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Genomes and Genes | J RaberSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
Androgens protect against apolipoprotein E4-induced cognitive deficitsJacob Raber
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94141, USA
J Neurosci 22:5204-9. 2002..Our findings suggest that apoE4 contributes to cognitive decline by reducing AR levels in the brain, and that stimulating AR-dependent pathways can reverse apoE4-induced cognitive deficits...
Effects of whole body (56)Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrusJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA Department of Neurology, ONPRC, Oregon Health and Science University, Portland, OR 97239, USA Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
Behav Brain Res 246:162-7. 2013....- Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)Jacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA Division of Neuroscience ONPRC, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
Behav Brain Res 246:69-75. 2013.... 
Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderlyGwendolen E Haley
Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR 97239, USA
Age (Dordr) 34:1-10. 2012..These results support that the NINL might be a valuable tool to assess age-related cognitive decline...- AR, apoE, and cognitive functionJacob Raber
Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Horm Behav 53:706-15. 2008..In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by epsilon4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction... - Irradiation enhances hippocampus-dependent cognition in mice deficient in extracellular superoxide dismutaseJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Hippocampus 21:72-80. 2011.... - Effects of ⁵⁶Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuliJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiat Res 176:521-6. 2011.... - ApoE genotype accounts for the vast majority of AD risk and AD pathologyJacob Raber
Departments of Behavioral Neuroscience and Neurology, L470, ONPRC, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97201, USA
Neurobiol Aging 25:641-50. 2004..Thus, the epidemiologic and basic science evidence suggest that apoE genotype accounts for the vast majority of AD risk and pathology... - Unintended effects of cranial irradiation on cognitive functionJacob Raber
Department of Behavioral Neuroscience, and Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
Toxicol Pathol 38:198-202. 2010..Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers... - Androgens, apoE, and Alzheimer's diseaseJacob Raber
Oregon Health and Science University, Portland, OR 97239, USA
Sci Aging Knowledge Environ 2004:re2. 2004..I also discuss potential interactions of androgens with other AD-related factors... - Histamine receptor-mediated signaling during development and brain function in adulthoodJ Raber
Departments of Behavioral Neuroscience and Neurology, Division of Neuroscience, ONPRC, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
Cell Mol Life Sci 64:735-41. 2007..Therefore, increased efforts are warranted to carefully evaluate the effects of drugs that directly or indirectly affect histamine receptor-mediated signaling during development on cognitive function later in life... - Apolipoprotein E and cognitive performanceJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco 94141-9100, USA
Nature 404:352-4. 2000 - Sex-dependent cognitive phenotype of mice lacking mGluR8Robert M Duvoisin
Department of Physiology and Pharmacology, Oregon Health and Science University, USA
Behav Brain Res 209:21-6. 2010..Thus, potential sex differences in the therapeutic effects of mGluR8 modulation to reduce measures of anxiety and improve cognitive performance should be carefully considered... - Role of circulating androgen levels in effects of apoE4 on cognitive functionTimothy Pfankuch
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Brain Res 1053:88-96. 2005..Thus, androgens have differential roles in object recognition and spatial learning and memory in the water maze, depending on whether or not apoE4 is present... - Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) miceSummer F Acevedo
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
Brain Res 1071:113-23. 2006.... - Behavioral performance of tfm mice supports the beneficial role of androgen receptors in spatial learning and memoryAngela Rizk
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Brain Res 1034:132-8. 2005..There were no differences in tfm and wild-type female and male mice in emotional learning and memory in the passive avoidance test. These findings support a beneficial role for androgen receptors in spatial learning and memory... - Anxiety and cognition in histamine H3 receptor-/- miceAngela Rizk
Department of Behavioural Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Eur J Neurosci 19:1992-6. 2004..These findings support a role for H3Rs in mediating histamine effects on spatial learning and memory and measures of anxiety... - Testosterone and dihydrotestosterone differentially improve cognition in aged female miceTed S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Learn Mem 16:479-85. 2009..These data support that androgen supplementation in old female mice improves cognitive performance differentially depending upon the type of hormone treatment and cognitive task... - Tfm-AR modulates the effects of ApoE4 on cognitionAngela Rizk-Jackson
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
J Neurochem 105:63-7. 2008..These data support an important role for AR in protecting against the detrimental effects of apoE4 on hippocampus-dependent learning and memory... - apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- miceJennifer Robertson
