroke
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Epidemiol 56:479-86. 2003
    ..Control of diabetes and the encouragement of active lifestyles in the elderly seem to be especially important...
  37. ncbi request reprint Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program)
    Robert D Abbott
    Division of Biostatistics and Epidemiology, Department of Health Evaluation Sciences, University of Virginia School of Medicine, PO Box 800717, Charlottesville, VA 22908 0717, USA
    Am J Cardiol 92:665-9. 2003
    ..We conclude that the intake of dietary Mg is associated with a reduced risk of CHD. Whether increases in dietary Mg intake can alter the future risk of disease warrants further study...
  38. ncbi request reprint Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study
    Robert D Abbott
    University of Virginia Health System, Department of Health Evaluation Sciences, 800717, Charlottesville, Virginia 22908 0717, USA
    J Neurol 250:III30-9. 2003
    ..This report describes the relations between environmental, life-style, and physical attributes and the incidence of PD that have been observed in the Honolulu-Asia Aging Study...
  39. ncbi request reprint Risk of hospitalized stroke in men enrolled in the Honolulu Heart Program and the Framingham Study: A comparison of incidence and risk factor effects
    Beatriz L Rodriguez
    Division of Clinical Epidemiology, John A Burns School of Medicine, University of Hawaii at Manoa, USA
    Stroke 33:230-6. 2002
    ..Our purpose was to compare the 20-year incidence of hospitalized stroke between Japanese-American men in the Honolulu Heart Program and white men in the Framingham Study...
  40. ncbi request reprint Relationship of blood pressure with degree of Hawaiian ancestry
    Andrew Grandinetti
    Pacific Biomedical Research Center, University of Hawaii at Manoa, USA
    Ethn Dis 12:221-8. 2002
    ..These results suggest that percentage of Hawaiian ancestry may act as a marker for important cultural or genetic risk factors for hypertension...
  41. ncbi request reprint Walking and dementia in physically capable elderly men
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, USA
    JAMA 292:1447-53. 2004
    ..Evidence suggests that physical activity may be related to the clinical expression of dementia. Whether the association includes low-intensity activity such as walking is not known...
  42. ncbi request reprint Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study
    Nagako Okuda
    Department of Health Science, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Atherosclerosis 178:371-9. 2005
    ..011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men...
  43. ncbi request reprint C-reactive protein and myocardial infarction
    Pamela Sakkinen
    Laboratory for Clinical Biochemistry Research, University of Vermont, Burlington, VT, USA
    J Clin Epidemiol 55:445-51. 2002
    ....
  44. ncbi request reprint Age-related changes in risk factor effects on the incidence of coronary heart disease
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Ann Epidemiol 12:173-81. 2002
    ..The purpose of this report is to examine the potential for risk factor effects on the incidence of CHD to change over a broad range of ages from middle adulthood to late-life...
  45. ncbi request reprint Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 162:404-14. 2005
    ..These analyses have implications for both the design and the analysis of observational studies...
  46. ncbi request reprint Combined analysis of Women's Health Initiative observational and clinical trial data on postmenopausal hormone treatment and cardiovascular disease
    Ross L Prentice
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 163:589-99. 2006
    ..An application to postmenopausal hormone treatment effects on coronary heart disease among younger women is also provided...
  47. ncbi request reprint Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study
    Reinhold Schmidt
    Department of Neurology, Karl Franzens University, Graz, Austria
    Ann Neurol 52:168-74. 2002
    ..These data support the view that inflammatory markers may reflect not only peripheral disease, but also cerebral disease mechanisms related to dementia, and that these processes are measurable long before clinical symptoms appear...
  48. doi request reprint Health-related quality of life of children and adolescents with type 1 or type 2 diabetes mellitus: SEARCH for Diabetes in Youth Study
    Michelle J Naughton
    Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest University School of Medicine, 2000 W First St, Winston Salem, NC 27104, USA
    Arch Pediatr Adolesc Med 162:649-57. 2008
    ..To examine the associations between demographic and diabetes management variables and the health-related quality of life (HRQOL) of youths with type 1 or type 2 diabetes mellitus (DM)...
  49. pmc Abdominal aortic aneurysm events in the women's health initiative: cohort study
    Frank A Lederle
    VA Medical Center, Minneapolis, MN 55417, USA
    BMJ 337:a1724. 2008
    ..To assess the association between potential risk factors and subsequent clinically important abdominal aortic aneurysm events (repairs and ruptures) in women...
  50. pmc Effect of calcium and vitamin D supplementation on blood pressure: the Women's Health Initiative Randomized Trial
    Karen L Margolis
    HealthPartners Research Foundation, Box 1524, Mailstop 21111R, Minneapolis, Minnesota 55440 1524, USA
    Hypertension 52:847-55. 2008
    ..01 (95% CI: 0.96 to 1.06.) In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up...
