Maret Traber

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi request reprint Vitamin E regulatory mechanisms
    Maret G Traber
    Department of Nutrition and Exercise Science, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Annu Rev Nutr 27:347-62. 2007
  2. pmc α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 51:2031-40. 2011
  3. ncbi request reprint Vitamin E regulation
    Maret G Traber
    Linus Pauling Institute, Oregon State University Corvallis, Oregon 97331, USA
    Curr Opin Gastroenterol 21:223-7. 2005
  4. doi request reprint Vitamin E revisited: do new data validate benefits for chronic disease prevention?
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Curr Opin Lipidol 19:30-8. 2008
  5. pmc Vitamin E, antioxidant and nothing more
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 43:4-15. 2007
  6. ncbi request reprint Vitamin E trafficking
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Ann N Y Acad Sci 1031:1-12. 2004
  7. ncbi request reprint Heart disease and single-vitamin supplementation
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 85:293S-299S. 2007
  8. ncbi request reprint Relationship of vitamin E metabolism and oxidation in exercising human subjects
    Maret G Traber
    Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Br J Nutr 96:S34-7. 2006
  9. pmc Burn and smoke inhalation injury in sheep depletes vitamin E: kinetic studies using deuterated tocopherols
    M G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 42:1421-9. 2007
  10. ncbi request reprint Vitamin E, nuclear receptors and xenobiotic metabolism
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, 97331 6512, USA
    Arch Biochem Biophys 423:6-11. 2004

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Vitamin E regulatory mechanisms
    Maret G Traber
    Department of Nutrition and Exercise Science, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Annu Rev Nutr 27:347-62. 2007
    ..As a result of these various mechanisms, liver alpha-tocopherol and other vitamin E concentrations are closely regulated; thus, any potential adverse vitamin E effects are limited...
  2. pmc α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymes
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 51:2031-40. 2011
    ..Thus, an overload of hepatic α-tocopherol increases its own metabolism and increases expression of genes of transporters that are postulated to lead to increased excretion of both vitamin E and its metabolites...
  3. ncbi request reprint Vitamin E regulation
    Maret G Traber
    Linus Pauling Institute, Oregon State University Corvallis, Oregon 97331, USA
    Curr Opin Gastroenterol 21:223-7. 2005
    ..This review describes these regulatory mechanisms...
  4. doi request reprint Vitamin E revisited: do new data validate benefits for chronic disease prevention?
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Curr Opin Lipidol 19:30-8. 2008
    ..Vitamin E benefits in human health and chronic disease prevention are evaluated with respect to established alpha-tocopherol functions during vitamin E deficiency, adequacy, and excess...
  5. pmc Vitamin E, antioxidant and nothing more
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 43:4-15. 2007
    ....
  6. ncbi request reprint Vitamin E trafficking
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Ann N Y Acad Sci 1031:1-12. 2004
    ..Clearly, critical information is lacking in our understanding of the mechanism by which alpha-TTP facilitates the preferential enrichment of VLDLs with alpha-tocopherol...
  7. ncbi request reprint Heart disease and single-vitamin supplementation
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 85:293S-299S. 2007
    ..It is noteworthy that in most trials, biomarkers were not used nor were oxidative stress and lipid peroxidation markers used or plasma vitamin E concentrations measured...
  8. ncbi request reprint Relationship of vitamin E metabolism and oxidation in exercising human subjects
    Maret G Traber
    Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Br J Nutr 96:S34-7. 2006
    ..These results suggest that the mechanism of oxidative damage is operating independently of the inflammatory and muscle damage responses...
  9. pmc Burn and smoke inhalation injury in sheep depletes vitamin E: kinetic studies using deuterated tocopherols
    M G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 42:1421-9. 2007
    ..These findings suggest that alpha-tocopherol should be administered to burn patients to prevent vitamin E depletion and to protect against oxidative stress from burn injury...
