Research Topics
Species | Andrey RyabininSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behaviorAndrey E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Alcohol 46:349-57. 2012..Because of complex distribution of Ucns in the nervous system, advances in this field will critically depend on development of new tools allowing site-specific analyses of the roles of Ucns and CRF...- Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumptionA E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Neuroscience 151:780-90. 2008..Taken together, these studies confirm the importance of lateral septum innervation by Ucn1 in the regulation of alcohol consumption... 
The urocortin 1 neurocircuit: ethanol-sensitivity and potential involvement in alcohol consumptionAndrey E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, 97239, USA
Brain Res Rev 52:368-80. 2006..This paper reviews the current knowledge of the Ucn1 neurocircuit and the evidence for its involvement in alcohol-related behaviors, and proposes a mechanism for its involvement in the regulation of alcohol consumption...- Selective effects of alcohol drinking on restraint-induced expression of immediate early genes in mouse brainA E Ryabinin
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
Alcohol Clin Exp Res 23:1272-80. 1999..In this study, immunohistochemical expression analysis of immediate early genes c-fos, fosB, and zif268 was performed in brain of C57BL/6J mice after voluntary alcohol consumption... - Urocortin 1-containing neurons in the human Edinger-Westphal nucleusA E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
Neuroscience 134:1317-23. 2005.... - High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleusAndrey E Ryabinin
Department of Behavioral Neuroscience, L470, Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Psychopharmacology (Berl) 165:296-305. 2003..Previous studies mapping changes in brain activity used rodent models of alcohol drinking with relatively low alcohol intakes... - The corticotropin-releasing factor/urocortin system and alcoholAndrey E Ryabinin
Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland 97201 3098, USA
Alcohol Clin Exp Res 26:714-22. 2002..Mehmert, R. Camarini, Joseph A. Kim, Heather N. Koenig, Michelle A. Nannini, and Clyde W. Hodge; and (5) Selective sensitivity of urocortin-containing neurons to alcohol self-administration, by Andrey E. Ryabinin and Ryan K. Bachtell... - Cocaine- and alcohol-mediated expression of inducible transcription factors is blocked by pentobarbital anesthesiaA E Ryabinin
Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Brain Res 877:251-61. 2000..Our data suggest that in the absence of conscious awareness of drug-associated cues, cocaine and alcohol activate only a fraction of the neural elements engaged in the unanesthetized state... - ITF expression in mouse brain during acquisition of alcohol self-administrationA E Ryabinin
Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Brain Res 890:192-5. 2001..Stronger expression of c-Fos in EW was found in animals repeatedly consuming ethanol-containing solutions. These findings underscore the potential importance of EW in alcohol-related behaviors... - ITF mapping after drugs of abuse: pharmacological versus perceptional effectsA E Ryabinin
Department of Behavioral Neuroscience, Oregon Health Sciences University L470, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
Acta Neurobiol Exp (Wars) 60:547-55. 2000..Given the low resolution of invasive techniques, ITF mapping experiments will continually contribute to our understanding of mechanisms of drug addiction and alcoholism... - Alcohol drinking produces brain region-selective changes in expression of inducible transcription factorsR K Bachtell
Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Brain Res 847:157-65. 1999..Second, they suggest a relationship between ITF expression in AcbC, CeMPV and EW and the level of alcohol intoxication... - Effects of acute alcohol administration on object recognition learning in C57BL/6J miceAndrey E Ryabinin
Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Pharmacol Biochem Behav 71:307-12. 2002..Our results show that in C57BL/6J mice, ethanol intoxication interferes with exploratory activity during object exploration, but not with consolidation of memory... - The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumptionRyan K Bachtell
Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, Oregon 97239, USA
J Neurosci 23:2477-87. 2003..Taken together, these studies provide substantial evidence for involvement of the EW-LS Ucn pathway in alcohol consumption... - Lesions of the Edinger-Westphal nucleus in C57BL/6J mice disrupt ethanol-induced hypothermia and ethanol consumptionRyan K Bachtell
Department of Behavioural Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
Eur J Neurosci 20:1613-23. 2004..Taken together, the findings suggest that the EW may function as a sensor for ethanol, which can influence ethanol consumption and preference... - FOS expression induced by an ethanol-paired conditioned stimulusKatherine G Hill
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, United States
Pharmacol Biochem Behav 87:208-21. 2007..Overall, these data suggest an important role for the mesolimbic dopamine pathway, extended amygdala and hippocampus in ethanol-induced conditioning... - Brain region-specific regulation of urocortin 1 innervation and corticotropin-releasing factor receptor type 2 binding by ethanol exposureAdam Z Weitemier
Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, Oregon 97239, USA
Alcohol Clin Exp Res 29:1610-20. 2005..We investigated whether repeated ethanol exposure affects Ucn1 and Ucn1-responsive corticotropin-releasing factor type-2 receptors (CRF2)... - Expression of c-Fos in the mouse Edinger-Westphal nucleus following ethanol administration is not secondary to hypothermia or stressVictoria F Turek
Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland, OR 97239, USA
Brain Res 1063:132-9. 2005..These data demonstrate that activation of EW after EtOH is unrelated to hypothermia or stress... - Patterns of brain activation associated with contextual conditioning to methamphetamine in miceJustin S Rhodes
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, USA
Behav Neurosci 119:759-71. 2005..A batch effect among immunohistochemical assays was demonstrated. Results implicate specific brain regions in classical conditioning to meth and demonstrate the importance of considering locomotor activity and batch in a c-Fos study... - Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysisAdam Z Weitemier
