Zili Zhang

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Low dose rapamycin exacerbates autoimmune experimental uveitis
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e36589. 2012
  2. pmc Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia
    Jinyong Wu
    Ruijin Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    BMC Mol Biol 10:77. 2009
  3. pmc Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis
    Zili Zhang
    Departments of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Pathol 177:2912-20. 2010
  4. doi request reprint Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, 97239, USA
    Semin Immunopathol 32:55-70. 2010
  5. pmc Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Cytokine 46:79-91. 2009
  6. pmc Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis
    Zili Zhang
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e81154. 2013
  7. pmc CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Exp Eye Res 89:522-31. 2009
  8. pmc Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis
    Xiumei Wu
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Invest Ophthalmol Vis Sci 52:8520-6. 2011
  9. ncbi request reprint After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Int Immunopharmacol 7:409-16. 2007
  10. ncbi request reprint Chemokines orchestrate leukocyte trafficking in inflammatory bowel disease
    Wenwei Zhong
    Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines Street, Portland, OR 97239, USA
    Front Biosci 13:1654-64. 2008

Research Grants

  1. IL-23, ThIL-17, and Uveitis
    Zili Zhang; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc Low dose rapamycin exacerbates autoimmune experimental uveitis
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e36589. 2012
    ..Unexpectedly, recent research has demonstrated that low dose rapamycin enhances the memory T cell population and function. However, it is unclear how low dose rapamycin influences the immune response in the setting of uveitis...
  2. pmc Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia
    Jinyong Wu
    Ruijin Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China
    BMC Mol Biol 10:77. 2009
    ..In the present study, we investigated whether suppression of rat HO-1 (rHO-1) expression by small interference RNAs (siRNAs) reduces bilirubin levels in hyperbilirubinemic rats...
  3. pmc Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis
    Zili Zhang
    Departments of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Pathol 177:2912-20. 2010
    ..This study thus enhances our knowledge of costimulatory molecule-mediated immunopathological mechanisms of uveitis and suggests a future therapeutic strategy to treat uveitis by the targeting of OX40...
  4. doi request reprint Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, 97239, USA
    Semin Immunopathol 32:55-70. 2010
    ....
  5. pmc Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Cytokine 46:79-91. 2009
    ..Our study suggests that IL-17 is implicated in the pathogenesis of this T cell-mediated model of uveitis in part through neutrophil chemotaxis as a downstream effect of IL-17...
  6. pmc Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis
    Zili Zhang
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e81154. 2013
    ..In addition, recent research has implicated CdK2 in T cell activation. Thus, we sought to test the immunosuppressive effect of roscovitine, a potent CdK2 inhibitor, on CD4+ T cell activation, proliferation, and function...
  7. pmc CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Exp Eye Res 89:522-31. 2009
    ..This study not only enhances our knowledge of the immunopathological mechanism of uveitis but also provides a novel rationale to target CXCR4 as an anti-inflammatory strategy to treat uveitis...
  8. pmc Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis
    Xiumei Wu
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Invest Ophthalmol Vis Sci 52:8520-6. 2011
    ..Although the costimulatory molecule OX40 promotes T-cell function and expansion, it is unclear whether OX40 is implicated in ocular inflammation. The purpose of this study was to examine the role of OX40 in uveitis...
  9. ncbi request reprint After interleukin-12p40, are interleukin-23 and interleukin-17 the next therapeutic targets for inflammatory bowel disease?
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Int Immunopharmacol 7:409-16. 2007
    ..Controlling the expression/production of IL-23 and IL-17 is an approach that would allow the development of a novel treatment strategy with more anti-inflammatory efficacy and potentially with less suppressive effects on host defenses...
  10. ncbi request reprint Chemokines orchestrate leukocyte trafficking in inflammatory bowel disease
    Wenwei Zhong
    Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines Street, Portland, OR 97239, USA
    Front Biosci 13:1654-64. 2008
    ..Controlling the expression and neutralizing the function of chemokines are an approach that would allow the development of a novel treatment strategy with effective anti-inflammatory effect...
  11. pmc The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity
    Tammy M Martin
    Oregon Health and Science University, Portland, OR 79239, USA
    Arthritis Rheum 60:611-8. 2009
    ..Furthermore, functional studies demonstrate that caspase 1-mediated release of IL-1beta also involves NOD-2. The aim of this study was to test the hypothesis that IL-1beta may mediate the inflammation seen in patients with Blau syndrome...
  12. doi request reprint T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?
    Zili Zhang
    Department of Pediatrics, Case Western Reserve University School of Medicine, 11000 Euclid Avenue, Cleveland, OH 44106, USA
    Dig Dis Sci 58:1497-506. 2013
    ..Our goal is to provide the rationale for the development of novel therapy therapies that target co-stimulatory molecules. ..
  13. doi request reprint Diagnosis of autoimmune pancreatitis vs neoplasms in children with pancreatic mass and biliary obstruction
    Joel Friedlander
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Clin Gastroenterol Hepatol 10:1051-5.e1. 2012
    ..However, frozen section needle core biopsy samples can be used to distinguish children with AIP from those with neoplasia. Children with pancreatic mass and biliary obstruction are more likely to have AIP than neoplasms...
  14. doi request reprint Pediatric eosinophilic esophagitis: single-center experience in northwestern USA
    Yasemen Eroglu
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    Pediatr Int 51:612-6. 2009
    ....
  15. ncbi request reprint Critical role of IL-17 receptor signaling in acute TNBS-induced colitis
    Zili Zhang
    Department of Pediatrics, Oregon Health Sciences Center, Portland, USA
    Inflamm Bowel Dis 12:382-8. 2006
    ..Infiltration of CD4 lymphocytes and neutrophils is one of the predominant features of IBD...

Research Grants2

  1. IL-23, ThIL-17, and Uveitis
    Zili Zhang; Fiscal Year: 2007
    ..By targeting IL-23 or IL-17, we hope to develop a novel therapeutic strategy with more anti-inflammatory efficacy and less suppressive effect on host defense. ..