Genomes and Genes
H L Rosenzweig
Affiliation: Oregon Health and Science University
- Rosenzweig H, Jann M, Vance E, Planck S, Rosenbaum J, Davey M. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum. 2010;62:1051-9 pubmed publisher..Whereas NOD-2 and TLR-2 are both critical for the development of PG-induced arthritis, they appear to elicit inflammation independently of each other. Our findings indicate that NOD-2 plays an inflammatory role in arthritis. ..
- Rosenzweig H, Galster K, Vance E, Ensign Lewis J, Nunez G, Davey M, et al. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Invest Ophthalmol Vis Sci. 2011;52:4106-12 pubmed publisher..NOD2 may serve differential roles in the eye to promote inflammation while also tempering cell responses to PGN akin to what has been reported in colitis. ..
- Rosenzweig H, Clowers J, Nunez G, Rosenbaum J, Davey M. Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Inflamm Res. 2011;60:705-14 pubmed publisher..Together, Dectin-1 and NOD2 are critical, sentinel receptors in the arthritogenic effects of zymosan. Our data identify a novel role for NOD2 during inflammatory responses within joints. ..
- Lee E, Brown B, Vance E, Snow P, Silver P, Heinrichs D, et al. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. J Immunol. 2016;196:3148-58 pubmed publisher..The newly identified role of Mincle and Syk/Card9-coupled signaling axis in autoimmune uveitis could provide novel targets for treatment of patients with ocular inflammatory disease. ..