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Neurobiol Aging 26:637-43. 2005..Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety... - Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivityT S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
Neuroscience 137:413-23. 2006..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice... - Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic miceL Villasana
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiats Biol Radioecol 48:167-70. 2008.... - Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterationsJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
J Neurosci 20:2064-71. 2000..These results support a key role for apoE in the tonic inhibition of steroidogenesis and HPA axis activity and have important implications for the behavioral analysis of Apoe(-/-) mice... - Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of femalesJ Raber
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94141 9100, USA
Proc Natl Acad Sci U S A 95:10914-9. 1998..These results could be pertinent to cognitive impairments observed in human APOE epsilon4 carriers. NSE-apoE mice and similar models may facilitate the preclinical assessment of treatments for apoE-related cognitive deficits... - Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) miceSummer F Acevedo
Department of Behavioral Neuroscience L470, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
Behav Brain Res 168:92-9. 2006.... - ApoE isoform-dependent deficits in extinction of contextual fear conditioningR H J Olsen
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Genes Brain Behav 11:806-12. 2012..These data along with clinical data showing an association of apoE2 with susceptibility to specific symptom clusters in PTSD supports an important role for apoE isoform in the extinction of conditioned fear... - Impairments in spatial memory retention of GFAP-apoE4 female micePeter Van Meer
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
Behav Brain Res 176:372-5. 2007..Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes... - Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairmentsRamadevi Pullela
Department of Pediatrics, University of California, San Francisco, CA 94143-0520, USA
Dev Neurosci 28:396-409. 2006..Behavioral changes are a likely consequence of regional-specific neuronal degeneration... - Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- miceGerald Bongers
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA
Neuropsychopharmacology 29:441-9. 2004..As H(3) antagonists increase measures of anxiety and impair object recognition in wild-type mice, the use of H(3) antagonists in cognitive disorders may be counterproductive and should be carefully evaluated... - Acute pharmacological modulation of mGluR8 reduces measures of anxietyRobert M Duvoisin
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
Behav Brain Res 212:168-73. 2010..The effects of mGluR8 positive allosteric modulators, which only affect neurotransmission in the presence of extracellular glutamate, seem particularly promising for patients with anxiety disorders showing benzodiazepine insensitivity... - Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposureSummer F Acevedo
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Neuropsychopharmacology 32:665-72. 2007..This model could be used to determine the role of genetic and environmental factors in MA-dependent cognitive impairments and to develop therapeutic strategies to inhibit them... - Sex- and APOE isoform-dependent effects of radiation on cognitive functionLaura Villasana
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiat Res 166:883-91. 2006..Radiation had no effects on water maze or passive avoidance learning and memory of male APOE2, APOE3 or APOE4 mice, indicating that the effects of radiation on cognitive performance are dependent on sex- and APOE isoform... - Dihydrotestosterone modulates spatial working-memory performance in male miceTed S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurochem 110:902-11. 2009..These data support that in male mice androgens specifically affect spatial working memory performance, and that the neurobiological processes underlying spatial memory formation may be differentially affected by androgens... - Effects of 137Cs gamma irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female miceSummer E Acevedo
Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiat Res 170:422-8. 2008.... - Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction methodS M Elsas
Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
Phytomedicine 17:940-9. 2010..Instead of the anxiolytic effects described by others, anxiogenic effects in the elevated plus maze were seen in mice receiving any of the 5 Passiflora extracts... - Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderlyF Berteau-Pavy
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Neuroscience 147:6-17. 2007..In men, salivary cortisol levels correlated with object recognition. These results show that object recognition and spatial navigation tests are useful to assess cognitive function in the elderly... - Acetylcholine receptor and behavioral deficits in mice lacking apolipoprotein EJessica A Siegel
Department of Behavioral Neuroscience, Oregon Health and Science University, 8131 SW Sam Jackson Park Road, Portland, OR 97239, USA
Neurobiol Aging 32:75-84. 2011..Impaired apoE functioning may result in cholinergic deficits that contribute to the cognitive impairments seen in AD... - Effects of epsilon4 on object recognition in the non-demented elderlyGwendolen E Haley
