THOMAS SODERLING

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint CaM-kinases: modulators of synaptic plasticity
    T R Soderling
    Vollum Institute, L 474 Oregon Health Sciences University, Portland, OR 97201, USA
    Curr Opin Neurobiol 10:375-80. 2000
  2. ncbi request reprint The Ca-calmodulin-dependent protein kinase cascade
    T R Soderling
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Trends Biochem Sci 24:232-6. 1999
  3. ncbi request reprint Structure and regulation of calcium/calmodulin-dependent protein kinases II and IV
    T R Soderling
    Vollum Institute, Oregon Health Sciences University, Portland 97225, USA
    Biochim Biophys Acta 1297:131-8. 1996
  4. pmc Characterization of a calmodulin kinase II inhibitor protein in brain
    B H Chang
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 95:10890-5. 1998
  5. ncbi request reprint Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II
    S Mukherji
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Biol Chem 270:14062-7. 1995
  6. ncbi request reprint Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain
    B H Chang
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Neuroscience 102:767-77. 2001
  7. ncbi request reprint Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    S Yano
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 396:584-7. 1998
  8. ncbi request reprint Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    Biochemistry 36:12823-7. 1997
  9. ncbi request reprint Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
    A Barria
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Science 276:2042-5. 1997
  10. ncbi request reprint Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade
    G A Wayman
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 272:16073-6. 1997

