Megan L Troxell

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review
    M L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
    Clin Nephrol 66:120-7. 2006
  2. pmc Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody
    Kristin A D Sauter
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Infect Immun 76:4469-78. 2008
  3. doi request reprint Light chain renal amyloidosis with prominent giant cells
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR Electronic address
    Am J Kidney Dis 62:1193-7. 2013
  4. doi request reprint Enteric oxalate nephropathy in the renal allograft: an underrecognized complication of bariatric surgery
    M L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR, USA
    Am J Transplant 13:501-9. 2013
  5. doi request reprint Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions
    Megan L Troxell
    Department of Pathology and Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    Mod Pathol 25:930-7. 2012
  6. ncbi request reprint Acute kidney injury with cryoglobulinemic peritubular neutrophilic capillaritis
    M L Troxell
    Department of Pathology, Oregon Health Science University, Portland, OR 97239, USA
    Clin Nephrol 76:159-64. 2011
  7. doi request reprint Pancreas allograft rejection: analysis of concurrent renal allograft biopsies and posttherapy follow-up biopsies
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Transplantation 90:75-84. 2010
  8. doi request reprint High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
    Megan L Troxell
    Department of Pathology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mod Pathol 23:27-37. 2010
  9. doi request reprint Renal pathology in hematopoietic cell transplantation recipients
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Mod Pathol 21:396-406. 2008
  10. ncbi request reprint Immunohistochemical staining of papillary breast lesions
    Megan L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Appl Immunohistochem Mol Morphol 15:145-53. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review
    M L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
    Clin Nephrol 66:120-7. 2006
    ..The sequential or simultaneous presentation of anti-glomerular basement membrane disease with membranous glomerulonephritis has been infrequently described...
  2. pmc Mouse model of hemolytic-uremic syndrome caused by endotoxin-free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti-Stx2 antibody
    Kristin A D Sauter
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Infect Immun 76:4469-78. 2008
    ..These results indicate that, when performed during progression of HUS, passive immunization of mice with anti-Stx2 antibody prevented the lethal effects of Stx2...
  3. doi request reprint Light chain renal amyloidosis with prominent giant cells
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR Electronic address
    Am J Kidney Dis 62:1193-7. 2013
    ..Together with prior studies of tumoral nonrenal amyloid and renal amyloid A, we suggest that the amyloid fibril constituents κ and serum amyloid A have some predilection for inciting the rare multinucleated giant cell reaction. ..
  4. doi request reprint Enteric oxalate nephropathy in the renal allograft: an underrecognized complication of bariatric surgery
    M L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR, USA
    Am J Transplant 13:501-9. 2013
    ..As the incidence of obesity and pretransplant bariatric surgery increases in the transplant population, allograft oxalate nephropathy is likely to be an increasing cause of allograft dysfunction...
  5. doi request reprint Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions
    Megan L Troxell
    Department of Pathology and Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    Mod Pathol 25:930-7. 2012
    ..These findings raise interesting questions about the role of PIK3CA/AKT pathway in breast carcinogenesis, and the biologic/precursor potential of columnar cell lesions...
  6. ncbi request reprint Acute kidney injury with cryoglobulinemic peritubular neutrophilic capillaritis
    M L Troxell
    Department of Pathology, Oregon Health Science University, Portland, OR 97239, USA
    Clin Nephrol 76:159-64. 2011
    ..Neutrophil predominant capillaritis and interstitial inflammation is an uncommon renal biopsy finding, with a broad differential diagnosis...
  7. doi request reprint Pancreas allograft rejection: analysis of concurrent renal allograft biopsies and posttherapy follow-up biopsies
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Transplantation 90:75-84. 2010
    ..Increased levels commonly prompt tissue biopsy, to diagnose cause of graft dysfunction. Historically, pancreas allografts were infrequently biopsied, although serum enzymes and renal rejection may be poor surrogates for pancreas status...
  8. doi request reprint High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
    Megan L Troxell
    Department of Pathology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Mod Pathol 23:27-37. 2010
    ..These findings indicate that approximately two-thirds of papillomas are driven by mutations in the PI3CA/AKT pathway. Some papillary carcinomas may arise from these lesions, but others may have different molecular origins...
