CHARLES EUGENE ROSELLI

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Expression of steroid hormone receptors in the fetal sheep brain during the critical period for sexual differentiation
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Brain Res 1110:76-80. 2006
  2. pmc Ontogeny of cytochrome p450 aromatase mRNA expression in the developing sheep brain
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97201 3098, USA
    J Neuroendocrinol 24:443-52. 2012
  3. pmc Separate critical periods exist for testosterone-induced differentiation of the brain and genitals in sheep
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Endocrinology 152:2409-15. 2011
  4. ncbi request reprint Sexual partner preference, hypothalamic morphology and aromatase in rams
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Physiol Behav 83:233-45. 2004
  5. pmc Prenatal programming of sexual partner preference: the ram model
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, OR 97201 3098, USA
    J Neuroendocrinol 21:359-64. 2009
  6. ncbi request reprint The ovine sexually dimorphic nucleus of the medial preoptic area is organized prenatally by testosterone
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    Endocrinology 148:4450-7. 2007
  7. pmc Brain aromatase: roles in reproduction and neuroprotection
    Charles F Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    J Steroid Biochem Mol Biol 106:143-50. 2007
  8. doi request reprint Prolactin expression in the sheep brain
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oreg 97201 3098, USA
    Neuroendocrinology 87:206-15. 2008
  9. pmc The volume of the ovine sexually dimorphic nucleus of the preoptic area is independent of adult testosterone concentrations
    C E Roselli
    Department of Physiology and Pharmacology, L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Brain Res 1249:113-7. 2009
  10. pmc Brain aromatization: classic roles and new perspectives
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Semin Reprod Med 27:207-17. 2009

Research Grants

  1. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES EUGENE ROSELLI; Fiscal Year: 2010
  2. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES EUGENE ROSELLI; Fiscal Year: 2010
  3. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2009
  4. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2009
  5. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2006
  6. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2007
  7. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2002
  8. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Expression of steroid hormone receptors in the fetal sheep brain during the critical period for sexual differentiation
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Brain Res 1110:76-80. 2006
    ..We conclude that the fetal brain is a target site for circulating steroid hormones. These data have implications for the steroid dependent development of sexually dimorphic brain functions in sheep...
  2. pmc Ontogeny of cytochrome p450 aromatase mRNA expression in the developing sheep brain
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97201 3098, USA
    J Neuroendocrinol 24:443-52. 2012
    ....
  3. pmc Separate critical periods exist for testosterone-induced differentiation of the brain and genitals in sheep
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Endocrinology 152:2409-15. 2011
    ..05 vs. C). These results demonstrate that the prenatal critical period for androgen-dependent differentiation of the oSDN occurs later than, and can be separated temporally from, the period for development of masculine genitals...
  4. ncbi request reprint Sexual partner preference, hypothalamic morphology and aromatase in rams
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Physiol Behav 83:233-45. 2004
    ..In this review, we provide an overview of sexual behavior in rams and discuss the multiple factors that may contribute to the development and adult expression of same-sex partner preferences in rams...
  5. pmc Prenatal programming of sexual partner preference: the ram model
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, OR 97201 3098, USA
    J Neuroendocrinol 21:359-64. 2009
    ..Thus, we propose that oSDN morphology and male-typical partner preferences may instead be programmed through an androgen receptor mechanism not involving aromatisation...
  6. ncbi request reprint The ovine sexually dimorphic nucleus of the medial preoptic area is organized prenatally by testosterone
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, Oregon 97239 3098, USA
    Endocrinology 148:4450-7. 2007
    ..Taken together, these data demonstrate that testosterone acts during a prenatal critical period to organize the development of aromatase-expressing neurons into the male-typical oSDN in sheep...
  7. pmc Brain aromatase: roles in reproduction and neuroprotection
    Charles F Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    J Steroid Biochem Mol Biol 106:143-50. 2007
    ..It is anticipated that a better appreciation of the physiological and pathophysiological functions of aromatase will lead to important clinical insights...
  8. doi request reprint Prolactin expression in the sheep brain
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oreg 97201 3098, USA
    Neuroendocrinology 87:206-15. 2008
    ....
