Genomes and Genes
Robynn V Schillace
Affiliation: Oregon Health and Science University
- Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulationR V Schillace
Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
J Biol Chem 276:12128-34. 2001..These experiments indicate that regulation of PP1 activity by AKAP220 involves a complex network of intra- and intermolecular interactions...
- The role of protein kinase A and A-kinase anchoring proteins in modulating T-cell activation: progress and future directionsRobynn V Schillace
Veterans Affairs Medical Center, Department of Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Crit Rev Immunol 26:113-31. 2006....
- A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell linesAngela L Asirvatham
Veterans Affairs Medical Center, Oregon Health and Sciences University, Portland 97239, USA
J Immunol 173:4806-14. 2004..In summary, these data suggest that AKAPs interact with both PKA and PDE in T lymphocytes and thus are a key component of the signaling complex regulating T cell activation...
- The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune systemRobynn V Schillace
Veterans Affairs Medical Center, Department of Endocrinology, Oregon Health and Science University, Portland, 97239, USA
J Immunol 174:6847-53. 2005....
- Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanismsSonemany Salinthone
Portland Veterans Affairs Medical Center, Portland, OR 97239, USA Department of Neurology, Oregon Health and Sciences University, Portland, OR 97239, USA
J Nutr Biochem 22:681-90. 2011..These novel findings provide information to better understand the mechanisms of action of LA, which can help facilitate the use of LA as a therapeutic for various diseases...
- Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated mannerSarah E Fiedler
VA Medical Center and Department of Endocrinology, Oregon Health and Sciences University, Portland, OR 97239, USA
FEBS Lett 584:873-7. 2010..Collectively, these data suggest a possible mechanism for the targeting and integration of adenosine 3',5'-cyclic monophosphate (cAMP) and semaphorin signaling in immune cells...
- A-kinase anchoring in dendritic cells is required for antigen presentationRobynn V Schillace
Portland Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 4:e4807. 2009..In other cells, the ability of these molecules to convey their signals has been shown to be dependent on A-kinase anchoring proteins (AKAPs). Here we present evidence for the existence and functional importance of AKAPs in human DC...
- AKAPs in lipid rafts are required for optimal antigen presentation by dendritic cellsRobynn V Schillace
Portland Veterans Affairs Medical Center, Portland, OR 97239, USA
Immunol Cell Biol 89:650-8. 2011....
- Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytesRobynn V Schillace
Veterans Affairs Medical Center and Department of Medicine, Oregon Health and Sciences University, Portland, OR 97201, USA
J Immunol 168:1590-9. 2002..These experiments represent the first report of AKAPs in T cells and suggest that MTG16b is a novel AKAP that targets PKA to the Golgi of T lymphocytes...
- Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cellsSonemany Salinthone
Portland Veterans Affairs Medical Center and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
J Neuroimmunol 199:46-55. 2008..In addition, LA suppressed interleukin (IL)-12/IL-18 induced IFNgamma secretion and cytotoxicity in NK cells. These novel findings suggest that LA may inhibit NK cell function via the cAMP signaling pathway...