David E Williams

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies
    David E Williams
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Comp Biochem Physiol C Toxicol Pharmacol 149:175-81. 2009
  2. pmc The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention
    David E Williams
    Department of Environmental and Molecular Toxicology, The Superfund Center and The Linus Pauling Institute, Oregon State University, Weniger 435, Corvallis, OR 97331 6503, USA
    Comp Biochem Physiol C Toxicol Pharmacol 155:121-7. 2012
  3. pmc Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 30:315-20. 2009
  4. pmc Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, ALS 1007, Corvallis, OR 97331 7301, USA
    Cancer Prev Res (Phila) 1:128-34. 2008
  5. pmc Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
    Environ Health Perspect 116:1047-55. 2008
  6. pmc Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:1581-6. 2008
  7. pmc Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K
    Sharon K Krueger
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Drug Metab Dispos 37:1785-91. 2009
  8. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007
  9. pmc Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 USA
    Toxicol Appl Pharmacol 270:60-9. 2013
  10. pmc Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:834-9. 2008

Research Grants

  1. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2005
  2. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
  3. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2006
  4. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2006
  5. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2007
  6. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2007
  7. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
  8. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2005
  9. FLAVIN-CONTAINING MONOOXYGENASES IN LUNG
    David Williams; Fiscal Year: 1992
  10. FLAVIN-CONTAINING MONOOXYGENASES IN LUNG
    David Williams; Fiscal Year: 1993

