J T Rosenbaum

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Immunohistology of antigen-presenting cells in vivo: a novel method for serial observation of fluorescently labeled cells
    Matthias D Becker
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 44:2004-9. 2003
  2. ncbi request reprint HLA-B27-associated uveitis: overview and current perspectives
    Eric B Suhler
    Casey Eye Institute, Oregon Health and Science University, and Portland VA Medical Center, Ophthalmology Service, 97239, USA
    Curr Opin Ophthalmol 14:378-83. 2003
  3. ncbi request reprint Antigen-specific accumulation of naïve, memory and effector CD4 T cells during anterior uveitis monitored by intravital microscopy
    Per A Dullforce
    Department of Ophthalmology at Casey Eye Institute, Oregon Health and Science University, Portland, 97239, USA
    Cell Immunol 239:49-60. 2006
  4. doi request reprint A piece of my mind. In defense of phobias
    James T Rosenbaum
    JAMA 299:2368. 2008
  5. ncbi request reprint Does the microbiome play a causal role in spondyloarthritis?
    James T Rosenbaum
    Division of Arthritis and Rheumatic Diseases and Department of Ophthalmology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd L467Ad, Portland, OR, 97239, USA
    Clin Rheumatol 33:763-7. 2014
  6. doi request reprint Innate immune signals in autoimmune and autoinflammatory uveitis
    James T Rosenbaum
    Oregon Health and Science University, Casey Eye Institute, Portland, OR, USA
    Int Rev Immunol 32:68-75. 2013
  7. ncbi request reprint Patients with retinal vasculitis rarely suffer from systemic vasculitis
    James T Rosenbaum
    Department of Ophthalmology, Oregon Health and Science University, Portland, OR 97239, USA
    Semin Arthritis Rheum 41:859-65. 2012
  8. pmc Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis
    Jelena M Kezic
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arthritis Res Ther 14:R18. 2012
  9. doi request reprint Management of comorbidities in ankylosing spondylitis
    James Rosenbaum
    Department of Ophthalmology, Oregon Health and Science University, Portland, 97239, USA
    Am J Med Sci 343:364-6. 2012
  10. pmc Gene expression profiling of whole blood: comparison of target preparation methods for accurate and reproducible microarray analysis
    Kristina Vartanian
    Gene Microarray Shared Resource, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 10:2. 2009

Research Grants

  1. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2007
  2. Endotoxin-induced Uveitis Revisited
    James T Rosenbaum; Fiscal Year: 2010
  3. UVEITIS GENE-EXPRESSOIN PROFILING
    James Rosenbaum; Fiscal Year: 2006
  4. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2006
  5. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2006
  6. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2005
  7. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2005
  8. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2004
  9. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2004
  10. FOUR DIMENTIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2003

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Immunohistology of antigen-presenting cells in vivo: a novel method for serial observation of fluorescently labeled cells
    Matthias D Becker
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 44:2004-9. 2003
    ..This report documents a method to identify and observe these cells over time in a living animal and thereby to visualize them during a dynamic immune response...
  2. ncbi request reprint HLA-B27-associated uveitis: overview and current perspectives
    Eric B Suhler
    Casey Eye Institute, Oregon Health and Science University, and Portland VA Medical Center, Ophthalmology Service, 97239, USA
    Curr Opin Ophthalmol 14:378-83. 2003
    ....
  3. ncbi request reprint Antigen-specific accumulation of naïve, memory and effector CD4 T cells during anterior uveitis monitored by intravital microscopy
    Per A Dullforce
    Department of Ophthalmology at Casey Eye Institute, Oregon Health and Science University, Portland, 97239, USA
    Cell Immunol 239:49-60. 2006
    ..Intravital microscopy revealed the early arrival and antigen-specific accumulation of CD4 T cells in inflamed tissue and should be helpful in understanding T cell migration to other organs...
  4. doi request reprint A piece of my mind. In defense of phobias
    James T Rosenbaum
    JAMA 299:2368. 2008
  5. ncbi request reprint Does the microbiome play a causal role in spondyloarthritis?
    James T Rosenbaum
    Division of Arthritis and Rheumatic Diseases and Department of Ophthalmology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd L467Ad, Portland, OR, 97239, USA
    Clin Rheumatol 33:763-7. 2014
    ..Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged. ..
  6. doi request reprint Innate immune signals in autoimmune and autoinflammatory uveitis
    James T Rosenbaum
    Oregon Health and Science University, Casey Eye Institute, Portland, OR, USA
    Int Rev Immunol 32:68-75. 2013
    ....
  7. ncbi request reprint Patients with retinal vasculitis rarely suffer from systemic vasculitis
    James T Rosenbaum
    Department of Ophthalmology, Oregon Health and Science University, Portland, OR 97239, USA
    Semin Arthritis Rheum 41:859-65. 2012
    ..Systemic vasculitis is often mistakenly assumed to be a common cause of retinal vasculitis. We sought to determine the relationship between retinal vasculitis and systemic vasculitis...
  8. pmc Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis
    Jelena M Kezic
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Arthritis Res Ther 14:R18. 2012
    ....
