Arthur Vandenbark

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance
    Arthur A Vandenbark
    Research Service, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA Neuroimmunology Research, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Autoimmun 40:96-110. 2013
  2. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
  3. ncbi request reprint Diminished frequency of interleukin-10-secreting, T-cell receptor peptide-reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene
    A A Vandenbark
    Tykeson MS Research Laboratory, Neuroimmunology Research, VA Medical Center, Portland, OR 97207, USA
    J Neurosci Res 66:171-6. 2001
  4. pmc Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 123:66-78. 2008
  5. pmc Autologous T-cell vaccination for multiple sclerosis: a perspective on progress
    Arthur A Vandenbark
    Neuroimmunology Research, Veterans Affairs Medical Center, Department of Neurology, Oregon Health and Science University, Portland, Oregon 97207, USA
    BioDrugs 22:265-73. 2008
  6. doi request reprint Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis
    Arthur A Vandenbark
    Department of Veterans Affairs Medical Center, Portland, OR, USA
    J Neuroimmunol 215:125-8. 2009
  7. pmc Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 125:1-13. 2008
  8. ncbi request reprint Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis
    Richard E Jones
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 170:1690-8. 2003
  9. pmc IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 S W U S Veterans Hospital Road, Portland, OR 97239, USA
    J Immunol 180:2679-85. 2008
  10. ncbi request reprint Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 176:6523-31. 2006

Research Grants

  1. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
  2. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2004
  3. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
  4. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2007
  5. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur Vandenbark; Fiscal Year: 2009
  6. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2009
  7. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
  8. REGULATION OF AUTOIMMUNITY WITH T-CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 1999
  9. REGULATION OF AUTOIMMUNITY WITH T-CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 1993
  10. GENETIC BASIS OF T CELL RESPONSE TO MYELIN BASIC PROTEIN
    Arthur Vandenbark; Fiscal Year: 1992

