PHILIP WHANGER

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi request reprint Selenocompounds in plants and animals and their biological significance
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    J Am Coll Nutr 21:223-32. 2002
  2. ncbi request reprint Selenium and the brain: a review
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Nutr Neurosci 4:81-97. 2001
  3. ncbi request reprint Selenoprotein W: a review
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Cell Mol Life Sci 57:1846-52. 2000
  4. ncbi request reprint Tumorigenesis, metabolism, speciation, bioavailability, and tissue deposition of selenium in selenium-enriched ramps (Allium tricoccum)
    P D Whanger
    Department of Horticulture, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Agric Food Chem 48:5723-30. 2000
  5. ncbi request reprint Selenium and its relationship to cancer: an update
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Br J Nutr 91:11-28. 2004
  6. ncbi request reprint Tissue distribution and influence of selenium status on levels of selenoprotein W
    J Y Yeh
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    FASEB J 9:392-6. 1995
  7. ncbi request reprint Effects of various dietary levels of selenium as selenite or selenomethionine on tissue selenium levels and glutathione peroxidase activity in rats
    P D Whanger
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Nutr 118:846-52. 1988
  8. ncbi request reprint Glutathione peroxidase activity and chemical forms of selenium in tissues of rats given selenite or selenomethionine
    M A Beilstein
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Inorg Biochem 33:31-46. 1988
  9. ncbi request reprint Selenoprotein W in overexpressed and underexpressed rat glial cells in culture
    Y Sun
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    J Inorg Biochem 84:151-6. 2001
  10. ncbi request reprint Metabolism of selenite and selenomethionine in the rhesus monkey
    J A Butler
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Nutr 120:751-9. 1990

Research Grants

Collaborators

  • C Ip
  • D A Malencik
  • Neil E Forsberg
  • A Amantana
  • Q P Gu
  • W Ream
  • L A Hooven
  • Jan Ying Yeh
  • S C Vendeland
  • Yeong Chul Park
  • J A Butler
  • A T Bauman
  • W R Vorachek
  • Y Sun
  • M A Beilstein
  • Judy A Butler
  • L W Ream
  • Yu Chuan Liang
  • J Butler
  • Bor Rung Ou
  • Joel Burchfiel
  • J Y Yeh
  • S R Anderson
  • Woon Gye Chung
  • Hai Won Chung
  • Jung Ho Han
  • Yong Heo
  • E Barofsky
  • Jong Bong Kim
  • Dong Cheol Park
  • D F Barofsky
  • In Sun Lee
  • N D Costa
  • A Lugade
  • M J Tripp
  • J S Andrews
  • J A Schmitz
  • N M Patton
  • A J Kaneps

