HOLLY LALLMAN ROSENZWEIG

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Investigation of the peptidoglycan sensing molecule, PGLYRP-2, in murine inflammatory uveitis
    Jenna S Clowers
    VA Medical Center, Portland, Oregon 97239, USA
    Br J Ophthalmol 97:504-10. 2013
  2. pmc Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis
    Jelena M Kezic
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arthritis Res Ther 14:R18. 2012
  3. pmc Impact of IL-1 signalling on experimental uveitis and arthritis
    Stephen R Planck
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Ann Rheum Dis 71:753-60. 2012
  4. pmc Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis
    Jelena M Kezic
    Oregon Health and Science University, Portland, OR 97239, USA
    Arthritis Rheum 64:762-71. 2012
  5. pmc The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Inflamm Res 61:225-31. 2012
  6. pmc BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance
    Balint Farkas
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, 1735 W, Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
    Arthritis Res Ther 11:R21. 2009
  7. doi request reprint Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ophthalmic Res 40:189-92. 2008
  8. pmc NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 49:1518-24. 2008
  9. pmc Investigation of the differential potentials of TLR agonists to elicit uveitis in mice
    Jordan J Allensworth
    Casey Eye Institute, Portland, Oregon, USA
    J Leukoc Biol 90:1159-66. 2011
  10. pmc NLRs in immune privileged sites
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Curr Opin Pharmacol 11:423-8. 2011

Research Grants

  1. NOD2 and Uveitis
    HOLLY LALLMAN ROSENZWEIG; Fiscal Year: 2010
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2007
  3. NOD2 and Uveitis
    Holly Rosenzweig; Fiscal Year: 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Investigation of the peptidoglycan sensing molecule, PGLYRP-2, in murine inflammatory uveitis
    Jenna S Clowers
    VA Medical Center, Portland, Oregon 97239, USA
    Br J Ophthalmol 97:504-10. 2013
    ....
  2. pmc Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis
    Jelena M Kezic
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arthritis Res Ther 14:R18. 2012
    ....
  3. pmc Impact of IL-1 signalling on experimental uveitis and arthritis
    Stephen R Planck
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Ann Rheum Dis 71:753-60. 2012
    ....
  4. pmc Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis
    Jelena M Kezic
    Oregon Health and Science University, Portland, OR 97239, USA
    Arthritis Rheum 64:762-71. 2012
    ..The aim of this study was to elucidate the characteristics of uveitis and test the impact of interferon-γ (IFNγ) deficiency on the eye versus the joint and spine...
  5. pmc The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Inflamm Res 61:225-31. 2012
    ....
  6. pmc BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance
    Balint Farkas
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush University Medical Center, 1735 W, Harrison Street, Cohn Research Building, Chicago, IL 60612, USA
    Arthritis Res Ther 11:R21. 2009
    ....
  7. doi request reprint Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ophthalmic Res 40:189-92. 2008
    ....
  8. pmc NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 49:1518-24. 2008
    ..As a first step toward understanding the role of NOD2 in the pathogenesis of uveitis, the authors developed a mouse model of MDP-dependent uveitis...
  9. pmc Investigation of the differential potentials of TLR agonists to elicit uveitis in mice
    Jordan J Allensworth
    Casey Eye Institute, Portland, Oregon, USA
    J Leukoc Biol 90:1159-66. 2011
    ..Our data demonstrate the eye's responsiveness to a diverse array of microbial products, which activates TLRs, and reveal differences in relative cellular response among the various TLR agonists in vivo...
  10. pmc NLRs in immune privileged sites
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Curr Opin Pharmacol 11:423-8. 2011
    ..Many NLRs are expressed within the brain and eye and in this review, we discuss their roles in the inflammation of the central nervous system (CNS) and uveitis...
  11. pmc Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice
    Holly L Rosenzweig
    Oregon Health and Science University, Mail stop L467 AD, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Inflamm Res 60:705-14. 2011
    ..Activation of pattern recognition receptors (PRR) may contribute to arthritis. Here, we elucidated the role of NOD2, a genetic cause of inflammatory arthritis, and several other PRR in a murine model of inflammatory arthritis...
  12. pmc NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 52:4106-12. 2011
    ..Whether NOD2 exerts a similar capacity in the regulation of ocular inflammation to PGN has not been explored...
  13. pmc Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan
    Holly L Rosenzweig
    Oregon Health and Science University, Portland, OR 97239, USA
    Arthritis Rheum 62:1051-9. 2010
    ..This study was undertaken to investigate NOD-2 function in an experimental model of arthritis and to explore the potential interplay between Toll-like receptor 2 (TLR-2) and NOD-2 in joint inflammation...
  14. pmc Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97219, USA
    J Leukoc Biol 85:711-8. 2009
    ..However, the absence of NOD2 does not alter the course of inflammatory arthritis, in contrast to models of intestinal inflammation...
  15. pmc Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1739-45. 2009
    ....
  16. pmc NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1746-53. 2009
    ..Nonetheless, the role of NOD1 in intraocular inflammation has not been explored. The induction of uveitis by iE-DAP in mice and the potential contribution of interleukin (IL)-1beta were investigated...
  17. pmc Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling
    H L Rosenzweig
    Department of Ophthalmology, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Mail Stop L467 IM, Portland, OR 97239, USA
    J Leukoc Biol 84:529-36. 2008
    ..This report reveals a new in vivo function of NOD2 within the eye yet importantly, distinguishes NOD2-dependent from NALP3-dependent inflammation, as ocular inflammation in mice occurred independently of IL-1beta...
  18. doi request reprint Uveitis secondary to bacterial products
    James T Rosenbaum
    Oregon Health and Science University, Portland, OR 97239, USA
    Ophthalmic Res 40:165-8. 2008
    ..Since a mutation in a gene that codes for a protein which senses a bacterial product consistently results in uveitis, it is critical to understand more fully the mechanisms by which bacterial products cause uveitis in laboratory animals...
  19. ncbi request reprint Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice
    Holly L Rosenzweig
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Stroke 35:2576-81. 2004
    ..We postulated that LPS preconditioning modulates the cellular inflammatory response after cerebral ischemia, resulting in neuroprotection...
  20. ncbi request reprint Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states
    Mary P Stenzel-Poore
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Lancet 362:1028-37. 2003
    ..We developed a mouse model of neuroprotection in stroke and did gene expression profiling to identify potential neuroprotective genes and their associated pathways...
  21. ncbi request reprint Endotoxin preconditioning protects against the cytotoxic effects of TNFalpha after stroke: a novel role for TNFalpha in LPS-ischemic tolerance
    Holly L Rosenzweig
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 27:1663-74. 2007
    ....
  22. ncbi request reprint Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks
    Susan E Murray
    Department of Molecular Microbiology and Immunology, Mail Code L220, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    J Neuroimmunol 156:31-41. 2004
    ....

Research Grants4

  1. NOD2 and Uveitis
    HOLLY LALLMAN ROSENZWEIG; Fiscal Year: 2010
    ..The connection between a single gene and uveitis offers enormous potential to study the pathogenesis of uveitis. ..
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2007
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogenesis of uveitis. ..
  3. NOD2 and Uveitis
    Holly Rosenzweig; Fiscal Year: 2009
    ..The connection between a single gene and uveitis offers enormous potential to study the pathogenesis of uveitis. ..