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Curr Aging Sci 3:127-37. 2010..Thus, the NINL test could be a valuable tool in detecting pre-clinical signs of age-related cognitive impairments, particularly those associated with epsilon4 risk... - Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- micePeter Van Meer
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
J Neurochem 103:124-30. 2007..Such changes were not seen in the hypothalamus, hippocampus, or cortex. In Apoe-/- mice, chronically decreased histamine levels and reduced histamine release in the amygdala might contribute to increased measures of anxiety... - Object recognition analysis in mice using nose-point digital video trackingT S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
J Neurosci Methods 168:422-30. 2008..Video tracking with nose-point detection generates useful analyses of rodent object recognition task performance and possibly for other behavioral tests... - Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) miceAnita J Bechtholt
Department of Behavioral Neuroscience, MC L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098
Pharmacol Biochem Behav 77:783-92. 2004..While the exact mechanisms underlying these effects of apoE are unknown, these data support a possible role for apoE in modulating the conditioned rewarding properties of ethanol... - Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesisJacob Raber
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
Radiat Res 162:39-47. 2004..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments... - Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficitsJacob Raber
Departments of Behavioral Neuroscience and Neurology, Oregon Health and Science University, Portland, OR, USA
Ann Neurol 55:381-9. 2004..These impairments after cerebral global ischemia under conditions of reduced neurogenesis support a role for the production of new cells in mediating functional recovery... - Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8Robert M Duvoisin
Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
Eur J Neurosci 22:425-36. 2005.... - Transgenic expression of androgen receptors improves spatial memory retention in both sham-irradiated and 137Cs gamma-irradiated female miceSummer F Acevedo
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Radiat Res 170:572-8. 2008..These data support an important role for AR in spatial memory retention in water maze probe trials in female mice under baseline conditions and after cranial irradiation... - Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in miceJessica A Siegel
Departments of aBehavioral Neuroscience bNeurology cDivision of Neuroscience ONPRC, Oregon Health and Science University, Portland, Oregon, USA
Behav Pharmacol 21:602-14. 2010..Thus, the cholinergic system, but not apolipoprotein E isoform, might play an important role in the long-term methamphetamine-induced cognitive deficits in adulthood... - Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in miceScott H Soderling
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 100:1723-8. 2003..Thus WAVE-1 is required for normal neural functioning... - Circadian activity associated with spatial learning and memory in aging rhesus monkeysG E Haley
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Exp Neurol 217:55-62. 2009..These data support the usefulness of this spatial navigational test to assess spatial learning and memory in rhesus monkeys and the importance of circadian activity in performance... - Role of H(3) receptor-mediated signaling in cognitionG Bongers
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
Inflamm Res 53:S51-2. 2004 - Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effectsJ Raber
Gladstone Molecular Neurobiology Program and the Department of Neurology, University of California, San Francisco, California 94141 9100, USA
J Biol Chem 272:15057-60. 1997..An imbalance between the effects of OB on corticotropin-releasing factor release from the hypothalamus and on adrenocorticotrophic hormone release from the pituitary could contribute to obesity... - Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DgatS J Smith
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
Nat Genet 25:87-90. 2000..Our findings indicate that multiple mechanisms exist for triglyceride synthesis and suggest that the selective inhibition of Dgat-mediated triglyceride synthesis may be useful for treating obesity... - Apolipoprotein E4 and sex affect neurobehavioral performance in primary school childrenSummer F Acevedo
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Pediatr Res 67:293-9. 2010..Thus, apoE4 may affect neurobehavioral performance, particularly spatial memory, and antenatal health decades before any clinical expression of neurodegenerative processes... - Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young miceRadoslaw Rola
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
Exp Neurol 188:316-30. 2004..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits... - Sex-dependent effects of 56Fe irradiation on contextual fear conditioning in C57BL/6J miceLaura Villasana
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
Hippocampus 20:19-23. 2010..Such impairment was not seen for hippocampus-independent cued fear conditioning. Thus, the effects of (56)Fe irradiation on hippocampus-dependent contextual fear conditioning are critically modulated by sex... - A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memoryScott H Soderling
Howard Hughes Medical Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 27:355-65. 2007..This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior... - Castration and training in a spatial task alter the number of immature neurons in the hippocampus of male miceTed S Benice