Collaborators

Detail Information

Publications60

  1. pmc A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance
    Arthur A Vandenbark
    Research Service, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA Neuroimmunology Research, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Autoimmun 40:96-110. 2013
    ..These findings implicate binding of RTL constructs to CD74 as a key step in both antigen-driven and bystander T-cell tolerance important in treatment of inflammatory diseases...
  2. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
    ..The mechanisms by which RTLs impede local recruitment and retention of inflammatory cells in the CNS, however, are not completely understood...
  3. ncbi request reprint Diminished frequency of interleukin-10-secreting, T-cell receptor peptide-reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene
    A A Vandenbark
    Tykeson MS Research Laboratory, Neuroimmunology Research, VA Medical Center, Portland, OR 97207, USA
    J Neurosci Res 66:171-6. 2001
    ..These results suggest that MS patients have diminished frequencies of innate TCR-reactive T cells that may allow oligoclonal expansion of activated autoreactive Th1 effector cells expressing cognate V genes...
  4. pmc Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 123:66-78. 2008
    ....
  5. pmc Autologous T-cell vaccination for multiple sclerosis: a perspective on progress
    Arthur A Vandenbark
    Neuroimmunology Research, Veterans Affairs Medical Center, Department of Neurology, Oregon Health and Science University, Portland, Oregon 97207, USA
    BioDrugs 22:265-73. 2008
    ..However, these hopeful trends reported in a number of pilot trials await validation in larger proof-of-principle trials that are now in progress...
  6. doi request reprint Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis
    Arthur A Vandenbark
    Department of Veterans Affairs Medical Center, Portland, OR, USA
    J Neuroimmunol 215:125-8. 2009
    ..This striking enhancement of two prominent immunoregulatory pathways lends support to the idea that beneficial effects of IFN-beta-1a in MS include control of pernicious autoimmunity...
  7. pmc Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 125:1-13. 2008
    ..However, Treg cells specific for the pathogenic T effector cells themselves have largely been overlooked and deserve consideration in future studies...
  8. ncbi request reprint Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis
    Richard E Jones
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 170:1690-8. 2003
    ..The results provide direct experimental evidence relevant to discussions on the mechanisms of disease progression in MS and EAE...
  9. pmc IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 S W U S Veterans Hospital Road, Portland, OR 97239, USA
    J Immunol 180:2679-85. 2008
    ....
  10. ncbi request reprint Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 176:6523-31. 2006
    ....
  11. ncbi request reprint Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci Res 84:370-8. 2006
    ..These novel findings indicate that E2-induced immunomodulation is mediated in part through potentiation in BM-DC of the PD-1 costimulatory pathway...
  12. ncbi request reprint Self-presentation of beryllium by BAL CD4+ T cells: T cell-T cell interactions and their potential role in chronic beryllium disease
    Andrew P Fontenot
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Eur J Immunol 36:930-9. 2006
    ....
  13. ncbi request reprint Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medicial Center, Department of Neurology, Oregon Health and Science University, Portland, 97239, USA
    Int Rev Immunol 24:447-77. 2005
    ..The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS...
  14. ncbi request reprint Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Neuroimmunol 170:85-92. 2005
    ..APC that both contribute to overt suppression, but such effects are overcome and focused towards enhanced suppression in inflammatory environments produced during pregnancy and EAE...
  15. ncbi request reprint Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 175:4103-11. 2005
    ....
  16. ncbi request reprint Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    ..These data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system...
  17. ncbi request reprint Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta
    Sandhya Subramanian
    Neuroimmunology Research R and D 31, Portland Veterans Affairs Medical Center, 3710 SE U S Veterans Hospital Road, Portland, OR 97239, USA
    Clin Immunol 115:162-72. 2005
    ..This is the first report demonstrating effective treatment of joint inflammation and clinical signs of CIA with orally administered ethinyl estradiol, thus supporting its possible clinical use for treating rheumatoid arthritis in humans...
  18. ncbi request reprint TCR peptide vaccination in multiple sclerosis: boosting a deficient natural regulatory network that may involve TCR-specific CD4+CD25+ Treg cells
    Arthur A Vandenbark
    Neuroimmunology Research, Veterans Affairs Medical Center, and Department of Neurology and Molecular Microbiology, Oregon Health and Science University, Portland, OR 97201, USA
    Curr Drug Targets Inflamm Allergy 4:217-29. 2005
    ..These data provide a strong foundation for future TCR vaccination studies that will critically test the ability of the tripeptide mixture to induce significantly enhanced Treg activity and possible clinical and MRI benefits in vivo...
  19. ncbi request reprint Treatment of autoimmune anterior uveitis with recombinant TCR ligands
    Grazyna Adamus
    Neurological Sciences Institute, Department of Ophthalmology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, USA
    Invest Ophthalmol Vis Sci 47:2555-61. 2006
    ..RTLs comprise the rat RT1.B beta1alpha1 domains, linked either to the guinea pig MBP69-89 peptide (RTL201), to the corresponding rat MBP69-89 peptide (RTL200), or to the cardiac myosin peptide CM-2 (RTL203)...
  20. ncbi request reprint AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, 97239, and Department of Neurology, Oregon Health and Science University, USA
    J Neuroimmunol 176:51-62. 2006
    ..These results suggest that alphaB-specific T cells are immunocompetent but not encephalitogenic in 129SvEv mice, and that immune tolerance may not be the main factor that limits the encephalitogenic potential of alphaB...
  21. pmc MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis
    Jianya Huan
    Neuroimmunology Research, Veterans Affairs Medical Center, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland 97201, USA
    J Immunol 180:1249-57. 2008
    ..This is the first report demonstrating effective prevention of joint inflammation and clinical signs of CIA with an I-Aq-derived RTL, thus supporting the possible clinical use of this approach for treating rheumatoid arthritis in humans...
  22. ncbi request reprint Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice
    Jason M Link
    Portland V A Medical Center, Neuroimmunology Research R and D 31, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    Clin Immunol 123:95-104. 2007
    ....
  23. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
    ..Our study distinguishes, for the first time, the respective contributions of nuclear and membrane E2 receptors in negative regulation of thymic development...
  24. ncbi request reprint A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci 27:12531-9. 2007
    ..These findings indicate that targeted immunotherapy of antigen-specific T-cells can result in a reversal of CNS lesion formation and lend strong support to the application of the RTL approach for therapy in MS...
  25. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase
    Elena N Klyushnenkova
    Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Prostate 67:1019-28. 2007
    ..One of the antigens implicated in the development of autoimmunity in the prostate is prostatic acid phosphatase (PAP), which is also considered a promising target for prostate cancer immunotherapy...
  26. pmc T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
    Patricia D Hurn
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
    J Cereb Blood Flow Metab 27:1798-805. 2007
    ....
  27. ncbi request reprint Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, R and D 31, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Int Immunol 19:337-43. 2007
    ..These data clearly demonstrate that E2 can affect multiple regulatory elements that influence Treg suppression, including both PD-1-dependent and PD-1-independent pathways...
  28. ncbi request reprint Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells
    Andrew P Fontenot
    Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Immunol 177:3874-83. 2006
    ..Thus, the rHLA-DP2 molecules described herein provide a template for engineering variants that retain the ability to tolerize pathogenic CD4+ T cells, but do so in the absence of the beryllium Ag...
  29. pmc Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Neurochem 98:1817-27. 2006
    ..These findings indicate that RTL therapy targeting encephalitogenic T cells may promote CNS neuroregenerative processes...
