Ov Slayden

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Polidocanol induced tubal occlusion in nonhuman primates: immunohistochemical detection of collagen I-V
    Ov D Slayden
    Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, 97006, USA Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, 97239, USA Electronic address
    Contraception 94:521-526. 2016
  2. doi request reprint Translational In Vivo Models for Women's Health: The Nonhuman Primate Endometrium--A Predictive Model for Assessing Steroid Receptor Modulators
    Ov Daniel Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N W 185th Ave, Beaverton, OR, 97006, USA
    Handb Exp Pharmacol 232:191-202. 2016
  3. ncbi request reprint Role of progesterone in the structural and biochemical remodeling of the primate endometrium
    O D Slayden
    Oregon National Primate Research Center, Division of Reproductive Sciences, Beaverton 97006 3448, USA
    Ernst Schering Res Found Workshop . 2005
  4. pmc Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)
    Kristof Chwalisz
    TAP Pharmaceutical Products Inc, Lake Forest, Illinois, USA
    Reprod Biol Endocrinol 4:S8. 2006
  5. pmc A critical period of progesterone withdrawal precedes menstruation in macaques
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Reprod Biol Endocrinol 4:S6. 2006
  6. ncbi request reprint Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:393-409. 2004
  7. ncbi request reprint Chronic progesterone antagonist-estradiol therapy suppresses breakthrough bleeding and endometrial proliferation in a menopausal macaque model
    O D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA
    Hum Reprod 21:3081-90. 2006
  8. ncbi request reprint Estrogen enhances cystatin C expression in the macaque vagina
    Ov D Slayden
    Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 89:883-91. 2004
  9. ncbi request reprint Role of progesterone in nonhuman primate implantation
    Ov Daniel Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 25:418-30. 2007
  10. ncbi request reprint Assessment of menstruation in the vervet (Cercopithecus aethiops)
    Rebecca L Carroll
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Am J Primatol 69:901-16. 2007

