C J Wilhelm

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage
    C J Wilhelm
    Department of Veterans Affairs Medical Center, Portland, OR 97239, USA Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
    Neuroscience 279:168-86. 2014
  2. doi request reprint Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling
    Clare J Wilhelm
    VA Portland Health Care System, Portland, OR 97239, USA Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
    Brain Res 1601:102-16. 2015
  3. pmc Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol
    Clare J Wilhelm
    Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol Alcohol 47:518-24. 2012
  4. ncbi request reprint Mouse lines selected for alcohol consumption differ on certain measures of impulsivity
    Clare J Wilhelm
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 31:1839-45. 2007
  5. pmc Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes
    C J Wilhelm
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 7:705-13. 2008
  6. pmc Strain differences in delay discounting using inbred rats
    C J Wilhelm
    Departments of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 8:426-34. 2009
  7. pmc Response bias is unaffected by delay length in a delay discounting paradigm
    Clare J Wilhelm
    Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
    Behav Processes 84:445-9. 2010
  8. pmc Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration
    Clare J Wilhelm
    Research and Development Service, Portland VA Medical Center, 3710 SW U S Veterans Hospital Rd, Portland, OR 97239, USA
    Neuropharmacology 62:313-21. 2012
  9. pmc D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking
    C M Helms
    Oregon National Primate Research Center, Division of Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Biochem Behav 90:387-93. 2008

Research Grants

  1. Transporter maintenance of dopamine homeostasis
    CLARE WILHELM; Fiscal Year: 2005

Collaborators

Detail Information

Publications9

  1. pmc Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage
    C J Wilhelm
    Department of Veterans Affairs Medical Center, Portland, OR 97239, USA Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
    Neuroscience 279:168-86. 2014
    ..genetic background and support the development of stage- and sex-specific therapies for alcohol withdrawal and the maintenance of sobriety. ..
  2. doi request reprint Females uniquely vulnerable to alcohol-induced neurotoxicity show altered glucocorticoid signaling
    Clare J Wilhelm
    VA Portland Health Care System, Portland, OR 97239, USA Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
    Brain Res 1601:102-16. 2015
    ..Thus, distinct glucocorticoid signaling pathways are associated with sexually dimorphic neurotoxicity, suggesting one mechanism by which EtOH-exposed females are particularly vulnerable to the damaging effects of alcohol in the CNS. ..
  3. pmc Acute ethanol does not always affect delay discounting in rats selected to prefer or avoid ethanol
    Clare J Wilhelm
    Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol Alcohol 47:518-24. 2012
    ..The purpose of this study was to determine whether animals predisposed to prefer alcohol possess an altered acute response to alcohol on a delay discounting task relative to animals predisposed to avoid alcohol...
  4. ncbi request reprint Mouse lines selected for alcohol consumption differ on certain measures of impulsivity
    Clare J Wilhelm
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 31:1839-45. 2007
    ..The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10% ethanol...
  5. pmc Rats bred for high alcohol drinking are more sensitive to delayed and probabilistic outcomes
    C J Wilhelm
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 7:705-13. 2008
    ..Sensitivity to delayed or probabilistic outcomes may be predictive of future drinking in genetically predisposed individuals...
  6. pmc Strain differences in delay discounting using inbred rats
    C J Wilhelm
    Departments of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 8:426-34. 2009
    ..Additional research will be required to disentangle genetic influences from maternal effects and to determine how these factors influence the underlying association between heightened delay discounting and neuropsychiatric disorders...
  7. pmc Response bias is unaffected by delay length in a delay discounting paradigm
    Clare J Wilhelm
    Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
    Behav Processes 84:445-9. 2010
    ..These results indicate that response bias was stable and suggests a relative aversion for the adjusting alternative, which may be due to the variability in reward size associated with that alternative...
  8. pmc Corticotropin releasing factor-1 receptor antagonism alters the biochemical, but not behavioral effects of repeated interleukin-1β administration
    Clare J Wilhelm
    Research and Development Service, Portland VA Medical Center, 3710 SW U S Veterans Hospital Rd, Portland, OR 97239, USA
    Neuropharmacology 62:313-21. 2012
    ..Thus, additional studies will be needed to determine whether CRF(1) antagonism is an effective treatment for cytokine-induced sickness. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  9. pmc D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking
    C M Helms
    Oregon National Primate Research Center, Division of Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Biochem Behav 90:387-93. 2008
    ..For both genotypes, more impulsive mice habituated less in the novel open field. These data suggest that the absence of D(4)Rs is not sufficient to cause psychopathologies associated with heightened impulsivity and novelty seeking...

Research Grants1

  1. Transporter maintenance of dopamine homeostasis
    CLARE WILHELM; Fiscal Year: 2005
    ....