Research Topics
Species | Ruikang K WangSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary studyRuikang K Wang
Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 15:056005. 2010..We demonstrate that the PSOCT system is feasible to image the meaningful vibration of cellular compartments within the OC with an unprecedented sensitivity down to ∼0.5 Å...- Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivoRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 17:8926-40. 2009..Finally, we compare the in vivo imaging performance of DOMAG with that of PRDOCT, and show that DOMAG delivers at least 15-fold increase over the PRDOCT method in terms of the lower limit of flow velocity that can be detected... - Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97237, USA
Opt Lett 35:1467-9. 2010..We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology... - Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segmentRuikang K Wang
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 15:020502. 2010..Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology... - In vivo outer hair cell length changes expose the active process in the cochleaDingjun Zha
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 7:e32757. 2012..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification... - High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiographyLin An
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97237, USA
J Biomed Opt 15:026011. 2010..Finally, we compare the clinical fluorescein angiography and indocyanine green angiography imaging results with the OMAG results of blood perfusion map within the retina and choroid, and show excellent agreement between these modalities... - Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiographyHrebesh M Subhash
Biophotonics and Imaging Laboratory, Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
IEEE Trans Med Imaging 30:224-30. 2011.... - In vivo optical imaging of revascularization after brain trauma in miceYali Jia
Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
Microvasc Res 81:73-80. 2011.... 
In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiographyLin An
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 16:11438-52. 2008..The depth-resolved volumetric views of the separate retina and choroid vasculatures are also presented. In the end of this paper, we provide a comparison of the OMAG results with those from Doppler OCT and optical coherence angiography...- Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivoRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Phys Med Biol 52:N531-7. 2007..The approach is experimentally demonstrated by imaging of a flow phantom and then cerebro-vascular perfusion of a live mouse with cranium intact... - Directional blood flow imaging in volumetric optical microangiography achieved by digital frequency modulationRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Opt Lett 33:1878-80. 2008..The method is experimentally validated by a flow phantom and is tested for imaging of cerebral vascular blood perfusion in a live mouse with the cranium left intact... - Fourier domain optical coherence tomography achieves full range complex imaging in vivo by introducing a carrier frequency during scanningRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Phys Med Biol 52:5897-907. 2007..The author finally demonstrates experimentally the system and algorithms for true in vivo imaging at a rate of 20,000 axial scans per second... - Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffoldsYali Jia
Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 14:034014. 2009..49+/-0.3 dyn cm(-2) and 0.38+/-0.2 dyn cm(-2), respectively. In addition, we show that the scaffold's porosity and interconnectivity can be quantified by combining analyses of the 3D structural and flow images obtained from DOCT... - Extracting cardiac shapes and motion of the chick embryo heart outflow tract from four-dimensional optical coherence tomography imagesXin Yin
Oregon Health and Science University, Department of Biomedical Engineering, Portland, Oregon 97239, USA
J Biomed Opt 17:96005-1. 2012..The extracted shapes captured the dynamics of the chick embryonic heart outflow tract wall, enabling further analysis of cardiac motion... - A differentially amplified motion in the ear for near-threshold sound detectionFangyi Chen
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
Nat Neurosci 14:770-4. 2011..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented... - Statistics of local speckle contrastDonald D Duncan
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Opt Soc Am A Opt Image Sci Vis 25:9-15. 2008..Performance of the model is illustrated with some typical optical coherence tomography data... - Quantitative temporal speckle contrast imaging for tissue mechanicsSean J Kirkpatrick
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Opt Soc Am A Opt Image Sci Vis 24:3728-34. 2007..Applications to tissue mechanics are shown, although the discussion is equally relevant for fluid motion studies... - Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue bedsLin An
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
Opt Express 18:8220-8. 2010..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases... - Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometryHrebesh M Subhash
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 18:036003. 2013..The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane... - In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiographyJia Qin
Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
Lasers Surg Med 43:122-9. 2011.... - Optimization of image-forming optics for transmission optical projection tomographyYi Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Appl Opt 46:6815-20. 2007..007 and 0.014, with which the spatial resolution of 25 microm is achieved. The optimal configuration is validated by TOPT of a phantom sample and a fixed five-day chick embryo... - Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometryHrebesh M Subhash
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Ave, Portland, Oregon 97239
J Biomed Opt 17:060505. 2012..5 nm at 1 kHz of acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at a nanometer scale... - High-resolution computed tomography of refractive index distribution by transillumination low-coherence interferometryYi Wang
Department of Biomedical Engineering, Oregon Heath and Science University, Portland, Oregon 97239, USA
Opt Lett 35:91-3. 2010..We experimentally demonstrate this method by imaging a phantom. We show that this method can achieve a precision of 0.01 in determining the refractive index and a spatial resolution of 40 microm... - Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Opt Lett 31:3001-3. 2006..We experimentally demonstrate this method by real-time imaging of a flow phantom... - Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intactYali Jia
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
J Biophotonics 4:57-63. 2011.... 
Changes in wall motion and blood flow in the outflow tract of chick embryonic hearts observed with optical coherence tomography after outflow tract banding and vitelline-vein ligationSandra Rugonyi
Division of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, CH13B, Portland, OR 97239, USA
Phys Med Biol 53:5077-91. 2008..Our results therefore establish the utility of spectral domain OCT to study the influence of hemodynamic conditions on heart development in intact, in vivo chicken embryo models...- Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomographyHrebesh M Subhash
Oregon Health and Science University, School of Medicine, Department of Biomedical Engineering, Biophotonics and Imaging Laboratory, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
J Biomed Opt 15:036024. 2010.... - Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic strokeMichelle A Berny-Lang
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
Stroke 42:1736-41. 2011..Therefore, we investigated the outcome of WE-treated experimental ischemic stroke in mice... - Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in miceYali Jia
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
J Neurosci Methods 194:108-15. 2010..The results indicate that OMAG can be a useful tool to study therapeutic strategies in preclinical animal models in order to mitigate various pathologies that are mainly related to the meningeal circulations... - A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomographyRuikang K Wang
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
Phys Med Biol 51:3231-9. 2006..This is updated continuously frame by frame. The method is tested on a volume-rate (C-mode) SOCT system to image the human fingertip in vivo with a volume rate at 8 s... - Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiographyZhongwei Zhi
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA, and Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
Biomed Opt Express 2:1059-68. 2011..Finally, we attempt to show the capability of OMAG to provide quantitative analysis about velocity changes in a single capillary vessel (down to tens of microns per second) in response to the ischemic event... - Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemiaWenri Zhang
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 29:1475-81. 2009..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...
Research Grants
- Label-free optical imaging of 3D structural and functional microcirculationsRuikang Wang; Fiscal Year: 2009..This novel imaging technique will become an important tool to investigate blood supply to tissues, and may help diagnosis, monitoring, and therapeutic interventions in diseases with vascular involvement. ..
- Volumetric imaging of blood perfusion and tissue morphology in the cochleaRuikang Wang; Fiscal Year: 2009..This novel imaging instrument will become an important tool to improve the understanding, diagnosis and treatment of sudden sensorineural hearing loss and Meniere's disease ..
- High resolution 3D functional imaging of cerebrovascular perfusion in miceRuikang Wang; Fiscal Year: 2009..The OMAG system that we intend to develop in the proposed research will be compact, fast, optically stable, and easily implemented and adaptable in both research laboratories and clinical environments. ..