DANIEL ROCKEY

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA
    Damir Alzhanov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804 USA
    BMC Microbiol 4:24. 2004
  2. ncbi Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223
    Damir T Alzhanov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 9:2. 2009
  3. ncbi Intrastrain and interstrain genetic variation within a paralogous gene family in Chlamydia pneumoniae
    Wasna Viratyosin
    Department of Microbiology, Oregon State University, Corvallis, 97331 3804, USA
    BMC Microbiol 2:38. 2002
  4. ncbi Proteins in the chlamydial inclusion membrane
    Daniel D Rockey
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
    Microbes Infect 4:333-40. 2002
  5. ncbi Unraveling the basic biology and clinical significance of the chlamydial plasmid
    Daniel D Rockey
    Department of Biomedical Sciences, Oregon State University College of Veterinary Medicine, Corvallis, OR 97331, USA
    J Exp Med 208:2159-62. 2011
  6. ncbi Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene
    Jae Dugan
    Department of Biomedical Sciences, Oregon State University, 106 Dryden Hall, Corvallis, OR 97331 4804, USA
    Antimicrob Agents Chemother 48:3989-95. 2004
  7. ncbi Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusions
    Daniel D Rockey
    Department of Microbiology, Oregon State University, Corvallis OR 97331 3804, USA
    Microbiology 148:2497-505. 2002
  8. ncbi Host alpha-adducin is redistributed and localized to the inclusion membrane in chlamydia- and chlamydophila-infected cells
    Hencelyn G Chu
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4804, USA
    Microbiology 154:3848-55. 2008
  9. ncbi Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombination
    Brendan M Jeffrey
    Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon 97331 4804, USA
    Infect Immun 78:2544-53. 2010
  10. ncbi Functional characterization of IScs605, an insertion element carried by tetracycline-resistant Chlamydia suis
    Jae Dugan
    Department of Biomedical Sciences, College of Veterinary Medicine and the Molecular and Cellular Biology Program, Oregon State University, Corvallis, OR 97331, USA
    Microbiology 153:71-9. 2007

