PETER A ZUBER

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit
    Michiko M Nakano
    Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, Oregon, USA
    PLoS ONE 5:e8664. 2010
  2. pmc Transcriptomic and phenotypic analysis of paralogous spx gene function in Bacillus anthracis Sterne
    SKYE BARENDT
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, Oregon
    Microbiologyopen 2:695-714. 2013
  3. pmc Evidence that a single monomer of Spx can productively interact with RNA polymerase in Bacillus subtilis
    Ann A Lin
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, OR, USA
    J Bacteriol 194:1697-707. 2012
  4. pmc Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis
    Peter Zuber
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, Oregon, United States of America
    PLoS ONE 6:e25066. 2011
  5. doi request reprint Management of oxidative stress in Bacillus
    Peter Zuber
    Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Annu Rev Microbiol 63:575-97. 2009
  6. pmc Spx-RNA polymerase interaction and global transcriptional control during oxidative stress
    Peter Zuber
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Bacteriol 186:1911-8. 2004
  7. pmc Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation
    Dindo Y Reyes
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    Mol Microbiol 69:765-79. 2008
  8. pmc Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis
    Montira Leelakriangsak
    OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97229, USA
    J Bacteriol 189:1736-44. 2007
  9. doi request reprint Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis
    Montira Leelakriangsak
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
    Mol Microbiol 67:1108-24. 2008
  10. pmc Mutational analysis of the Bacillus subtilis RNA polymerase alpha C-terminal domain supports the interference model of Spx-dependent repression
    Ying Zhang
    EBS OGI School of Science and Engineering, OHSU, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    J Bacteriol 188:4300-11. 2006

Collaborators

Detail Information

Publications23

  1. pmc Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit
    Michiko M Nakano
    Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, Oregon, USA
    PLoS ONE 5:e8664. 2010
    ..Spx activates trxA (thioredoxin) and trxB (thioredoxin reductase) in response to thiol stress, and bears an N-terminal C10XXC13 redox disulfide center that is oxidized in active Spx...
  2. pmc Transcriptomic and phenotypic analysis of paralogous spx gene function in Bacillus anthracis Sterne
    SKYE BARENDT
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, Oregon
    Microbiologyopen 2:695-714. 2013
    ..The data indicate that spxA1 and spxA2 are transcriptional regulators involved in relieving disulfide stress but also control a set of genes whose products function in other cellular processes...
  3. pmc Evidence that a single monomer of Spx can productively interact with RNA polymerase in Bacillus subtilis
    Ann A Lin
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, OR, USA
    J Bacteriol 194:1697-707. 2012
    ..The results strongly argue for a model in which a single Spx monomer engages RNAP to generate an active transcriptional complex...
  4. pmc Phenotype enhancement screen of a regulatory spx mutant unveils a role for the ytpQ gene in the control of iron homeostasis
    Peter Zuber
    Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health and Science University, Beaverton, Oregon, United States of America
    PLoS ONE 6:e25066. 2011
    ..In vitro transcription analysis indicated that Spx stimulates transcription from the ytpPQR operon within which the ytpQ gene resides. The work uncovers a link between Spx and control of iron homeostasis...
  5. doi request reprint Management of oxidative stress in Bacillus
    Peter Zuber
    Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Annu Rev Microbiol 63:575-97. 2009
    ..An important unknown is the nature and influence of the low-molecular-weight thiols that mediate the buffering of the redox environment...
  6. pmc Spx-RNA polymerase interaction and global transcriptional control during oxidative stress
    Peter Zuber
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Bacteriol 186:1911-8. 2004
  7. pmc Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation
    Dindo Y Reyes
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    Mol Microbiol 69:765-79. 2008
    ..These data are consistent with a model that Spx activation requires contact between the Spx/RNAP complex and upstream promoter DNA, which allows Spx-induced engagement of the sigma and large subunits with the core promoter...
  8. pmc Dual negative control of spx transcription initiation from the P3 promoter by repressors PerR and YodB in Bacillus subtilis
    Montira Leelakriangsak
    OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97229, USA
    J Bacteriol 189:1736-44. 2007
    ..The study has uncovered a mechanism of dual negative control that relates to the oxidative stress response of gram-positive bacteria...
  9. doi request reprint Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis
    Montira Leelakriangsak
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR, USA
    Mol Microbiol 67:1108-24. 2008
    ..Thus, both azoreductases that are controlled by different regulatory mechanisms have common functions in quinone and azo-compound reduction to protect cells against the thiol reactivity of electrophiles...
  10. pmc Mutational analysis of the Bacillus subtilis RNA polymerase alpha C-terminal domain supports the interference model of Spx-dependent repression
    Ying Zhang
    EBS OGI School of Science and Engineering, OHSU, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    J Bacteriol 188:4300-11. 2006
    ..Evidence is also presented that oxidized Spx, while enhancing interference of activator-RNAP interaction, is not essential for negative control...
  11. ncbi request reprint Redox-sensitive transcriptional control by a thiol/disulphide switch in the global regulator, Spx
    Shunji Nakano
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Mol Microbiol 55:498-510. 2005
    ..The mechanism of Spx-dependent transcriptional activation is unique in that it does not involve initial Spx-DNA interaction...
  12. ncbi request reprint Regulation of respiratory genes by ResD-ResE signal transduction system in Bacillus subtilis
    Hao Geng
    Department of Environmental System, Oregon Health and Science University, Beaverton, Oregon, USA
    Methods Enzymol 422:448-64. 2007
    ..ResD, after undergoing ResE-mediated phosphorylation, interacts with the C-terminal domain of the alpha subunit of RNA polymerase to activate transcription initiation at ResDE-controlled promoters...
  13. pmc Transcription from the P3 promoter of the Bacillus subtilis spx gene is induced in response to disulfide stress
    Montira Leelakriangsak
    Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Bacteriol 189:1727-35. 2007
    ..The data indicate that spx transcription is under negative transcriptional control that is reversed when disulfide stress is encountered...
  14. ncbi request reprint Control of gene expression in Gram-positive bacteria: extensions of and departures from enteric paradigms
    Peter Zuber
    Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Front Biosci 7:d1857-66. 2002
    ..The accompanying reviews highlight the diversity and novel aspects of genetic control in Gram-positive bacteria, with descriptions of quorum-sensing systems, transcriptional control, and RNA processing mechanisms...
  15. pmc Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis
    Shunji Nakano
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 100:13603-8. 2003
    ....
  16. pmc Sulfate-dependent repression of genes that function in organosulfur metabolism in Bacillus subtilis requires Spx
    Kyle N Erwin
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    J Bacteriol 187:4042-9. 2005
    ..This work uncovers a new role for Spx in the control of sulfur metabolism in a gram-positive bacterium under nonstressful growth conditions...
  17. pmc The global regulator Spx functions in the control of organosulfur metabolism in Bacillus subtilis
    Soon Yong Choi
    OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Bacteriol 188:5741-51. 2006
    ..These experiments have uncovered additional roles for Spx in the control of gene expression during unperturbed, steady-state growth...
  18. pmc Requirement of the zinc-binding domain of ClpX for Spx proteolysis in Bacillus subtilis and effects of disulfide stress on ClpXP activity
    Ying Zhang
    Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    J Bacteriol 189:7669-80. 2007
    ..The results are consistent with the hypothesis that inhibition of ClpXP by disulfide stress is due to structural changes to the N-terminal ZBD of ClpX...
  19. pmc Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis
    Shunji Nakano
    Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, Oregon 97006 8921, USA
    J Bacteriol 184:3664-70. 2002
    ..Spx probably is degraded by ClpCP under as yet unidentified conditions. This study suggests that the level of Spx is tightly controlled by two different ClpP proteases...
  20. pmc The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx
    Saurabh K Garg
    Division of Environmental and Biomolecular Systems, Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Bacteriol 191:1268-77. 2009
    ..In conclusion, YjbH is proposed to be an adaptor for ClpXP-catalyzed Spx degradation, and a model of YjbH redox control involving Zn dissociation is presented...
  21. ncbi request reprint Spx (YjbD), a negative effector of competence in Bacillus subtilis, enhances ClpC-MecA-ComK interaction
    Michiko M Nakano
    Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006 8921, USA
    Mol Microbiol 44:1341-9. 2002
    ..Spx is a highly conserved protein among Gram-positive bacteria, in which it may function closely with the protease adaptor protein, MecA...
  22. pmc A regulatory protein that interferes with activator-stimulated transcription in bacteria
    Shunji Nakano
    Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 100:4233-8. 2003
    ..Spx represents a class of transcriptional regulators that inhibit activator-stimulated transcription by interaction with alpha...
  23. pmc YjbH-enhanced proteolysis of Spx by ClpXP in Bacillus subtilis is inhibited by the small protein YirB (YuzO)
    Sushma Kommineni
    Department of Science and Engineering, Division of Environmental and Biomolecular Systems, Oregon Health and Science University, 20000 NW Walker Rd, Beaverton, OR 97006, USA
    J Bacteriol 193:2133-40. 2011
    ..The activity of YirB is similar to that of the antiadaptor proteins that were previously shown to reduce proteolysis of a specific ClpXP substrate by interacting with a substrate-binding protein...