  9. pmc The volume of the ovine sexually dimorphic nucleus of the preoptic area is independent of adult testosterone concentrations
    C E Roselli
    Department of Physiology and Pharmacology, L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Brain Res 1249:113-7. 2009
    ..These results suggest that differences in the size of the oSDN in adult sheep were not influenced by adult exposure to testosterone...
  10. pmc Brain aromatization: classic roles and new perspectives
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Semin Reprod Med 27:207-17. 2009
    ..A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies...
  11. pmc The neurobiology of sexual partner preferences in rams
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Horm Behav 55:611-20. 2009
    ..Finally, we demonstrate that the sexual differentiation of brain and behavior in sheep does not depend critically on aromatization of testosterone to estradiol...
  12. pmc The ovine sexually dimorphic nucleus, aromatase, and sexual partner preferences in sheep
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    J Steroid Biochem Mol Biol 118:252-6. 2010
    ..The demonstration that the oSDN is organized prenatally by testosterone exposure suggests that the brain of the male-oriented ram may be under-androgenized during development...
  13. ncbi request reprint Sex differences in androgen-regulated cytochrome P450 aromatase mRNA in the rat brain
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health Sciences University, 4181 SW Sam Jackson Park Road, 97201 3098, Portland, OR
    Endocrine 5:59-65. 1996
    ....
  14. pmc The development of male-oriented behavior in rams
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, United States
    Front Neuroendocrinol 32:164-9. 2011
    ..The challenge for future research will be to construct an integrated picture of how hormones, genes, and experience shape sexual partner preference...
  15. ncbi request reprint The effect of aromatase inhibition on the sexual differentiation of the sheep brain
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Endocrine 29:501-11. 2006
    ....
  16. ncbi request reprint The volume of a sexually dimorphic nucleus in the ovine medial preoptic area/anterior hypothalamus varies with sexual partner preference
    Charles E Roselli
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Endocrinology 145:478-83. 2004
    ....
  17. ncbi request reprint Distribution of aromatase mRNA in the ram hypothalamus: an in situ hybridization study
    C E Roselli
    Department of Physiology and Pharmacology, School of Medicine, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Neuroendocrinol 12:656-64. 2000
    ..The distribution of aromatase mRNA in the ovine hypothalamus was similar to that described for other vertebrate species, suggesting a high degree of functional conservation across species...
  18. ncbi request reprint Cytochrome P450 aromatase (CYP19) in the non-human primate brain: distribution, regulation, and functional significance
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    J Steroid Biochem Mol Biol 79:247-53. 2001
    ....
  19. ncbi request reprint Interleukin-2 and -6 induce behavioral-activating effects in mice
    S Zalcman
    The Manitoba Institute of Cell Biology, University of Manitoba, 770 Bannatyne Ave, Winnipeg, MB, Canada
    Brain Res 811:111-21. 1998
    ..g., schizophrenia, anxious-like states, anxious depression, motor abnormalities) could develop should these cytokines be overproduced or dysregulated...
  20. ncbi request reprint Hormonal influences on sexual partner preference in rams
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, Oregon 97201, USA
    Arch Sex Behav 31:43-9. 2002
    ..It is anticipated that the male-oriented ram model will be useful for studies aimed at identifying both the activational and organizational components and the neuronal substrates of male sexual partner preferences...
  21. ncbi request reprint Sexual differentiation of aromatase activity in the rat brain: effects of perinatal steroid exposure
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland 97201 3098, USA
    Endocrinology 139:3193-201. 1998
    ....
  22. ncbi request reprint Sex differences in male-typical copulatory behaviors in response to androgen and estrogen treatment in rats
    C E Roselli
    Department of Physiology, Oregon Health Science University, Portland, Oreg, USA
    Neuroendocrinology 69:290-8. 1999
    ..The present results support the view that gender differences in the capacity for brain estrogen synthesis contribute to the sexually dimorphic display of T-stimulated male-typical sexual motivation and copulatory behavior in rats...