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Polidocanol induced tubal occlusion in nonhuman primates: immunohistochemical detection of collagen I-V
    Ov D Slayden
    Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, 97006, USA Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, 97239, USA Electronic address
    Contraception 94:521-526. 2016
    ..Intrauterine administration of polidocanol foam (PF) can create fallopian tube occlusion in nonhuman primates. The objective of this study was to determine if PF-induced tubal obstructions contain collagen in the extracellular matrix...
  2. doi request reprint Translational In Vivo Models for Women's Health: The Nonhuman Primate Endometrium--A Predictive Model for Assessing Steroid Receptor Modulators
    Ov Daniel Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N W 185th Ave, Beaverton, OR, 97006, USA
    Handb Exp Pharmacol 232:191-202. 2016
    ..Our goal is to outline the strengths of the nonhuman primate model for studies leading to improved therapies for women. ..
  3. ncbi request reprint Role of progesterone in the structural and biochemical remodeling of the primate endometrium
    O D Slayden
    Oregon National Primate Research Center, Division of Reproductive Sciences, Beaverton 97006 3448, USA
    Ernst Schering Res Found Workshop . 2005
  4. pmc Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)
    Kristof Chwalisz
    TAP Pharmaceutical Products Inc, Lake Forest, Illinois, USA
    Reprod Biol Endocrinol 4:S8. 2006
    ..These studies provided the first evidence of uterus-selective effects of asoprisnil and structurally related compounds, and the rationale for clinical development of asoprisnil...
  5. pmc A critical period of progesterone withdrawal precedes menstruation in macaques
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Reprod Biol Endocrinol 4:S6. 2006
    ..We concluded that upregulation of MMPs is essential to menses induction, but that after the critical period, menses will occur even if some MMPs are experimentally blocked...
  6. ncbi request reprint Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:393-409. 2004
    ..This endometrial antiproliferative effect is the basis of the clinical use of PA to control various diseases such as endometriosis...
  7. ncbi request reprint Chronic progesterone antagonist-estradiol therapy suppresses breakthrough bleeding and endometrial proliferation in a menopausal macaque model
    O D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA
    Hum Reprod 21:3081-90. 2006
    ....
  8. ncbi request reprint Estrogen enhances cystatin C expression in the macaque vagina
    Ov D Slayden
    Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 89:883-91. 2004
    ..Elevated cystatin C, by suppressing cysteine proteinase activity, may strengthen the vaginal wall and mitigate the potential for pelvic floor prolapse...
  9. ncbi request reprint Role of progesterone in nonhuman primate implantation
    Ov Daniel Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 25:418-30. 2007
    ..We propose that nonhuman primates, especially macaques, can provide a valuable animal model for experimentally testing the functional role of P-regulated genes on endometrial receptivity...
  10. ncbi request reprint Assessment of menstruation in the vervet (Cercopithecus aethiops)
    Rebecca L Carroll
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Am J Primatol 69:901-16. 2007
    ..Because strong similarities exist between the endometrium of vervets, macaques and women, we conclude that vervets can provide a useful animal model for studies on hormone regulation of menstruation...
  11. ncbi request reprint Flutamide counteracts the antiproliferative effects of antiprogestins in the primate endometrium
    Ov D Slayden
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 88:946-9. 2003
    ..1 +/- 3.8 (P < 0.05). FLU also blocked the hyalinizing degradation of the spiral arteries typically induced by APs. These results indicate that many of the antiendometrial effects of APs in primates may involve the AR...
  12. pmc Intrauterine administration of CDB-2914 (Ulipristal) suppresses the endometrium of rhesus macaques
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, OHSU, Beaverton, OR 97006, USA
    Contraception 81:336-42. 2010
    ..To test its effects when delivered by an intrauterine system (IUS), we prepared control and UPA-filled IUS and evaluated their effects in rhesus macaques...
  13. ncbi request reprint Steroid receptors in blood vessels of the rhesus macaque endometrium: a review
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Arch Histol Cytol 67:411-6. 2004
    ..We concluded that any direct effects of E on endometrial vessels would be mediated by ERbeta, and that the actions of P and A, and possibly some of E, were indirectly mediated through perivascular stromal cells...
  14. ncbi request reprint Progesterone receptor antagonists and the endometrial antiproliferative effect
    Robert M Brenner
    Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    Semin Reprod Med 23:74-81. 2005
    ..Various PR modulators have great promise as gynecological therapeutics, but additional research is needed to improve our understanding of their endometrial effects...
  15. ncbi request reprint A role for the androgen receptor in the endometrial antiproliferative effects of progesterone antagonists
    Robert M Brenner
    Oregon National Primate Research Center, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Steroids 68:1033-9. 2003
    ..These data implicate the AR as a functional component of the mechanism through which progesterone antagonists induce endometrial antiproliferative effects in the presence of estrogens...
  16. ncbi request reprint Immunocytochemical assessment of mitotic activity with an antibody to phosphorylated histone H3 in the macaque and human endometrium
    Robert M Brenner
    Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton 97006, USA
    Hum Reprod 18:1185-93. 2003
    ..We assessed the value of two mitotic markers as immunocytochemical reagents for measuring mitotic rates in endometrium...
  17. ncbi request reprint Anti-proliferative effects of progesterone antagonists in the primate endometrium: a potential role for the androgen receptor
    Robert M Brenner
    Oregon National Primate Research Center, Beaverton 97006, USA
    Reproduction 124:167-72. 2002
    ..This brief review evaluates the implications of these findings...
  18. ncbi request reprint Premenstrual and menstrual changes in the macaque and human endometrium: relevance to endometriosis
    Robert M Brenner
    Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton 97006, USA
    Ann N Y Acad Sci 955:60-74; discussion 86-8, 396-406. 2002
    ..Additional research on these and other factors in premenstrual and menstrual endometrium may deepen our understanding of both the establishment and progression of this debilitating disease...
  19. ncbi request reprint Estrogen increases collagen I and III mRNA expression in the pelvic support tissues of the rhesus macaque
    Amanda L Clark
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, USA
    Am J Obstet Gynecol 192:1523-9. 2005
    ..Our aim was to study the effect of estradiol and raloxifene on collagen synthesis, by measuring the expression collagen I and III mRNA...
  20. ncbi request reprint Human endometriotic xenografts in immunodeficient RAG-2/gamma(c)KO mice
    Laura H Greenberg
    Department of Obstetrics and Gynecology, Providence St Vincent Hospital, Portland, OR, USA
    Am J Obstet Gynecol 190:1788-95; discussion 1795-6. 2004
    ..The purpose of this study was to create a novel animal model for studies of endometriosis...
  21. pmc Androgen effects on adipose tissue architecture and function in nonhuman primates
    Oleg Varlamov
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 153:3100-10. 2012
    ....

Research Grants1

  1. Suppression of Breakthrough Bleeding in LNG-IUS Users
    Ov Slayden; Fiscal Year: 2006
    ..The proposal brings basic scientists and clinicians together for a "bench to bedside" approach that will advance women's health and improve contraceptive technology. ..