H S Sekhon

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys
    Becky J Proskocil
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avene, Beaverton, OR 97006, USA
    Am J Respir Crit Care Med 171:1032-9. 2005
  2. ncbi request reprint Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys
    H S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Am J Respir Crit Care Med 164:989-94. 2001
  3. ncbi request reprint Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors
    Harmanjatinder S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Am J Respir Cell Mol Biol 26:31-41. 2002
  4. ncbi request reprint Identification of cytomegalovirus in a liquid-based gynecologic sample using morphology, immunohistochemistry, and DNA real-time PCR detection
    Harmanjatinder S Sekhon
    Division of Cytopathology and Division of Molecular Diagnostics, Department of Pathology, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    Diagn Cytopathol 30:411-7. 2004
  5. ncbi request reprint Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels
    H S Sekhon
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Eur Respir J 23:906-15. 2004
  6. ncbi request reprint Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque
    K L Grove
    Division of Neuroscience, Oregon Regional Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 86:5420-6. 2001
  7. pmc Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys
    H S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Invest 103:637-47. 1999
  8. ncbi request reprint Synthesis of acetylcholine by lung cancer
    P Song
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Life Sci 72:2159-68. 2003
  9. ncbi request reprint Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure
    Harmanjatinder S Sekhon
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 97006, USA
    Cell Tissue Res 320:287-97. 2005
  10. ncbi request reprint Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:129-44. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys
    Becky J Proskocil
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avene, Beaverton, OR 97006, USA
    Am J Respir Crit Care Med 171:1032-9. 2005
    ..These findings suggest that vitamin C supplementation may potentially be clinically useful to limit the deleterious effects of maternal smoking during pregnancy on offspring's lung function...
  2. ncbi request reprint Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys
    H S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Am J Respir Crit Care Med 164:989-94. 2001
    ..This suggests that the interaction of nicotine with nAChR in developing lung is responsible for the altered pulmonary mechanics observed in human infants whose mothers smoked during pregnancy...
  3. ncbi request reprint Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors
    Harmanjatinder S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    Am J Respir Cell Mol Biol 26:31-41. 2002
    ....
  4. ncbi request reprint Identification of cytomegalovirus in a liquid-based gynecologic sample using morphology, immunohistochemistry, and DNA real-time PCR detection
    Harmanjatinder S Sekhon
    Division of Cytopathology and Division of Molecular Diagnostics, Department of Pathology, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    Diagn Cytopathol 30:411-7. 2004
    ..These observations suggest that a liquid-based preparation can be used to assess CMV infection morphologically, immunohistochemically, and by real-time PCR...
  5. ncbi request reprint Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels
    H S Sekhon
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Eur Respir J 23:906-15. 2004
    ....
  6. ncbi request reprint Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque
    K L Grove
    Division of Neuroscience, Oregon Regional Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Clin Endocrinol Metab 86:5420-6. 2001
    ..These data suggest that nicotine exposure during pregnancy may increase energy expenditure in the developing fetus through actions on hypothalamic systems, resulting in lower birth weights and body fat levels...
  7. pmc Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys
    H S Sekhon
    Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, Oregon 97006, USA
    J Clin Invest 103:637-47. 1999
    ....
  8. ncbi request reprint Synthesis of acetylcholine by lung cancer
    P Song
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA
    Life Sci 72:2159-68. 2003
    ....
  9. ncbi request reprint Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure
    Harmanjatinder S Sekhon
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 97006, USA
    Cell Tissue Res 320:287-97. 2005
    ..Thus, lynx1 is co-expressed with nAChR in the lung. Alteration of lynx1 levels is a potential new mechanism by which nicotine affects lung development...
  10. ncbi request reprint Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:129-44. 2005
    ....
  11. ncbi request reprint Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells
    Becky J Proskocil
    Division of Neuroscience, Oregon National Primate Research Center, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 145:2498-506. 2004
    ..This pathway may also explain some of the effects of nicotine on fetal development and also provides additional mechanisms by which smoking affects lung cancer growth and development...
  12. pmc Activated cholinergic signaling provides a target in squamous cell lung carcinoma
    Pingfang Song
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon, USA
    Cancer Res 68:4693-700. 2008
    ..Thus, cholinergic signaling is broadly up-regulated in SCC and blocking cholinergic signaling can limit basal and nicotine-stimulated growth of SCC...
  13. ncbi request reprint Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma
    Pingfang Song
    Department of Pathology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Cancer Res 63:214-21. 2003
    ..These findings demonstrate that SCLC can synthesize, secrete, and degrade ACh and that released ACh stimulates SCLC cell growth. Identification of this new autocrine loop provides a potential new target for therapeutic intervention...