  10. ncbi request reprint Vitamin E, nuclear receptors and xenobiotic metabolism
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, 97331 6512, USA
    Arch Biochem Biophys 423:6-11. 2004
    ..Vitamin E acting as a PXR ligand could alter these PXR-mediated reactions. Unfortunately, the extent to which pharmacologic doses of vitamin E modulate these pathways in vivo has not been determined...
  11. doi request reprint Vitamin E and K interactions--a 50-year-old problem
    Maret G Traber
    Linus Pauling Institute, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, Oregon 97331, USA
    Nutr Rev 66:624-9. 2008
    ....
  12. pmc Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Nutr Biochem 21:1193-9. 2010
    ..Since they did have higher hepatic α-CEHC concentrations, these data suggest metabolism was up-regulated in the AhR-null mice in order to maintain the hepatic tocopherol concentrations similar to those of wild-type mice...
  13. pmc α-Tocopherol adipose tissue stores are depleted after burn injury in pediatric patients
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Am J Clin Nutr 92:1378-84. 2010
    ..Adipose tissue α-tocopherol concentrations are generally accepted to reflect long-term vitamin E status...
  14. pmc Vitamins C and E: beneficial effects from a mechanistic perspective
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 51:1000-13. 2011
    ..Mechanism-based effects of vitamin C and E supplementation on biomarkers and on clinical outcomes from randomized, placebo-controlled trials are emphasized in this review...
  15. doi request reprint Regulation of xenobiotic metabolism, the only signaling function of alpha-tocopherol?
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mol Nutr Food Res 54:661-8. 2010
    ..We suggest that the most relevant cytochrome P450-mediated pathway is the one that is most important for the regulation and activation of vitamin K, specifically the one dependent on CYP4F2...
  16. ncbi request reprint Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners
    Angela Mastaloudis
    Departments of Exercise and Sport Science, Oregon State University, Corvallis, OR 97731, USA
    Free Radic Biol Med 36:1329-41. 2004
    ..03). Markers of inflammation were increased dramatically in response to the run regardless of treatment group. Thus, AO supplementation prevented endurance exercise-induced lipid peroxidation but had no effect on inflammatory markers...
  17. ncbi request reprint Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol diets
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 38:773-85. 2005
    ..These data support the hypothesis that alpha-tocopherol modulates xenobiotic metabolism by increasing Cyp3a expression, gamma-CEHC formation, and the excretion of both gamma-tocopherol and gamma-CEHC...
  18. ncbi request reprint Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation
    Richard S Bruno
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 40:689-97. 2006
    ....
  19. ncbi request reprint Alpha-tocopherol regulation of hepatic cytochrome P450s and ABC transporters in rats
    Debbie J Mustacich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 41:1069-78. 2006
    ..Thus hepatic alpha-tocopherol concentrations altered hepatic proteins involved in metabolism and disposition of xenobiotic agents...
  20. pmc Dietary zinc restriction and repletion affects DNA integrity in healthy men
    Yang Song
    Department of Nutrition and Exercise Sciences and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 90:321-8. 2009
    ..Zinc plays an important role in antioxidant defense and the maintenance of cellular DNA integrity. However, no experimental human studies have been performed to examine the role of zinc status on DNA damage...
  21. ncbi request reprint Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers
    Richard S Bruno
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 81:1052-9. 2005
    ..Cigarette smoking increases the fractional disappearance rates of alpha-tocopherol and is associated with increased oxidative stress, but its effects on alpha-tocopherol metabolism are unknown...
  22. ncbi request reprint Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, Corvallis, USA
    Am J Clin Nutr 75:555-60. 2002
    ..In humans, 2R-alpha-tocopherol stereoisomers are preferentially maintained in the plasma, a function that has been attributed to hepatic alpha-tocopherol transfer protein (alpha-TTP), but this hypothesis has not been tested...
  23. pmc Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice
    Debbie J Mustacich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 20:469-76. 2009
    ....
