J Raber

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Androgens protect against apolipoprotein E4-induced cognitive deficits
    Jacob Raber
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94141, USA
    J Neurosci 22:5204-9. 2002
  2. pmc Role of apolipoprotein E in anxiety
    Jacob Raber
    Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neural Plast 2007:91236. 2007
  3. doi request reprint Effects of whole body (56)Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 246:162-7. 2013
  4. doi request reprint Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 246:69-75. 2013
  5. pmc Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly
    Gwendolen E Haley
    Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR 97239, USA
    Age (Dordr) 34:1-10. 2012
  6. ncbi request reprint Androgens, apoE, and Alzheimer's disease
    Jacob Raber
    Oregon Health and Science University, Portland, OR 97239, USA
    Sci Aging Knowledge Environ 2004:re2. 2004
  7. doi request reprint Unintended effects of cranial irradiation on cognitive function
    Jacob Raber
    Department of Behavioral Neuroscience, and Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Pathol 38:198-202. 2010
  8. ncbi request reprint ApoE genotype accounts for the vast majority of AD risk and AD pathology
    Jacob Raber
    Departments of Behavioral Neuroscience and Neurology, L470, ONPRC, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97201, USA
    Neurobiol Aging 25:641-50. 2004
  9. ncbi request reprint Effects of ⁵⁶Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiat Res 176:521-6. 2011
  10. pmc AR, apoE, and cognitive function
    Jacob Raber
    Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Horm Behav 53:706-15. 2008

Research Grants

  1. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2010
  2. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2009
  3. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2007
  4. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Androgens protect against apolipoprotein E4-induced cognitive deficits
    Jacob Raber
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94141, USA
    J Neurosci 22:5204-9. 2002
    ..Our findings suggest that apoE4 contributes to cognitive decline by reducing AR levels in the brain, and that stimulating AR-dependent pathways can reverse apoE4-induced cognitive deficits...
  2. pmc Role of apolipoprotein E in anxiety
    Jacob Raber
    Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neural Plast 2007:91236. 2007
    ..Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses...
  3. doi request reprint Effects of whole body (56)Fe radiation on contextual freezing and Arc-positive cells in the dentate gyrus
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 246:162-7. 2013
    ....
  4. doi request reprint Effects of (56)Fe radiation on hippocampal function in mice deficient in chemokine receptor 2 (CCR2)
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 246:69-75. 2013
    ....
  5. pmc Novel image-novel location object recognition task sensitive to age-related cognitive decline in nondemented elderly
    Gwendolen E Haley
    Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR 97239, USA
    Age (Dordr) 34:1-10. 2012
    ..These results support that the NINL might be a valuable tool to assess age-related cognitive decline...
  6. ncbi request reprint Androgens, apoE, and Alzheimer's disease
    Jacob Raber
    Oregon Health and Science University, Portland, OR 97239, USA
    Sci Aging Knowledge Environ 2004:re2. 2004
    ..I also discuss potential interactions of androgens with other AD-related factors...
  7. doi request reprint Unintended effects of cranial irradiation on cognitive function
    Jacob Raber
    Department of Behavioral Neuroscience, and Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Pathol 38:198-202. 2010
    ..Further, we will discuss potential mechanisms contributing to these events, including alterations in neurogenesis and increased oxidative stress following irradiation and potential alterations in synaptic and dendritic markers...
  8. ncbi request reprint ApoE genotype accounts for the vast majority of AD risk and AD pathology
    Jacob Raber
    Departments of Behavioral Neuroscience and Neurology, L470, ONPRC, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97201, USA
    Neurobiol Aging 25:641-50. 2004
    ..Thus, the epidemiologic and basic science evidence suggest that apoE genotype accounts for the vast majority of AD risk and pathology...
  9. ncbi request reprint Effects of ⁵⁶Fe-particle cranial radiation on hippocampus-dependent cognition depend on the salience of the environmental stimuli
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiat Res 176:521-6. 2011
    ....
  10. pmc AR, apoE, and cognitive function
    Jacob Raber
    Department of Behavioral Neuroscience, Division of Neuroscience, ONPRC, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Horm Behav 53:706-15. 2008
    ..In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by epsilon4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction...
  11. ncbi request reprint Histamine receptor-mediated signaling during development and brain function in adulthood
    J Raber
    Departments of Behavioral Neuroscience and Neurology, Division of Neuroscience, ONPRC, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Cell Mol Life Sci 64:735-41. 2007
    ..Therefore, increased efforts are warranted to carefully evaluate the effects of drugs that directly or indirectly affect histamine receptor-mediated signaling during development on cognitive function later in life...
