Cyrus J Bacchi

Summary

Affiliation: Pace University
Country: USA

Publications

  1. pmc Chemotherapy of human african trypanosomiasis
    Cyrus J Bacchi
    Department of Biological and Health Sciences, Haskins Laboratory, Pace University, New York, NY 10038, USA
    Interdiscip Perspect Infect Dis 2009:195040. 2009
  2. pmc Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor
    Cyrus J Bacchi
    Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038, USA
    Antimicrob Agents Chemother 53:3269-72. 2009
  3. pmc Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi
    Cyrus J Bacchi
    Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038, USA
    Antimicrob Agents Chemother 53:2599-604. 2009
  4. pmc Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues
    Cyrus J Bacchi
    Department of Biology, Pace University, New York, NY 10038, USA
    Microbiology 150:1215-24. 2004
  5. ncbi request reprint Polyamine metabolism in the Microsporidia
    C J Bacchi
    Department of Biology, Pace University, New York, NY 10038, U S A
    Biochem Soc Trans 31:420-3. 2003
  6. ncbi request reprint Polyamine metabolism as chemotherapeutic target in protozoan parasites
    C J Bacchi
    Haskins Laboratories and Department of Biology, Pace University, 41 Park Row, New York, NY 10038, USA
    Mini Rev Med Chem 2:553-63. 2002
  7. pmc Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection
    Cyrus J Bacchi
    Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038 1598, USA
    Antimicrob Agents Chemother 46:55-61. 2002
  8. ncbi request reprint Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi
    C J Bacchi
    Haskins Laboratory, Pace University, New York, New York 10038, USA
    J Eukaryot Microbiol 48:374-81. 2001
  9. ncbi request reprint In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    B Goldberg
    Department of Biology, St Francis College, 180 Remsen Street, Brooklyn Heights, 11201, Brooklyn, NY, USA
    Biochem Pharmacol 61:449-57. 2001
  10. pmc In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors
    C J Bacchi
    Haskins Laboratories, Pace University, New York, New York 10038, USA
    Antimicrob Agents Chemother 40:1448-53. 1996

