R L Sack

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint Host melatonin secretion is a timing signal for the release of W. bancrofti microfilaria into the circulation
    Robert L Sack
    Psychiatry, Oregon Health and Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Med Hypotheses 73:147-9. 2009
  2. doi request reprint The pathophysiology of jet lag
    Robert L Sack
    Sleep Disorders Medicine Program, Department of Psychiatry, Oregon Health and Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Travel Med Infect Dis 7:102-10. 2009
  3. ncbi request reprint Entrainment of free-running circadian rhythms by melatonin in blind people
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    N Engl J Med 343:1070-7. 2000
  4. ncbi request reprint Use of melatonin for sleep and circadian rhythm disorders
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Ann Med 30:115-21. 1998
  5. ncbi request reprint Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Brain Res 918:96-100. 2001
  6. ncbi request reprint The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement
    R J Hughes
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, USA
    Sleep 21:52-68. 1998
  7. ncbi request reprint Melatonin treatment of winter depression: a pilot study
    A J Lewy
    Department of Psychiatry, Oregon Health Sciences University, Portland 97201 3098, USA
    Psychiatry Res 77:57-61. 1998
  8. ncbi request reprint Effects of aging on the intrinsic circadian period of totally blind humans
    A R Kendall
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Biol Rhythms 16:87-95. 2001
  9. ncbi request reprint Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms?
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, USA
    Sleep 20:908-15. 1997
  10. ncbi request reprint Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment
    A J McArthur
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Sleep 19:544-53. 1996

Collaborators

Detail Information

Publications19

  1. doi request reprint Host melatonin secretion is a timing signal for the release of W. bancrofti microfilaria into the circulation
    Robert L Sack
    Psychiatry, Oregon Health and Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Med Hypotheses 73:147-9. 2009
    ..It follows that exogenous melatonin administration during the day would also trigger release of microfilaria in the blood and could be used as a provocative diagnostic test for filariasis...
  2. doi request reprint The pathophysiology of jet lag
    Robert L Sack
    Sleep Disorders Medicine Program, Department of Psychiatry, Oregon Health and Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Travel Med Infect Dis 7:102-10. 2009
    ..Clinical field trials that have tested the application of circadian rhythm based interventions are then reviewed...
  3. ncbi request reprint Entrainment of free-running circadian rhythms by melatonin in blind people
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    N Engl J Med 343:1070-7. 2000
    ..We investigated whether a daily dose of melatonin could entrain their circadian rhythms to a normal 24-hour cycle...
  4. ncbi request reprint Use of melatonin for sleep and circadian rhythm disorders
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Ann Med 30:115-21. 1998
    ..Melatonin has not been proven safe by the usual clinical trial criteria, but to date no catastrophes have been related to its use. Also, there is little information about the safety and efficacy of chronic administration...
  5. ncbi request reprint Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Brain Res 918:96-100. 2001
    ..5 mg initially capture free-running rhythms? Following withdrawal of the stepped-down 0.5 mg dose and consequent release into a free-run, the same three individuals were given 0.5 mg of melatonin de novo. All entrained within a few weeks...
  6. ncbi request reprint The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement
    R J Hughes
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, USA
    Sleep 21:52-68. 1998
    ..Total sleep time and sleep efficiency were correlated with the timing of the endogenous melatonin rhythm, and particularly with the phase-relationship between habitual bedtime and the phase of the circadian timing system...
  7. ncbi request reprint Melatonin treatment of winter depression: a pilot study
    A J Lewy
    Department of Psychiatry, Oregon Health Sciences University, Portland 97201 3098, USA
    Psychiatry Res 77:57-61. 1998
    ..If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported...
  8. ncbi request reprint Effects of aging on the intrinsic circadian period of totally blind humans
    A R Kendall
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    J Biol Rhythms 16:87-95. 2001
    ..The results do not support the commonly held view that tau shortens during human aging. On the contrary, tau appears to slightly, but significantly, lengthen during at least 1 decade in midlife...
  9. ncbi request reprint Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms?
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, USA
    Sleep 20:908-15. 1997
    ....
  10. ncbi request reprint Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment
    A J McArthur
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Sleep 19:544-53. 1996
    ..1 hours, albeit at a somewhat delayed phase. A 14-month follow-up interview revealed that the patient continued to take melatonin daily, and his sleep-wake schedule was stable to a near 24-hour schedule...
  11. ncbi request reprint A comparison of sleep detection by wrist actigraphy, behavioral response, and polysomnography
    M L Blood
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Sleep 20:388-95. 1997
    ..It is concluded that BRM has some important advantages as a simple, minimally invasive method for monitoring sleep...
  12. ncbi request reprint Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person
    H Nakagawa
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201
    Sleep 15:330-6. 1992
    ....
  13. ncbi request reprint Melatonin rhythms in night shift workers
    R L Sack
    Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland 97201
    Sleep 15:434-41. 1992
    ..Thus, the sleep times selected by night shift workers may not be well-synchronized to their melatonin rhythm, assumed to mark the phase of their underlying circadian pacemaker...
  14. ncbi request reprint Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Neurosci Lett 313:158-60. 2001
    ..Comp. Physiol., 106 (1976) 291-331]...
  15. ncbi request reprint Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period
    Alfred J Lewy
    Department of Psychiatry, Oregon Health and Science University, Portland, USA
    Chronobiol Int 19:649-58. 2002
    ..We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve...
  16. ncbi request reprint Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
    Chronobiol Int 20:837-52. 2003
    ....
  17. ncbi request reprint Relative coordination to unknown "weak zeitgebers" in free-running blind individuals
    Jonathan S Emens
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland 97239, USA
    J Biol Rhythms 20:159-67. 2005
    ..Sighted individuals may also be affected by such weak zeitgebers, which may be obscured by the stronger light/dark cycle...
  18. pmc Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review
    Robert L Sack
    Department of Psychiatry, Oregon Health Sciences University, Portland, OR, USA
    Sleep 30:1484-501. 2007
    ..We herein report on the accumulated evidence regarding the evaluation and treatment of Advamced Sleep Phase Disorder (ASPD), Delayed Sleep Phase Disorder (DSPD), Free-Running Disorder (FRD) and Irregular Sleep-Wake Rhythm ISWR)...
  19. ncbi request reprint Assessment and management of insomnia
    Carlos H Schenck
    Department of Psychiatry, Minnesota Regional Sleep Disorders Center, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis 55415, USA
    JAMA 289:2475-9. 2003