Detail Information

Publications21

  1. ncbi request reprint Selenocompounds in plants and animals and their biological significance
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    J Am Coll Nutr 21:223-32. 2002
    ..Se-methylselenocysteine is the major selenocompound in selenium enriched plants such as garlic, onions, broccoli florets and sprouts, and wild leeks...
  2. ncbi request reprint Selenium and the brain: a review
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Nutr Neurosci 4:81-97. 2001
    ..Even though selenium counteracts the neurotoxicity of mercury, cadmium, lead and vanadium, it causes them to accumulate in the brain, presumably in a nontoxic complex...
  3. ncbi request reprint Selenoprotein W: a review
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Cell Mol Life Sci 57:1846-52. 2000
    ..Studies with tissue cultures of muscle and brain cells indicated that selenium influenced Se-W levels. Although the metabolic function of Se-W is unknown, preliminary data suggest that it has an antioxidant function...
  4. ncbi request reprint Tumorigenesis, metabolism, speciation, bioavailability, and tissue deposition of selenium in selenium-enriched ramps (Allium tricoccum)
    P D Whanger
    Department of Horticulture, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Agric Food Chem 48:5723-30. 2000
    ..Therefore, Se-enriched ramps appear to have potential for the reduction of cancer in humans...
  5. ncbi request reprint Selenium and its relationship to cancer: an update
    P D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Br J Nutr 91:11-28. 2004
    ..Even though SeMCYS was shown to be the most effective seleno-compound in the reduction of mammary tumours, it may not be the most effective seleno-compound for reduction of colon tumours...
  6. ncbi request reprint Tissue distribution and influence of selenium status on levels of selenoprotein W
    J Y Yeh
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    FASEB J 9:392-6. 1995
    ..1 ppm selenium in the diet, and much higher in muscle from rats fed 4 ppm selenium diet. In a species comparison, Western blots indicated the presence of selenoprotein W in muscle of rabbits, sheep, and cattle...
  7. ncbi request reprint Effects of various dietary levels of selenium as selenite or selenomethionine on tissue selenium levels and glutathione peroxidase activity in rats
    P D Whanger
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Nutr 118:846-52. 1988
    ..These results indicate that the chemical forms of dietary Se can have a marked influence on biological responses, including bioavailability of dietary Se...
  8. ncbi request reprint Glutathione peroxidase activity and chemical forms of selenium in tissues of rats given selenite or selenomethionine
    M A Beilstein
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Inorg Biochem 33:31-46. 1988
    ..These results indicate that the form of Se administered will influence the form in the tissues, the percentage of Se with GPx and the body burden of Se...
  9. ncbi request reprint Selenoprotein W in overexpressed and underexpressed rat glial cells in culture
    Y Sun
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    J Inorg Biochem 84:151-6. 2001
    ..There was a greater survival rate of overexpressed than control cells when incubated with 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH), suggesting SeW possibly has an antioxidant function...
  10. ncbi request reprint Metabolism of selenite and selenomethionine in the rhesus monkey
    J A Butler
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Nutr 120:751-9. 1990
    ..The possible implications of these results for humans are discussed, including the reasons for poor correlations of GPX activity and blood Se levels...
  11. pmc Rat skeletal muscle selenoprotein W: cDNA clone and mRNA modulation by dietary selenium
    S C Vendeland
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331, USA
    Proc Natl Acad Sci U S A 92:8749-53. 1995
    ..Dietary selenium at 0.1 ppm as selenite increased muscle mRNA 4-fold relative to a selenium-deficient diet. Higher dietary selenium produced no further increase in mRNA levels...
  12. ncbi request reprint Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species
    Q P Gu
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331, USA
    Gene 193:187-96. 1997
    ..The selenoprotein W SECIS elements contained an additional highly conserved base-paired stem that may prevent inappropriate selenocysteine incorporation at the UGA stop codons...
  13. ncbi request reprint Microarray analysis of selenium-depleted and selenium-supplemented mice
    L A Hooven
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Biol Trace Elem Res 109:173-79. 2006
    ....
  14. ncbi request reprint Selenoprotein W gene regulation by selenium in L8 cells
    Q P Gu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Biometals 15:411-20. 2002
    ..Selenium treatment increased the selenoprotein W mRNA half-life 2-fold. These data suggest that selenium stabilizes selenoprotein W mRNA but has no effect on transcription...
  15. ncbi request reprint Identification of putative transcription factor binding sites in rodent selenoprotein W promoter
    A Amantana
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    J Inorg Biochem 98:1513-20. 2004
    ..The MRE, GRE, AP-1 and LF-A1 sites were also tested but no evidence was obtained for specific binding as indicated by lack of competition with unlabeled probes...
  16. ncbi request reprint Selective production of rat mutant selenoprotein W with and without bound glutathione
    A T Bauman
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Biochem Biophys Res Commun 313:308-13. 2004
    ..Additional steps, including polyvalent metal ion binding (PMIB) resin chromatography and CM-cellulose chromatography, were necessary after elution from the Ni-NTA agarose column, in order to maintain solubility of the purified protein...
  17. ncbi request reprint Effect of copper, zinc and cadmium on the promoter of selenoprotein W in glial and myoblast cells
    A Amantana
    Department of Environmental and Molecular Toxicology, Agricultural and Life Sciences 1007, Oregon State University, Corvallis, OR 97331 7301, USA
    J Inorg Biochem 91:356-62. 2002
    ..The results suggest that SeW expression in glial cells can be increased on exposure to copper and zinc and that this response is dependent on the MRE sequence present in the SeW promoter...
  18. ncbi request reprint Calcium uptake and ATPase activity of sarcoplasmic reticulum vesicles isolated from control and selenium deficient lambs
    M J Tripp
    Department of Agricultural Chemistry, Oregon State University, Corvallis 97331
    J Trace Elem Electrolytes Health Dis 7:75-82. 1993
    ..Injection of selenium in WMD lambs resulted in a marked decrease in plasma CPK activity and a significant increase of glutathione peroxidase activity in the blood...
  19. ncbi request reprint Metabolism of subtoxic level of selenite by double-perfused small intestine in rats
    Yeong Chul Park
    Natural Science Institute, Catholic University of Daegu, 330 Kumrak 1 ri, Hayang Up, Kyongsan si, Kyongbuk, 710 702, Korea
    Biol Trace Elem Res 98:143-57. 2004
    ..There was a corresponding increase of all metabolites with increased levels of selenite with time of absorption, but not with increased concentration of luminal selenite...
  20. ncbi request reprint Selenoprotein W
    Philip D Whanger
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Methods Enzymol 347:179-87. 2002
  21. ncbi request reprint Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells
    Jan Ying Yeh
    Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan, ROC
    Biometals 19:611-21. 2006
    ..The proliferation inhibition by H-SeB in C6 cells is apparently related to the increased H(2)O(2) with the elevated cGPX activity, but the inhibition by L-SeB was H(2)O(2)-independent without change in cGPX activity...

Research Grants5

  1. WHAT IS THE METABOLIC FUNCTION OF SELENOPROTEIN W?
    PHILIP WHANGER; Fiscal Year: 2003
    ..These animals will also be supplemented with selenium to determine the effects upon selenoprotein W and GPX1 and GPX4 induction. ..