  9. doi request reprint Renal pathology in hematopoietic cell transplantation recipients
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Mod Pathol 21:396-406. 2008
    ....
  10. ncbi request reprint Immunohistochemical staining of papillary breast lesions
    Megan L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Appl Immunohistochem Mol Morphol 15:145-53. 2007
    ..Thus, P-cadherin and CD44s are not useful in the characterization of papillary lesions. Given increased specificity as compared with SMA, the combination of p63 and calponin is recommended for analysis of breast papillary lesions...
  11. ncbi request reprint Glomerular and tubular basement membrane calcinosis: case report and literature review
    Megan L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, CA, USA
    Am J Kidney Dis 47:e23-6. 2006
    ....
  12. ncbi request reprint Renal juxtaglomerular apparatus hyperplasia
    Megan L Troxell
    OHSU Department of Pathology, OHSU L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Nephrol Dial Transplant 20:2282-3. 2005
  13. doi request reprint Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
    Jennifer Dunlap
    Department of Pathology, Oregon Health and Science University, L471, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA
    Breast Cancer Res Treat 120:409-18. 2010
    ....
  14. doi request reprint PIK3CA-AKT pathway mutations in micropapillary breast carcinoma
    Ellen Flatley
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Pathol 44:1320-7. 2013
    ..The non-micropapillary components and precursor lesions occasionally had different mutations...
  15. doi request reprint Glomerular fibrin thrombi in ABO and crossmatch compatible renal allograft biopsies
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR, United States
    Pathol Res Pract 207:15-23. 2011
    ..Despite aggressive treatment, both short and long-term graft survival may be compromised...
  16. doi request reprint Mucinous breast carcinomas lack PIK3CA and AKT1 mutations
    Elizabeth L Kehr
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Pathol 43:2207-12. 2012
    ..This series represents the largest study, to date, of PIK3CA genotyping in mucinous carcinoma and supports the unique pathogenetics of invasive mucinous breast carcinoma...
  17. doi request reprint Immunohistochemical and molecular markers in breast phyllodes tumors
    Veselina B Korcheva
    Department of Pathology, L471, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Appl Immunohistochem Mol Morphol 19:119-25. 2011
    ..The significance of the FBX4 substitution deserves further investigation...
  18. doi request reprint Biphasic papillary and lobular breast carcinoma with PIK3CA and IDH1 mutations
    Daphne Ang
    Department of Pathology, Oregon Health and Science University, Portland, USA
    Diagn Mol Pathol 21:221-4. 2012
    ..The characterization of activating point mutations in morphologic special types of breast carcinoma may suggest avenues amenable to targeted therapy...
  19. doi request reprint Frequent PIK3CA mutations in radial scars
    Katie L Wolters
    Department of Pathology Knight Cancer Institute, Oregon Health and Science University, Portland, OR
    Diagn Mol Pathol 22:210-4. 2013
    ..Additional larger studies are indicated to confirm and extend these observations in understanding the pathogenesis of radial scars and their relationship to breast cancer. ..
  20. doi request reprint Novel method for PIK3CA mutation analysis: locked nucleic acid--PCR sequencing
    Daphne Ang
    Department of Pathology, Oregon Health and Science University, Portland, OR, USA
    J Mol Diagn 15:312-8. 2013
    ..The novel LNA-PCR shows higher sensitivity than standard Sanger sequencing and did not amplify the known pseudogene...
  21. doi request reprint Novel mutations in neuroendocrine carcinoma of the breast: possible therapeutic targets
    Daphne Ang
    Department of Pathology Knight Cancer Institute, Oregon Health and Science University, Portland, OR Department of Pathology, Stanford University, Stanford, CA
    Appl Immunohistochem Mol Morphol 23:97-103. 2015
    ..Our findings demonstrate the utility of broad-based genotyping in the study of rare tumors such as neuroendocrine breast cancer. ..
  22. doi request reprint Comparative validation of online nomograms for predicting nonsentinel lymph node status in sentinel lymph node-positive breast cancer
    Crystal J Hessman
    Department of Surgery, Oregon Health and Science University, Knight Cancer Institute, Portland, OR 97239, USA
    Arch Surg 146:1035-40. 2011
    ..Online nomograms are available to predict risk of NSLN disease...