  12. pmc Irradiation enhances hippocampus-dependent cognition in mice deficient in extracellular superoxide dismutase
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Hippocampus 21:72-80. 2011
    ....
  13. ncbi request reprint Apolipoprotein E and cognitive performance
    J Raber
    Gladstone Institute of Neurological Disease, University of California, San Francisco 94141 9100, USA
    Nature 404:352-4. 2000
  14. ncbi request reprint Behavioral performance of tfm mice supports the beneficial role of androgen receptors in spatial learning and memory
    Angela Rizk
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1034:132-8. 2005
    ..There were no differences in tfm and wild-type female and male mice in emotional learning and memory in the passive avoidance test. These findings support a beneficial role for androgen receptors in spatial learning and memory...
  15. pmc Sex-dependent cognitive phenotype of mice lacking mGluR8
    Robert M Duvoisin
    Department of Physiology and Pharmacology, Oregon Health and Science University, USA
    Behav Brain Res 209:21-6. 2010
    ..Thus, potential sex differences in the therapeutic effects of mGluR8 modulation to reduce measures of anxiety and improve cognitive performance should be carefully considered...
  16. ncbi request reprint Role of circulating androgen levels in effects of apoE4 on cognitive function
    Timothy Pfankuch
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1053:88-96. 2005
    ..Thus, androgens have differential roles in object recognition and spatial learning and memory in the water maze, depending on whether or not apoE4 is present...
  17. ncbi request reprint Anxiety and cognition in histamine H3 receptor-/- mice
    Angela Rizk
    Department of Behavioural Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Eur J Neurosci 19:1992-6. 2004
    ..These findings support a role for H3Rs in mediating histamine effects on spatial learning and memory and measures of anxiety...
  18. ncbi request reprint Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice
    Summer F Acevedo
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
    Brain Res 1071:113-23. 2006
    ....
  19. pmc Testosterone and dihydrotestosterone differentially improve cognition in aged female mice
    Ted S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Learn Mem 16:479-85. 2009
    ..These data support that androgen supplementation in old female mice improves cognitive performance differentially depending upon the type of hormone treatment and cognitive task...
  20. ncbi request reprint Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity
    T S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, 97239, USA
    Neuroscience 137:413-23. 2006
    ..Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice...
  21. ncbi request reprint Passive avoidance learning and memory of 56Fe sham-irradiated and irradiated human apoE transgenic mice
    L Villasana
    Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiats Biol Radioecol 48:167-70. 2008
    ....
  22. ncbi request reprint Tfm-AR modulates the effects of ApoE4 on cognition
    Angela Rizk-Jackson
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurochem 105:63-7. 2008
    ..These data support an important role for AR in protecting against the detrimental effects of apoE4 on hippocampus-dependent learning and memory...
  23. ncbi request reprint apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice
    Jennifer Robertson
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neurobiol Aging 26:637-43. 2005
    ..Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety...
  24. ncbi request reprint Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations
    J Raber
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 20:2064-71. 2000
    ..These results support a key role for apoE in the tonic inhibition of steroidogenesis and HPA axis activity and have important implications for the behavioral analysis of Apoe(-/-) mice...
  25. pmc Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females
    J Raber
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94141 9100, USA
    Proc Natl Acad Sci U S A 95:10914-9. 1998
    ..These results could be pertinent to cognitive impairments observed in human APOE epsilon4 carriers. NSE-apoE mice and similar models may facilitate the preclinical assessment of treatments for apoE-related cognitive deficits...
  26. ncbi request reprint Effects of sex and APOE epsilon4 on object recognition and spatial navigation in the elderly
    F Berteau-Pavy
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 147:6-17. 2007
    ..In men, salivary cortisol levels correlated with object recognition. These results show that object recognition and spatial navigation tests are useful to assess cognitive function in the elderly...
  27. pmc ApoE isoform-dependent deficits in extinction of contextual fear conditioning
    R H J Olsen
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 11:806-12. 2012
    ..These data along with clinical data showing an association of apoE2 with susceptibility to specific symptom clusters in PTSD supports an important role for apoE isoform in the extinction of conditioned fear...
  28. ncbi request reprint Anxiety and cognition in female histidine decarboxylase knockout (Hdc(-/-)) mice
    Summer F Acevedo
    Department of Behavioral Neuroscience L470, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Behav Brain Res 168:92-9. 2006
    ....