  24. doi request reprint Vitamins C and E improve regrowth and reduce lipid peroxidation of blackberry shoot tips following cryopreservation
    Esther E Uchendu
    Department of Horticulture, Oregon State University, Corvallis, OR 97331 7304, USA
    Plant Cell Rep 29:25-35. 2010
    ..This is the first report of the application of vitamins for improving cryopreservation of plant tissues by minimizing oxidative damage...
  25. ncbi request reprint Endurance exercise results in DNA damage as detected by the comet assay
    Angela Mastaloudis
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 36:966-75. 2004
    ..Thus, endurance exercise resulted in DNA damage as shown by the comet assay and AO seemed to enhance recovery in women but not in men...
  26. ncbi request reprint Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
    Anal Biochem 350:41-51. 2006
    ..Ours is the first validated quantitative assay using HPLC-tandem MS applied to plasma total 15-PGFs...
  27. doi request reprint Quantitation of plasma total 15-series F(2)-isoprostanes by sequential solid phase and liquid-liquid extraction
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Anal Biochem 396:319-21. 2010
    ..Both changes increased the overall sensitivity of the assay. MS/MS analysis served to confirm the identity of specific peaks that may be better biomarkers than the commonly measured 8-iso-PGF(2alpha)...
  28. pmc Alpha-tocopherol beta-oxidation localized to rat liver mitochondria
    Debbie J Mustacich
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 48:73-81. 2010
    ..An unexpected finding was that alpha-CEHC, the end product of alpha-tocopherol metabolism, was found almost exclusively in mitochondria. These data are the first to indicate a mitochondrial role in alpha-tocopherol metabolism...
  29. ncbi request reprint Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress
    Deborah L Bella
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Lipids 41:105-12. 2006
    ..Thus, hepatic TTP concentrations may be at sufficient levels such that they are unaffected by either modulations of dietary vitamin E or by the conditions of environmentally related oxidative stress used in the present studies...
  30. pmc Regulatory mechanisms to control tissue alpha-tocopherol
    Debbie J Mustacich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 43:610-8. 2007
    ..88, p<0.05). Increased lung MDR1 may provide protection from exposure to environmental toxins by increasing alveolar space alpha-tocopherol...
  31. pmc Women and smokers have elevated urinary F(2)-isoprostane metabolites: a novel extraction and LC-MS methodology
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331 6512, USA
    Lipids 43:925-36. 2008
    ..05). Thus, our method simultaneously allows measurement of urinary F(2)-IsoPs and their metabolites for the determination of oxidative stress...
  32. ncbi request reprint Human vitamin E requirements assessed with the use of apples fortified with deuterium-labeled alpha-tocopheryl acetate
    Richard S Bruno
    Department of Food Science and Technology, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 83:299-304. 2006
    ..Little is known about factors that modulate dietary alpha-tocopherol bioavailability...
  33. ncbi request reprint Cigarette smoke alters human vitamin E requirements
    Richard S Bruno
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    J Nutr 135:671-4. 2005
    ..Last, the possibility of CEHC as a biomarker of vitamin E status will be assessed as will the question whether smokers have increased dietary requirements of vitamin E...
  34. ncbi request reprint Antioxidants did not prevent muscle damage in response to an ultramarathon run
    Angela Mastaloudis
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Med Sci Sports Exerc 38:72-80. 2006
    ..This study was conducted to determine if 6 wk of supplementation with vitamins E and C could alleviate exercise-induced muscle damage. We studied 22 runners during a 50-km ultramarathon...
  35. ncbi request reprint Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients
    Kylie Sherée Smith
    Department of Nutrition and Food Management, Oregon State University, Corvallis, Oregon 97331, USA
    Lipids 38:813-9. 2003
    ..Importantly, serum vitamin E metabolite concentrations that increased 10-fold within 30 d of supplementation did not increase further, suggesting routes other than urine for removal of metabolites...
  36. ncbi request reprint Cigarette smoking increases human vitamin E requirements as estimated by plasma deuterium-labeled CEHC
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Ann N Y Acad Sci 1031:357-60. 2004
    ..d(3)/d(6)-alpha-CEHC ratios were on average 0.29 +/- 0.05, confirming that all-rac-alpha-tocopherol is metabolized more efficiently. CEHC may be a good marker of vitamin E status, and smokers may have an increased vitamin E requirement...