  51. doi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  52. ncbi request reprint Overview: the Hawai'i Clinical and Translational Science Institute
    J David Curb
    John A Burns School of Medicine, University of Hawai i, USA
    Hawaii Med J 67:134-5. 2008
  53. ncbi request reprint Risk factor clustering in the insulin resistance syndrome and its relationship to cardiovascular disease in postmenopausal white, black, hispanic, and Asian/Pacific Islander women
    Barbara V Howard
    MedStar Research Institute, Washington, DC, USA
    Metabolism 52:362-71. 2003
    ..0434) and strongly in black women (P =.0095). Components of the IR syndrome appear to be associated with CVD in postmenopausal women, although the magnitude of these relationships differed by ethnicity...
  54. ncbi request reprint Genome-wide linkage scans for loci affecting total cholesterol, HDL-C, and triglycerides: the Family Blood Pressure Program
    Suzette J Bielinski
    University of Minnesota, Division of Epidemiology and Community Health, West Bank Office Building Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454, USA
    Hum Genet 120:371-80. 2006
    ..The identification of these loci affecting lipid phenotypes and the apparent congruence with previous linkage results provides increased support that these regions contain genes influencing lipid levels...
  55. ncbi request reprint Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program
    Aldi T Kraja
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63123, USA
    Hypertension 46:751-7. 2005
    ..5, and 30 additional ones with lod score >1.7, offer hope for dissecting the genetic architecture of metabolic syndrome with beneficial implications for molecular diagnosis, prognosis, and in potential medical intervention...
  56. ncbi request reprint Depressive symptoms and heart rate variability in postmenopausal women
    Chin K Kim
    Division of Cardiovascular Medicine, University of Florida, Gainesville 32610 0277, USA
    Arch Intern Med 165:1239-44. 2005
    ..Findings regarding a relationship between depressive symptoms and heart rate variability that could explain increased cardiovascular risk have been inconsistent across studies...
  57. ncbi request reprint Favorable effects of non-instrumental resistance training on fat distribution and metabolic profiles in healthy elderly people
    Shigeki Tsuzuku
    Body Design Medical Institute Japan, 5 2 10 Shin Imazato Ikuno ku, Osaka, 544 0001, Japan
    Eur J Appl Physiol 99:549-55. 2007
    ..Relatively short-term, non-instrumental resistance training using body weight as a load was effective in improving fat distribution and metabolic profiles in healthy elderly people without weight loss...
  58. ncbi request reprint Referral management and the care of patients with diabetes: the Translating Research Into Action for Diabetes (TRIAD) study
    Catherine Kim
    Division of General Internal Medicine, Department of Medicine, University of Michigan, Ann Arbor, Mich, USA
    Am J Manag Care 10:137-43. 2004
    ..To examine the effect of referral management on diabetes care...
  59. pmc Coronary artery calcification in Japanese men in Japan and Hawaii
    Robert D Abbott
    Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, VA 22908 0717, USA
    Am J Epidemiol 166:1280-7. 2007
    ..0 (95% confidence interval: 2.2, 7.4). Further studies are needed to identify factors that protect against atherosclerosis in Japanese men in Japan...
  60. doi request reprint A whole-genome scan for stroke or myocardial infarction in family blood pressure program families
    Richard Sherva
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA
    Stroke 39:1115-20. 2008
    ..Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families...
  61. ncbi request reprint Statin use and incident frailty in women aged 65 years or older: prospective findings from the Women's Health Initiative Observational Study
    Andrea Z LaCroix
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Gerontol A Biol Sci Med Sci 63:369-75. 2008
    ..This study examines associations between current use, duration, and potency of statin medications and incident frailty in initially nonfrail women 65 years old or older...
  62. ncbi request reprint [Electron-beam computed tomography for identification of high-risk persons in primary prevention of coronary heart disease in the United States and its implication for Japan]
    Akira Sekikawa
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Nihon Koshu Eisei Zasshi 50:183-93. 2003
    ..It is, therefore, important to evaluate subclinical atherosclerosis measured by EBCT in men in recent birth cohorts in Japan and compare it to that in men in the US in order to predict future trend in CHD in Japan...
  63. doi request reprint The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe
    Hung Yuan Li
    Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Am J Hypertens 21:471-6. 2008
    ..In order to minimize confounding effects from unidentified factors, a family-based design was employed to explore the relationship...

Research Grants6

  1. PACIFIC GENETIC EPIDEMIOLOGIC STUDY ON AGING
    J Curb; Fiscal Year: 2002
    ..During this first phase the PacGen Network will develop and submit proposals for more comprehensive genetic epidemiologic studies (Phase II). ..
  2. The Family Blood Pressure Program (SAPPHIRe Network)
    JESS CURB; Fiscal Year: 2007
    ..End of Abstract) ..
  3. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    J Curb; Fiscal Year: 2003
    ..Better understanding the reasons for the low Japanese rates may help us find new methods for prevention of CHD in all populations. ..
  4. Epidemiology of CHD of Men Aged 40+ in US, Hawaii, Japan
    J Curb; Fiscal Year: 2006
    ..Better understanding the reasons for the low Japanese rates may help us find new methods for prevention of CHD in all populations. ..