DENNIS ROYAL TRUNE

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Mouse middle ear ion homeostasis channels and intercellular junctions
    Lisa M Morris
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e39004. 2012
  2. pmc Corticosteroid therapy for hearing and balance disorders
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Anat Rec (Hoboken) 295:1928-43. 2012
  3. pmc Simultaneous measurement of multiple ear proteins with multiplex ELISA assays
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code NRC04, Portland, OR 97239 3098, USA
    Hear Res 275:1-7. 2011
  4. pmc Low dose combination steroids control autoimmune mouse hearing loss
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Neuroimmunol 229:140-5. 2010
  5. pmc Ion homeostasis in the ear: mechanisms, maladies, and management
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Curr Opin Otolaryngol Head Neck Surg 18:413-9. 2010
  6. ncbi request reprint Steroid treatment improves cochlear function in the MRL.MpJ-Fas(lpr) autoimmune mouse
    D R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 137:160-6. 1999
  7. ncbi request reprint Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Hear Res 226:209-17. 2007
  8. ncbi request reprint Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery Oregon Health and Science University, Mail Code NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Hear Res 212:22-32. 2006
  9. ncbi request reprint Steroid treatment in young MRL.MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction
    D R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 137:167-73. 1999
  10. ncbi request reprint Aldosterone and prednisolone control of cochlear function in MRL/MpJ-Fas(lpr) autoimmune mice
    D R Trune
    Oregon Hearing Research Center, Mail Code NRC04, Department of Otolaryngology, Head and Neck Surgery, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201 3098, Portland, OR, USA
    Hear Res 155:9-20. 2001

Research Grants

  1. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2007
  2. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
  3. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
  4. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2010
  5. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
  6. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
  7. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2006
  8. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
  9. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2006
  10. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2002