  30. ncbi request reprint Identification of HLA-DRB1*1501-restricted T-cell epitopes from prostate-specific antigen
    Elena N Klyushnenkova
    Urology Section, VA Maryland Health Care System, and Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland 21202, USA
    Clin Cancer Res 11:2853-61. 2005
    ..The use of these peptides for the immunotherapy of prostate cancer is under investigation...
  31. ncbi request reprint Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis
    Yuan K Chou
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 174:4316-24. 2005
    ..These results indicate a prominent role for HLA-DP and LFA-1 in BAL CD4(+) T cell activation and further suggest that specific Abs to these molecules could serve as a possible therapy for chronic beryllium disease...
  32. ncbi request reprint CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon
    J Neurosci Res 73:667-78. 2003
    ....
  33. ncbi request reprint Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation
    Chunhe Wang
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 171:1934-40. 2003
    ....
  34. ncbi request reprint 17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97201, USA
    Arch Immunol Ther Exp (Warsz) 51:185-93. 2003
    ..The identification of genes with altered expression patterns in the spinal cords of estrogen-treated mice provides unique insight into the process that ultimately results in protection against EAE...
  35. ncbi request reprint Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice
    Arthur A Vandenbark
    Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center and Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 171:127-33. 2003
    ....
  36. ncbi request reprint Transfer of severe experimental autoimmune encephalomyelitis by IL-12- and IL-18-potentiated T cells is estrogen sensitive
    Atsushi Ito
    Department of Experimental Pathology, Institute for Medical Sciences, Kyoto University, Kyoto, Japan
    J Immunol 170:4802-9. 2003
    ....
  37. ncbi request reprint Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system
    Sandhya Subramanian
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201, USA
    J Immunol 170:1548-55. 2003
    ..These results suggest that oral ethinyl estradiol might be a successful candidate as therapy for multiple sclerosis...
  38. ncbi request reprint Endogenous CD4+BV8S2- T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 71:89-103. 2003
    ..These three Sp-EAE protective T cell subpopulations possessed distinctive properties and induced a variety of effects in T/R- recipients, thus implicating differing mechanisms of protection...
  39. ncbi request reprint Estrogen inhibition of EAE involves effects on dendritic cell function
    Hong Yan Liu
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 70:238-48. 2002
    ..Thus, E2 treatment appears to have multiple effects on the DC population, which may contribute to a down-regulation or block in the activation of Th1 cells involved in the induction of EAE...
  40. ncbi request reprint A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE
    Halina Offner
    Department of Neurology, Oregon Health and Science University, 97201, Portland, OR, USA
    J Neuroimmunol 130:128-39. 2002
    ..These observations suggest that HE2500 and/or HE2200 limit the production of autoimmune Th1 associated cytokines, and ultimately may be beneficial for patients with MS or other autoimmune diseases...
  41. ncbi request reprint Inhibitory effects of incomplete Freund's adjuvant on experimental autoimmune encephalomyelitis
    Alex Zamora
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201, USA
    Autoimmunity 35:21-8. 2002
    ..These data demonstrate for the first time a direct inhibitory effect of IFA/saline on EAE, and re-emphasize the need to properly control experiments using IFA to induce antigen-specific tolerance...
  42. ncbi request reprint Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 67:680-8. 2002
    ..Our results not only identify the cellular source of chemokines in CNS, but also implicate MIP-1alpha, MIP-2, and MCP-1 in controlling CNS inflammation and severity of EAE...
  43. ncbi request reprint Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis
    Atsushi Ito
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Clin Immunol 102:275-82. 2002
    ..We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-alpha expression and local (CNS) recruitment of inflammatory cells, with modest effects on TNF-alpha expression by resident CNS microglial cells...
  44. ncbi request reprint Evaluation of the effects of 17beta-estradiol (17beta-e2) on gene expression in experimental autoimmune encephalomyelitis using DNA microarray
    Agata Matejuk
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA
    Endocrinology 143:313-9. 2002
    ..These results implicate a limited set of known and previously unsuspected E2-sensitive genes that may be crucial for inhibition of EAE and potentially the human disease, multiple sclerosis...
  45. pmc The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am J Pathol 163:1599-605. 2003
    ..These results indicate that the immunomodulatory effects of E2 in EAE are dependent on Esr1 and not Esr2 signaling...
  46. ncbi request reprint Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity
    Laura Tsaknaridis
    Neuroimmunology Research and Tykeson MS Research Laboratory, Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 74:296-308. 2003
    ..Our results are highly consistent with those reported for murine Treg cells and are the first to demonstrate that suppressive activity of human CD4+CD25+ T cells declines with age...
  47. ncbi request reprint Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 174:2387-95. 2005
    ..These data are the first to define age-dependent differences in EAE expression and response to hormone therapy...
  48. pmc T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Orgeon, USA
    Am J Pathol 165:2069-77. 2004
    ....
  49. ncbi request reprint HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes
    Thomas P Finn
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci Res 78:100-14. 2004
    ....
  50. ncbi request reprint T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice
    Yuan K Chou
    Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center, and Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 77:670-80. 2004
    ....
  51. ncbi request reprint Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 173:2227-30. 2004
    ..In summary, our data suggest E2 promotes tolerance by expanding the regulatory T cell compartment...
  52. ncbi request reprint Estrogen treatment induces a novel population of regulatory cells, which suppresses experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 77:119-26. 2004
    ....
  53. pmc Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Pathol 164:1915-24. 2004
    ..These results indicate that the heterotic effect at Esr2 is a function of the nonhematopoietic compartment...
  54. ncbi request reprint Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice
    Cathleen Rich
    Veterans Affairs Medical Center, Portland, OR 97207, USA
    Eur J Immunol 34:1251-61. 2004
    ..These findings demonstrate potent encephalitogenic activity of the mMOG-35-55 peptide in association with HLA-DR2, thus providing a strong rationale for further study of hMOG-35-55 peptide as a potential pathogenic determinant in humans...
  55. ncbi request reprint Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 76:129-40. 2004
    ..Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants...
  56. ncbi request reprint Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch
    Jianya Huan
    Department of Neurology, Oregon Health and Science University, Portland, OR 97207, USA
    J Immunol 172:4556-66. 2004
    ..These results strongly support the clinical application of this novel class of peptide/MHC class II constructs in patients with multiple sclerosis who have focused T cell responses to known encephalitogenic myelin peptides...
  57. ncbi request reprint CD4 T-cell epitopes of human alpha B-crystallin
    Yuan K Chou
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci Res 75:516-23. 2004
    ..Taken together, these findings suggest that autoreactive alpha B-crystallin-specific Th1 cells may have the potential to contribute to MS pathogenesis...
  58. ncbi request reprint Decreased FOXP3 levels in multiple sclerosis patients
    Jianya Huan
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 81:45-52. 2005
    ..Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen...
  59. ncbi request reprint Opposing roles for TGF-beta1 and TGF-beta3 isoforms in experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97201, USA
    Cytokine 25:45-51. 2004
    ..Of crucial importance, the TGF-beta3 isoform displayed anti-proliferative properties towards encephalitogenic cells in vitro. We propose that the TGF-beta1 and TGF-beta3 isoforms play opposing roles in the expression of EAE...
  60. doi request reprint Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection
    Susan Smyk-Pearson
    Division of Gastroenterology and Hepatology, Hepatitis C Center, University of Colorado Health Sciences Center, GI Division, 4200 E 9th Ave, B 158, Denver, CO 80262, USA
    J Infect Dis 197:46-57. 2008
    ....