  37. ncbi request reprint Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Free Radic Biol Med 38:857-66. 2005
    ..04) in urine. Thus, gamma-tocopherol is rapidly metabolized to gamma-CEHC, and to a greater degree in women than in men, whereas alpha-tocopherol is maintained in the plasma and little is metabolized to alpha-CEHC...
  38. ncbi request reprint Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations
    Yunsook Lim
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Ann N Y Acad Sci 1031:328-9. 2004
  39. pmc Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats
    Yang Song
    Department of Nutrition and Exercise Science and 5Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 139:1626-31. 2009
    ..These results suggest interactions among zinc deficiency, DNA integrity, oxidative stress, and DNA repair and suggested a role for zinc in maintaining DNA integrity...
  40. ncbi request reprint Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response
    John Sowell
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 827:139-45. 2005
    ..In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress...
  41. ncbi request reprint Vitamin E delivery to human skin: studies using deuterated alpha-tocopherol measured by APCI LC-MS
    Heather Vaule
    Department of Nutrition and Food Management, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 36:456-63. 2004
    ..Plasma percentage d3 peaked at day 8, while skin surface lipid percentage d3 increased on average until day 19. Apparently skin employs a mechanism to deliver alpha-tocopherol into skin via lipid secretions...
  42. pmc From animals to humans: evidence linking oxidative stress as a causative factor in muscle atrophy
    Tyler Barker
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Physiol 583:421-2. 2007
  43. ncbi request reprint Vitamin E
    Debbie J Mustacich
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Vitam Horm 76:1-21. 2007
    ..It is expected that the continued studies of these regulatory pathways will provide new insights into vitamin E function from which additional human health benefits will evolve...
  44. ncbi request reprint Effects of vitamin E on cholesterol levels of hypercholesterolemic patients receiving statins
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Am J Health Syst Pharm 64:2257-66. 2007
    ..The effects of vitamin E supplementation on the cholesterol levels of hypercholesterolemic patients receiving statin therapy were studied...
  45. ncbi request reprint Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Lipid Res 46:1068-75. 2005
    ..Thus, LC-MS can be successfully used to quantitate alpha- and gamma-CEHC in liver samples. These data suggest that in times of excess liver alpha-tocopherol, increased metabolism of alpha-tocopherol to alpha-CEHC occurs...
  46. ncbi request reprint 5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 35:1560-7. 2003
    ..Our results show that LC-MS can be successfully used for NGT quantitation in biologic samples. Importantly, NGT in smokers' plasma suggests that cigarette smoking causes increased nitrosative stress...
  47. ncbi request reprint Vitamin E bioavailability from fortified breakfast cereal is greater than that from encapsulated supplements
    Scott W Leonard
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 79:86-92. 2004
    ..Conflicting results from vitamin E intervention studies suggest supplemental vitamin E malabsorption...
  48. ncbi request reprint Vitamin E and transfer proteins
    Daisy E Kaempf-Rotzoll
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Curr Opin Lipidol 14:249-54. 2003
    ..Recently, the intracellular transport as well as cellular uptake and excretion of alpha-tocopherol, the major representative of vitamin E, have been elucidated...
  49. ncbi request reprint Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep
    Naoki Morita
    Department of Anaesthesiology, The University of Texas Medical Branch, Galveston, Texas 77555 0833, USA
    Shock 25:277-82. 2006
    ..Vitamin E nebulization therapy improved the clinical responses to burn and smoke inhalation-induced acute lung injury...
  50. ncbi request reprint The ABCs of vitamin E and beta-carotene absorption
    Maret G Traber
    Am J Clin Nutr 80:3-4. 2004
  51. ncbi request reprint Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues
    Kaori Minehira-Castelli
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    J Lipid Res 47:1733-8. 2006
    ..We conclude that the absence of VLDL secretion has little effect on the stores of alpha-tocopherol in peripheral tissues, at least in the mouse...