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Brain Res 995:55-65. 2004..The present study confirms differential activation of hippocampal subregions in Delay and Trace fear conditioning... - Alcohol-induced memory impairment in trace fear conditioning: a hippocampus-specific effectAdam Z Weitemier
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
Hippocampus 13:305-15. 2003.... - Biological contribution to social influences on alcohol drinking: evidence from animal modelsAllison M J Anacker
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Pk Rd L470, Portland, OR 97239, USA
Int J Environ Res Public Health 7:473-93. 2010..These findings strongly suggest that mechanisms by which social factors influence drinking have biological roots, and can be studied using rapidly developing new animal models... - Ataxia and c-Fos expression in mice drinking ethanol in a limited access sessionAmanda L Sharpe
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Alcohol Clin Exp Res 29:1419-26. 2005..Thus, the goal of this study was to demonstrate ataxia and to examine changes in c-Fos expression in mice after self-administration of intoxicating doses of ethanol... - Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanismRaul Pastor
Departments of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 105:9070-5. 2008..A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH... - Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanismsRyan K Bachtell
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
J Pharmacol Exp Ther 302:516-24. 2002.... - Identification of temperature-sensitive neural circuits in mice using c-Fos expression mappingRyan K Bachtell
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Brain Res 960:157-64. 2003.... - Lesions of the Edinger-Westphal nucleus alter food and water consumptionAdam Z Weitemier
Department of Behavioral Neuroscience, Oregon Health and Science University, USA
Behav Neurosci 119:1235-43. 2005..EW lesion had no effect on indices of basal metabolic activity, including plasma glucose level and body temperature. These effects suggest that the peptidergic neurons of the EW regulate food consumption... - Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J miceAnita Cservenka
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Brain Res 1319:33-43. 2010..The lack of brain Ucn 1 immunoreactivity at birth and the gradual postnatal increase in Ucn 1 in pIIIu suggests that this peptide plays a greater behavioral role in adulthood than during the early postnatal development of an organism... - Differences in the urocortin 1 system between long-sleep and short-sleep miceVictoria F Turek
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 92121, USA
Genes Brain Behav 7:113-9. 2008..In addition, these results lend further support to previous findings implicating Ucn1-containing projections from npEW to the dorsal raphe in ethanol-induced hypothermia... - Post-retrieval disruption of a cocaine conditioned place preference by systemic and intrabasolateral amygdala beta2- and alpha1-adrenergic antagonistsRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Learn Mem 16:777-89. 2009..These systemic and site-specific injections, as well as the FOS immunohistochemical analyses, implicate the importance of specific noradrenergic signaling mechanisms within the BLA in post-retrieval plasticity... - Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring ratsIrina Fonareva
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
Alcohol Clin Exp Res 33:1956-65. 2009..Furthermore, the effects of gender on the relationship between Ucn 1 and tyrosine hydroxylase (TH) in pIII and alcohol preference in rats have not been previously assessed... - Comparison of the distributions of urocortin-containing and cholinergic neurons in the perioculomotor midbrain of the cat and macaquePaul J May
Department of Anatomy, University of Mississippi Medical Center, Jackson, Mississippi 39202, USA
J Comp Neurol 507:1300-16. 2008..This will allow more effective scientific discourse on the connections and function of groups such as the periculomotor urocortin (pIII(U)) and preganglionic (pIII(PG)) populations... - CRF receptors in the nucleus accumbens modulate partner preference in prairie volesMiranda M Lim
Center for Behavioral Neuroscience and Department of Psychiatry and Behavioral Sciences, 954 Gatewood Road NE, Emory University, Atlanta, GA 30322, USA
Horm Behav 51:508-15. 2007..This supports the hypothesis that local CRF release into NAcc could activate CRF(1) or CRF(2) receptors in the region. Taken together, our results reveal a novel role for accumbal CRF systems in social behavior... - New neuronal networks involved in ethanol reinforcementKalervo Kiianmaa
Department of Mental Helath and Alcohol Research, National Public Health Institute, Helsinki, Finland
Alcohol Clin Exp Res 27:209-19. 2003..Finn, and (6) Potential contribution of the urocortin system to regulation of alcohol self-administration, by Andrey E. Ryabinin and Ryan K. Bachtell.(B).. - Distribution of corticotropin-releasing factor and urocortin 1 in the vole brainMiranda M Lim
Center for Behavioral Neuroscience, Emory University School of Medicine, Atlanta, GA, USA
Brain Behav Evol 68:229-40. 2006..Our findings generate novel hypotheses regarding the evolutionary mechanisms underlying the neural circuitry of species-typical social behaviors... - Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptorsIgor Ponomarev
Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
J Neurosci 26:5673-83. 2006....
Research Grants
- Perioculomotor area and alcoholAndrey Ryabinin; Fiscal Year: 2009..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
- Excessive drinking and urocortin 1 neurocircuitAndrey Ryabinin; Fiscal Year: 2007....
- Alcohol drinking in affiliative rodentsAndrey Ryabinin; Fiscal Year: 2007....
- Urocortin, Edinger-Westphal nucleus & EtOH consumptionAndrey Ryabinin; Fiscal Year: 2007..The long-term goal of these studies is to understand the mechanisms regulating alcohol consumption. Such knowledge is important for development of pharmacotherapy of alcoholism ..
- NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIAAndrey Ryabinin; Fiscal Year: 2001..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
- Perioculomotor area and alcoholAndrey E Ryabinin; Fiscal Year: 2010..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..