Ruikang K Wang

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:020502. 2010
  2. pmc Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:056005. 2010
  3. pmc Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97237, USA
    Opt Lett 35:1467-9. 2010
  4. pmc Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 17:8926-40. 2009
  5. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
  6. pmc Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
    Hrebesh M Subhash
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 18:036003. 2013
  7. pmc High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography
    Lin An
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97237, USA
    J Biomed Opt 15:026011. 2010
  8. pmc Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography
    Hrebesh M Subhash
    Biophotonics and Imaging Laboratory, Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    IEEE Trans Med Imaging 30:224-30. 2011
  9. pmc In vivo optical imaging of revascularization after brain trauma in mice
    Yali Jia
    Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
    Microvasc Res 81:73-80. 2011
  10. ncbi request reprint In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 16:11438-52. 2008

Collaborators

Detail Information

Publications34

  1. pmc Optical microangiography provides depth-resolved images of directional ocular blood perfusion in posterior eye segment
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:020502. 2010
    ..Finally, we show superior performance of OMAG in providing functional images of capillary level microcirculation at different depths of retina and choroid that correlate well with the standard retinal pathology...
  2. pmc Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study
    Ruikang K Wang
    Oregon Health and Science University, Department of Biomedical Engineering, CH13B, 3303 Southwest Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 15:056005. 2010
    ..We demonstrate that the PSOCT system is feasible to image the meaningful vibration of cellular compartments within the OC with an unprecedented sensitivity down to ∼0.5 Å...
  3. pmc Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon 97237, USA
    Opt Lett 35:1467-9. 2010
    ..We show the superior imaging performance of OMAG to provide functional images of capillary level microcirculation at different land-marked depths within retina and choroid that correlate well with the standard retinal pathology...
  4. pmc Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 17:8926-40. 2009
    ..Finally, we compare the in vivo imaging performance of DOMAG with that of PRDOCT, and show that DOMAG delivers at least 15-fold increase over the PRDOCT method in terms of the lower limit of flow velocity that can be detected...
  5. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
    ..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification...
  6. pmc Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
    Hrebesh M Subhash
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 18:036003. 2013
    ..The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane...
  7. pmc High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography
    Lin An
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97237, USA
    J Biomed Opt 15:026011. 2010
    ..Finally, we compare the clinical fluorescein angiography and indocyanine green angiography imaging results with the OMAG results of blood perfusion map within the retina and choroid, and show excellent agreement between these modalities...
  8. pmc Volumetric in vivo imaging of microvascular perfusion within the intact cochlea in mice using ultra-high sensitive optical microangiography
    Hrebesh M Subhash
    Biophotonics and Imaging Laboratory, Division of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    IEEE Trans Med Imaging 30:224-30. 2011
    ....
  9. pmc In vivo optical imaging of revascularization after brain trauma in mice
    Yali Jia
    Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
    Microvasc Res 81:73-80. 2011
    ....
  10. ncbi request reprint In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 16:11438-52. 2008
    ..The depth-resolved volumetric views of the separate retina and choroid vasculatures are also presented. In the end of this paper, we provide a comparison of the OMAG results with those from Doppler OCT and optical coherence angiography...
  11. pmc Doppler optical coherence tomography imaging of local fluid flow and shear stress within microporous scaffolds
    Yali Jia
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 South West Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 14:034014. 2009
    ..49+/-0.3 dyn cm(-2) and 0.38+/-0.2 dyn cm(-2), respectively. In addition, we show that the scaffold's porosity and interconnectivity can be quantified by combining analyses of the 3D structural and flow images obtained from DOCT...
  12. pmc Directional blood flow imaging in volumetric optical microangiography achieved by digital frequency modulation
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    Opt Lett 33:1878-80. 2008
    ..The method is experimentally validated by a flow phantom and is tested for imaging of cerebral vascular blood perfusion in a live mouse with the cranium left intact...
  13. ncbi request reprint Three-dimensional optical micro-angiography maps directional blood perfusion deep within microcirculation tissue beds in vivo
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Phys Med Biol 52:N531-7. 2007
    ..The approach is experimentally demonstrated by imaging of a flow phantom and then cerebro-vascular perfusion of a live mouse with cranium intact...
  14. ncbi request reprint Fourier domain optical coherence tomography achieves full range complex imaging in vivo by introducing a carrier frequency during scanning
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    Phys Med Biol 52:5897-907. 2007
    ..The author finally demonstrates experimentally the system and algorithms for true in vivo imaging at a rate of 20,000 axial scans per second...
  15. pmc Extracting cardiac shapes and motion of the chick embryo heart outflow tract from four-dimensional optical coherence tomography images
    Xin Yin
    Oregon Health and Science University, Department of Biomedical Engineering, Portland, Oregon 97239, USA
    J Biomed Opt 17:96005-1. 2012
    ..The extracted shapes captured the dynamics of the chick embryonic heart outflow tract wall, enabling further analysis of cardiac motion...
  16. pmc Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
    Lin An
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97237, USA
    Opt Express 18:8220-8. 2010
    ..The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases...
  17. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
    ..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented...