  29. ncbi request reprint Effects of 137Cs gamma irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice
    Summer E Acevedo
    Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiat Res 170:422-8. 2008
    ....
  30. doi request reprint Dihydrotestosterone modulates spatial working-memory performance in male mice
    Ted S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurochem 110:902-11. 2009
    ..These data support that in male mice androgens specifically affect spatial working memory performance, and that the neurobiological processes underlying spatial memory formation may be differentially affected by androgens...
  31. pmc Impairments in spatial memory retention of GFAP-apoE4 female mice
    Peter Van Meer
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Behav Brain Res 176:372-5. 2007
    ..Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes...
  32. ncbi request reprint Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments
    Ramadevi Pullela
    Department of Pediatrics, University of California, San Francisco, CA 94143 0520, USA
    Dev Neurosci 28:396-409. 2006
    ..Behavioral changes are a likely consequence of regional-specific neuronal degeneration...
  33. pmc Acute pharmacological modulation of mGluR8 reduces measures of anxiety
    Robert M Duvoisin
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA
    Behav Brain Res 212:168-73. 2010
    ..The effects of mGluR8 positive allosteric modulators, which only affect neurotransmission in the presence of extracellular glutamate, seem particularly promising for patients with anxiety disorders showing benzodiazepine insensitivity...
  34. ncbi request reprint Sex- and histamine-dependent long-term cognitive effects of methamphetamine exposure
    Summer F Acevedo
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Neuropsychopharmacology 32:665-72. 2007
    ..This model could be used to determine the role of genetic and environmental factors in MA-dependent cognitive impairments and to develop therapeutic strategies to inhibit them...
  35. ncbi request reprint Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- mice
    Gerald Bongers
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA, USA
    Neuropsychopharmacology 29:441-9. 2004
    ..As H(3) antagonists increase measures of anxiety and impair object recognition in wild-type mice, the use of H(3) antagonists in cognitive disorders may be counterproductive and should be carefully evaluated...
  36. ncbi request reprint Sex- and APOE isoform-dependent effects of radiation on cognitive function
    Laura Villasana
    Department of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiat Res 166:883-91. 2006
    ..Radiation had no effects on water maze or passive avoidance learning and memory of male APOE2, APOE3 or APOE4 mice, indicating that the effects of radiation on cognitive performance are dependent on sex- and APOE isoform...
  37. pmc Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method
    S M Elsas
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Phytomedicine 17:940-9. 2010
    ..Instead of the anxiolytic effects described by others, anxiogenic effects in the elevated plus maze were seen in mice receiving any of the 5 Passiflora extracts...
  38. ncbi request reprint Object recognition analysis in mice using nose-point digital video tracking
    T S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurosci Methods 168:422-30. 2008
    ..Video tracking with nose-point detection generates useful analyses of rodent object recognition task performance and possibly for other behavioral tests...
  39. ncbi request reprint Effects of epsilon4 on object recognition in the non-demented elderly
    Gwendolen E Haley
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Curr Aging Sci 3:127-37. 2010
    ..Thus, the NINL test could be a valuable tool in detecting pre-clinical signs of age-related cognitive impairments, particularly those associated with epsilon4 risk...
  40. ncbi request reprint Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits
    Jacob Raber
    Departments of Behavioral Neuroscience and Neurology, Oregon Health and Science University, Portland, OR, USA
    Ann Neurol 55:381-9. 2004
    ..These impairments after cerebral global ischemia under conditions of reduced neurogenesis support a role for the production of new cells in mediating functional recovery...
  41. doi request reprint Transgenic expression of androgen receptors improves spatial memory retention in both sham-irradiated and 137Cs gamma-irradiated female mice
    Summer F Acevedo
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Radiat Res 170:572-8. 2008
    ..These data support an important role for AR in spatial memory retention in water maze probe trials in female mice under baseline conditions and after cranial irradiation...
  42. pmc Acetylcholine receptor and behavioral deficits in mice lacking apolipoprotein E
    Jessica A Siegel
    Department of Behavioral Neuroscience, Oregon Health and Science University, 8131 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neurobiol Aging 32:75-84. 2011
    ..Impaired apoE functioning may result in cholinergic deficits that contribute to the cognitive impairments seen in AD...
  43. pmc Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
    Scott H Soderling
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 100:1723-8. 2003
    ..Thus WAVE-1 is required for normal neural functioning...
