Genomes and Genes
Affiliation: Oregon State University
- HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanatesPraveen Rajendran
Linus Pauling Institute Oregon State University Corvallis, OR USA
Epigenetics 8:612-23. 2013..Future studies will address the mechanistic basis for dietary ITCs preferentially exploiting HDAC turnover mechanisms and faulty DNA repair pathways in colon cancer cells vs. normal cells...
- Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsPraveen Rajendran
Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
Clin Epigenetics 3:4. 2011....
- Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassemblyPraveen Rajendran
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Mol Cancer 10:68. 2011..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells...
- Metabolism as a key to histone deacetylase inhibitionPraveen Rajendran
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
Crit Rev Biochem Mol Biol 46:181-99. 2011..g. pyruvate), the yin-yang of HDAC inhibition versus HDAC activation, and the screening assays that might be most appropriate for discovery of novel HDAC inhibitors in the future...