Shaun Jordan

Summary

Affiliation: Otsuka Maryland Research Institute
Country: USA

Publications

  1. ncbi request reprint The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
    Shaun Jordan
    Neuroscience Department, Maryland Research Laboratories, Otsuka Maryland Research Institute, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 441:137-40. 2002
  2. ncbi request reprint In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function
    Shaun Jordan
    Neuroscience Department, Maryland Research Laboratories, Otsuka Maryland Research Institute, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 483:45-53. 2004
  3. ncbi request reprint In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 517:165-73. 2005
  4. ncbi request reprint Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:348-56. 2007
  5. ncbi request reprint In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900, Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 540:53-6. 2006
  6. ncbi request reprint In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    J Psychopharmacol 21:620-7. 2007
  7. doi request reprint Aripiprazole protects cortical neurons from glutamate toxicity
    Vuk Koprivica
    CNS Drug Discovery and Development, Otsuka Maryland Medicinal Laboratories, Inc, Rockville, MD 20850, USA
    Eur J Pharmacol 651:73-6. 2011
  8. ncbi request reprint Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies
    Arlene D Stark
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
    Psychopharmacology (Berl) 190:373-82. 2007
  9. ncbi request reprint Altered emotional behaviors in the diabetes mellitus OLETF type 1 congenic rat
    Akihito Watanabe
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Kanazawa, 920 8640, Japan
    Brain Res 1178:114-24. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
    Shaun Jordan
    Neuroscience Department, Maryland Research Laboratories, Otsuka Maryland Research Institute, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 441:137-40. 2002
    ..Combined with previous studies demonstrating the potent partial agonism of aripiprazole at dopamine D2 receptors, this study suggests aripiprazole is the first dopamine-serotonin system stabilizer...
  2. ncbi request reprint In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function
    Shaun Jordan
    Neuroscience Department, Maryland Research Laboratories, Otsuka Maryland Research Institute, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 483:45-53. 2004
    ....
  3. ncbi request reprint In vitro profile of the antidepressant candidate OPC-14523 at rat and human 5-HT1A receptors
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 517:165-73. 2005
    ..Taken together, these data support the development of OPC-14523 as an antidepressant whose mechanism of action involves potent partial agonist activity at 5-HT1A receptors...
  4. ncbi request reprint Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:348-56. 2007
    ..This study also highlights the limitations of using [(35)S]GTPgammaS binding assays to identify dopamine D(2) receptor partial agonists...
  5. ncbi request reprint In vitro biochemical evidence that the psychotomimetics phencyclidine, ketamine and dizocilpine (MK-801) are inactive at cloned human and rat dopamine D2 receptors
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900, Medical Center Drive, Rockville, MD 20850, USA
    Eur J Pharmacol 540:53-6. 2006
    ....
  6. ncbi request reprint In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling
    Shaun Jordan
    Department of Neuroscience Research, Otsuka Maryland Medicinal Laboratories, 9900 Medical Center Drive, Rockville, MD 20850, USA
    J Psychopharmacol 21:620-7. 2007
    ....
  7. doi request reprint Aripiprazole protects cortical neurons from glutamate toxicity
    Vuk Koprivica
    CNS Drug Discovery and Development, Otsuka Maryland Medicinal Laboratories, Inc, Rockville, MD 20850, USA
    Eur J Pharmacol 651:73-6. 2011
    ..Further experiments are required to determine the biochemical nature of aripiprazole-induced neuroprotection and whether any such activity might have clinical relevance...
  8. ncbi request reprint Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies
    Arlene D Stark
    Neuroscience Drug Discovery, Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA
    Psychopharmacology (Berl) 190:373-82. 2007
    ..Aripiprazole interacts with a range of receptors, including serotonin [5-hydroxytryptamine (5-HT)] and dopamine receptors...
  9. ncbi request reprint Altered emotional behaviors in the diabetes mellitus OLETF type 1 congenic rat
    Akihito Watanabe
    Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Kanazawa, 920 8640, Japan
    Brain Res 1178:114-24. 2007
    ..On the basis of these observations, the GPR10 might be a novel target for the developing new drugs against anxiety and/or other stress-related diseases...