  9. doi request reprint Management of comorbidities in ankylosing spondylitis
    James Rosenbaum
    Department of Ophthalmology, Oregon Health and Science University, Portland, 97239, USA
    Am J Med Sci 343:364-6. 2012
    ..The pathogenic mechanism to account for the coexistence of comorbidities remains largely unknown. In some instances, the comorbidity has a major impact on the choice of therapy...
  10. pmc Gene expression profiling of whole blood: comparison of target preparation methods for accurate and reproducible microarray analysis
    Kristina Vartanian
    Gene Microarray Shared Resource, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 10:2. 2009
    ..no treatment; ii. treatment with GLOBINclear; or iii. treatment with globin PNA oligos. In the fourth method cDNA targets were prepared with the Ovation amplification and labeling system...
  11. pmc Insights in to the pathogenesis of axial spondyloarthropathy based on gene expression profiles
    Srilakshmi M Sharma
    Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon, 97239, USA
    Arthritis Res Ther 11:R168. 2009
    ..This study tested the hypothesis that SpA is characterized by a distinct pattern of gene expression in peripheral blood of affected individuals compared with healthy controls...
  12. ncbi request reprint Anti-TNF therapy for eye involvement in spondyloarthropathy
    J T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland 97201 4197, USA
    Clin Exp Rheumatol 20:S143-5. 2002
    ..In this manuscript, we review briefly the clinical manifestations of the uveitis associated with spondyloarthropathy and discuss several potential novel therapeutic approaches, primarily anti-tumor necrosis factor (TNF) therapy...
  13. pmc Contrasting ocular effects of local versus systemic endotoxin
    James T Rosenbaum
    Casey Eye Institute, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 52:6472-7. 2011
    ..The hypothesis that systemic LPS desensitizes leukocytes to the stimuli responsible for transmigration offers a plausible explanation for this discordance...
  14. doi request reprint Uveitis secondary to bacterial products
    James T Rosenbaum
    Oregon Health and Science University, Portland, OR 97239, USA
    Ophthalmic Res 40:165-8. 2008
    ..Since a mutation in a gene that codes for a protein which senses a bacterial product consistently results in uveitis, it is critical to understand more fully the mechanisms by which bacterial products cause uveitis in laboratory animals...
  15. pmc Hypothesis: sarcoidosis is a STAT1-mediated disease
    James T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Immunol 132:174-83. 2009
    ....
  16. pmc How do you know?
    J T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239 4197, USA
    Br J Ophthalmol 88:980-1. 2004
  17. doi request reprint The influence of uveitis on patients with immune-mediated inflammatory disease
    James T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    J Rheumatol Suppl 88:26-30. 2011
    ..We provide an overview of the occurrence and significance of uveitis in patients with IMID, its consequences, and the role of tumor necrosis factor-α inhibitors in overall treatment approaches...
  18. ncbi request reprint With a mere nod, uveitis enters a new era
    James T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Ophthalmol 136:729-32. 2003
    ..To advance the knowledge of the ophthalmologist with regard to new developments in the genetics and pathologic mechanisms of uveitis...
  19. pmc Sugar creates a sticky business: round up the usual suspects
    James T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am J Pathol 160:1547-50. 2002
  20. ncbi request reprint In vivo confocal microscopy of keratic precipitates
    Michael S Wertheim
    Casey Eye Institute, Oregon Health and Science University, Portland 97201, USA
    Arch Ophthalmol 122:1773-81. 2004
    ..To evaluate the heterogeneity of keratic precipitates (KP) in varying subtypes of uveitis by in vivo confocal microscopy (IVCM)...
  21. doi request reprint Future for biological therapy for uveitis
    James T Rosenbaum
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Curr Opin Ophthalmol 21:473-7. 2010
    ..To review biological therapies as they pertain to the treatment of inflammatory eye diseases, especially uveitis...
  22. pmc The expression of STAT-1 and phosphorylated STAT-1 in conjunctival granulomas
    James T Rosenbaum
    Casey Eye Institute, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Ocul Immunol Inflamm 18:261-4. 2010
    ..They explored the potential contribution of STAT-1 in an ocular manifestation of this disease...
  23. doi request reprint Rituximab for treatment of ocular inflammatory disease: a series of four cases
    P A Kurz
    Mail Code L467AD, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Br J Ophthalmol 93:546-8. 2009
    ..The ongoing pilot study will hopefully provide additional insight into the benefit of rituximab for treatment of scleritis and idiopathic orbital inflammatory disease...
  24. ncbi request reprint Toward new therapies for ocular inflammation
    J T Rosenbaum
    Case Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Arch Soc Esp Oftalmol 75:511-4. 2000
    ..We believe that this technology can eventually be applied to the treatment of inflammatory diseases involving other body systems, as well as those primarily involving the eye...
  25. ncbi request reprint The treatment of refractory uveitis with intravenous immunoglobulin
    J T Rosenbaum
    Department of Ophthalmology, Oregon Health Sciences University, Casey Eye Institute, Portland, USA
    Am J Ophthalmol 127:545-9. 1999
    ..Intravenous immunoglobulin (IVIg) effectively treats a variety of autoimmune diseases, but it has not been adequately studied in the treatment of uveitis...
