H L Rosenzweig


Affiliation: Oregon Health and Science University
Country: USA


  1. Napier R, Lee E, Vance E, Snow P, Samson K, Dawson C, et al. Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis. J Immunol. 2018;201:1889-1898 pubmed publisher
    ..Based on our findings, future studies aimed at understanding a negative regulatory function of Nod2 within autoreactive T cells could provide novel therapeutic strategies for treatment of patients with arthritis. ..
  2. Rosenzweig H, Jann M, Glant T, Martin T, Planck S, van Eden W, et al. Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis. J Leukoc Biol. 2009;85:711-8 pubmed publisher
    ..However, the absence of NOD2 does not alter the course of inflammatory arthritis, in contrast to models of intestinal inflammation. ..
  3. Kezic J, Davey M, Glant T, Rosenbaum J, Rosenzweig H. Interferon-? regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis. Arthritis Rheum. 2012;64:762-71 pubmed publisher
    ..Our observations provide a great opportunity for understanding the pathogenesis of a relatively common but poorly understood disease. ..
  4. Rosenzweig H, Planck S, Rosenbaum J. NLRs in immune privileged sites. Curr Opin Pharmacol. 2011;11:423-8 pubmed publisher
    ..Many NLRs are expressed within the brain and eye and in this review, we discuss their roles in the inflammation of the central nervous system (CNS) and uveitis. ..
  5. Lee E, Vance E, Brown B, Snow P, Clowers J, Sakaguchi S, et al. Investigation of the relationship between the onset of arthritis and uveitis in genetically predisposed SKG mice. Arthritis Res Ther. 2015;17:218 pubmed publisher
  6. Rosenzweig H, Martin T, Jann M, Planck S, Davey M, Kobayashi K, et al. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci. 2008;49:1518-24 pubmed publisher
    ..Thus, innate immune responses mediated by NOD2 may participate in the development of uveitis in response to bacterial products. ..
  7. Rosenzweig H, Martin T, Planck S, Galster K, Jann M, Davey M, et al. Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling. J Leukoc Biol. 2008;84:529-36 pubmed publisher
    ..This report reveals a new in vivo function of NOD2 within the eye yet importantly, distinguishes NOD2-dependent from NALP3-dependent inflammation, as ocular inflammation in mice occurred independently of IL-1beta. ..
  8. Rosenzweig H, Galster K, Planck S, Rosenbaum J. NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice. Invest Ophthalmol Vis Sci. 2009;50:1746-53 pubmed publisher
    ..Characterizing the differences between NOD1 and NOD2 responses may provide insight into the pathogenesis of uveitis. ..
  9. Rosenzweig H, Kawaguchi T, Martin T, Planck S, Davey M, Rosenbaum J. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci. 2009;50:1739-45 pubmed publisher
    ..Extrapolation of these findings in mice suggests that the dysregulation of IFN-gamma may occur in patients with Blau syndrome, thereby contributing to the granulomatous nature of the disease. ..

More Information


  1. Rosenzweig H, Jann M, Vance E, Planck S, Rosenbaum J, Davey M. Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan. Arthritis Rheum. 2010;62:1051-9 pubmed publisher
    ..Whereas NOD-2 and TLR-2 are both critical for the development of PG-induced arthritis, they appear to elicit inflammation independently of each other. Our findings indicate that NOD-2 plays an inflammatory role in arthritis. ..
  2. Rosenzweig H, Galster K, Vance E, Ensign Lewis J, Nunez G, Davey M, et al. NOD2 deficiency results in increased susceptibility to peptidoglycan-induced uveitis in mice. Invest Ophthalmol Vis Sci. 2011;52:4106-12 pubmed publisher
    ..NOD2 may serve differential roles in the eye to promote inflammation while also tempering cell responses to PGN akin to what has been reported in colitis. ..
  3. Rosenzweig H, Clowers J, Nunez G, Rosenbaum J, Davey M. Dectin-1 and NOD2 mediate cathepsin activation in zymosan-induced arthritis in mice. Inflamm Res. 2011;60:705-14 pubmed publisher
    ..Together, Dectin-1 and NOD2 are critical, sentinel receptors in the arthritogenic effects of zymosan. Our data identify a novel role for NOD2 during inflammatory responses within joints. ..
  4. Lee E, Brown B, Vance E, Snow P, Silver P, Heinrichs D, et al. Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of Autoimmune Disease of the Eye. J Immunol. 2016;196:3148-58 pubmed publisher
    ..The newly identified role of Mincle and Syk/Card9-coupled signaling axis in autoimmune uveitis could provide novel targets for treatment of patients with ocular inflammatory disease. ..