M F Pittenger

Summary

Affiliation: Osiris Therapeutics
Country: USA

Publications

  1. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
  2. doi Mesenchymal stem cells from adult bone marrow
    Mark F Pittenger
    Cardiology Dept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 449:27-44. 2008
  3. ncbi Mesenchymal stem cells and their potential as cardiac therapeutics
    Mark F Pittenger
    Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Circ Res 95:9-20. 2004
  4. pmc Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction
    Dara L Kraitchman
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 112:1451-61. 2005
  5. pmc Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia
    Piotr Walczak
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Stroke 39:1569-74. 2008
  6. ncbi Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow
    A M Mackay
    Osiris Therapeutics, Inc, Baltimore, Maryland 21231 2001, USA
    Tissue Eng 4:415-28. 1998
  7. ncbi Human mesenchymal stem cells maintain transgene expression during expansion and differentiation
    K Lee
    Osiris Therapeutics, Inc, 2001 Aliceanna Street, Baltimore, Maryland 21231-2001, USA
    Mol Ther 3:857-66. 2001
  8. ncbi Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation
    G Mbalaviele
    Osiris Therapeutics, Inc, Baltimore, Maryland 21231, USA
    J Biol Chem 275:14388-93. 2000
  9. ncbi 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction
    B B Chin
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nucl Med Commun 24:1149-54. 2003
  10. ncbi Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects
    Jay G Shake
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 73:1919-25; discussion 1926. 2002

Collaborators

Detail Information

Publications16

  1. ncbi Multilineage potential of adult human mesenchymal stem cells
    M F Pittenger
    Osiris Therapeutics, 2001 Aliceanna Street, Baltimore, MD 21231 3043, USA
    Science 284:143-7. 1999
    ..These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential...
  2. doi Mesenchymal stem cells from adult bone marrow
    Mark F Pittenger
    Cardiology Dept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Methods Mol Biol 449:27-44. 2008
    ..The methods provided here have been used in many laboratories around the world and the reader can begin by following the methods presented here, and then test other methods if these prove unsatisfactory for your intended purpose...
  3. ncbi Mesenchymal stem cells and their potential as cardiac therapeutics
    Mark F Pittenger
    Osiris Therapeutics, Inc, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Circ Res 95:9-20. 2004
    ....
  4. pmc Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction
    Dara L Kraitchman
    Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 112:1451-61. 2005
    ..However, the histological interpretation of postmortem tissue, on which many of these studies are based, has recently been widely debated...
  5. pmc Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia
    Piotr Walczak
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Stroke 39:1569-74. 2008
    ..We assessed the suitability of laser Doppler flow (LDF) signal measurements and magnetic resonance (MR) imaging for noninvasive dual monitoring of targeted IA cell delivery...
  6. ncbi Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow
    A M Mackay
    Osiris Therapeutics, Inc, Baltimore, Maryland 21231 2001, USA
    Tissue Eng 4:415-28. 1998
    ..Increased understanding of the induction of chondrogenic differentiation should lead to further progress in defining the mechanisms responsible for the generation of cartilaginous tissues, their maintenance, and their regeneration...
  7. ncbi Human mesenchymal stem cells maintain transgene expression during expansion and differentiation
    K Lee
    Osiris Therapeutics, Inc, 2001 Aliceanna Street, Baltimore, Maryland 21231-2001, USA
    Mol Ther 3:857-66. 2001
    ..These results illustrate the ability of hMSCs to express genes of therapeutic potential and demonstrate their potential clinical utility as cellular vehicles for systemic gene delivery...
  8. ncbi Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation
    G Mbalaviele
    Osiris Therapeutics, Inc, Baltimore, Maryland 21231, USA
    J Biol Chem 275:14388-93. 2000
    ..These data establish a link between PPAR-gamma and OPGL signaling within Ocl progenitors, and support a role for PPAR-gamma pathway in the modulation of osteoclastogenesis...
  9. ncbi 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction
    B B Chin
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nucl Med Commun 24:1149-54. 2003
    ..Because intravenous administration of MSCs results in significant lung activity that obscures the assessment of myocardial cell trafficking, alternative routes of administration should be investigated for this application...
  10. ncbi Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects
    Jay G Shake
    The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Ann Thorac Surg 73:1919-25; discussion 1926. 2002
    ..The purpose of this study was to investigate whether implantation of autologous MSCs results in sustained engraftment, myogenic differentiation, and improved cardiac function in a swine myocardial infarct model...
  11. ncbi Feridex-labeled mesenchymal stem cells: cellular differentiation and MR assessment in a canine myocardial infarction model
    Jeff W M Bulte
    Dept of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Acad Radiol 12:S2-6. 2005
  12. ncbi Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis
    Lisa Kostura
    Osiris Therapeutics Inc, Baltimore, MD, USA
    NMR Biomed 17:513-7. 2004
    ..On the other hand, no detrimental effects of Feridex-labeling are anticipated for MR-guided osteogenic or adipogenic transplantation studies...
  13. ncbi Chondrogenic differentiation of mesenchymal stem cells is inhibited after magnetic labeling with ferumoxides
    Jeff W M Bulte
    Blood 104:3410-2; author reply 3412-3. 2004
  14. ncbi Human mesenchymal stem cells modulate allogeneic immune cell responses
    Sudeepta Aggarwal
    Osiris Therapeutics, 2001 Aliceanna St, Baltimore, MD 21231, USA
    Blood 105:1815-22. 2005
    ....
  15. ncbi In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction
    Dara L Kraitchman
    Johns Hopkins University, School of Medicine, Department of Radiology, 601 N Caroline St, Suite 4231, Baltimore, MD 21287 0845, USA
    Circulation 107:2290-3. 2003
    ..We investigated the potential of magnetic resonance imaging (MRI) to track magnetically labeled mesenchymal stem cells (MR-MSCs) in a swine myocardial infarction (MI) model...
  16. ncbi Cell therapy in the heart: cell production, transplantation, and applications
    Kevin S Cahill
    Department of Pediatrics, University of Florida School of Medicine, Gainesville, USA
    Methods Mol Biol 219:73-81. 2003