  26. ncbi request reprint Intravitreally injected platelet activating factor induces retinitis in experimental animals
    J T Rosenbaum
    Department of Medicine, Oregon Health Sciences University, Casey Eye Institute, Portland 97201 4197, USA
    Curr Eye Res 18:342-8. 1999
    ....
  27. ncbi request reprint Can medical schools teach high school students to be scientists?
    James T Rosenbaum
    Oregon Health and Science University, 3181 SW Sam Jackson Park Rd L467Ad, Portland, OR 97239, USA
    FASEB J 21:1954-7. 2007
    ..A federal initiative could facilitate student opportunities to pursue research...
  28. ncbi request reprint Digital video-imaging of leukocyte migration in the iris: intravital microscopy in a physiological model during the onset of endotoxin-induced uveitis
    M D Becker
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201, USA
    J Immunol Methods 240:23-37. 2000
    ..The resolution and quantifiable nature of this technique are such that the methodology can be applied to repetitive observation of leukocyte-endothelial dynamics during an immune response...
  29. ncbi request reprint The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis
    J T Rosenbaum
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Ocul Immunol Inflamm 8:111-3. 2000
    ..Although it was plausible to believe that the two rare diseases were causally related, the scleritis resolved while the gammopathy progressed...
  30. ncbi request reprint IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Invest Ophthalmol Vis Sci 40:2583-9. 1999
    ..To determine the role of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the induction of uveitis by a reverse passive Arthus reaction (RPAR)...
  31. ncbi request reprint Reduced leukocyte migration, but normal rolling and arrest, in interleukin-8 receptor homologue knockout mice
    M D Becker
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201, USA
    Invest Ophthalmol Vis Sci 41:1812-7. 2000
    ....
  32. ncbi request reprint Efficacy of antibodies to adhesion molecules, CD11a or CD18, in rabbit models of uveitis
    J T Rosenbaum
    Oregon Health Sciences University, Casey Eye Institute, Portland 97201
    Curr Eye Res 12:827-31. 1993
    ..These observations demonstrate that leukocyte migration into the anterior segment of the eye is dependent on the CD11a/CD18 complex...
  33. ncbi request reprint Cell adhesion molecule expression in cultured human iris endothelial cells
    M D Silverman
    Department of Ophthalmology, Casey Eye Institute, Portland, OR, USA
    Invest Ophthalmol Vis Sci 42:2861-6. 2001
    ..In addition, this is the first demonstration of the regulated expression of ICAM-2 in any ocular microvascular cells...
  34. pmc Activation of nucleotide oligomerization domain 2 exacerbates a murine model of proteoglycan-induced arthritis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97219, USA
    J Leukoc Biol 85:711-8. 2009
    ..However, the absence of NOD2 does not alter the course of inflammatory arthritis, in contrast to models of intestinal inflammation...
  35. ncbi request reprint Differential E-selectin expression by iris versus retina microvascular endothelial cells cultured from the same individuals
    Matthew D Silverman
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Microvasc Res 70:32-42. 2005
    ..Thus, cultured EC derived from adjacent microvascular beds are biologically distinct. Such endothelial diversity could play a role in the pathogenesis of tissue-specific inflammation, infection, neovascularization, and malignancy...
  36. ncbi request reprint Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis
    J R Smith
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201 4197, USA
    Curr Eye Res 21:906-12. 2000
    ..We investigated the possibility of preventing the inflammation with monoclonal antibody directed against rat intercellular adhesion molecule 1 (ICAM-1)...
  37. ncbi request reprint Tumor necrosis factor-alpha is not essential in endotoxin induced eye inflammation: studies in cytokine receptor deficient mice
    J T Rosenbaum
    Casey Eye Institute, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland 97201 4197, USA
    J Rheumatol 25:2408-16. 1998
    ..Interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) have been implicated in the pathogenesis of these diseases. We evaluate the need for these cytokines in a model of anterior uveitis...
  38. pmc Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling
    H L Rosenzweig
    Department of Ophthalmology, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Mail Stop L467 IM, Portland, OR 97239, USA
    J Leukoc Biol 84:529-36. 2008
    ..This report reveals a new in vivo function of NOD2 within the eye yet importantly, distinguishes NOD2-dependent from NALP3-dependent inflammation, as ocular inflammation in mice occurred independently of IL-1beta...
  39. ncbi request reprint Simultaneous in vivo imaging of leukocyte migration: heterogeneity among iris, limbus, and choroid vessels
    J T Rosenbaum
    Casey Eye Institute, Oregon Health Sciences University, Portland 97201, USA
    Curr Eye Res 24:214-8. 2002
    ..This study describes a method to visualize and compare leukocyte-endothelial interactions in three vascular beds within the same eye in mice...
  40. doi request reprint Anterior uveitis accompanies joint disease in a murine model resembling ankylosing spondylitis
    H L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ophthalmic Res 40:189-92. 2008
    ....