Research Grants

  1. TRAINING PROGRAM IN NEURONAL SIGNALING
    THOMAS SODERLING; Fiscal Year: 2007
  2. Calmodulin Dependent Protein Kinase Kinase
    THOMAS SODERLING; Fiscal Year: 2005
  3. REGULATORY PHOSPHORYLATION OF GLUTAMATE RECEPTORS
    THOMAS SODERLING; Fiscal Year: 2002
  4. Regulation of Synaptic Plasticity by Calmodulin-Kinases
    THOMAS SODERLING; Fiscal Year: 2007
  5. Calmodulin-dependent kinases regulate neuronal development
    Thomas R Soderling; Fiscal Year: 2010
  6. Calmodulin-dependent kinases regulate neuronal development
    THOMAS SODERLING; Fiscal Year: 2007
  7. CALMODULIN DEPENDENT PROTEIN KINASES
    THOMAS SODERLING; Fiscal Year: 2001
  8. CALCIUM-CALMODULIN KINASE II--BRAIN SUBSTRATES
    THOMAS SODERLING; Fiscal Year: 1993
  9. CALCIUM/CALMODLIN-DEPENDENT PROTEIN KINASE 11
    THOMAS SODERLING; Fiscal Year: 1993
  10. Regulation of Synaptic Plasticity by Calmodulin-Kinases
    Thomas R Soderling; Fiscal Year: 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint CaM-kinases: modulators of synaptic plasticity
    T R Soderling
    Vollum Institute, L 474 Oregon Health Sciences University, Portland, OR 97201, USA
    Curr Opin Neurobiol 10:375-80. 2000
    ..More prolonged responses may be effected through enhanced dendritic protein synthesis of CaM-KII and regulation of nuclear gene transcription by CaM-KIV...
  2. ncbi request reprint The Ca-calmodulin-dependent protein kinase cascade
    T R Soderling
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Trends Biochem Sci 24:232-6. 1999
    ..Activation of PKB by CaMKK appears to be important in protection of neurons from programmed cell death during development...
  3. ncbi request reprint Structure and regulation of calcium/calmodulin-dependent protein kinases II and IV
    T R Soderling
    Vollum Institute, Oregon Health Sciences University, Portland 97225, USA
    Biochim Biophys Acta 1297:131-8. 1996
  4. pmc Characterization of a calmodulin kinase II inhibitor protein in brain
    B H Chang
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 95:10890-5. 1998
    ..These results characterize a potent and specific cellular inhibitor of CaM-KII that may have an important role in the physiological regulation of this key protein kinase...
  5. ncbi request reprint Mutational analysis of Ca(2+)-independent autophosphorylation of calcium/calmodulin-dependent protein kinase II
    S Mukherji
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Biol Chem 270:14062-7. 1995
    ....
  6. ncbi request reprint Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain
    B H Chang
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Neuroscience 102:767-77. 2001
    ..These results suggest a localized function for CaM-KIIN in inhibiting specialized pools of CaM-kinase II...
  7. ncbi request reprint Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    S Yano
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 396:584-7. 1998
    ..These results identify a Ca2+-triggered signalling cascade in which CaM-KK activates PKB, which in turn phosphorylates BAD and protects cells from apoptosis...
  8. ncbi request reprint Calcium/calmodulin-dependent protein kinase kinase: identification of regulatory domains
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    Biochemistry 36:12823-7. 1997
    ..Tokumitsu, H., and Soderling, T. R. (1997) J. Biol. Chem. 272, 16073-16076], was blocked by prior binding of Ca2+/CaM to CaM-KK...
  9. ncbi request reprint Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
    A Barria
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Science 276:2042-5. 1997
    ..This covalent modulation of AMPA-Rs in LTP provides a postsynaptic molecular mechanism for synaptic plasticity...
  10. ncbi request reprint Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade
    G A Wayman
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 272:16073-6. 1997
    ..These results demonstrate that the CaM kinase cascade is negatively regulated in cells by the cAMP/PKA pathway...
  11. ncbi request reprint Requirements for calcium and calmodulin in the calmodulin kinase activation cascade
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 271:5617-22. 1996
    ....
  12. ncbi request reprint Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation
    H Enslen
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:15520-7. 1994
    ..In addition multiple protein phosphatases, including calcineurin, may exert a modulatory effect on transcription depending on which site they dephosphorylate...
  13. ncbi request reprint Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase
    H Tokumitsu
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Biol Chem 269:28640-7. 1994
    ..Sun, P., Brickey, D., Soderling, S. H., Klamo, E., and Soderling, T.R. (1994) J. Biol. Chem. 269, 15520-15527)...
  14. pmc Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate glutamate receptors
    J L Yakel
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Proc Natl Acad Sci U S A 92:1376-80. 1995
    ..This CaM-kinase II regulatory phosphorylation site is conserved in all AMPA/kainate-type glutamate receptors, and its phosphorylation may be important in enhancing postsynaptic responsiveness as occurs during synaptic plasticity...
  15. ncbi request reprint Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006
    ..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
  16. ncbi request reprint Regulatory mechanisms of AMPA receptors in synaptic plasticity
    Victor A Derkach
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Nat Rev Neurosci 8:101-13. 2007
    ..These relationships offer new insights into the regulation of AMPARs and synaptic strength by cellular signalling...
  17. pmc Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex
    Takeo Saneyoshi
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neuron 57:94-107. 2008
    ..This activity-dependent signaling pathway can promote synapse formation during neuronal development and in structural plasticity...
  18. pmc Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I
    Eric S Guire
    Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97225, USA
    J Neurosci 28:6000-9. 2008
    ..Thus, synaptic expression of CP-AMPARs is a very efficient mechanism for rapid enhancement of synaptic strength that depends on CaMKK/CaMKI signaling, actin dynamics, and the pattern of synaptic activity used to induce CA1 LTP...
  19. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  20. ncbi request reprint Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
    ....
  21. ncbi request reprint Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
    John M Schmitt
    Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Neurosci 25:1281-90. 2005
    ..These data indicate an essential role for CaMKK and CaMKI to link NMDA receptor-mediated Ca2+ elevation with ERK-dependent LTP...
  22. ncbi request reprint Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3
    Monika A Davare
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 279:52191-9. 2004
    ..We conclude that binding of 14-3-3 to CaMKK stabilizes its inhibition by PKA-mediated phosphorylation, which may have important consequences in the regulation of CaMKI, CaMKIV, protein kinase B, and ERK signaling pathways...
  23. ncbi request reprint Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II
    Coleen M Atkins
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 24:5193-201. 2004
    ..These results demonstrate that CPEB phosphorylation and translation are regulated by CaMKII activity and provide a possible mechanism for how dendritic protein synthesis in the hippocampus may be stimulated during synaptic plasticity...
  24. ncbi request reprint Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
    Soren Impey
    The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
    Neuron 34:235-44. 2002
    ..Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301...
  25. pmc Calmodulin-kinases: modulators of neuronal development and plasticity
    Gary A Wayman
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neuron 59:914-31. 2008
    ..The technical challenges of mapping cellular protein kinase signaling pathways are also discussed...
  26. ncbi request reprint Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation
    Coleen M Atkins
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 25:5604-10. 2005
    ....
  27. ncbi request reprint Calcium activation of ERK mediated by calmodulin kinase I
    John M Schmitt
    Vollum Institute, Oregon Health and Sciences University, Portland 97239, USA
    J Biol Chem 279:24064-72. 2004
    ..These data are the first to suggest that ERK activation and neurite outgrowth in response to depolarization are mediated by CaMKK activation of CaMKI...

