Holger Willenbring

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Therapeutic liver reconstitution with murine cells isolated long after death
    Laura Erker
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Gastroenterology 139:1019-29. 2010
  2. ncbi Myelomonocytic cells are sufficient for therapeutic cell fusion in liver
    Holger Willenbring
    Department of Molecular and Medical Genetics, Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Med 10:744-8. 2004
  3. ncbi Delineating the hepatocyte's hematopoietic fusion partner
    Holger Willenbring
    Oregon Stem Cell Center and Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
    Cell Cycle 3:1489-91. 2004
  4. ncbi In vivo genetic selection of renal proximal tubules
    Patrice K Held
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Ther 13:49-58. 2006
  5. ncbi Myeloid lineage progenitors give rise to vascular endothelium
    Alexis S Bailey
    Oregon Stem Cell Center, Center for Hematologic Malignancies, Division of Hematology and Medical Oncology, Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, 97239, USA
    Proc Natl Acad Sci U S A 103:13156-61. 2006
  6. ncbi Bone marrow-derived cells fuse with normal and transformed intestinal stem cells
    Adnan Z Rizvi
    Department of Surgery, Division of Hematology and Medical Oncology, and Oregon Cancer Institute, Oregon Stem Cell Center, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:6321-5. 2006
  7. ncbi Cell fusion is the principal source of bone-marrow-derived hepatocytes
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 422:897-901. 2003
  8. ncbi Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases
    Arndt Vogel
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 130:104-19. 2006
  9. ncbi Embryonic versus adult stem cell pluripotency: in liver only fusion matters
    Holger Willenbring
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Assist Reprod Genet 20:393-4. 2003
  10. ncbi Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis
    Holger Willenbring
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 14:59-67. 2008

Collaborators

Detail Information

Publications11

  1. ncbi Therapeutic liver reconstitution with murine cells isolated long after death
    Laura Erker
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Gastroenterology 139:1019-29. 2010
    ..For some liver diseases, hepatocyte transplantation could be a viable alternative, but donor cells currently are procured from the same sources as whole organs, and thus the supply is severely limited...
  2. ncbi Myelomonocytic cells are sufficient for therapeutic cell fusion in liver
    Holger Willenbring
    Department of Molecular and Medical Genetics, Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Med 10:744-8. 2004
    ..Because stable bone marrow engraftment or HSCs are not required for this process, macrophages or their highly proliferative progenitors provide potential for targeted and well-tolerated cell therapy aimed at organ regeneration...
  3. ncbi Delineating the hepatocyte's hematopoietic fusion partner
    Holger Willenbring
    Oregon Stem Cell Center and Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
    Cell Cycle 3:1489-91. 2004
    ..Now it should be feasible to increase the efficiency and assess the potential of cell fusion for the correction of a broad range of somatic cell types that can be targeted by fusion...
  4. ncbi In vivo genetic selection of renal proximal tubules
    Patrice K Held
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Ther 13:49-58. 2006
    ..These data demonstrate that extensive regeneration of the renal proximal tubule compartment can be achieved through genetic selection of functional cells...
  5. ncbi Myeloid lineage progenitors give rise to vascular endothelium
    Alexis S Bailey
    Oregon Stem Cell Center, Center for Hematologic Malignancies, Division of Hematology and Medical Oncology, Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, 97239, USA
    Proc Natl Acad Sci U S A 103:13156-61. 2006
    ..Our findings indicate that endothelial cells are an intrinsic component of myeloid lineage differentiation and underscore the close functional relationship between the hematopoietic and vascular systems...
  6. ncbi Bone marrow-derived cells fuse with normal and transformed intestinal stem cells
    Adnan Z Rizvi
    Department of Surgery, Division of Hematology and Medical Oncology, and Oregon Cancer Institute, Oregon Stem Cell Center, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:6321-5. 2006
    ..Fusion of BMDCs with neoplastic epithelium did not result in tumor initiation. Our findings suggest an unexpected role for BMDCs in both regeneration and tumorigenesis of the intestine...
  7. ncbi Cell fusion is the principal source of bone-marrow-derived hepatocytes
    Xin Wang
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 422:897-901. 2003
    ..We conclude that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells...
  8. ncbi Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases
    Arndt Vogel
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 130:104-19. 2006
    ..To clarify whether stress-induced apoptosis resistance is a general feature of chronic liver diseases, an animal model of chronic cholestasis was examined...
  9. ncbi Embryonic versus adult stem cell pluripotency: in liver only fusion matters
    Holger Willenbring
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Assist Reprod Genet 20:393-4. 2003
  10. ncbi Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis
    Holger Willenbring
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 14:59-67. 2008
    ..Thus, p21's antiproliferative function is indispensable for the suppression of carcinogenesis from chronically injured liver and renal epithelial cells and cannot be compensated by apoptosis...
  11. ncbi A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice
    Claudia Mitchell
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Nat Protoc 3:1167-70. 2008
    ..As this protocol is not associated with mortality and gives highly reproducible results, we hope that it will be widely used and serve to standardize 2/3 PH in mice...