  41. ncbi request reprint Inhibition of leukocyte sticking and infiltration, but not rolling, by antibodies to ICAM-1 and LFA-1 in murine endotoxin-induced uveitis
    M D Becker
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 42:2563-6. 2001
    ..The dynamic in vivo images clearly support the hypothesis that integrin-mediated cell adhesion is more critical for the firm adhesion of sticking cells than for leukocyte rolling...
  42. ncbi request reprint The effect of genetic deficiency of adhesion molecules on the course of endotoxin-induced uveitis
    S R Planck
    Casey Eye Institute, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland 97201 4197, USA
    Curr Eye Res 17:941-6. 1998
    ..This study addresses the question of which adhesion molecules are specifically involved in endotoxin-induced uveitis...
  43. ncbi request reprint Paradoxical effects of IL-10 in endotoxin-induced uveitis
    J T Rosenbaum
    Oregon Health Sciences University, Casey Eye Institute, Portland 97201, USA
    J Immunol 155:4090-4. 1995
    ..Intraperitoneally injected IL-10 can either inhibit or suppress endotoxin-induced eye inflammation in a dose-dependent manner...
  44. ncbi request reprint Differential efficacy of tumor necrosis factor inhibition in the management of inflammatory eye disease and associated rheumatic disease
    J R Smith
    Casey Eye Institute, Oregon Health Sciences University, Portland 97201-4197, USA
    Arthritis Rheum 45:252-7. 2001
    ....
  45. ncbi request reprint Murine endotoxin-induced uveitis, but not immune complex-induced uveitis, is dependent on the IL-8 receptor homolog
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland, USA
    Curr Eye Res 19:76-85. 1999
    ....
  46. ncbi request reprint Constitutive and inflammatory mediator-regulated fractalkine expression in human ocular tissues and cultured cells
    Matthew D Silverman
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 44:1608-15. 2003
    ..In the current study, constitutive expression of FKN was identified in human iris and retina, and its regulation by various cytokines in endothelial cells (ECs) and stromal cells from human iris, retina, and choroid was investigated...
  47. pmc CXCR4 but not CXCR7 is mainly implicated in ocular leukocyte trafficking during ovalbumin-induced acute uveitis
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Exp Eye Res 89:522-31. 2009
    ..This study not only enhances our knowledge of the immunopathological mechanism of uveitis but also provides a novel rationale to target CXCR4 as an anti-inflammatory strategy to treat uveitis...
  48. ncbi request reprint Soluble forms of EphrinB2 and EphB4 reduce retinal neovascularization in a model of proliferative retinopathy
    David O Zamora
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, 97239, USA
    Invest Ophthalmol Vis Sci 46:2175-82. 2005
    ..The hypothesis was that these molecules also play a role in pathologic neovascularization (NV) in the mouse model of oxygen-induced retinopathy...
  49. ncbi request reprint Prevalence of serologic evidence of cat scratch disease in patients with neuroretinitis
    E B Suhler
    Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland 97035, USA
    Ophthalmology 107:871-6. 2000
    ..To determine the prevalence of Bartonella henselae seropositivity in patients with a clinical diagnosis of neuroretinitis...
  50. pmc Susceptibility to endotoxin induced uveitis is not reduced in mice deficient in BLT1, the high affinity leukotriene B4 receptor
    J R Smith
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR, USA
    Br J Ophthalmol 88:273-5. 2004
    ..To investigate the role of arachidonic acid derived chemotactic factor, LTB(4), in the development of endotoxin induced uveitis (EIU), using mice deficient in the BLT1 gene which encodes the high affinity LTB(4) receptor...
  51. pmc A role for methotrexate in the management of non-infectious orbital inflammatory disease
    J R Smith
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201 4197, USA
    Br J Ophthalmol 85:1220-4. 2001
    ..To evaluate the clinical usefulness of methotrexate for patients with non-infectious orbital inflammatory disease who fail to respond to systemic corticosteroids and/or orbital irradiation...
  52. ncbi request reprint The human leukocyte antigen complex and chronic ocular inflammatory disorders
    M P Davey
    Department of Veteran Affairs Medical Center, Department of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Am J Ophthalmol 129:235-43. 2000
    ..To review the role of gene products from the human leukocyte antigen (HLA) complex in the normal functioning of the immune system, ocular inflammation, and models of autoimmunity...
  53. ncbi request reprint The role of T cells in autoimmune uveitis
    M D Becker
    Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Ocul Immunol Inflamm 8:93-100. 2000
    ..Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease...
  54. ncbi request reprint Endotoxin upregulates CCR7 and its ligands in the lymphatic-free mouse iris
    F Mackensen
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Mol Vis 13:2209-13. 2007
    ..We hypothesized that DCs in an inflamed iris might show a different chemokine receptor and ligand profile, thus explaining the DC's inability to migrate...
  55. pmc Endotoxin-induced uveitis is primarily dependent on radiation-resistant cells and on MyD88 but not TRIF
    J Kezic
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    J Leukoc Biol 90:305-11. 2011
    ..Only WT → TLR4(-/-) chimeric mice were resistant to EIU, and this suggests, surprisingly, that non-BM-derived (radiation-resistant) cells in the eye play a greater role than BM-derived cells...