Research Grants40

  1. TRAINING PROGRAM IN NEURONAL SIGNALING
    THOMAS SODERLING; Fiscal Year: 2007
    ..Trainees will meet bimonthly as a group with mentors and present updates on their research. ..
  2. Calmodulin Dependent Protein Kinase Kinase
    THOMAS SODERLING; Fiscal Year: 2005
    ..These studies will further our understanding of the functions of CaM-KK in cellular Ca2+ signaling and their roles in neurotransmitter/hormone responses, neuronal development and cell death, and synaptic plasticity. ..
  3. REGULATORY PHOSPHORYLATION OF GLUTAMATE RECEPTORS
    THOMAS SODERLING; Fiscal Year: 2002
    ..The results of these studies have strong implications for modulating synaptic efficiency in paradigms of learning and memory and for neuronal excitability in epilepsy. ..
  4. Regulation of Synaptic Plasticity by Calmodulin-Kinases
    THOMAS SODERLING; Fiscal Year: 2007
    ..The results of this study will provide biochemical details of multiple mechanisms of synaptic plasticity including modulation of AMPA-Rs, regulation of gene transcription and modulation of dendritic protein synthesis. ..
  5. Calmodulin-dependent kinases regulate neuronal development
    Thomas R Soderling; Fiscal Year: 2010
    ..Thus, these studies have strong implications for underlying causes of mental diseases. ..
  6. Calmodulin-dependent kinases regulate neuronal development
    THOMAS SODERLING; Fiscal Year: 2007
    ..Thus, these studies have strong implications for underlying causes of mental diseases. ..
  7. CALMODULIN DEPENDENT PROTEIN KINASES
    THOMAS SODERLING; Fiscal Year: 2001
    ..These studies will further our understanding of the enzymatic and regulatory properties of these key signaling proteins, thereby furthering our understanding of their roles in hormone actions, learning and memory, epilepsy and stroke. ..
  8. CALCIUM-CALMODULIN KINASE II--BRAIN SUBSTRATES
    THOMAS SODERLING; Fiscal Year: 1993
    ..The NMDA channel is of special relevance due to its likely involvement in synaptic plasticity such as long-term potentiation and kindling, and perhaps in epilepsy...
  9. CALCIUM/CALMODLIN-DEPENDENT PROTEIN KINASE 11
    THOMAS SODERLING; Fiscal Year: 1993
    ..These studies will further our understanding of the regulation and function of this multifunctional Ca++ -dependent kinase...
  10. Regulation of Synaptic Plasticity by Calmodulin-Kinases
    Thomas R Soderling; Fiscal Year: 2010
    ..Lastly, we will investigate mechanisms for formation of functional dendritic spines, which are abnormal in several forms of mental retardation (e.g., Fragile X, Rett and Down's syndromes). ..