Research Grants

  1. PROTEINS IN THE CHLAMYDIAL INCLUSION MEMBRANE
    DANIEL ROCKEY; Fiscal Year: 2002
  2. CHLAMYDIA TRACHOMATIS INCA MUTANTS
    DANIEL ROCKEY; Fiscal Year: 2005
  3. Genetic transformation system for Chlamydia suis
    DANIEL ROCKEY; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incA
    Damir Alzhanov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804 USA
    BMC Microbiol 4:24. 2004
    ..Little information exists regarding the interaction of Inc proteins with the eukaryotic cell. To examine these interactions, Vaccinia virus vectors and mammalian plasmid-based systems were used to express inc genes in mammalian cells...
  2. ncbi Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223
    Damir T Alzhanov
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    BMC Microbiol 9:2. 2009
    ..The inc gene CT223 is one of a sequential set of orfs that encode or are predicted to encode Inc proteins. CT223p is localized to the inclusion membrane in all tested C. trachomatis serovars...
  3. ncbi Intrastrain and interstrain genetic variation within a paralogous gene family in Chlamydia pneumoniae
    Wasna Viratyosin
    Department of Microbiology, Oregon State University, Corvallis, 97331 3804, USA
    BMC Microbiol 2:38. 2002
    ..Each member encodes a polypeptide with a hydrophobic domain characteristic of proteins localized to the inclusion membrane...
  4. ncbi Proteins in the chlamydial inclusion membrane
    Daniel D Rockey
    Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
    Microbes Infect 4:333-40. 2002
    ..Several proteins have recently been identified that are localized to the inclusion membrane. The following is a discussion of how inclusion membrane proteins might participate in the chlamydial developmental process...
  5. ncbi Unraveling the basic biology and clinical significance of the chlamydial plasmid
    Daniel D Rockey
    Department of Biomedical Sciences, Oregon State University College of Veterinary Medicine, Corvallis, OR 97331, USA
    J Exp Med 208:2159-62. 2011
    ..Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections...
  6. ncbi Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like gene
    Jae Dugan
    Department of Biomedical Sciences, Oregon State University, 106 Dryden Hall, Corvallis, OR 97331 4804, USA
    Antimicrob Agents Chemother 48:3989-95. 2004
    ..These genomic islands represent the first examples of horizontally acquired DNA integrated into a natural isolate of chlamydiae or within any other obligate intracellular bacterium...
  7. ncbi Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusions
    Daniel D Rockey
    Department of Microbiology, Oregon State University, Corvallis OR 97331 3804, USA
    Microbiology 148:2497-505. 2002
    ..trachomatis isolates. No change in the structure or the fusogenicity of the inclusions was associated with the presence or absence of CT223p...
  8. ncbi Host alpha-adducin is redistributed and localized to the inclusion membrane in chlamydia- and chlamydophila-infected cells
    Hencelyn G Chu
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4804, USA
    Microbiology 154:3848-55. 2008
    ..The demonstration of alpha-adducin and Raf-1 redistribution within cells infected by different chlamydiae provides novel opportunities for analysis of host-pathogen interactions in this system...
  9. ncbi Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombination
    Brendan M Jeffrey
    Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon 97331 4804, USA
    Infect Immun 78:2544-53. 2010
    ..This work demonstrated that whole-genome sequencing along with comparative genomics is an effective approach for discovering variable loci in Chlamydia spp. that are associated with clinical presentation...
  10. ncbi Functional characterization of IScs605, an insertion element carried by tetracycline-resistant Chlamydia suis
    Jae Dugan
    Department of Biomedical Sciences, College of Veterinary Medicine and the Molecular and Cellular Biology Program, Oregon State University, Corvallis, OR 97331, USA
    Microbiology 153:71-9. 2007
    ..suis chromosome...
  11. ncbi Chlamydia vaccine candidates and tools for chlamydial antigen discovery
    Daniel D Rockey
    Associate Professor, College of Veterinary Medicine, Oregon State University, 211 Dryden Hall, Corvallis, OR 97331 4804, USA
    Expert Rev Vaccines 8:1365-77. 2009
    ..In this article, we will summarize progress in these areas with a focus on chlamydial vaccine antigen discovery, and discuss future directions towards the development of a safe and effective chlamydial vaccine...
  12. ncbi Clonal isolation of chlamydia-infected cells using flow cytometry
    Damir T Alzhanov
    Department of Microbiology, College of Science, Oregon State University, Corvallis, OR 97331, USA
    J Microbiol Methods 68:201-8. 2007
    ..It is anticipated that FACS-based sorting of live chlamydia-infected cells will be a significant technical tool for the isolation of clonal populations of any chlamydial strain...
  13. ncbi Development of secondary inclusions in cells infected by Chlamydia trachomatis
    Robert J Suchland
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle 98105, USA
    Infect Immun 73:3954-62. 2005
    ....
  14. ncbi Chlamydia trachomatis variant with nonfusing inclusions: growth dynamic and host-cell transcriptional response
    Minsheng Xia
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 192:1229-36. 2005
    ..The variant strain grew significantly more slowly and induced a modified host-cell transcriptional response, compared with the prototype strain...

Research Grants8

  1. PROTEINS IN THE CHLAMYDIAL INCLUSION MEMBRANE
    DANIEL ROCKEY; Fiscal Year: 2002
    ..These different approaches will examine the unique biology of IncA/B/C as well as explore new technologies for investigating chlamydial interactions with mammalian cells. ..
  2. CHLAMYDIA TRACHOMATIS INCA MUTANTS
    DANIEL ROCKEY; Fiscal Year: 2005
    ..Study of these natural mutants will lead to a better understanding of chlamydial growth, development and pathogenesis. ..
  3. Genetic transformation system for Chlamydia suis
    DANIEL ROCKEY; Fiscal Year: 2007
    ..This will assist in the identification and analysis of novel vaccine candidates and to a clearer understanding of the mechanism of virulence in these important pathogens. ..