Research Grants8

  1. SRF OPERON--REGULATION AND ROLE IN GENETIC COMPETENCE
    Peter Zuber; Fiscal Year: 2001
    ..These studies will further understanding of the functional links between stress-induced proteins and the regulation of prokaryotic cellular differentiation. ..
  2. SRF OPERON--REGULATION AND ROLE IN GENETIC COMPETENCE
    Peter Zuber; Fiscal Year: 2002
    ..These studies will further understanding of the functional links between stress-induced proteins and the regulation of prokaryotic cellular differentiation. ..
  3. SRF OPERON--REGULATION AND ROLE IN GENETIC COMPETENCE
    Peter Zuber; Fiscal Year: 2003
    ..These studies will further understanding of the functional links between stress-induced proteins and the regulation of prokaryotic cellular differentiation. ..
  4. Transcriptional Control by the Global Regulator Spx
    Peter Zuber; Fiscal Year: 2005
    ..The effects of oxidants on Zn release and C1pXP activity will be determined in vitro. ..
  5. Transcriptional Control by the Global Regulator Spx
    Peter Zuber; Fiscal Year: 2006
    ..The effects of oxidants on Zn release and C1pXP activity will be determined in vitro. ..
  6. Transcriptional Control by the Global Regulator Spx
    Peter Zuber; Fiscal Year: 2007
    ..The effects of oxidants on Zn release and C1pXP activity will be determined in vitro. ..
  7. Transcriptional Control by the Global Regulator Spx
    PETER A ZUBER; Fiscal Year: 2010
    ..The regulatory protein Spx controls important components of the bacterial response to oxidative attack, and the study of its mechanism of action will uncover targets for neutralizing infectious microorganisms. ..