Collaborators

Detail Information

Publications30

  1. pmc Mouse middle ear ion homeostasis channels and intercellular junctions
    Lisa M Morris
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e39004. 2012
    ..The middle ear contains homeostatic mechanisms that control the movement of ions and fluids similar to those present in the inner ear, and are altered during inflammation...
  2. pmc Corticosteroid therapy for hearing and balance disorders
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Anat Rec (Hoboken) 295:1928-43. 2012
    ..The function of the glucocorticoid receptor is to provide anti-inflammatory and antiapoptotic signals by mediating survival factors...
  3. pmc Simultaneous measurement of multiple ear proteins with multiplex ELISA assays
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code NRC04, Portland, OR 97239 3098, USA
    Hear Res 275:1-7. 2011
    ..Thus, the multiplex ELISA procedures appear suitable and reliable for the study of hearing related proteins, providing accurate, quantitative, reproducible results with considerable improvement in sensitivity and economy...
  4. pmc Low dose combination steroids control autoimmune mouse hearing loss
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Neuroimmunol 229:140-5. 2010
    ..This efficacy of combined steroids at low doses suggests the potential for reducing the side effects of glucocorticoids in the therapeutic control of hearing disorders...
  5. pmc Ion homeostasis in the ear: mechanisms, maladies, and management
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Curr Opin Otolaryngol Head Neck Surg 18:413-9. 2010
    ..To describe ion and water homeostatic mechanisms in the inner ear, how they are compromised in hearing disorders, and what treatments are employed to restore auditory function...
  6. ncbi request reprint Steroid treatment improves cochlear function in the MRL.MpJ-Fas(lpr) autoimmune mouse
    D R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 137:160-6. 1999
    ..This could apply to autoimmune sensorineural hearing loss, as well as any hearing disorder for which steroid therapy is recommended...
  7. ncbi request reprint Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H/HeJ mice
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Hear Res 226:209-17. 2007
    ..MRL-Fas(lpr) mice are steroid-responsive, but normal hemopoiesis and organ functions can be significantly compromised. This mouse model may be useful for studies of the detrimental side effects of steroid treatments for hearing loss...
  8. ncbi request reprint Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery Oregon Health and Science University, Mail Code NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Hear Res 212:22-32. 2006
    ..It was concluded the inner ear mineralocorticoid receptor is a significant target of glucocorticoids and a factor that should be considered in therapeutic treatments for steroid-responsive hearing loss...
  9. ncbi request reprint Steroid treatment in young MRL.MpJ-Fas(lpr) autoimmune mice prevents cochlear dysfunction
    D R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health Sciences University, NRC04, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 137:167-73. 1999
    ..The autoimmune mouse should serve as a valuable model for future studies of the cochlear mechanisms responsive to steroid treatment in autoimmune hearing loss...
  10. ncbi request reprint Aldosterone and prednisolone control of cochlear function in MRL/MpJ-Fas(lpr) autoimmune mice
    D R Trune
    Oregon Hearing Research Center, Mail Code NRC04, Department of Otolaryngology, Head and Neck Surgery, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201 3098, Portland, OR, USA
    Hear Res 155:9-20. 2001
    ....
  11. ncbi request reprint Female MRL.MpJ-Fas(lpr) autoimmune mice have greater hearing loss than males
    Dennis R Trune
    Oregon Hearing Research Center, Mail Code NRC04, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Hear Res 167:170-4. 2002
    ..This potential gender influence in autoimmune inner ear disease must be better understood for effective evaluation and treatment of this disorder...
  12. pmc Blocking the glucocorticoid receptor with RU-486 does not prevent glucocorticoid control of autoimmune mouse hearing loss
    Dennis R Trune
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA truned ohsu edu
    Audiol Neurootol 14:423-31. 2009
    ..Therefore, to better characterize the role of the glucocorticoid receptor in autoimmune hearing loss therapy, its function was blocked with the antagonist RU-486 (mifepristone) during glucocorticoid (prednisolone) treatments...
  13. ncbi request reprint Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice
    Neil D Gross
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97201 3998, USA
    Laryngoscope 112:298-303. 2002
    ..We hypothesized that corticosteroids reverse autoimmune hearing loss through the mineralocorticoid receptor and that blocking the mineralocorticoid receptor will prevent glucocorticoid effects...
  14. ncbi request reprint Otoprotective effects of dexamethasone in the management of pneumococcal meningitis: an animal study
    Harold H Kim
    Wilson Ear Clinic, Portland, Oregon 97209, USA
    Laryngoscope 117:1209-15. 2007
    ..To determine whether treating pneumococcal meningitis with a combined antibiotic and steroid regime will prevent cochlear damage, a common pneumococcal meningitis side effect...
  15. ncbi request reprint Autoimmune mouse antibodies recognize multiple antigens proposed in human immune-mediated hearing loss
    Steven H Hefeneider
    Department of Immunology, Veteran s Affairs Medical Center, Portland, Oregon, USA
    Otol Neurotol 25:250-6. 2004
    ..Autoimmune diseased mice with hearing loss will have autoantibodies against the various cochlear antigens proposed in clinical autoimmune inner ear disease...
  16. pmc Steroid control of acute middle ear inflammation in a mouse model
    Carol J Macarthur
    Department of Otolaryngology Head and Neck Surgery and Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arch Otolaryngol Head Neck Surg 135:453-7. 2009
    ..Glucocorticoids and mineralocorticoids have differential effects on inflammation and fluid absorption, but little is known of their control of middle and inner ear manifestations of acute otitis media...
  17. ncbi request reprint Cochlear cytokine gene expression in murine acute otitis media
    Bobak A Ghaheri
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Laryngoscope 117:22-9. 2007
    ..It is widely accepted that inflammatory cytokines diffuse across the round window membrane to exert cytotoxic effects. This study addresses whether inner ear cells are capable of expressing genes for inflammatory cytokines...
  18. pmc Altered expression of middle and inner ear cytokines in mouse otitis media
    Carol J Macarthur
    Department of Otolaryngology, Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Laryngoscope 121:365-71. 2011
    ....
  19. pmc The cochlear pericytes
    Xiaorui Shi
    Oregon Hearing Research Center NRC04, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Microcirculation 15:515-29. 2008
    ....
  20. pmc Control of chronic otitis media and sensorineural hearing loss in C3H/HeJ mice: glucocorticoids vs mineralocorticoids
    Carol J Macarthur
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR, USA
    Otolaryngol Head Neck Surg 139:646-53. 2008
    ..The impact of glucocorticoids and mineralocorticoids on chronic otitis media (COM) in toll-like receptor 4-deficient C3H/HeJ mice was investigated...
  21. ncbi request reprint Gram-negative pathogen Klebsiella oxytoca is associated with spontaneous chronic otitis media in Toll-like receptor 4-deficient C3H/HeJ mice
    Carol J Macarthur
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, OR, USA
    Acta Otolaryngol 128:132-8. 2008
    ..Identification of the bacterial pathogen supports the C3H/HeJ mouse as an excellent model for spontaneous chronic otitis media and its effects on the middle and inner ear...
  22. ncbi request reprint C3H/HeJ mouse model for spontaneous chronic otitis media
    Carol J Macarthur
    Department of Otolaryngology and Oregon Hearing Research Center, Oregon Health and Science University, and the Department of Immunology, Veteran s Affairs Medical Center, Portland, Oregon, USA
    Laryngoscope 116:1071-9. 2006
    ..As a result, these mice cannot clear Gram-negative bacteria. The chronically inflamed middle ear in this animal provides us the opportunity to study spontaneous chronic otitis media...
  23. ncbi request reprint Evaluation of the mouse model for acute otitis media
    Carol J Macarthur
    Department of Otolaryngology and Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, PV 01, Portland, OR 97239 3098, USA
    Hear Res 219:12-23. 2006
    ..The induction of middle ear inflammation in the mouse demonstrated the applicability of this model for investigations of otitis media...
  24. ncbi request reprint Mouse models of otitis media
    Carol J Macarthur
    Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Curr Opin Otolaryngol Head Neck Surg 14:341-6. 2006
    ..Problems arising from antibiotic use have led to considerable animal research efforts to better understand the mechanisms of acute otitis media and to develop new strategies for its prevention and treatment...
  25. ncbi request reprint Hearing loss in the laminin-deficient dy mouse model of congenital muscular dystrophy
    De Ann M Pillers
    Department of Pediatrics, Oregon Retinal Degeneration Center, Oregon Child Health Research Center, Doernbecher Children s Hospital, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97201 3042, USA
    Mol Genet Metab 76:217-24. 2002
    ..Furthermore, the dy congenital muscular dystrophy mouse offers a novel model for evaluation of sensorineural hearing loss associated with muscular dystrophy...
  26. ncbi request reprint Cochlear cytokine gene expression in murine chronic otitis media
    Bobak A Ghaheri
    Department of Otolaryngology Head and Neck Surgery, Oregon Hearing Research Center, Portland, Oregon 97239, USA
    Otolaryngol Head Neck Surg 137:332-7. 2007
    ..To investigate chronic otitis media (COM) induction of cochlear cytokine genes...
  27. ncbi request reprint Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form
    Christopher A Hargunani
    Oregon Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97201 3998, USA
    Otol Neurotol 27:564-9. 2006
    ..Intratympanically injected dexamethasone 21-phosphate is converted to its active form dexamethasone in the inner ear and follows the distribution of the glucocorticoid receptor...
  28. ncbi request reprint Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation
    Sharon L McCoy
    National Center for Rehabilitative Auditory Research and Department of Immunology, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 174:3006-14. 2005
    ..The identification of this peptide that selectively targets TLR-dependent signaling may have application in the treatment of chronic inflammation initiated by bacterial or viral infections...
  29. pmc Mouse models for human otitis media
    Dennis R Trune
    Oregon Hearing Research Center, Mail Code NRC04, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Brain Res 1277:90-103. 2009
    ..Furthermore, the completion of the mouse genome sequence has offered a powerful set of tools for investigating gene function and is generating a rich resource of mouse mutants for studying the genetic factors underlying OM...
  30. ncbi request reprint Activation of RAW264.7 macrophages by bacterial DNA and lipopolysaccharide increases cell surface DNA binding and internalization
    Sharon L McCoy
    Department of Immunology, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Biol Chem 279:17217-23. 2004
    ....

