Affiliation: Oregon State University
- Chlamydial development is blocked in host cells transfected with Chlamydophila caviae incADamir Alzhanov
Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804 USA
BMC Microbiol 4:24. 2004..Little information exists regarding the interaction of Inc proteins with the eukaryotic cell. To examine these interactions, Vaccinia virus vectors and mammalian plasmid-based systems were used to express inc genes in mammalian cells...
- Cytokinesis is blocked in mammalian cells transfected with Chlamydia trachomatis gene CT223Damir T Alzhanov
Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
BMC Microbiol 9:2. 2009..The inc gene CT223 is one of a sequential set of orfs that encode or are predicted to encode Inc proteins. CT223p is localized to the inclusion membrane in all tested C. trachomatis serovars...
- Intrastrain and interstrain genetic variation within a paralogous gene family in Chlamydia pneumoniaeWasna Viratyosin
Department of Microbiology, Oregon State University, Corvallis, 97331 3804, USA
BMC Microbiol 2:38. 2002..Each member encodes a polypeptide with a hydrophobic domain characteristic of proteins localized to the inclusion membrane...
- Proteins in the chlamydial inclusion membraneDaniel D Rockey
Department of Microbiology, Oregon State University, Corvallis, OR 97331 3804, USA
Microbes Infect 4:333-40. 2002..Several proteins have recently been identified that are localized to the inclusion membrane. The following is a discussion of how inclusion membrane proteins might participate in the chlamydial developmental process...
- Unraveling the basic biology and clinical significance of the chlamydial plasmidDaniel D Rockey
Department of Biomedical Sciences, Oregon State University College of Veterinary Medicine, Corvallis, OR 97331, USA
J Exp Med 208:2159-62. 2011..Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections...
- Tetracycline resistance in Chlamydia suis mediated by genomic islands inserted into the chlamydial inv-like geneJae Dugan
Department of Biomedical Sciences, Oregon State University, 106 Dryden Hall, Corvallis, OR 97331 4804, USA
Antimicrob Agents Chemother 48:3989-95. 2004..These genomic islands represent the first examples of horizontally acquired DNA integrated into a natural isolate of chlamydiae or within any other obligate intracellular bacterium...
- Diversity within inc genes of clinical Chlamydia trachomatis variant isolates that occupy non-fusogenic inclusionsDaniel D Rockey
Department of Microbiology, Oregon State University, Corvallis OR 97331 3804, USA
Microbiology 148:2497-505. 2002..trachomatis isolates. No change in the structure or the fusogenicity of the inclusions was associated with the presence or absence of CT223p...
- Host alpha-adducin is redistributed and localized to the inclusion membrane in chlamydia- and chlamydophila-infected cellsHencelyn G Chu
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 4804, USA
Microbiology 154:3848-55. 2008..The demonstration of alpha-adducin and Raf-1 redistribution within cells infected by different chlamydiae provides novel opportunities for analysis of host-pathogen interactions in this system...
- Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombinationBrendan M Jeffrey
Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon 97331 4804, USA
Infect Immun 78:2544-53. 2010..This work demonstrated that whole-genome sequencing along with comparative genomics is an effective approach for discovering variable loci in Chlamydia spp. that are associated with clinical presentation...
- Functional characterization of IScs605, an insertion element carried by tetracycline-resistant Chlamydia suisJae Dugan
Department of Biomedical Sciences, College of Veterinary Medicine and the Molecular and Cellular Biology Program, Oregon State University, Corvallis, OR 97331, USA
Microbiology 153:71-9. 2007..suis chromosome...
- Chlamydia vaccine candidates and tools for chlamydial antigen discoveryDaniel D Rockey
Associate Professor, College of Veterinary Medicine, Oregon State University, 211 Dryden Hall, Corvallis, OR 97331 4804, USA
Expert Rev Vaccines 8:1365-77. 2009..In this article, we will summarize progress in these areas with a focus on chlamydial vaccine antigen discovery, and discuss future directions towards the development of a safe and effective chlamydial vaccine...
- Clonal isolation of chlamydia-infected cells using flow cytometryDamir T Alzhanov
Department of Microbiology, College of Science, Oregon State University, Corvallis, OR 97331, USA
J Microbiol Methods 68:201-8. 2007..It is anticipated that FACS-based sorting of live chlamydia-infected cells will be a significant technical tool for the isolation of clonal populations of any chlamydial strain...
- Development of secondary inclusions in cells infected by Chlamydia trachomatisRobert J Suchland
Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle 98105, USA
Infect Immun 73:3954-62. 2005....
- Chlamydia trachomatis variant with nonfusing inclusions: growth dynamic and host-cell transcriptional responseMinsheng Xia
Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, USA
J Infect Dis 192:1229-36. 2005..The variant strain grew significantly more slowly and induced a modified host-cell transcriptional response, compared with the prototype strain...
- PROTEINS IN THE CHLAMYDIAL INCLUSION MEMBRANEDANIEL ROCKEY; Fiscal Year: 2002..These different approaches will examine the unique biology of IncA/B/C as well as explore new technologies for investigating chlamydial interactions with mammalian cells. ..
- CHLAMYDIA TRACHOMATIS INCA MUTANTSDANIEL ROCKEY; Fiscal Year: 2005..Study of these natural mutants will lead to a better understanding of chlamydial growth, development and pathogenesis. ..
- Genetic transformation system for Chlamydia suisDANIEL ROCKEY; Fiscal Year: 2007..This will assist in the identification and analysis of novel vaccine candidates and to a clearer understanding of the mechanism of virulence in these important pathogens. ..