  18. ncbi request reprint Statistics of local speckle contrast
    Donald D Duncan
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Opt Soc Am A Opt Image Sci Vis 25:9-15. 2008
    ..Performance of the model is illustrated with some typical optical coherence tomography data...
  19. ncbi request reprint Quantitative temporal speckle contrast imaging for tissue mechanics
    Sean J Kirkpatrick
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Opt Soc Am A Opt Image Sci Vis 24:3728-34. 2007
    ..Applications to tissue mechanics are shown, although the discussion is equally relevant for fluid motion studies...
  20. pmc Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice
    Philberta Y Leung
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA Aronora, LLC, Beaverton, OR 97006, USA
    Transl Stroke Res 3:381-9. 2012
    ..Consistent with the neuroprotective phenotype of FXII-deficient mice, our data suggest that a single molecular event, FXII-mediated FXI activation, contributes to the development of experimental AIS. ..
  21. pmc In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography
    Jia Qin
    Department of Biomedical Engineering, School of Medicine, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    Lasers Surg Med 43:122-9. 2011
    ....
  22. ncbi request reprint Optimization of image-forming optics for transmission optical projection tomography
    Yi Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Appl Opt 46:6815-20. 2007
    ..007 and 0.014, with which the spatial resolution of 25 microm is achieved. The optimal configuration is validated by TOPT of a phantom sample and a fixed five-day chick embryo...
  23. pmc Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry
    Hrebesh M Subhash
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Ave, Portland, Oregon 97239
    J Biomed Opt 17:060505. 2012
    ..5  nm at 1 kHz of acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at a nanometer scale...
  24. pmc High-resolution computed tomography of refractive index distribution by transillumination low-coherence interferometry
    Yi Wang
    Department of Biomedical Engineering, Oregon Heath and Science University, Portland, Oregon 97239, USA
    Opt Lett 35:91-3. 2010
    ..We experimentally demonstrate this method by imaging a phantom. We show that this method can achieve a precision of 0.01 in determining the refractive index and a spatial resolution of 40 microm...
  25. doi request reprint Changes in wall motion and blood flow in the outflow tract of chick embryonic hearts observed with optical coherence tomography after outflow tract banding and vitelline-vein ligation
    Sandra Rugonyi
    Division of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, CH13B, Portland, OR 97239, USA
    Phys Med Biol 53:5077-91. 2008
    ..Our results therefore establish the utility of spectral domain OCT to study the influence of hemodynamic conditions on heart development in intact, in vivo chicken embryo models...
  26. ncbi request reprint Real-time flow imaging by removing texture pattern artifacts in spectral-domain optical Doppler tomography
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Opt Lett 31:3001-3. 2006
    ..We experimentally demonstrate this method by real-time imaging of a flow phantom...
  27. pmc Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact
    Yali Jia
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
    J Biophotonics 4:57-63. 2011
    ....
  28. pmc Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke
    Michelle A Berny-Lang
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Stroke 42:1736-41. 2011
    ..Therefore, we investigated the outcome of WE-treated experimental ischemic stroke in mice...
  29. pmc Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice
    Yali Jia
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurosci Methods 194:108-15. 2010
    ..The results indicate that OMAG can be a useful tool to study therapeutic strategies in preclinical animal models in order to mitigate various pathologies that are mainly related to the meningeal circulations...
  30. pmc Volumetric in vivo imaging of intracochlear microstructures in mice by high-speed spectral domain optical coherence tomography
    Hrebesh M Subhash
    Oregon Health and Science University, School of Medicine, Department of Biomedical Engineering, Biophotonics and Imaging Laboratory, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Biomed Opt 15:036024. 2010
    ....
  31. ncbi request reprint A practical approach to eliminate autocorrelation artefacts for volume-rate spectral domain optical coherence tomography
    Ruikang K Wang
    Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA
    Phys Med Biol 51:3231-9. 2006
    ..This is updated continuously frame by frame. The method is tested on a volume-rate (C-mode) SOCT system to image the human fingertip in vivo with a volume rate at 8 s...
  32. pmc Highly sensitive imaging of renal microcirculation in vivo using ultrahigh sensitive optical microangiography
    Zhongwei Zhi
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA, and Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    Biomed Opt Express 2:1059-68. 2011
    ..Finally, we attempt to show the capability of OMAG to provide quantitative analysis about velocity changes in a single capillary vessel (down to tens of microns per second) in response to the ischemic event...
  33. doi request reprint Intracisternal administration of tissue plasminogen activator improves cerebrospinal fluid flow and cortical perfusion after subarachnoid hemorrhage in mice
    Dominic A Siler
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Pk Rd, UHN 2, Portland, OR, 97239 3098, USA
    Transl Stroke Res 5:227-37. 2014
    ....
  34. pmc Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1475-81. 2009
    ..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...

Research Grants5

  1. Label-free optical imaging of 3D structural and functional microcirculations
    Ruikang Wang; Fiscal Year: 2009
    ..This novel imaging technique will become an important tool to investigate blood supply to tissues, and may help diagnosis, monitoring, and therapeutic interventions in diseases with vascular involvement. ..
  2. Volumetric imaging of blood perfusion and tissue morphology in the cochlea
    Ruikang Wang; Fiscal Year: 2009
    ..This novel imaging instrument will become an important tool to improve the understanding, diagnosis and treatment of sudden sensorineural hearing loss and Meniere's disease ..
  3. High resolution 3D functional imaging of cerebrovascular perfusion in mice
    Ruikang Wang; Fiscal Year: 2009
    ..The OMAG system that we intend to develop in the proposed research will be compact, fast, optically stable, and easily implemented and adaptable in both research laboratories and clinical environments. ..