  56. ncbi request reprint Cloning, sequencing and expression analysis of the mouse NOD2/CARD15 gene
    Y Iwanaga
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Inflamm Res 52:272-6. 2003
    ..The objective of the present study was to clone the murine form of NOD2 and characterize its tissue distribution, function and response to inflammatory stimuli...
  57. ncbi request reprint Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina
    Binoy Appukuttan
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 48:3775-82. 2007
    ..The purpose of this study was to determine whether transcriptional enhancer factor 1-related (RTEF-1) was present within ocular vascular endothelial cells and whether it played a role in the control of the transcription of the VEGF gene...
  58. ncbi request reprint Long-term follow-up of patients with birdshot retinochoroidopathy treated with systemic immunosuppression
    Matthias D Becker
    Casey Eye Institute, Oregon Health Sciences University, Portland, OR, USA
    Ocul Immunol Inflamm 13:289-93. 2005
    ..Corticosteroid-sparing strategies with agents such as cyclosporine A or azathioprine have been suggested for this disease...
  59. pmc The role of choroidal and retinal biopsies in the diagnosis and management of atypical presentations of uveitis
    Lyndell L Lim
    Casey Eye Institute, Oregon Health and Sciences University, Portland Oregon, USA
    Trans Am Ophthalmol Soc 103:84-91; discussion 91-2. 2005
    ..The most common indication is atypical uveitis, in which a diagnosis of malignancy or infection may be suspected. Here, we describe our experience at the Casey Eye Institute...
  60. pmc Use of corticosteroid sparing systemic immunosuppression for treatment of corticosteroid dependent optic neuritis not associated with demyelinating disease
    T D Myers
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Br J Ophthalmol 88:673-80. 2004
    ....
  61. pmc T cell-antigen-presenting cell interactions visualized in vivo in a model of antigen-specific inflammation
    James T Rosenbaum
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Clin Immunol 126:270-6. 2008
    ..10 versus HA clonotype 6.5 T cells. Further studies with this model system should clarify the contribution of T cell-APC communication at a site of inflammation, infection, or immunization...
  62. ncbi request reprint Bilateral uveitis manifesting as a complication of chronic graft-versus-host disease after allogeneic bone marrow transplantation
    Michael Wertheim
    The Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ocul Immunol Inflamm 13:403-4. 2005
    ..To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD)...
  63. pmc Methotrexate for ocular inflammatory diseases
    Sapna Gangaputra
    Department of Ophthalmology, The Fundus Photograph Reading Center, University of Wisconsin, Madison, Wisconsin, USA
    Ophthalmology 116:2188-98.e1. 2009
    ..To evaluate the outcome of treatment with methotrexate for noninfectious ocular inflammation...
  64. ncbi request reprint APCs in the anterior uveal tract do not migrate to draining lymph nodes
    Per A Dullforce
    Department of Ophthalmology at Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 172:6701-8. 2004
    ..The inability of anterior uveal tissue APCs to migrate to lymph nodes may contribute to deviant immune responses that dominate after Ags are introduced into the anterior chamber...
  65. ncbi request reprint Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome
    Friederike Mackensen
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Ophthalmology 114:995-9. 2007
    ..Thus, it is frequently overlooked in differential diagnosis. We hypothesized that recognition of subsets of uveitis can facilitate the diagnosis of rare entities such as TINU...
  66. pmc Retention time for corticosteroid-sparing systemic immunosuppressive agents in patients with inflammatory eye disease
    K B Baker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Br J Ophthalmol 90:1481-5. 2006
    ..The retention time was compared for corticosteroid-sparing immunosuppressive agents in patients attending our tertiary referral inflammatory eye disease clinic...
  67. doi request reprint Invasion of human retinal vascular endothelial cells by Toxoplasma gondii tachyzoites
    D O Zamora
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Br J Ophthalmol 92:852-5. 2008
    ..Human retinal endothelial cells (HREC) are more susceptible to infection with T gondii tachyzoites than other subpopulations of endothelial cells. It is hypothesised that this phenomenon reflects differences in invasion efficiency...
  68. ncbi request reprint Trauma and alkali burns induce distinct patterns of cytokine gene expression in the rat cornea
    S R Planck
    Department of Medicine, Casey Eye Institute, Oregon Helath Sciences University, Portland 97201, USA
    Ocul Immunol Inflamm 5:95-100. 1997
    ..Our data are consistent with the hypothesis that corneal tissues respond to different types of injury with different patterns of cytokine gene expression...
  69. ncbi request reprint Modification of the Woodruff-Stamper assay demonstrates binding of Toxoplasma gondii tachyzoites to retinal vascular endothelium
    T J Chipps
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    J Immunol Methods 312:209-13. 2006
    ..gondii on the retinal vascular endothelium. In addition, the assay suggests a methodology that could be used to examine adhesion of other microbes to microvasculature in different tissues...
