Stephen M Smith

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals
    Wenyan Chen
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 5:e8563. 2010
  2. pmc Fast inhibition of glutamate-activated currents by caffeine
    Nicholas P Vyleta
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    PLoS ONE 3:e3155. 2008
  3. pmc Calcium regulation of spontaneous and asynchronous neurotransmitter release
    Stephen M Smith
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, United States
    Cell Calcium 52:226-33. 2012
  4. ncbi request reprint Ultradian variation of blood glucose in intensive care unit patients receiving insulin infusions
    Stephen M Smith
    Pulmonary and Critical Care Medicine, Biomedical Research Building UHN 67, 3181 SW Sam Jackson Park Rd, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Diabetes Care 30:2503-5. 2007
  5. pmc Calcium-sensing receptor activation depresses synaptic transmission
    Cecilia G Phillips
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 28:12062-70. 2008
  6. pmc Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA
    Courtney Williams
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 15:1195-7. 2012
  7. pmc Calcium-sensing receptor: a high-affinity presynaptic target for aminoglycoside-induced weakness
    Mark T Harnett
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Neuropharmacology 57:502-5. 2009
  8. pmc Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor
    Nicholas P Vyleta
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 31:4593-606. 2011
  9. pmc Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons
    James H Peters
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuron 65:657-69. 2010
  10. pmc Modulation of neuronal voltage-activated calcium and sodium channels by polyamines and pH
    Wenyan Chen
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Channels (Austin) 1:281-90. 2007

Research Grants

  1. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2003
  2. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2004
  3. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2005
  4. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2006

Collaborators

Detail Information

Publications16

  1. pmc Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals
    Wenyan Chen
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 5:e8563. 2010
    ..Here, we identify the first component in a presynaptic calcium signaling pathway...
  2. pmc Fast inhibition of glutamate-activated currents by caffeine
    Nicholas P Vyleta
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    PLoS ONE 3:e3155. 2008
    ..Caffeine stimulates calcium-induced calcium release (CICR) in many cell types. In neurons, caffeine stimulates CICR presynaptically and thus modulates neurotransmitter release...
  3. pmc Calcium regulation of spontaneous and asynchronous neurotransmitter release
    Stephen M Smith
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, United States
    Cell Calcium 52:226-33. 2012
    ....
  4. ncbi request reprint Ultradian variation of blood glucose in intensive care unit patients receiving insulin infusions
    Stephen M Smith
    Pulmonary and Critical Care Medicine, Biomedical Research Building UHN 67, 3181 SW Sam Jackson Park Rd, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Diabetes Care 30:2503-5. 2007
  5. pmc Calcium-sensing receptor activation depresses synaptic transmission
    Cecilia G Phillips
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 28:12062-70. 2008
    ..In summary, reduced CaSR function enhanced synaptic transmission and CaSR stimulation had the opposite effect. Thus CaSR provides a mechanism that may compensate for the fall in release probability that accompanies decreases in [Ca](o)...
  6. pmc Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA
    Courtney Williams
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 15:1195-7. 2012
    ..Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type...
  7. pmc Calcium-sensing receptor: a high-affinity presynaptic target for aminoglycoside-induced weakness
    Mark T Harnett
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Neuropharmacology 57:502-5. 2009
    ..Thus, at clinically relevant concentrations, aminoglycoside-induced weakness is likely precipitated by enhanced CaSR activation and subsequent decrease in terminal excitability rather than through direct inhibition of VACCs themselves...
  8. pmc Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor
    Nicholas P Vyleta
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 31:4593-606. 2011
    ..Overall these results indicate that extracellular Ca(2+) does not trigger spontaneous glutamate release by simply increasing calcium influx but stimulates CaSR and thereby promotes resting spontaneous glutamate release...
  9. pmc Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons
    James H Peters
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuron 65:657-69. 2010
    ..This activity-dependent TPRV1-mediated facilitation is a form of synaptic plasticity that brings a unique central integrative feature to the CNS and autonomic regulation...
  10. pmc Modulation of neuronal voltage-activated calcium and sodium channels by polyamines and pH
    Wenyan Chen
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Channels (Austin) 1:281-90. 2007
    ..Many of the observed effects can be explained by a model incorporating polyamine binding, H(+) binding and surface charge screening...
  11. ncbi request reprint Extravascular lung water in sepsis-associated acute respiratory distress syndrome: indexing with predicted body weight improves correlation with severity of illness and survival
    Charles R Phillips
    Division of Pulmonary and Critical Care Medicine and Center for Intensive Care Research, Oregon Health and Science University, Portland, OR, USA
    Crit Care Med 36:69-73. 2008
    ....
  12. pmc Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval
    Stephen M Smith
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Trends Neurosci 31:559-68. 2008
    ..We are of the opinion that both fast and slow modes of endocytosis co-exist at central nervous system nerve terminals and that one mode can predominate depending on stimulus strength, temperature and synaptic maturation...
  13. pmc Vasopressin inhibits glutamate release via two distinct modes in the brainstem
    Timothy W Bailey
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:6131-42. 2006
    ..Thus, AVP regulates NTS neurons by two distinct novel and state-dependent mechanisms: one, an analog, graded presynaptic inhibition of terminal glutamate release and the other, a binary, extraterminal block of conducted excitation...
  14. pmc Baclofen and gamma-hydroxybutyrate withdrawal
    Jennifer L LeTourneau
    Division of Pulmonary and Critical Care Medicine and Center for Intensive Care Research, Department of Medicine, Oregon Health and Science University, Biomedical Research Building UHN 67, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Neurocrit Care 8:430-3. 2008
    ..Benzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABA(B) agonists, such as baclofen, will be a more effective strategy...
  15. ncbi request reprint N-acetylcysteine for patients with prolonged hypotension as prophylaxis for acute renal failure (NEPHRON)
    Jeffrey A Komisarof
    Department of Medicine, Division of Nephrology, General Clinical Research Center, Oregon Health and Science University, Portland, OR, USA
    Crit Care Med 35:435-41. 2007
    ..N-acetylcysteine is an antioxidant and anti-inflammatory agent that may counteract some of the pathophysiologic derangements in shock states...
  16. doi request reprint Glucose variance in ICU patients receiving insulin infusions
    Stephen M Smith
    Chest 133:1288. 2008

Research Grants4

  1. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2003
    ..abstract_text> ..
  2. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2004
    ..abstract_text> ..
  3. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2005
    ..abstract_text> ..
  4. Nerve Terminal Regulation in the Cerebral Cortex
    Stephen Smith; Fiscal Year: 2006
    ..abstract_text> ..