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Brain Res 1329:21-9. 2010..Thus, in mice, castration disrupts spatial memory and reduces immature neuron number, but there is no strong link between these effects... - The use and validation of the spatial navigation Memory Island test in primary school childrenBrian J Piper
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Brain Res 210:257-62. 2010.... - Glutathione peroxidase activity modulates recovery in the injured immature brainKyoko Tsuru-Aoyagi
Department of Neurological Surgery, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA
Ann Neurol 65:540-9. 2009..Here we consider glutathione peroxidase (GPx) activity as a determinant of recovery in the injured immature brain... - Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brainSummer F Acevedo
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurochem 107:976-86. 2008..These data support a role for histamine in the effects of MA on the developing brain... - Effects of sex on object recognition and spatial navigation in humansAngela M Rizk-Jackson
Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
Behav Brain Res 173:181-90. 2006..These tests might be useful to compare assessments of object recognition and spatial learning and memory in humans and animal models... - NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticityALISON O'MAHONY
Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
Mol Cell Biol 26:7283-98. 2006..These findings suggest that NF-kappaB/Rel transcription factors act as pivotal regulators of activity-dependent inhibitory and excitatory neuronal function regulating synaptic plasticity and memory... - Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficitsJorge J Palop
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, CA 94141, USA
Proc Natl Acad Sci U S A 100:9572-7. 2003.... - Role of apolipoprotein E in anxietyJacob Raber
Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Neural Plast 2007:91236. 2007..Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses... - Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer proteinKishorchandra Gohil
Center for Comparative Respiratory and Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA
Free Radic Biol Med 35:1343-54. 2003..The repression of specific genes that determine synaptic plasticity and neuronal development may account for suppressed electrophysiological activities of cortex and impaired behavior in Ttpa(-/-) mice... - Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia functionClaudio Mastronardi
Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Neurosci 26:13167-79. 2006.... - Loss of AKAP150 perturbs distinct neuronal processes in miceBrian J Tunquist
Howard Hughes Medical Institute, Oregon Health and Science University, 3181 South West Sam Jackson Park Road, Portland, Oregon 97239, USA
Proc Natl Acad Sci U S A 105:12557-62. 2008..These studies argue that distinct AKAP150-enzyme complexes regulate context-dependent neuronal signaling events in vivo... - Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity following (137)Cs irradiationLaura Villasana
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Radiat Environ Biophys 49:421-6. 2010..Together, these data indicate that brains of apoE3 mice respond differently to (137)Cs irradiation than those of apoE2 or apoE4 mice... - Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic miceLuke Esposito
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
J Neurosci 26:5167-79. 2006..Whereas reductions in Sod2 would be expected to trigger or exacerbate neuronal and vascular pathology in AD, increasing Sod2 activity might be of therapeutic benefit... - Mouse behavioural analysis in systems biologyPeter Van Meer
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Biochem J 389:593-610. 2005..Finally, common behavioural tests used to assess brain function are reviewed, and it is illustrated how behavioural tests are used to increase our understanding of the role of histaminergic neurotransmission in brain function... - Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptorSeema Bhatnagar
Department of Psychology and the Neuroscience Program, Box 1109, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
Physiol Behav 81:545-55. 2004..Together, these data suggest that the 5-HT-3A receptor does not have a unitary role in the regulation of anxiety- and fear-related behaviors but has a potentially substantial role in the regulation of HPA activity... - Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cellsAlexandra Peister
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
Exp Neurol 201:266-9. 2006..These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases... - Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulationLora K Heisler
Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
J Neurosci 27:6956-64. 2007.... - Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase CepsilonClyde W Hodge
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
J Clin Invest 110:1003-10. 2002..The findings also suggest PKCepsilon as a possible therapeutic target for development of anxiolytics... - The presence of apoE4, not the absence of apoE3, contributes to AD pathologyBruce Teter
UCLA-SFVP MC151 and VA-6LAHS, Sepulveda, CA 91343, USA
J Alzheimers Dis 4:155-63. 2002
Research Grants
- The Role of mGluR8 in AnxietyJacob Raber; Fiscal Year: 2009..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..
- The Role of mGluR8 in AnxietyJacob Raber; Fiscal Year: 2007..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..
- Androgens and apoE4 induced cognitive impairmentsJacob Raber; Fiscal Year: 2005....
- The Role of mGluR8 in AnxietyJacob Raber; Fiscal Year: 2010..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..