  70. doi request reprint Gender and laterality affect recurrences of acute anterior uveitis
    S Agnani
    School of Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Br J Ophthalmol 94:1643-7. 2010
    ..Acute anterior uveitis (AAU) associated with HLA-B27 or axial spondyloarthritis (axial SpA) is primarily unilateral and recurrent. We tested the hypotheses that disease laterality and gender affected recurrences of AAU...
  71. ncbi request reprint Anterior uveitis: current concepts of pathogenesis and interactions with the spondyloarthropathies
    Tammy M Martin
    Oregon Health and Science University, Casey Eye Institute, Portland, Oregon 97201, USA
    Curr Opin Rheumatol 14:337-41. 2002
    ..Here, we review recent insights into anterior uveitis with regard to clinical presentation, immune mechanisms, genetics, and anti-tumor necrosis factor therapy...
  72. pmc Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis
    Zili Zhang
    Departments of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Pathol 177:2912-20. 2010
    ..This study thus enhances our knowledge of costimulatory molecule-mediated immunopathological mechanisms of uveitis and suggests a future therapeutic strategy to treat uveitis by the targeting of OX40...
  73. ncbi request reprint Uveitis in patients with sarcoidosis is not associated with mutations in NOD2 (CARD15)
    Tammy M Martin
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Ophthalmol 136:933-5. 2003
    ..Both Blau syndrome and Crohn disease involve granulomatous inflammation and uveitis, as does sarcoidosis. We sought to determine if NOD2 mutations were present in patients with sarcoidosis, especially those with uveitis...
  74. doi request reprint Experimental melanin-induced uveitis: experimental model of human acute anterior uveitis
    Justine R Smith
    Department of Cell and Developmental Biology, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Ophthalmic Res 40:136-40. 2008
    ..In addition, EMIU has also been used to evaluate various biologic interventions with potential implications for the treatment of human disease...
  75. pmc NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 49:1518-24. 2008
    ..As a first step toward understanding the role of NOD2 in the pathogenesis of uveitis, the authors developed a mouse model of MDP-dependent uveitis...
  76. ncbi request reprint Management of uveitis: a rheumatologic perspective
    Justine R Smith
    Casey Eye Institute, Oregon Health Sciences University, 3375 Terwilliger Blvd, Portland, OR 97201 4197, USA
    Arthritis Rheum 46:309-18. 2002
  77. doi request reprint Characterizing extravascular neutrophil migration in vivo in the iris
    Stephen R Planck
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Inflammation 31:105-11. 2008
    ..Characterization of extravascular migration of neutrophils has important implications for understanding infection and immunity...
  78. ncbi request reprint Vitreous hemorrhage is a common complication of pediatric pars planitis
    Andreas Katsuya Lauer
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Hospital, Portland, OR 97201, USA
    Ophthalmology 109:95-8. 2002
    ..To report the prevalence of vitreous hemorrhage in pars planitis and to compare the prevalence of hemorrhage for children and adults with the disease...
  79. ncbi request reprint Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma
    Justine R Smith
    Casey Eye Institute and Department of Pathology, Oregon Health and Science University, Portland, OR 97201, USA
    Blood 101:815-21. 2003
    ..In PCNSL, expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to CNS...
  80. pmc Nucleotide-binding oligomerization domain 2 and Toll-like receptor 2 function independently in a murine model of arthritis triggered by intraarticular peptidoglycan
    Holly L Rosenzweig
    Oregon Health and Science University, Portland, OR 97239, USA
    Arthritis Rheum 62:1051-9. 2010
    ..This study was undertaken to investigate NOD-2 function in an experimental model of arthritis and to explore the potential interplay between Toll-like receptor 2 (TLR-2) and NOD-2 in joint inflammation...
  81. doi request reprint Incidence and prevalence of uveitis in Veterans Affairs Medical Centers of the Pacific Northwest
    Eric B Suhler
    Portland Veterans Administration Medical Center, Portland, Oregon 97239, USA
    Am J Ophthalmol 146:890-6.e8. 2008
    ..To ascertain the frequency of uveitis in Veterans Affairs (VA) patients in the Pacific Northwest and to compare disease rates with those in previously published epidemiologic studies...
  82. pmc Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Cytokine 46:79-91. 2009
    ..Our study suggests that IL-17 is implicated in the pathogenesis of this T cell-mediated model of uveitis in part through neutrophil chemotaxis as a downstream effect of IL-17...
  83. pmc Epifluorescence intravital microscopy of murine corneal dendritic cells
    Ellen J Lee
    Departments of Ophthalmology, Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:2101-8. 2010
    ..In vivo imaging reveals minimal lateral migration of corneal DCs after various stimuli. In contrast, DCs within the central cornea after initial TNF-alpha injection are more likely to respond to a secondary insult with lateral migration...
  84. pmc Hypopyon in patients with uveitis
    Ali A Zaidi
    Department of Ophthalmology, The University of Pennsylvania, The Ocular Inflammation Service and Center for Preventive Ophthalmology and Biostatistics, Philadelphia, Pennsylvania, USA
    Ophthalmology 117:366-72. 2010
    ..To evaluate the risk of and risk factors for hypopyon among patients with uveitis and to evaluate the risk of visual changes and complications after hypopyon...