Research Grants29

  1. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur A Vandenbark; Fiscal Year: 2010
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  2. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2004
    ..The approach outlined in this proposal thus has the potential to define the set of TCR determinants needed to restore deficient regulatory responses in each patient. ..
  3. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    ..The proposed studies will address key milestones to establish clinical safety of VG1000 needed for subsequent proof-of-principle trials to evaluate inhibition of MOG-specific T cell responses and clinical efficacy. ..
  4. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2007
    ....
  5. REGULATION OF EAE WITH RECOMBINANT TCR LIGANDS
    Arthur Vandenbark; Fiscal Year: 2009
    ....
  6. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 2009
    ..abstract_text> ..
  7. REGULATION OF AUTOIMMUNITY WITH T CELL RECEPTOR PEPTIDES
    Arthur A Vandenbark; Fiscal Year: 2010
    ..abstract_text> ..
  8. REGULATION OF AUTOIMMUNITY WITH T-CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 1999
    ..We will evaluate each T cell clonotype and affinity purified antibodies for their ability to regulate autologous V-beta-5.2+ BP-reactive T cells in vitro and in the SCID-Hu mouse. ..
  9. REGULATION OF AUTOIMMUNITY WITH T-CELL RECEPTOR PEPTIDES
    Arthur Vandenbark; Fiscal Year: 1993
    ..We will evaluate each T cell clonotype and affinity purified antibodies for their ability to regulate autologous V-beta-5.2+ BP-reactive T cells in vitro and in the SCID-Hu mouse...
  10. GENETIC BASIS OF T CELL RESPONSE TO MYELIN BASIC PROTEIN
    Arthur Vandenbark; Fiscal Year: 1992
    ..Thus, the current proposal is the critical link between a very successful approach for the selective regulation of EAE and the opportunity to test definitively the hypothesis that autoimmunity to BP contributes to the pathogenesis of MS...