Research Topics
Species | Ruikang K WangSummaryAffiliation: Oregon Health and Science University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivoRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Phys Med Biol 52:N531-7. 2007..The approach is experimentally demonstrated by imaging of a flow phantom and then cerebro-vascular perfusion of a live mouse with cranium intact...
Directional blood flow imaging in volumetric optical microangiography achieved by digital frequency modulationRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Opt Lett 33:1878-80. 2008..The method is experimentally validated by a flow phantom and is tested for imaging of cerebral vascular blood perfusion in a live mouse with the cranium left intact...- A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
Phys Med Biol 51:3231-9. 2006..This is updated continuously frame by frame. The method is tested on a volume-rate (C-mode) SOCT system to image the human fingertip in vivo with a volume rate at 8 s... - Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Opt Lett 31:3001-3. 2006..We experimentally demonstrate this method by real-time imaging of a flow phantom... - Fourier domain optical coherence tomography achieves full range complex imaging in vivo by introducing a carrier frequency during scanningRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Phys Med Biol 52:5897-907. 2007..The author finally demonstrates experimentally the system and algorithms for true in vivo imaging at a rate of 20,000 axial scans per second... - In vivo outer hair cell length changes expose the active process in the cochleaDingjun Zha
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 7:e32757. 2012..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification... - High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiographyLin An
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97237, USA
J Biomed Opt 15:026011. 2010..Finally, we compare the clinical fluorescein angiography and indocyanine green angiography imaging results with the OMAG results of blood perfusion map within the retina and choroid, and show excellent agreement between these modalities... - Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivoRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 17:8926-40. 2009..Finally, we compare the in vivo imaging performance of DOMAG with that of PRDOCT, and show that DOMAG delivers at least 15-fold increase over the PRDOCT method in terms of the lower limit of flow velocity that can be detected... - Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiographyHrebesh M Subhash
Biophotonics and Imaging Laboratory, Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
IEEE Trans Med Imaging 30:224-30. 2011.... - In vivo optical imaging of revascularization after brain trauma in miceYali Jia
Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
Microvasc Res 81:73-80. 2011.... - Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97237, USA
Opt Lett 35:1467-9. 2010..We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology... - Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffoldsYali Jia
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 14:034014. 2009..49+/-0.3 dyn cm(-2) and 0.38+/-0.2 dyn cm(-2), respectively. In addition, we show that the scaffold's porosity and interconnectivity can be quantified by combining analyses of the 3D structural and flow images obtained from DOCT... - Statistics of local speckle contrastDonald D Duncan
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Opt Soc Am A Opt Image Sci Vis 25:9-15. 2008..Performance of the model is illustrated with some typical optical coherence tomography data... - Extracting cardiac shapes and motion of the chick embryo heart outflow tract from four-dimensional optical coherence tomography imagesXin Yin
Oregon Health and Science University, Department of Biomedical Engineering, Portland, Oregon 97239, USA
J Biomed Opt 17:96005-1. 2012..The extracted shapes captured the dynamics of the chick embryonic heart outflow tract wall, enabling further analysis of cardiac motion... - Optimization of image-forming optics for transmission optical projection tomographyYi Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Appl Opt 46:6815-20. 2007..007 and 0.014, with which the spatial resolution of 25 microm is achieved. The optimal configuration is validated by TOPT of a phantom sample and a fixed five-day chick embryo... - Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue bedsLin An
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 18:8220-8. 2010..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases... - A differentially amplified motion in the ear for near-threshold sound detectionFangyi Chen
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
Nat Neurosci 14:770-4. 2011..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented... - Quantitative temporal speckle contrast imaging for tissue mechanicsSean J Kirkpatrick
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Opt Soc Am A Opt Image Sci Vis 24:3728-34. 2007..Applications to tissue mechanics are shown, although the discussion is equally relevant for fluid motion studies... - Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometryHrebesh M Subhash
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 18:036003. 2013..The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane... - In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiographyLin An
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 16:11438-52. 2008..The depth-resolved volumetric views of the separate retina and choroid vasculatures are also presented. In the end of this paper, we provide a comparison of the OMAG results with those from Doppler OCT and optical coherence angiography... - In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiographyJia Qin
Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
Lasers Surg Med 43:122-9. 2011.... - Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometryHrebesh M Subhash
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Ave, Portland, Oregon 97239
J Biomed Opt 17:060505. 2012..5 nm at 1 kHz of acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at a nanometer scale... - Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segmentRuikang K Wang
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 15:020502. 2010..Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology... - High-resolution computed tomography of refractive index distribution by transillumination low-coherence interferometryYi Wang
Department of Biomedical Engineering, Oregon Heath and Science University, Portland, Oregon 97239, USA
Opt Lett 35:91-3. 2010..We experimentally demonstrate this method by imaging a phantom. We show that this method can achieve a precision of 0.01 in determining the refractive index and a spatial resolution of 40 microm... 