  52. ncbi request reprint Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in plasma of smokers
    Marion Dietrich
    Department of Nutritional Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 11:7-13. 2002
    ..The intake of antioxidants may help prevent smoking-related diseases. Smoking cessation should still be considered the most effective way to prevent smoking-related diseases...
  53. ncbi request reprint Enhanced inflammatory responses in alpha-tocopherol transfer protein null mice
    Bettina C Schock
    Division of Pulmonary and Critical Care Medicine and Center for Comparative Respiratory Biology and Medicine, University of California School of Medicine, Davis, CA 95616, USA
    Arch Biochem Biophys 423:162-9. 2004
    ..Taken together, these results demonstrate that alpha-tocopherol is important for proper modulation of inflammatory responses and that sub-optimal alpha-tocopherol concentrations may derange inflammatory-immune responses...
  54. ncbi request reprint Vitamins E and C are safe across a broad range of intakes
    John N Hathcock
    Council for Responsible Nutrition, Washington, DC, USA
    Am J Clin Nutr 81:736-45. 2005
    ....
  55. pmc Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model
    Yunsook Lim
    Department of Internal Medicine, Center for Comparative Lung Biology and Disease, School of Medicine, Davis, CA 95616, USA
    Free Radic Res 42:387-96. 2008
    ..It is concluded that the initial stimulation of immune responses by the TTP(-/-) mice were generally blunted compared to the TTP(+/+) mice, thus diminishing some aspects of subsequent allergic inflammatory processes...
  56. ncbi request reprint Gamma-tocopherol, the new vitamin E?
    Sridevi Devaraj
    Am J Clin Nutr 77:530-1. 2003
  57. pmc Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 44:1203-8. 2008
    ....
  58. ncbi request reprint Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury
    Naoki Morita
    The University of Texas Medical Branch, Department of Anaesthesiology and Shriners Burns Hospital for Children, Galveston, Texas, USA
    Redox Rep 11:61-70. 2006
    ..We hypothesized that vitamin E supplementation (alpha-tocopherol) would attenuate acute lung injury induced by burn and smoke inhalation injury...
  59. ncbi request reprint Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age
    Kishorchandra Gohil
    Center for Comparative Respiratory and Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Ann N Y Acad Sci 1031:109-26. 2004
    ..In conclusion, gene-expression profiling studies have identified novel alpha-T-modulated genes and cells in the CNS that may be causatively linked with delayed neurodegeneration and age-related decline in behavioral repertoires...
  60. ncbi request reprint Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes
    Richard S Bruno
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 18:509-18. 2007
    ..Collectively, zinc deficiency increased oxidative stress, which may be partially explained by increased CYP activity and reductions in hepatic alpha-tocopherol and gamma-tocopherol and in plasma uric acid...
  61. ncbi request reprint How much vitamin E? ... Just enough!
    Maret G Traber
    Am J Clin Nutr 84:959-60. 2006
  62. ncbi request reprint Lactating sows and suckling piglets preferentially incorporate RRR- over all-rac-alpha-tocopherol into milk, plasma and tissues
    Charlotte Lauridsen
    Department of Animal Nutrition and Physiology, Research Centre Foulum, DK 8830 Tjele, Denmark
    J Nutr 132:1258-64. 2002
    ....
  63. ncbi request reprint Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakes
    Marion Dietrich
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Am J Clin Nutr 77:160-6. 2003
    ..Free radicals in cigarette smoke may cause oxidative damage to macromolecules, contributing to cardiovascular diseases and cancer. Decreased plasma antioxidant concentrations may indicate cigarette smoke-related oxidative stress...
  64. ncbi request reprint Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolites in humans
    Jan Frank
    Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, 750 07 Uppsala, Sweden
    Ann N Y Acad Sci 1031:365-7. 2004
    ..In conclusion, a single dose of sesame oil, containing 136 mg sesame lignans (sesamin and sesamolin), reduces the urinary excretion of co-administered gamma-T in humans...