Collaborators

Detail Information

Publications62

  1. pmc Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies
    David E Williams
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Comp Biochem Physiol C Toxicol Pharmacol 149:175-81. 2009
    ..0. Such studies demonstrate the statistical power of the trout cancer model and strengthen the case for incorporation of these data-sets into risk assessment for these environmental human carcinogens...
  2. pmc The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention
    David E Williams
    Department of Environmental and Molecular Toxicology, The Superfund Center and The Linus Pauling Institute, Oregon State University, Weniger 435, Corvallis, OR 97331 6503, USA
    Comp Biochem Physiol C Toxicol Pharmacol 155:121-7. 2012
    ..These contributions to elucidation of mechanisms of liver cancer, induced by environmental chemicals and the remarkable datasets generated with ED(001) studies, make important contributions to carcinogenesis and chemoprevention...
  3. pmc Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 30:315-20. 2009
    ..005). This is the first demonstration that CHL can provide potent chemoprotection in a transplacental carcinogenesis model and support a mechanism involving complex-mediated reduction of carcinogen uptake...
  4. pmc Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyrene
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, ALS 1007, Corvallis, OR 97331 7301, USA
    Cancer Prev Res (Phila) 1:128-34. 2008
    ..0). These data confirm that cyp1b1 bioactivation of DBP occurs in fetal target tissues, following transplacental exposure, with the thymus and lung as primary and secondary targets, respectively...
  5. pmc Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
    Environ Health Perspect 116:1047-55. 2008
    ..Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure...
  6. pmc Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:1581-6. 2008
    ..This is the first demonstration that maternal ingestion of green tea, during pregnancy and nursing, provides protection against transplacental carcinogenesis...
  7. pmc Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K
    Sharon K Krueger
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Drug Metab Dispos 37:1785-91. 2009
    ..Although these allelic variants are expected to occur infrequently as mutations to the FMO2*1 allele, they contribute to our overall understanding of mammalian FMO structure and function...
  8. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007
    ..They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis...
  9. pmc Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 USA
    Toxicol Appl Pharmacol 270:60-9. 2013
    ..These findings provide justification for further study of the safety and bioactivity of cruciferous vegetable phytochemicals at supplemental concentrations during the perinatal period...
  10. pmc Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:834-9. 2008
    ..These findings are discussed in the context of epidemiological data which do not support an adverse effect of tea and coffee on colon tumor outcome-indeed, some such studies suggest a protective role for caffeinated beverages...
  11. pmc Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study
    Tammie J McQuistan
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 50:341-52. 2012
    ..This finding questions the human relevance of chemoprevention studies carried out at high carcinogen doses that are not proven to lie within a linear, or at least monotonic, endpoint dose-response range...
  12. pmc Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 317:49-55. 2012
    ..This study highlights the importance of developmental stage in susceptibility to environmental carcinogens...
  13. pmc MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mol Nutr Food Res 56:1259-69. 2012
    ..A systems biology approach was used to examine, for the first time, miRNAs altered in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine carcinogen from cooked meat...
  14. ncbi request reprint Toxicogenomic profiling of the hepatic tumor promoters indole-3-carbinol, 17beta-estradiol and beta-naphthoflavone in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center and Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Toxicol Sci 90:61-72. 2006
    ..These data indicate I3C promotes hepatocarcinogenesis through estrogenic mechanisms in trout liver and suggest DIM may be an even more potent hepatic tumor promoter in this model...
  15. pmc Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver
    Abby D Benninghoff
    Department of Environmental and Molecular Toxicology, the Marine and Freshwater Biomedical Sciences Center, 1007 Agricultural and Life Sciences Building, Corvallis, OR 97331, USA
    Toxicol Sci 101:65-80. 2008
    ..A set of estrogen-responsive genes has been identified that can serve as a biomarker of environmental exposure to xenoestrogens...
  16. pmc Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Pharmacogenet Genomics 15:245-56. 2005
    ..23,238C (p.Q472) and 124 previously genotyped as homozygous g.23,238 T (p.X472); (2) determine FMO2 haplotypes in this population; and (3) assess the functional impact of SNPs in expressed proteins...
  17. ncbi request reprint Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 27:2116-23. 2006
    ..Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults...
  18. pmc Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Cancer 10:68. 2011
    ..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells...
  19. pmc Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 46:1014-24. 2008
    ..001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism...
  20. pmc Lymphoma and lung cancer in offspring born to pregnant mice dosed with dibenzo[a,l]pyrene: the importance of in utero vs. lactational exposure
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Toxicol Appl Pharmacol 233:454-8. 2008
    ..Our results demonstrate that short exposure to DBP during late gestation presents a greater risk to offspring than exposure to this very hydrophobic PAH following 3 weeks of nursing...
  21. pmc beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Cancer Sci 99:1754-9. 2008
    ..Thus, during the early stages of colon carcinogenesis, alternating exposure to heterocyclic amines and a high-fat diet might facilitate molecular changes resulting in dysregulated beta-catenin and c-myc expression...
  22. pmc Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mutat Res 601:11-8. 2006
    ..Thus, further studies are warranted on the mechanisms that upregulate beta-catenin at the transcriptional level in human and rodent colon cancers...
  23. pmc Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study
    George S Bailey
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 22:1264-76. 2009
    ..They provide the first experimental estimation in any model of the degree of conservatism that may exist for the EPA default linear assumption for a genotoxic carcinogen...
  24. pmc Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Int J Cancer 132:1004-12. 2013
    ....
  25. pmc Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin
    Andrew Larkin
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Toxicol Appl Pharmacol 267:192-9. 2013
    ..The aryl hydrocarbon receptor repressor (Ahrr) was determined to be the most significant input variable for model predictions using back-propagation and normalization of FNN weights...
  26. pmc 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
    Laura M Beaver
    Linus Pauling Institute, Oregon State University, 307 Linus Pauling Science Center, Corvallis, OR 97331, USA
    Toxicol Appl Pharmacol 263:345-51. 2012
    ..The ability of DIM to target aberrant epigenetic patterns, in addition to its effects on detoxification of carcinogens, may make it an effective chemopreventive agent by targeting multiple stages of prostate carcinogenesis...
  27. pmc Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms
    Lisbeth K Siddens
    Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States
    Biochem Pharmacol 75:570-9. 2008
    ..Measurement of activity in heated and unheated lung and liver microsomes verified relative transcript abundance. Our results show that dual Fmo1/2 knockouts will be required to model the human lung FMO profile...
  28. ncbi request reprint Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, 97331, USA
    Toxicol Sci 88:319-30. 2005
    ....
  29. pmc Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse
    Lisbeth K Siddens
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Toxicol Appl Pharmacol 264:377-86. 2012
    ..BaP and mixtures up-regulated phase 1 and phase 2 metabolizing enzymes while DBC did not. The carcinogenicity with DBC and two of the mixtures was much greater than would be predicted based on published Relative Potency Factors (RPFs)...
  30. pmc 3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells
    Lyndsey E Shorey
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 7:e34975. 2012
    ..Taken together, our results demonstrate a potential for therapeutic application of DIM in T-ALL...
  31. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
    ..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon...
  32. pmc Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    John D Clarke
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Pharm Res 28:3171-9. 2011
    ..To determine the metabolism and tissue distribution of the dietary chemoprotective agent sulforaphane following oral administration to wild-type and Nrf2 knockout (Nrf2(-/-)) mice...
  33. pmc E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin
    Korakod Chimploy