Changes in wall motion and blood flow in the outflow tract of chick embryonic hearts observed with optical coherence tomography after outflow tract banding and vitelline-vein ligationSandra Rugonyi
Division of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, CH13B, Portland, OR 97239, USA
Phys Med Biol 53:5077-91. 2008..Our results therefore establish the utility of spectral domain OCT to study the influence of hemodynamic conditions on heart development in intact, in vivo chicken embryo models...- Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intactYali Jia
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
J Biophotonics 4:57-63. 2011.... - Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic strokeMichelle A Berny-Lang
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
Stroke 42:1736-41. 2011..Therefore, we investigated the outcome of WE-treated experimental ischemic stroke in mice... - Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in miceYali Jia
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
J Neurosci Methods 194:108-15. 2010..The results indicate that OMAG can be a useful tool to study therapeutic strategies in preclinical animal models in order to mitigate various pathologies that are mainly related to the meningeal circulations... - Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomographyHrebesh M Subhash
Oregon Health and Science University, School of Medicine, Department of Biomedical Engineering, Biophotonics and Imaging Laboratory, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
J Biomed Opt 15:036024. 2010.... - Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary studyRuikang K Wang
Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 15:056005. 2010..We demonstrate that the PSOCT system is feasible to image the meaningful vibration of cellular compartments within the OC with an unprecedented sensitivity down to ∼0.5 Å... - Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiographyZhongwei Zhi
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA, and Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Biomed Opt Express 2:1059-68. 2011..Finally, we attempt to show the capability of OMAG to provide quantitative analysis about velocity changes in a single capillary vessel (down to tens of microns per second) in response to the ischemic event... - Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemiaWenri Zhang
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 29:1475-81. 2009..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia... - Use of optical coherence tomography in delineating airways microstructure: comparison of OCT images to histopathological sectionsYing Yang
Institute of Science and Technology in Medicine, Keele University, Stoke-on-Trent ST4 7QB, UK
Phys Med Biol 49:1247-55. 2004..These data support OCT as a highly feasible, optical biopsy tool, which merits further exploration for early diagnosis of human airway epithelial pathology... - Improvement of low-level light imaging performance using optical clearing methodYonghong He
Biophotonics Laboratory, Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire, MK45 4DT, UK
Biosens Bioelectron 20:460-7. 2004..This method could have potential applications for the in vivo low-level light imaging techniques... - Imaging of non-parabolic velocity profiles in converging flow with optical coherence tomographySergey G Proskurin
Biophotonics Laboratory, Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK
Phys Med Biol 48:2907-18. 2003..Stable concave, blunted and parabolic profiles are obtained at different distances of the inlet length. Application of the technique for the blood circulation is also discussed... - Investigation of changes in optical attenuation of bone and neuronal cells in organ culture or three-dimensional constructs in vitro with optical coherence tomography: relevance to cytochrome oxidase monitoringXiangqun Xu
Centre for Science and Technology in Medicine, School of Medicine, Keele University/North Staffordshire Hospital Trust, Stoke-on-Trent, ST4 7QB, UK
Eur Biophys J 32:355-62. 2003..Our results suggest the potential application of OCT in providing high-resolution tomographic imaging of tissues in organ culture and cells grown in three-dimensional constructs in vitro... - Matrix approach to quantitative refractive index analysis by Fourier domain optical coherence tomographyPeter H Tomlins
National Physical Laboratory, Teddington, Middlesex, UK
J Opt Soc Am A Opt Image Sci Vis 23:1897-907. 2006..This approach introduces a powerful tool for the analysis of layer-dependent optical properties that could have an important role in the differentiation of healthy and diseased tissue... - Signal degradation by multiple scattering in optical coherence tomography of dense tissue: a Monte Carlo study towards optical clearing of biotissuesRuikang K Wang
Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire, UK
Phys Med Biol 47:2281-99. 2002.... - Doppler optical coherence imaging of converging flowSergey G Proskurin
Biophotonics Laboratory, Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK
Phys Med Biol 49:1265-76. 2004..Concave, blunted, parabolic and triangular profiles are obtained at different distances after the entry. Application of the technique to the study of blood circulation is discussed... - Random media characterization using the analysis of diffusing light data on the basis of an effective medium modelDmitry A Zimnyakov
Optics Department, Saratov State University, Russia
J Opt Soc Am A Opt Image Sci Vis 24:711-23. 2007..6 at 473 nm. This peculiarity is caused by the very large scattering efficiency of scatterers in the vicinity of the first Mie resonance... - The role of water desorption on optical clearing of biotissue: studied with near infrared reflectance spectroscopyXiangqun Xu
Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire MK45 4DT, United Kingdom