  23. doi request reprint Evolution of immunoglobulin deposition in C3-dominant membranoproliferative glomerulopathy
    Eric Kerns
    Department of Medicine, Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR, USA
    Pediatr Nephrol 28:2227-31. 2013
    ..Aberrations of alternative complement pathway (AP) have been found in many C3GN patients...
  24. doi request reprint An abundance of IgG4+ plasma cells is not specific for IgG4-related tubulointerstitial nephritis
    Donald C Houghton
    Department of Pathology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Mod Pathol 24:1480-7. 2011
    ..We conclude that the presence of numerous IgG4+PC is essential to, but not sufficient for, the diagnosis of IgG4-TIN...
  25. ncbi request reprint Comparison of C4d immunostaining methods in renal allograft biopsies
    Megan L Troxell
    Oregon Health and Science University, Department of Pathology, L471, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Clin J Am Soc Nephrol 1:583-91. 2006
    ..Direct comparison demonstrates that IHC staining of formalin-fixed, paraffin-embedded tissue with anti-C4d polyclonal antibody has acceptable sensitivity and specificity, as compared with IF staining of frozen tissue with the Quidel mAb...
  26. ncbi request reprint Evaluation of C4d staining in liver and small intestine allografts
    Megan L Troxell
    Department of Pathology, Stanford University Medical Center, Stanford, Calif, USA
    Arch Pathol Lab Med 130:1489-96. 2006
    ..C4d deposition in allograft biopsy specimens occurs at sites of antibody-mediated complement activation and has become one of the histopathologic criteria for diagnosis of humoral rejection in the kidney and the heart...
  27. doi request reprint Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions
    Daphne C Ang
    1 Department of Pathology, Oregon Health and Science University, Portland, OR, USA 2 Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA
    Mod Pathol 27:740-50. 2014
    ..Further, these data suggest that proliferative breast lesions are heterogeneous and may represent non-obligate precursors of invasive carcinoma. ..
  28. pmc The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma
    Jody E Hooper
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Pathol 43:1583-9. 2012
    ..01). The combination of both markers provided even better specificity and positive likelihood ratios. We conclude that HPC2 and N-cadherin significantly improve accurate classification of pancreatic cancer and cholangiocarcinoma...
  29. doi request reprint Factors influencing accuracy of axillary sentinel lymph node frozen section for breast cancer
    Amariek J Jensen
    Department of Pathology, Division of Surgical Oncology, Oregon Health and Science University, Portland, OR, USA
    Am J Surg 199:629-35. 2010
    ..Intraoperative sentinel lymph node (SLN) frozen section (FS) guides immediate axillary lymph node dissection in breast cancer patients...
  30. doi request reprint Androgen receptor immunohistochemistry in genitourinary neoplasms
    Elizabeth M Williams
    Department of Pathology, L471, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA
    Int Urol Nephrol 47:81-5. 2015
    ..Androgen receptor (AR) is a recognized immunohistochemical marker of prostate cancer. However, the sensitivity and specificity of AR for prostate cancer in the setting of other genitourinary neoplasms has not been rigorously studied...
  31. doi request reprint Renal pathology associated with hematopoietic stem cell transplantation
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR Department of Pathology, Stanford University Medical Center, Stanford, CA
    Adv Anat Pathol 21:330-40. 2014
    ..Given the complexity and variability of HCT protocols, clinicopathologic correlation is needed. ..
  32. doi request reprint Hematopoietic stem cell transplantation: graft versus host disease and pathology of gastrointestinal tract, liver, and lung
    Neeraja Kambham
    Department of Pathology, Stanford University School of Medicine, Stanford, CA Department of Pathology, Oregon Health and Science University, Portland, OR
    Adv Anat Pathol 21:301-20. 2014
    ..The pulmonary biopsy yields clinically unsuspected diagnoses in the majority of cases and its utilization is likely to increase. The pathology of the skin and kidney in HCT patients are detailed in accompanying articles. ..
  33. pmc Genome evolution during progression to breast cancer
    Daniel E Newburger
    Biomedical Informatics Training Program, Stanford, California 94305, USA
    Genome Res 23:1097-108. 2013
    ..Aneuploidies that occur in common ancestors of neoplastic and tumor cells are the earliest events that affect a large number of genes and may predispose breast tissue to eventual development of invasive carcinoma. ..