  23. ncbi request reprint The effect of anabolic-androgenic steroids on aromatase activity and androgen receptor binding in the rat preoptic area
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Brain Res 792:271-6. 1998
    ..The present results help explain the behavioral effects of AAS compounds in rats...
  24. ncbi request reprint Relationship of serum testosterone concentrations to mate preferences in rams
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Biol Reprod 67:263-8. 2002
    ..Instead, functional differences must exist between the brains of rams that differ in sexual preference expression...
  25. ncbi request reprint Estrogen synthesis in fetal sheep brain: effect of maternal treatment with an aromatase inhibitor
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Biol Reprod 68:370-4. 2003
    ..They also demonstrate that AA can be inhibited in the fetal lamb brain by treating the mother with ATD, without harming fetal development...
  26. ncbi request reprint Anatomic distribution and regulation of aromatase gene expression in the rat brain
    C E Roselli
    Department of Physiology and Pharmacology and The Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland 97201 3098, USA
    Biol Reprod 58:79-87. 1998
    ..Moreover, they demonstrate the necessity of using a molecular probe that can distinguish between P450arom variants in the brain...
  27. ncbi request reprint Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland 97201 3098, U S A
    J Steroid Biochem Mol Biol 61:365-74. 1997
    ..Taken together these results demonstrate a sexually dimorphic mechanism that could potentially limit the action of T in females, and may relate to the enhanced expression of T-stimulated sexual behaviors in males...
  28. ncbi request reprint Expression of the orphan receptor steroidogenic factor-1 mRNA in the rat medial basal hypothalamus
    C E Roselli
    Department of Physiology and Pharmacology, The Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland 97201 3090, USA
    Brain Res Mol Brain Res 44:66-72. 1997
    ..These results demonstrate that the gene encoding SF-1 is expressed in a discrete region of the rat hypothalamus and appears to be developmentally regulated, but not affected by gonadal hormones in adults...
  29. ncbi request reprint Role of aromatization in anticipatory and consummatory aspects of sexual behavior in male rats
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97210, USA
    Horm Behav 44:146-51. 2003
    ..These results support the view that aromatization is important for maintaining both the appetitive and the consummatory aspects of sexual behavior in male rats...
  30. ncbi request reprint Anatomic relationships between aromatase and androgen receptor mRNA expression in the hypothalamus and amygdala of adult male cynomolgus monkeys
    C E Roselli
    Department of Physiology and Pharmacology, Oregon Health Science University, Portland, Oregon 97201 3098, USA
    J Comp Neurol 439:208-23. 2001
    ....
  31. pmc Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression
    Michelle A Tanchuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol Clin Exp Res 33:2077-87. 2009
    ....
  32. ncbi request reprint The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches
    Deborah A Finn
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Pharmacol Ther 101:91-112. 2004
    ....
  33. pmc Estrogen, testosterone, and sequential movement in men
    Jessica A Siegel
    Department of Behavioral Neuroscience, Oregon Health and Science University, USA
    Behav Neurosci 122:955-62. 2008
    ....
  34. ncbi request reprint Role of P450 aromatase in sex-specific astrocytic cell death
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:135-41. 2007
    ..We conclude that astrocytes isolated from neonatal cortex exhibit marked sex differences in sensitivity to OGD, in part because of enhanced aromatization and estradiol formation in female cells...
  35. pmc Age-dependent effects of testosterone in experimental stroke
    Jian Cheng
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:486-94. 2009
    ..Lastly, stroke damage was not different in aging aromatase knockout mice versus wild-type controls. Our findings indicate that testosterone's effects in experimental stroke are age dependent, mediated via AR, but not cerebral aromatase...
  36. ncbi request reprint Effects of dietary saw palmetto on the prostate of transgenic adenocarcinoma of the mouse prostate model (TRAMP)
    Teri L Wadsworth
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Prostate 67:661-73. 2007
    ..This study investigated whether SPE could prevent the progression of CaP in a transgenic adenocarcinoma of the mouse prostate (TRAMP) model...
  37. ncbi request reprint In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats
    Teri Wadsworth
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    J Pharmacol Exp Ther 306:187-94. 2003
    ..Inhibition of CYP3A has important implications for potential herbal-drug interactions...
