Wei Jian Zhang

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 46:791-8. 2009
  2. pmc Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 50:1517-25. 2011
  3. pmc The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Exp Biol Med (Maywood) 235:633-41. 2010
  4. pmc Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512
    Proc Natl Acad Sci U S A 104:4077-82. 2007
  5. ncbi Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Circulation 117:421-8. 2008
  6. pmc Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice
    Hao Wei
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Atherosclerosis 223:306-13. 2012
  7. ncbi Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 34:674-82. 2003
  8. ncbi Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Cardiovasc Res 55:820-9. 2002
  9. pmc Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo
    Hao Wei
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Heart Circ Physiol 301:H712-20. 2011
  10. pmc Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 51:454-63. 2011

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 46:791-8. 2009
    ..Our findings suggest that NADPH oxidase-mediated ROS production and cellular redox signaling do not promote, but instead limit, LPS-induced acute inflammatory responses in vivo...
  2. pmc Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 50:1517-25. 2011
    ....
  3. pmc The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Exp Biol Med (Maywood) 235:633-41. 2010
    ..Whether eliminating excess iron is a useful adjunct for the prevention or treatment of atherosclerosis in humans remains to be investigated...
  4. pmc Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512
    Proc Natl Acad Sci U S A 104:4077-82. 2007
    ..Lipoic acid may be useful in the prevention of sepsis and inflammatory vascular diseases...
  5. ncbi Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Circulation 117:421-8. 2008
    ..Here, we investigated whether LA inhibits atherosclerosis in apolipoprotein E-deficient (apoE-/-) and apoE/low-density lipoprotein receptor-deficient mice, 2 well-established animal models of human atherosclerosis...
  6. pmc Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice
    Hao Wei
    Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Atherosclerosis 223:306-13. 2012
    ..These data indicate that TTM inhibits atherosclerosis in apoE-/- mice by reducing bioavailable copper and vascular inflammation, not by altering iron homeostasis or reducing oxidative stress...
  7. ncbi Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 34:674-82. 2003
    ..Our data suggest that intracellular, but not extracellular, transition metal ions mediate inflammatory cytokine-induced SP-1 activation and adhesion molecule expression in endothelial cells...
  8. ncbi Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Cardiovasc Res 55:820-9. 2002
    ..We hypothesized that albumin, the major plasma protein, acts as an anti-inflammatory agent towards endothelial cells...
  9. pmc Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo
    Hao Wei
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Heart Circ Physiol 301:H712-20. 2011
    ..Therefore, copper appears to play an important role in vascular inflammation, and TTM may have value as an anti-inflammatory or anti-atherogenic agent...
  10. pmc Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 51:454-63. 2011
    ....
  11. ncbi Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Atherosclerosis 165:241-9. 2002
    ..The ability of polyunsaturated phospholipids in HDL to affect endothelial activation remains to be further investigated...
  12. ncbi Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression
    Wei Jian Zhang
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Thromb Haemost 90:904-14. 2003
    ..We conclude that the ability of AS-IV to inhibit the NF-kappaB pathway might be one under-lying mechanism contributing to its anti-inflammatory potential in vivo...

Research Grants1