  85. pmc Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort
    Tammy M Martin
    Oregon Health and Science University, Portland, OR, USA
    Mol Vis 15:208-12. 2009
    ..In this study we have analyzed SNPs in PTPN22 and CTLA-4 in patients with AAU...
  86. ncbi request reprint Immune mechanisms in uveitis. What can be learned from in vivo imaging?
    Matthias D Becker
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ophthalmol Clin North Am 15:259-70. 2002
    ....
  87. doi request reprint Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?
    Zili Zhang
    Department of Pediatrics, Oregon Health and Science University, Portland, 97239, USA
    Semin Immunopathol 32:55-70. 2010
    ....
  88. pmc Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1739-45. 2009
    ....
  89. pmc NOD1 expression in the eye and functional contribution to IL-1beta-dependent ocular inflammation in mice
    Holly L Rosenzweig
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 50:1746-53. 2009
    ..Nonetheless, the role of NOD1 in intraocular inflammation has not been explored. The induction of uveitis by iE-DAP in mice and the potential contribution of interleukin (IL)-1beta were investigated...
  90. pmc The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity
    Tammy M Martin
    Oregon Health and Science University, Portland, OR 79239, USA
    Arthritis Rheum 60:611-8. 2009
    ..Furthermore, functional studies demonstrate that caspase 1-mediated release of IL-1beta also involves NOD-2. The aim of this study was to test the hypothesis that IL-1beta may mediate the inflammation seen in patients with Blau syndrome...
  91. ncbi request reprint Therapy insight: scleritis and its relationship to systemic autoimmune disease
    Justine R Smith
    Oregon Health and Science University, Portland, OR 97239, USA
    Nat Clin Pract Rheumatol 3:219-26. 2007
    ..New therapies presently under investigation for scleritis include local corticosteroid injections and various biologic agents...
  92. ncbi request reprint Intravital microscopy of leukocyte-endothelial dynamics using the Heidelberg confocal laser microscope in scleritis and allergic conjunctivitis
    Lyndell L Lim
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Vis 12:1302-5. 2006
    ....
  93. ncbi request reprint A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease
    Tammy M Martin
    Casey Eye Institute, CE RES, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
    Arthritis Rheum 52:269-74. 2005
    ..We sought to determine whether a unique genetic region could be implicated in a specific manifestation-AAU-of a multisystem, inflammatory, genetically complex disease, AS...
  94. ncbi request reprint Histopathological features of conjunctival sarcoid nodules using noninvasive in vivo confocal microscopy
    Michael S Wertheim
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Arch Ophthalmol 123:274-6. 2005
  95. ncbi request reprint Non-invasive detection of multinucleated giant cells in the conjunctiva of patients with sarcoidosis by in-vivo confocal microscopy
    Michael S Wertheim
    The Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Ocul Immunol Inflamm 14:203-6. 2006
    ..To explore the use of in-vivo confocal microscopy (IVCM) as a potential non-invasive adjunctive tool for diagnosing sarcoidosis...
  96. ncbi request reprint Borrelia hermsii causing relapsing Fever and uveitis
    Lyndell L Lim
    Ocular Inflammatory Diseases Unit, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Ophthalmol 142:348-9. 2006
    ..To describe a case of uveitis that is associated with Borrelia hermsii relapsing fever...
  97. ncbi request reprint Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide
    Michael P Davey
    Department of Veterans Affairs Medical Center, Portland, OR 97239 2999, USA
    Microvasc Res 71:103-7. 2006
    ....
  98. ncbi request reprint Susceptibility of retinal vascular endothelium to infection with Toxoplasma gondii tachyzoites
    Justine R Smith
    Casey Eye Institute and the Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 45:1157-61. 2004
    ..It is unknown whether T. gondii penetrates the CNS selectively or whether these sites of immune privilege have limited capacity to eradicate the parasite...
  99. ncbi request reprint A prospective trial of infliximab therapy for refractory uveitis: preliminary safety and efficacy outcomes
    Eric B Suhler
    Uveitis and Retina Divisions, Casey Eye Institute, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Arch Ophthalmol 123:903-12. 2005
    ..We conducted a prospective, open-label phase 2 clinical trial to assess the effectiveness of infliximab in treating refractory autoimmune uveitis...
  100. ncbi request reprint In vivo confocal microscopy: increased conjunctival or episcleral leukocyte adhesion in patients who wear contact lenses with lower oxygen permeability (Dk) values
    Thuy H Nguyen
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Cornea 23:695-700. 2004
    ..We tested the hypothesis that contact lens wear is associated with measurable inflammation in superficial vessels...
  101. ncbi request reprint Human leukocytes express ephrinB2 which activates microvascular endothelial cells
    David O Zamora
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, 3375 S W Terwilliger Blvd, Portland, OR 97239 4197, USA
    Cell Immunol 242:99-109. 2006
    ..This suggests a novel mechanism by which EC and lymphocytes communicate to regulate cell activation/migration during inflammation...