Collaborators

Detail Information

Publications19

  1. pmc Chemotherapy of human african trypanosomiasis
    Cyrus J Bacchi
    Department of Biological and Health Sciences, Haskins Laboratory, Pace University, New York, NY 10038, USA
    Interdiscip Perspect Infect Dis 2009:195040. 2009
    ..This article presents an update of classic chemotherapeutic agents, in use for >50 years and the recent development of promising non-toxic combination chemotherapy suitable for use in rural clinics...
  2. pmc Trypanocidal activity of 8-methyl-5'-{[(Z)-4-aminobut-2-enyl]-(methylamino)}adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor
    Cyrus J Bacchi
    Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038, USA
    Antimicrob Agents Chemother 53:3269-72. 2009
    ..This study shows that AdoMetDC remains an attractive chemotherapeutic target in African trypanosomes and that chemical changes in AdoMetDC inhibitors can produce more favorable drug characteristics than the lead compound...
  3. pmc Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi
    Cyrus J Bacchi
    Haskins Laboratories, Pace University, 41 Park Row, New York, NY 10038, USA
    Antimicrob Agents Chemother 53:2599-604. 2009
    ..cuniculi. The results in this study demonstrate competitive inhibition of oxidase activity by BW-1 and support further studies of this oxidase activity by the parasite and host...
  4. pmc Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues
    Cyrus J Bacchi
    Department of Biology, Pace University, New York, NY 10038, USA
    Microbiology 150:1215-24. 2004
    ..The interest in Enc. cuniculi polyamine metabolism and the biochemical effects of these polyamine analogues is warranted since they cure model infections of Enc. cuniculi in mice and are potential candidates for human clinical trials...
  5. ncbi request reprint Polyamine metabolism in the Microsporidia
    C J Bacchi
    Department of Biology, Pace University, New York, NY 10038, U S A
    Biochem Soc Trans 31:420-3. 2003
    ..In light of enhanced polyamine uptake in Enc. cuniculi, we have begun to study bis-aryl 3-7-3 and bis-ethyl oligoamine analogues as leads for chemotherapy of microsporidia...
  6. ncbi request reprint Polyamine metabolism as chemotherapeutic target in protozoan parasites
    C J Bacchi
    Haskins Laboratories and Department of Biology, Pace University, 41 Park Row, New York, NY 10038, USA
    Mini Rev Med Chem 2:553-63. 2002
    ..Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways...
  7. pmc Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection
    Cyrus J Bacchi
    Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038 1598, USA
    Antimicrob Agents Chemother 46:55-61. 2002
    ..25 to 5 mg/kg of body weight/day for a total of 10 days. Cured animals demonstrated no evidence of parasitemia by either PCR or histologic staining of tissues 30 days after untreated control animals died...
  8. ncbi request reprint Polyamine synthesis and interconversion by the Microsporidian Encephalitozoon cuniculi
    C J Bacchi
    Haskins Laboratory, Pace University, New York, New York 10038, USA
    J Eukaryot Microbiol 48:374-81. 2001
    ..Pre-emergent spores were metabolically active with respect to polyamine synthesis and interconversion, while intact mature spores harvested from culture supernatants had little metabolic activity...
  9. ncbi request reprint In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    B Goldberg
    Department of Biology, St Francis College, 180 Remsen Street, Brooklyn Heights, 11201, Brooklyn, NY, USA
    Biochem Pharmacol 61:449-57. 2001
    ..The significant ability of African trypanosomes to transport MTA and related intermediates is an important consideration in the design and development of selective chemotherapeutic agents...
  10. pmc In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors
    C J Bacchi
    Haskins Laboratories, Pace University, New York, New York 10038, USA
    Antimicrob Agents Chemother 40:1448-53. 1996
    ....
  11. ncbi request reprint Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine
    N Yarlett
    Haskins Laboratories, Department of Biology, Pace University, New York, NY 10038
    J Gen Microbiol 137:717-24. 1991
    ..The possible role of the enzyme in morphological control and its potential as a chemotherapeutic target are discussed...
  12. pmc Antitrypanosomal activity of a new triazine derivative, SIPI 1029, In vitro and in model infections
    C J Bacchi
    Haskins Laboratories, Pace University, New York, New York 10038, USA
    Antimicrob Agents Chemother 42:2718-21. 1998
    ..The activity of SIPI 1029 in this study indicates that this class of compounds (diaminotriazines) should be explored as leads for new human and veterinary trypanocides...
  13. ncbi request reprint Metabolic effects of a methylthioadenosine phosphorylase substrate analog on African trypanosomes
    C J Bacchi
    Department of Biology, Pace University, New York, NY 10038 1502, USA
    Biochem Pharmacol 57:89-96. 1999
    ..Thus, HETA interferes with a series of biochemical events involving the participation of AdoMet and methionine in polyamine synthesis, protein synthesis, and transmethylation reactions...
  14. pmc Synergism between 9-deazainosine and DL-alpha-difluoromethylornithine in treatment of experimental African trypanosomiasis
    C J Bacchi
    Department of Biology, Pace University, New York, New York 10038
    Antimicrob Agents Chemother 31:1406-13. 1987
    ..These studies indicate that 9-DINO is a potent, nontoxic purine analog which, in combination with DFMO, is capable of late-stage cures of African trypanosomiasis...
  15. pmc Novel trypanocidal analogs of 5'-(methylthio)-adenosine
    Janice R Sufrin
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Antimicrob Agents Chemother 52:211-9. 2008
    ..This suggests that additional biochemical mechanisms are associated with the trypanocidal effects of HETA and its analogs...
  16. ncbi request reprint Synthesis and evaluation of analogues of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine as inhibitors of tumor cell growth, trypanosomal growth, and HIV-1 infectivity
    Canio J Marasco
    Department of Pharmacology and Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Med Chem 45:5112-22. 2002
    ..Moreover, the acetylated derivative of 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine did inhibit HIV-1 growth and infectivity, whereas the parent compound did not...
  17. ncbi request reprint Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug
    Tien L Huang
    College of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA
    Int J Antimicrob Agents 30:555-61. 2007
    ..Three compounds (7, 11 and 15) provided 100% cure when administered parenterally. The results indicate that the nature of the substituents at the amidinium nitrogens of bisbenzamidines strongly influence their trypanocidal activity...
  18. pmc Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin
    Slavoljub Vujcic
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biochem J 367:665-75. 2002
    ....
  19. ncbi request reprint Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity
    Xiangdong Bi
    Department of Pharmaceutical Sciences, Wayne State University, 259 Mack Ave, Detroit, MI 48202, USA
    Bioorg Med Chem Lett 16:3229-32. 2006
    ..The most effective analogues, 7a, 7b and 8d, inhibited parasitic growth in vitro with IC50 values of 0.18, 0.09 and 0.18 microM, respectively. These agents represent a promising new class of potential antitrypanosomal agents...