Chao Ling Yang

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 117:3403-11. 2007
  2. ncbi request reprint WNK1 and WNK4 modulate CFTR activity
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem Biophys Res Commun 353:535-40. 2007
  3. pmc WNK kinases regulate thiazide-sensitive Na-Cl cotransport
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 111:1039-45. 2003
  4. pmc Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
    Chao Ling Yang
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, 97239, USA
    J Clin Invest 115:1379-87. 2005
  5. ncbi request reprint Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
    Arohan R Subramanya
    Division of Nephrology and Hypertension, Oregon Health and Science University, PP262, 3314 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Am J Physiol Renal Physiol 290:F619-24. 2006
  6. pmc WNK kinases and renal sodium transport in health and disease: an integrated view
    James A McCormick
    Division of Nephrology and Hypertension and Heart Research Center, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Hypertension 51:588-96. 2008
  7. doi request reprint Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Sci (Lond) 123:635-47. 2012
  8. pmc Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway
    David J Rozansky
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    J Clin Invest 119:2601-12. 2009
  9. pmc A SPAK isoform switch modulates renal salt transport and blood pressure
    James A McCormick
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Cell Metab 14:352-64. 2011
  10. pmc The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
    Ewout J Hoorn
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
    Nat Med 17:1304-9. 2011

Collaborators

Detail Information

Publications14

  1. pmc The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 117:3403-11. 2007
    ..The results provide a mechanistic explanation for the divergent effects of WT and FHHt-mutant WNK4 on NCC activity, and for the dominant nature of FHHt in humans and genetically modified mice...
  2. ncbi request reprint WNK1 and WNK4 modulate CFTR activity
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem Biophys Res Commun 353:535-40. 2007
    ..Taken together, these results suggest that WNK1 and WNK4 may modulate CFTR activity; they further suggest that WNK kinases may be potential therapeutic targets for cystic fibrosis...
  3. pmc WNK kinases regulate thiazide-sensitive Na-Cl cotransport
    Chao Ling Yang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 111:1039-45. 2003
    ..Together, these results identify WNK kinases as a previously unrecognized sodium regulatory pathway of the distal nephron. This pathway likely contributes to normal and pathological blood pressure homeostasis...
  4. pmc Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport
    Chao Ling Yang
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, 97239, USA
    J Clin Invest 115:1379-87. 2005
    ..These findings provide insight into the complex interrelationships between WNK1 and WNK4 and provide a molecular basis for FHHt...
  5. ncbi request reprint Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
    Arohan R Subramanya
    Division of Nephrology and Hypertension, Oregon Health and Science University, PP262, 3314 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Am J Physiol Renal Physiol 290:F619-24. 2006
    ..These observations suggest that KS-WNK1 plays an essential role in the renal molecular switch regulating Na+ and K+ balance; they provide insight into the kidney-specific phenotype of FHHt...
  6. pmc WNK kinases and renal sodium transport in health and disease: an integrated view
    James A McCormick
    Division of Nephrology and Hypertension and Heart Research Center, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Hypertension 51:588-96. 2008
  7. doi request reprint Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Sci (Lond) 123:635-47. 2012
    ..Together, these findings indicate that hyperinsulinaemia is an important driving force of NCC activity in the metabolic syndrome with possible consequences for BP regulation...
  8. pmc Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway
    David J Rozansky
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    J Clin Invest 119:2601-12. 2009
    ..These data thus delineate what we believe to be a novel mechanism for aldosterone activation of NCC through SGK1 signaling of WNK4 kinase...
  9. pmc A SPAK isoform switch modulates renal salt transport and blood pressure
    James A McCormick
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Cell Metab 14:352-64. 2011
    ..In mice, extracellular fluid volume depletion shifts SPAK isoform abundance to favor NaCl retention along both segments, indicating that a SPAK isoform switch modulates sodium avidity along the distal nephron...
  10. pmc The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
    Ewout J Hoorn
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
    Nat Med 17:1304-9. 2011
    ....
  11. pmc Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension
    James A McCormick
    Division of Nephrology and Hypertension, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code L463, Portland, OR 97239 3098, USA
    Hypertension 58:888-94. 2011
    ....
  12. ncbi request reprint Comparison of WNK4 and WNK1 kinase and inhibiting activities
    Zhaohong Wang
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Biochem Biophys Res Commun 317:939-44. 2004
    ..Together, these results suggest that WNK4 must be activated by currently unknown factors to exhibit kinase activity and that WNK4 contains an inhibitory domain that can inhibit the kinase activity of WNK1...
  13. ncbi request reprint Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension
    Andrew S Terker
    From the Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland A S T, C L Y, J A M, N P M, S L R, D H E Renal Section, VA Medical Center, Portland, OR C L Y, N P M, D H E Institute of Anatomy, University of Zurich, Zurich, Switzerland S G, K T, J L and Department of Anesthesiology, Vanderbilt University Medical School, Nashville, TN E D
    Hypertension 64:178-84. 2014
    ..The results have implications about device- and drug-based treatment of hypertension. ..
  14. pmc WNK1 kinase isoform switch regulates renal potassium excretion
    James B Wade
    Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:8558-63. 2006
    ..1 activity involves a WNK1 isoform switch and KS-WNK1-mediated release from L-WNK1 inhibition. Thus, these observations provide evidence for the physiological regulation of Na(+) and K(+) balance by a kinase isoform switch mechanism...