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Int J Cancer 125:2086-94. 2009
    ..We conclude that by inhibiting R1, R2, and p53R2, CHL has the potential to be effective in the clinical setting, when used alone or in combination with currently available cancer therapeutic agents...
  34. pmc Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells
    Carmen P Wong
    School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, United States of America Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America
    PLoS ONE 9:e86787. 2014
    ..Results from our study may provide new insights into the epigenetic mechanisms by which SFN and DIM exert their cancer chemopreventive effects. ..
  35. pmc The epigenome as a potential mediator of cancer and disease prevention in prenatal development
    Pushpinder Kaur
    Linus Pauling Science Center, Oregon State University, Corvallis, Oregon 97331, USA
    Nutr Rev 71:441-57. 2013
    ....
  36. pmc A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Clin Epigenetics 4:16. 2012
    ..abstract:..
  37. pmc MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals
    Mansi A Parasramka
    Department of Environmental and Molecular Toxicology, and Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Mol Carcinog 51:213-30. 2012
    ..We also discuss the mechanisms by which dietary factors regulate miRNA expression, in the context of chemoprevention versus therapy...
  38. pmc Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, USA
    Pharmacol Ther 106:357-87. 2005
    ..The consequences of these FMO genetic polymorphisms in drug metabolism and human health are areas of research requiring further exploration...
  39. pmc Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes
    Marilyn C Henderson
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Toxicol Appl Pharmacol 233:420-7. 2008
    ..Additionally, there may be therapeutic implications of efficacy and toxicity in human lung based on the FMO2 genetic polymorphism, though further studies are needed to confirm that suggestion...
  40. ncbi request reprint C-Terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubility
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology, Oregon State University, USA
    Arch Biochem Biophys 450:149-56. 2006
    ..His-fusion proteins, while active and useful for purification, did not affect solubility. Delta26 variants should prove useful for identifying conditions suitable for production of an FMO crystal...
  41. ncbi request reprint In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Cancer Res 66:755-62. 2006
    ....
  42. ncbi request reprint Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, 571 Weniger, Corvallis, OR 97331 6512, USA
    Drug Metab Dispos 30:34-41. 2002
    ..1 may partially explain why activity in post mortem human lung samples has previously been unreported. Individuals that have the FMO2*1 allele-encoding full-length hFMO2.1 may exhibit altered drug metabolism in the lung...
  43. pmc Dietary factors and epigenetic regulation for prostate cancer prevention
    Emily Ho
    Linus Pauling Institute, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Adv Nutr 2:497-510. 2011
    ..In particular, we focus on epigenetic dysregulation and the impact of specific nutrients and food components on DNA methylation and histone modifications that can alter gene expression and influence prostate cancer progression...
  44. pmc Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
    Anna Hsu
    School of Biological and Population Health Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Clin Epigenetics 3:3. 2011
    ..Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent...
  45. ncbi request reprint Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 38:773-85. 2005
    ..These data support the hypothesis that alpha-tocopherol modulates xenobiotic metabolism by increasing Cyp3a expression, gamma-CEHC formation, and the excretion of both gamma-tocopherol and gamma-CEHC...
  46. pmc Metabolism as a key to histone deacetylase inhibition
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Crit Rev Biochem Mol Biol 46:181-99. 2011
    ..g. pyruvate), the yin-yang of HDAC inhibition versus HDAC activation, and the screening assays that might be most appropriate for discovery of novel HDAC inhibitors in the future...
  47. pmc Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Pharmacol Res 55:224-36. 2007
    ....
  48. ncbi request reprint The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary amines
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
    Drug Metab Rev 38:139-47. 2006
    ..We collaborated with Dr. Kupfer's laboratory and recently determined that the low level of tamoxifen N-oxide production in human liver microsomes may be explained by the kinetics of FMO1 versus FMO3...
  49. pmc Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
    Praveen Rajendran
    Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
    Clin Epigenetics 3:4. 2011
    ....
  50. ncbi request reprint Effects of chlorophyllin on transport of dibenzo(a, l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and aflatoxin B(1) across Caco-2 cell monolayers
    John E Mata
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    Toxicology 196:117-25. 2004
    ....
  51. ncbi request reprint Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones
    Marilyn C Henderson
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Toxicol Appl Pharmacol 278:91-9. 2014
    ..The activities of the mouse and human FMO1 and FMO3 orthologs were in good agreement with the exception of some thiones for which activity was much greater with hFMO1 than mFMO1. ..
  52. ncbi request reprint Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descent
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Drug Metab Dispos 32:1337-40. 2004
    ..0066) that FMO2*1 is more common among Puerto Ricans (7%) than among individuals of Mexican descent (2%). The overall occurrence of FMO2*1 among Hispanics of all origins is estimated to be between 2 and 7%...
  53. ncbi request reprint Genetic polymorphisms of flavin-containing monooxygenase (FMO)
    Sharon K Krueger
    Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, USA
    Drug Metab Rev 34:523-32. 2002
    ..Polymorphic expression of functional FMO2 in the individuals of African and Hispanic descent may markedly influence drug metabolism and/or xenobiotic toxicity in the lung...
  54. ncbi request reprint S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2
    Marilyn C Henderson
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA
    Biochem Pharmacol 68:959-67. 2004
    ....
  55. ncbi request reprint Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione
    Marilyn C Henderson
    Department of Environmental and Molecular Toxicology, and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 17:633-40. 2004
    ..5-1.0 mM completely eliminated the sulfenic acid with resultant production of GSSG. These results indicate that individuals with the FMO21 allele may be at enhanced risk of pulmonary damage upon exposure to thioureas...
  56. ncbi request reprint Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbits
    Shelley A Larsen-Su
    Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, 1007 ALS, Corvallis, OR 97331, USA
    Biochem Pharmacol 63:1353-9. 2002
    ..The early developmental appearance of FMO1 suggests a possible role in the metabolism of xenobiotics through transplacental or lactational exposures...
  57. ncbi request reprint Biochemical and clinical aspects of the human flavin-containing monooxygenase form 3 (FMO3) related to trimethylaminuria
    John R Cashman
    Human BioMolecular Research Institute, San Diego, CA, USA
    Curr Drug Metab 4:151-70. 2003
    ..The remarkable progress in the biochemical, genetic, clinical basis for understanding the trimethylaminuria condition is summarized and points to needs in the treatment of individuals suffering from trimethylaminuria...
  58. ncbi request reprint Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts
    Orianna Carter
    Ohio University Southern, 1804 Liberty Avenue, Ironton, OH 45638, USA
    Nutr Cancer 58:60-5. 2007
    ..5 +/- 0.4 (P > 0.05, not significant). The data imply that white tea, caffeine, and EGCG may be most effective post-initiation, via the inhibition of cell proliferation in the colon and through the suppression of early lesions...
  59. ncbi request reprint The FMO2 gene of laboratory rats, as in most humans, encodes a truncated protein
    Virginie Lattard
    Unité de Toxicologie et de Métabolisme Comparés des Xénobiotiques, UMR INRA et DGER, Ecole Nationale Veterinaire de Lyon, Marcy l Etoile, France
    Biochem Biophys Res Commun 292:558-63. 2002
    ..Heterologous expression of the cDNA revealed that the truncated protein was catalytically inactive. By Western blotting, FMO2 was faintly detected at approximately 50 kDa in laboratory rat lung...
  60. ncbi request reprint Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases
    Piyush M Vyas
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA
    J Pharmacol Exp Ther 319:497-505. 2006
    ..Thus, our results suggest an important role for FMO3 and yet-to-be identified peroxidases in the bioactivation of sulfonamides in NHEKs...
  61. ncbi request reprint Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
    Ainslie B Parsons
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Cell 126:611-25. 2006
    ..This compendium should serve as a valuable key for interpreting cellular effects of novel compounds with similar activities...
  62. ncbi request reprint Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants
    Sevasti B Koukouritaki
    Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 320:266-73. 2007
    ....

