Kate Petersen Shay

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biogerontology 10:443-56. 2009
  2. ncbi (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria
    Jeffrey S Monette
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Pharmacol Res 63:23-9. 2011
  3. ncbi Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP)
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Curr Protoc Toxicol . 2010
  4. ncbi Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Biochim Biophys Acta 1823:1102-9. 2012
  5. ncbi Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochim Biophys Acta 1790:1149-60. 2009

Detail Information

Publications5

  1. ncbi Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biogerontology 10:443-56. 2009
    ..Furthermore, two phosphatases that antagonize Akt, PTEN and PP2A, were both partially inhibited by LA. Thus, LA may be a nutritive agent that can remediate loss of function in the Akt pathway and aid in the survival of liver cells...
  2. ncbi (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria
    Jeffrey S Monette
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Pharmacol Res 63:23-9. 2011
    ..In summary, LA treatment lowers ceramide levels to that seen in young rat heart mitochondria and restores Complex IV activity which otherwise declines with age...
  3. ncbi Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP)
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Curr Protoc Toxicol . 2010
    ..The simplest way to do this is to employ a chromatin immunoprecipitation (ChIP) assay along with an examination of cellular Nrf2 levels by immunoblotting...
  4. ncbi Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Biochim Biophys Acta 1823:1102-9. 2012
    ..Thus, translational control of Nrf2 synthesis, rather than reliance solely on pre-existing protein, may mediate the rapid burst of Nrf2 nuclear accumulation following stress stimuli...
  5. ncbi Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential
    Kate Petersen Shay
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochim Biophys Acta 1790:1149-60. 2009
    ..Current trials are investigating whether these beneficial properties of LA make it an appropriate treatment not just for diabetes, but also for the prevention of vascular disease, hypertension, and inflammation...