Med Phys 30:1246-53. 2003..As a consequence, due to its high refractive index and high dehydration capability, glycerol is a more effective agent in optical clearing than ethylene glycol... - Effect of dextran-induced changes in refractive index and aggregation on optical properties of whole bloodXiangqun Xu
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK
Phys Med Biol 48:1205-21. 2003..It represents a promising approach to increasing the imaging depth for in vivo optical imaging of biological tissue, for example optical coherence tomography... - Determination of flow velocity vector based on Doppler shift and spectrum broadening with optical coherence tomographySergey G Proskurin
Cranfield Biomedical Centre, Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire, MK45 4DT, UK
Opt Lett 28:1227-9. 2003..It is shown that the estimated values of the Doppler angle and average fluid velocity from the experiments agree well with the preset values... - Theoretical model of optical coherence tomography for system optimization and characterizationYinqi Feng
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire MK45 4DT, UK
J Opt Soc Am A Opt Image Sci Vis 20:1792-803. 2003..Experiments on tissue phantoms were carried out to verify the validity of this model... - Enhanced sensitivity and spatial resolution for in vivo imaging with low-level light-emitting probes by use of biocompatible chemical agentsYonghong He
Biophotonics Laboratory, Institute of BioScience and Technology, Cranfield University at Silsoe, Silsoe, Bedfordshire MK45 4DT, UK
Opt Lett 28:2076-8. 2003..The spatial resolution correspondingly increases approximately threefold... - Quantitative analysis on tongue inspection in traditional Chinese medicine using optical coherence tomographyHaixin Dong
South China Normal University, Ministry of Education Key Laboratory of Laser Life Science, Laboratory of Photonic Traditional Chinese Medicine, Guangzhou 510631, China
J Biomed Opt 13:011004. 2008..As a result, OCT technology has the potential to provide physicians with an objective diagnostic standard for visual TI in TCM clinical practice and research... - Penetration kinetics of dimethyl sulphoxide and glycerol in dynamic optical clearing of porcine skin tissue in vitro studied by Fourier transform infrared spectroscopic imagingJingying Jiang
Tianjin University, State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin 300072, China
J Biomed Opt 13:021105. 2008.... - The potential role of optical coherence tomography in the evaluation of vulnerable carotid atheromatous plaques: a pilot studyVikramaditya Prabhudesai
Diagnostic Imaging, St. Joseph's Hospital, Hamilton, L8N 4A6, Ontario, Canada
Cardiovasc Intervent Radiol 29:1039-45. 2006.... - Investigation of optical coherence tomography as an imaging modality in tissue engineeringYing Yang
Institute of Science and Technology in Medicine, Keele University, Staffs ST4 7QB, UK
Phys Med Biol 51:1649-59. 2006..The results show great potential for the use of OCT in non-invasive monitoring of cellular activities in 3D developing engineered tissues... - Time-resolved simultaneous measurement of group index and physical thickness during photopolymerization of resin-based dental compositePeter H Tomlins
National Physical Laboratory, Photonics Group, Hampton Road, Teddington, Middlesex TW11 0LW, United Kingdom
J Biomed Opt 12:014020. 2007..This relationship between the optical and physical density demonstrates the potential of this technique as a unique noninvasive tool for measurement of the conversion degree of curing dental composite materials... - Comparing the synergistic effects of oleic acid and dimethyl sulfoxide as vehicles for optical clearing of skin tissue in vitroJingying Jiang
Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire, MK45 4DT, UK
Phys Med Biol 49:5283-94. 2004..Therefore, in terms of optical application and clinic safety, the results presented reveal that oleic acid could be an optimal choice as an enhancer for optical clearing of skin tissue... - Propylene glycol as a contrasting agent for optical coherence tomography to image gastrointestinal tissuesRuikang K Wang
Medical Photonics Group, Center for Science and Technology in Medicine, School of Medicine, Keele University North Staffordshire Hospital Trust, Stoke on Trent, ST4 7QB, United Kingdom
Lasers Surg Med 30:201-8. 2002..In this work, we investigate the administration of chemical agents to the tissue as a means of improving the capability of OCT imaging of clinically relevant microstructures of the GI tract... - Synergistic effect of hyperosmotic agents of dimethyl sulfoxide and glycerol on optical clearing of gastric tissue studied with near infrared spectroscopyXiangqun Xu
Biophotonics Laboratory, Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire MK45 4DT, UK
Phys Med Biol 49:457-68. 2004..In other words, the clearing effect of glycerol is enhanced by adding DMSO into it. It is suggested that membrane penetration and carrier effect of DMSO probably accounts for this synergistic effect... - Dynamic optical clearing effect of tissue impregnated with hyperosmotic agents and studied with optical coherence tomographyYonghong He
Institute of BioScience and Technology, Cranfield Biomedical Centre, Cranfield University at Silsoe, Bedfordshire MK45 4DT, United Kingdom
J Biomed Opt 9:200-6. 2004..The first stage of diffusion is from the top tissue to the intercellular space, and the second is into the cell matrix. During the first stage, the imaging contrast could be improved by dehydration... - A novel optical coherence tomography-based micro-indentation technique for mechanical characterization of hydrogelsYing Yang
Institute of Science and Technology in Medicine, Keele University, Stoke on Trent, UK
J R Soc Interface 4:1169-73. 2007..g. hydrogel). This unique character can be applied for various biomechanical investigations such as monitoring reconstruction of engineered tissues...