  34. ncbi request reprint Evaluation of Her-2/neu status in carcinomas with amplified chromosome 17 centromere locus
    Megan L Troxell
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Clin Pathol 126:709-16. 2006
    ..Such additional data, correlated with immunohistochemical analysis, may help guide therapy in patients with breast carcinoma...
  35. doi request reprint PAX2 expression in Wilms tumors and other childhood neoplasms
    Jessica L Davis
    Department of Pathology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Am J Surg Pathol 35:1186-94. 2011
    ..However, PAX2 may be a helpful marker in certain diagnostic situations. We speculate that RMS and B-cell ALL staining could be due to antibody cross-reactivity with PAX family members with known expression in RMS and B-cell ALL...
  36. doi request reprint Glomerular endothelial vesicles in a renal allograft: an unusual pattern of immunoglobulin deposition in a patient with biclonal gammopathy of unknown significance
    Ellen M Flatley
    Department of Pathology, Oregon Health and Science University Compass Oncology Legacy Good Samaritan Medical Center Transplant Services, Portland, OR
    Am J Surg Pathol 39:864-9. 2015
    ..In addition, this case illustrates simultaneous different patterns of accumulation of monoclonal immunoglobulin and light chain components in this unique patient with biclonal gammopathy of unknown significance. ..
  37. pmc IgG4 immunostaining and its implications in orbital inflammatory disease
    Amanda J Wong
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 9:e109847. 2014
    ..In order to appreciate the implications of IgG4 immunostaining, we analyzed gene expression and the prevalence of IgG4- immunostaining among subjects with orbital inflammatory diseases...
  38. doi request reprint Utility of immunohistochemical markers in irradiated breast tissue: an analysis of the role of myoepithelial markers, p53, and Ki-67
    Kaeley Anderson
    Departments of Pathology Behavioral Neuroscience Knight Cancer Institute, Oregon Health and Science University, Portland, OR
    Am J Surg Pathol 38:1128-37. 2014
    ..Ki-67 may be helpful in some postradiation specimens; however, p53 staining is not reliable in this setting. ..
  39. doi request reprint Membranous glomerulonephritis with crescents
    Caroline M F Barrett
    Department of Pathology, Oregon Health and Science University, L471, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA
    Int Urol Nephrol 46:963-71. 2014
    ..Little is known about whether these lesions are causally related in any clinical setting...
  40. doi request reprint Polyoma virus nephropathy-related mass lesion in an apparently immunocompetent patient
    Stephanie Go
    Department of Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd L418, Portland, OR 97239, USA
    Int Urol Nephrol 44:1585-8. 2012
    ..This case adds polyoma virus nephropathy to the differential diagnosis of non-neoplastic and reactive masses, which may mimic renal malignancy...
  41. doi request reprint Distinctive morphology of renal cell carcinomas in tuberous sclerosis
    Andrew Schreiner
    Department of Pathology, Division of Urology and Renal Transplantation, Oregon Health and Science University, Portland, OR 97239, USA
    Int J Surg Pathol 18:409-18. 2010
    ..The histopathological features of these carcinomas illustrate characteristics of renal carcinoma that are probably related to genetic alterations of tuberous sclerosis...
  42. ncbi request reprint Fine-needle aspiration cytology of medullary breast carcinoma: report of two cases and review of the literature with emphasis on differential diagnosis
    Melinda M Racz
    Department of Pathology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Diagn Cytopathol 35:313-8. 2007
    ..However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis...
  43. ncbi request reprint p16INK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia
    Christina S Kong
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Surg Pathol 31:33-43. 2007
    ....
  44. ncbi request reprint Follicular dendritic cell immunohistochemical markers in angioimmunoblastic T-cell lymphoma
    Megan L Troxell
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    Appl Immunohistochem Mol Morphol 13:297-303. 2005
    ..Thus, CD21 remains the most reliable marker of follicular dendritic cells in angioimmunoblastic T-cell lymphoma...
  45. ncbi request reprint Renal tubular injury associated with anagrelide use
    Graham E J Rodwell
    Division of Nephrology, Stanford University School of Medicine, 300 Pasteur Drive, S161, MC5114, Stanford, CA 94305 5114, USA
    Nephrol Dial Transplant 20:988-90. 2005