Research Grants22

  1. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2005
    ..These highly integrated studies seek to ascertain the role of FMO2 in pulmonary drug metabolism and toxicity and improve the health of an under-represented minority group expressing this enzyme. ..
  2. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  3. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  4. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2006
    ..These highly integrated studies seek to ascertain the role of FMO2 in pulmonary drug metabolism and toxicity and improve the health of an under-represented minority group expressing this enzyme. ..
  5. Flavin-Containing Monooxygenase in Lung
    David Williams; Fiscal Year: 2007
    ..These highly integrated studies seek to ascertain the role of FMO2 in pulmonary drug metabolism and toxicity and improve the health of an under-represented minority group expressing this enzyme. ..
  6. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2007
    ..abstract_text> ..
  7. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..abstract_text> ..
  8. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2005
    ..abstract_text> ..
  9. FLAVIN-CONTAINING MONOOXYGENASES IN LUNG
    David Williams; Fiscal Year: 1992
    ....
  10. FLAVIN-CONTAINING MONOOXYGENASES IN LUNG
    David Williams; Fiscal Year: 1993
    ....
  11. FLAVIN CONTAINING MONOOXYGENASE IN LUNG
    David Williams; Fiscal Year: 1999
    ..Results from these studies will further the understanding of the importance of this enzyme in human health. ..
  12. Flavin-Containing Monooxygenase in Lung
    David E Williams; Fiscal Year: 2010
    ..The knowledge gained will improve treatment approaches in combating TB. ..