Research Grants21

  1. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2007
    ..This also will lay important groundwork for the potential development of steroid therapies more effective than those currently employed. ..
  2. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
    ..Finally, various treatments will be targeted to these specific phases of inflammation to suppress the immune responses and protect the inner ear from permanent damage. ..
  3. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
  4. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2010
    ..Finally, various treatments will be targeted to these specific phases of inflammation to suppress the immune responses and protect the inner ear from permanent damage. ..
  5. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2009
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
  6. Inner Ear Impact of Chronic Middle Ear Inflammation
    Dennis Trune; Fiscal Year: 2009
    ..Finally, various treatments will be targeted to these specific phases of inflammation to suppress the immune responses and protect the inner ear from permanent damage. ..
  7. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2006
    ..This also will lay important groundwork for the potential development of steroid therapies more effective than those currently employed. ..
  8. Otitis Media Impact on the Inner Ear
    Dennis Trune; Fiscal Year: 2007
    ..Cochlear immune-mediated processes will be assessed by measurement of inflammatory cytokines, cytokine gene expression, and ELISA of transcription factors, vascular related factors, and reactive oxygen species. ..
  9. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2006
    ..This also will lay important groundwork for the potential development of steroid therapies more effective than those currently employed. ..
  10. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2002
    ..This study also will lay important groundwork for the development of alternative steroid therapies that may be more effective than those currently employed for clinical hearing loss. ..
  11. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2003
    ..This study also will lay important groundwork for the development of alternative steroid therapies that may be more effective than those currently employed for clinical hearing loss. ..
  12. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2004
    ..This study also will lay important groundwork for the development of alternative steroid therapies that may be more effective than those currently employed for clinical hearing loss. ..
  13. Steroid Responsive Mechanisms in the Ear
    Dennis Trune; Fiscal Year: 2005
    ..This also will lay important groundwork for the potential development of steroid therapies more effective than those currently employed. ..
  14. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2010
    ..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..