  65. ncbi request reprint {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status
    Richard S Bruno
    Department of Human Nutrition, The Ohio State University, Columbus, OH, USA
    Am J Clin Nutr 81:95-103. 2005
    ..Cigarette smokers have enhanced oxidative stress from cigarette smoke exposure and from their increased inflammatory responses...
  66. ncbi request reprint Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein
    Kishorchandra Gohil
    Center for Comparative Respiratory and Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 35:1343-54. 2003
    ..The repression of specific genes that determine synaptic plasticity and neuronal development may account for suppressed electrophysiological activities of cortex and impaired behavior in Ttpa(-/-) mice...
  67. pmc Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects
    Jan Frank
    Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Am J Clin Nutr 87:1723-9. 2008
    ..Gamma-tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances gamma-tocopherol turnover...
  68. pmc gamma-Tocopherol nebulization by a lipid aerosolization device improves pulmonary function in sheep with burn and smoke inhalation injury
    Atsumori Hamahata
    University of Texas Medical Branch, Galveston, TX 77555, USA
    Free Radic Biol Med 45:425-33. 2008
    ..Pulmonary gT delivery along with a FO source may be a novel effective treatment strategy in management of patients with acute lung injury...
  69. ncbi request reprint A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes
    Tal Offer
    Nutritional Genomics Center, Children s Hospital of Oakland Research Institute, Oakland, California 94609, USA
    FASEB J 19:485-7. 2005
    ..This method, unlike available micronuclei assays, allows rapid evaluation of a large number of cells and therefore should prove to be useful in monitoring of human populations for genetic damage...
  70. ncbi request reprint Subcutaneous vitamin E ameliorates liver injury in an in vivo model of steatocholestasis
    Jason S Soden
    Pediatric Liver Center and Liver Transplantation Program, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Colorado at Denver Health Sciences Center, Denver, CO, USA
    Hepatology 46:485-95. 2007
    ..CONCLUSION: Steatosis sensitizes the liver to bile acid-induced necrotic hepatocyte injury, which is responsive to vitamin E therapy...
  71. ncbi request reprint Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review
    Marion Dietrich
    Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Nutritional Epidemiology, Boston, MA 02111, USA
    J Am Coll Nutr 25:292-9. 2006
    ..In this article, we review publications on dietary gamma-tocopherol intake, plasma gamma-tocopherol levels, cardiovascular disease and cancer risk in humans...
  72. pmc Genome wide responses of murine lungs to dietary alpha-tocopherol
    Saji Oommen
    Division of Pulmonary and Critical Care, Department of Internal Medicine, Genome and Biomedical Sciences Facility, University of California, Davis, CA 95616, USA
    Free Radic Res 41:98-109. 2007
    ..Immunohistochemical analyses of three of the encoded proteins suggest that they are expressed in lung vasculature and alveolar regions. The data suggest that the lung alpha-T status may modulate cytoarchitecture of lungs...

Research Grants15

  1. Vitamin E Requirements in Women,Obese Women and Diabetic Obese Women
    Maret G Traber; Fiscal Year: 2010
    ....
  2. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  3. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret Traber; Fiscal Year: 2009
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  4. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2009
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  5. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2006
    ....
  6. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2007
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  7. Oxidative Stress and Vitamin E Requirements
    Maret Traber; Fiscal Year: 2005
    ..These proposed studies will further our goal of understanding the role of vitamin E in the amelioration of oxidative damage in aging and in chronic diseases, such as heart disease, diabetes and cancer. ..
  8. Antioxidant Supplementation,Oxidative Stress & Enduranc*
    Maret Traber; Fiscal Year: 2002
    ..Finally, the investigators plan to measure markers of inflammatory response, such as C-oxidants increase and vitamin E decreases these markers. ..
  9. Vitamin E Requirements in Women,Obese Women and Diabetic Obese Women
    Maret G Traber; Fiscal Year: 2010
    ....