  38. pmc Cognition is not modified by large but temporary changes in sex hormones in men
    Laura A Young
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 95:280-8. 2010
    ..Little is known about the role of testosterone and estradiol on cognition in healthy older men...
  39. pmc Curcumin blocks CCL2-induced adhesion, motility and invasion, in part, through down-regulation of CCL2 expression and proteolytic activity
    Jeffery G Herman
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Int J Oncol 34:1319-27. 2009
    ..Curcumin exerts potential anti-metastatic effects in bone-derived PCa cells by blocking CCL2 mediated actions on invasion, adhesion and motility, in part through differential regulation of PKC and MMP-9 signaling...
  40. ncbi request reprint Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells
    Teri L Wadsworth
    Department of Physiology and Pharmacology L334, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, Oregon 97239, USA
    Endocrinology 145:3205-14. 2004
    ..SPE treatment may relieve symptoms of BPH, in part, by inhibiting specific components of the IGF-I signaling pathway and inducing JNK activation, thus mediating antiproliferative and proapoptotic effects on prostate epithelia...
  41. pmc The ram as a model for behavioral neuroendocrinology
    Anne Perkins
    Psychology Department, Carroll College, Helena, MT 59625, USA
    Horm Behav 52:70-7. 2007
    ..Neurochemical and neuroanatomical studies suggest that male-oriented ram behavior may be a consequence of individual variations in brain sexual differentiation...
  42. ncbi request reprint Lack of vasoactive intestinal peptide reduces testosterone levels and reproductive aging in mouse testis
    Arnaud Lacombe
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Gonda Center, University of California, Room 6357, 695 Charles Young Drive South, Los Angeles, California 90095 7088, USA
    J Endocrinol 194:153-60. 2007
    ..All together, these results suggest that 1) VIP is an important factor for regulating testosterone biosynthesis and FSH secretion and 2) VIP may influence testicular aging...
  43. pmc Delayed testicular aging in pituitary adenylate cyclase-activating peptide (PACAP) null mice
    Arnaud Lacombe
    Department of Human Genetics, University of California, Gonda Center, 695 Charles Young Drive South, Los Angeles, CA 90095 7088, USA
    Proc Natl Acad Sci U S A 103:3793-8. 2006
    ....
  44. ncbi request reprint [A neuropeptide at the origin of testicular aging?]
    Arnaud Lacombe
    Med Sci (Paris) 22:809-11. 2006

Research Grants15

  1. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES EUGENE ROSELLI; Fiscal Year: 2010
    ..Thus, we will test the hypothesis that individual variations in adult mate recognition and neuroendocrine function of males depend on developmental events influencing the timing or extent of brain exposure to androgens. ..
  2. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES EUGENE ROSELLI; Fiscal Year: 2010
    ..Thus, we will test the hypothesis that individual variations in adult mate recognition and neuroendocrine function of males depend on developmental events influencing the timing or extent of brain exposure to androgens. ..
  3. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2009
    ..Thus, we will test the hypothesis that individual variations in adult mate recognition and neuroendocrine function of males depend on developmental events influencing the timing or extent of brain exposure to androgens. ..
  4. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2009
    ..Thus, we will test the hypothesis that individual variations in adult mate recognition and neuroendocrine function of males depend on developmental events influencing the timing or extent of brain exposure to androgens. ..
  5. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2006
    ..The data from this study will contribute valuable information on whether SPE is an effective COX-2 inhibitor and test the popular notion that it has chemopreventative properties. ..
  6. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2007
    ..Further development of the sheep model will provide a valuable animal system for research in the important areas of sexual behavior, reproductive neuroendocrinology, and developmental biology. ..
  7. A RAM MODEL OF NEUROENDOCRINE FUNCTION
    CHARLES ROSELLI; Fiscal Year: 2002
    ..When completed, this research will have characterized a new and unique animal model that will be useful for understanding the complex interactions between hormones, development, sensory processes, and behavior. ..
  8. Androgenic And Antiandorgenic Interactions Of PC-SPES
    CHARLES ROSELLI; Fiscal Year: 2002
    ..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..