Research Grants44

  1. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2007
    ..The creation of a gene expression data base for patients with uveitis has the potential to clarify the pathogenesis of disease, establish new diagnostic tools, and provide a means for predicting prognosis. ..
  2. Endotoxin-induced Uveitis Revisited
    James T Rosenbaum; Fiscal Year: 2010
    ..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..
  3. UVEITIS GENE-EXPRESSOIN PROFILING
    James Rosenbaum; Fiscal Year: 2006
    ..The creation of a gene expression data base for patients with uveitis has the potential to clarify the pathogenesis of disease, establish new diagnostic tools, and provide a means for predicting prognosis. ..
  4. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2006
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  5. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2006
    ..These studies should result in a fundamental improvement in the understanding of how T cells behave within a site of inflammation. ..
  6. UVEITIS GENE-EXPRESSION PROFILING
    James Rosenbaum; Fiscal Year: 2005
    ..The creation of a gene expression data base for patients with uveitis has the potential to clarify the pathogenesis of disease, establish new diagnostic tools, and provide a means for predicting prognosis. ..
  7. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2005
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  8. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2004
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  9. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2004
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  10. FOUR DIMENTIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2003
    ..These studies offer a unique opportunity to develop modalities to image the immune response in vivo. ..
  11. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2003
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  12. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2007
    ..These studies should result in a fundamental improvement in the understanding of how T cells behave within a site of inflammation. ..
  13. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2007
    ..We believe that these aims are novel, innovative, especially suited to the skills and achievements demonstrated by our laboratory, and highly relevant to clarifying the pathogenesis of anterior uveitis. ..
  14. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James T Rosenbaum; Fiscal Year: 2010
    ..These studies should result in a fundamental improvement in the understanding of how T cells behave within a site of inflammation. ..
  15. Endotoxin-induced Uveitis Revisited
    James Rosenbaum; Fiscal Year: 2009
    ..Future studies can buil d on these observations to test anti-inflammtory molecules induced by endotoxin as these molecules are potentially useful in the treatment of uveitis and other inflammations. ..
  16. FOUR DIMENSIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2009
    ..These studies should result in a fundamental improvement in the understanding of how T cells behave within a site of inflammation. ..
  17. IMMUNOLOGY/MOLECULAR BIOLOGY TRAINING IN OPHTHALMOLOGY
    James Rosenbaum; Fiscal Year: 2007
    ..The quality of the institution, the talents of the specific faculty, the abilities of the applicant pool, and the proven success of the program areadditional strengths of this application. ..
  18. CHEMOTACTIC FACTORS IN MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2003
    ..These studies should clarify the role of the vascular endothelium in anterior uveitis. The studies have the potential to lead to novel, less toxic therapies for anterior uveitis. ..
  19. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2002
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  20. CHEMOTACTIC FACTORS IN MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 1999
    ..These studies should clarify the role of the vascular endothelium in anterior uveitis. The studies have the potential to lead to novel, less toxic therapies for anterior uveitis. ..
  21. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 1990
    ..These studies should serve to compare and contrast various forms of inflammation. They should lead to an enhanced understanding of the pathogenesis of anterior uveitis...
  22. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 1991
    ..These studies should serve to compare and contrast various forms of inflammation. They should lead to an enhanced understanding of the pathogenesis of anterior uveitis...
  23. FOUR DIMENTIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2002
    ..These studies offer a unique opportunity to develop modalities to image the immune response in vivo. ..
  24. CHEMOTACTIC FACTORS IN MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2002
    ..These studies should clarify the role of the vascular endothelium in anterior uveitis. The studies have the potential to lead to novel, less toxic therapies for anterior uveitis. ..
  25. FOUR DIMENTIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2001
    ..These studies offer a unique opportunity to develop modalities to image the immune response in vivo. ..
  26. CHEMOTACTIC FACTORS IN MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2001
    ..These studies should clarify the role of the vascular endothelium in anterior uveitis. The studies have the potential to lead to novel, less toxic therapies for anterior uveitis. ..
  27. Anterior Uveal Dendritic Cells
    James Rosenbaum; Fiscal Year: 2001
    ..These studies will clarify the function of the immune system within the eye and may suggest novel therapeutic approaches in the treatment of uveitis. ..
  28. FOUR DIMENTIONAL IMAGING OF THE IMMUNE RESPONSE IN VIVO
    James Rosenbaum; Fiscal Year: 2000
    ..These studies offer a unique opportunity to develop modalities to image the immune response in vivo. ..
  29. CHEMOTACTIC FACTORS IN MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 2000
    ..These studies should clarify the role of the vascular endothelium in anterior uveitis. The studies have the potential to lead to novel, less toxic therapies for anterior uveitis. ..
  30. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 1993
    ..These studies should serve to compare and contrast various forms of inflammation. They should lead to an enhanced understanding of the pathogenesis of anterior uveitis...
  31. CHEMOTACTIC FACTORS IN ANIMAL MODELS OF UVEITIS
    James Rosenbaum; Fiscal Year: 1992
    ..These studies should serve to compare and contrast various forms of inflammation. They should lead to an enhanced understanding of the pathogenesis of anterior uveitis...