  44. ncbi request reprint Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice
    Anita J Bechtholt
    Department of Behavioral Neuroscience, MC L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098
    Pharmacol Biochem Behav 77:783-92. 2004
    ..While the exact mechanisms underlying these effects of apoE are unknown, these data support a possible role for apoE in modulating the conditioned rewarding properties of ethanol...
  45. ncbi request reprint Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis
    Jacob Raber
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, 97239, USA
    Radiat Res 162:39-47. 2004
    ..The significant loss of proliferating SGZ cells and their progeny suggests a contributory role of reduced neurogenesis in the pathogenesis of radiation-induced cognitive impairments...
  46. pmc Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice
    Jessica A Siegel
    Departments of aBehavioral Neuroscience bNeurology cDivision of Neuroscience ONPRC, Oregon Health and Science University, Portland, Oregon, USA
    Behav Pharmacol 21:602-14. 2010
    ..Thus, the cholinergic system, but not apolipoprotein E isoform, might play an important role in the long-term methamphetamine-induced cognitive deficits in adulthood...
  47. ncbi request reprint Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice
    Peter Van Meer
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    J Neurochem 103:124-30. 2007
    ..Such changes were not seen in the hypothalamus, hippocampus, or cortex. In Apoe-/- mice, chronically decreased histamine levels and reduced histamine release in the amygdala might contribute to increased measures of anxiety...
  48. ncbi request reprint Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8
    Robert M Duvoisin
    Neurological Sciences Institute, Oregon Health and Science University, Portland, OR, USA
    Eur J Neurosci 22:425-36. 2005
    ....
  49. pmc Circadian activity associated with spatial learning and memory in aging rhesus monkeys
    G E Haley
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Exp Neurol 217:55-62. 2009
    ..These data support the usefulness of this spatial navigational test to assess spatial learning and memory in rhesus monkeys and the importance of circadian activity in performance...
  50. ncbi request reprint Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects
    J Raber
    Gladstone Molecular Neurobiology Program and the Department of Neurology, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 272:15057-60. 1997
    ..An imbalance between the effects of OB on corticotropin-releasing factor release from the hypothalamus and on adrenocorticotrophic hormone release from the pituitary could contribute to obesity...
  51. ncbi request reprint Role of H(3) receptor-mediated signaling in cognition
    G Bongers
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
    Inflamm Res 53:S51-2. 2004
  52. ncbi request reprint Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
    S J Smith
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California, USA
    Nat Genet 25:87-90. 2000
    ..Our findings indicate that multiple mechanisms exist for triglyceride synthesis and suggest that the selective inhibition of Dgat-mediated triglyceride synthesis may be useful for treating obesity...
  53. pmc A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory
    Scott H Soderling
    Howard Hughes Medical Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:355-65. 2007
    ..This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior...
  54. pmc Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children
    Summer F Acevedo
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Pediatr Res 67:293-9. 2010
    ..Thus, apoE4 may affect neurobehavioral performance, particularly spatial memory, and antenatal health decades before any clinical expression of neurodegenerative processes...
  55. ncbi request reprint Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..These data provide evidence that irradiation of young animals induces a long-term impairment of SGZ neurogenesis that is associated with hippocampal-dependent memory deficits...
  56. pmc Sex-dependent effects of 56Fe irradiation on contextual fear conditioning in C57BL/6J mice
    Laura Villasana
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Hippocampus 20:19-23. 2010
    ..Such impairment was not seen for hippocampus-independent cued fear conditioning. Thus, the effects of (56)Fe irradiation on hippocampus-dependent contextual fear conditioning are critically modulated by sex...
  57. pmc The use and validation of the spatial navigation Memory Island test in primary school children
    Brian J Piper
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 210:257-62. 2010
    ....
  58. pmc Castration and training in a spatial task alter the number of immature neurons in the hippocampus of male mice
    Ted S Benice
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1329:21-9. 2010
    ..Thus, in mice, castration disrupts spatial memory and reduces immature neuron number, but there is no strong link between these effects...
  59. pmc Glutathione peroxidase activity modulates recovery in the injured immature brain
    Kyoko Tsuru-Aoyagi
    Department of Neurological Surgery, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Neurol 65:540-9. 2009
    ..Here we consider glutathione peroxidase (GPx) activity as a determinant of recovery in the injured immature brain...
  60. pmc Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain
    Summer F Acevedo
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurochem 107:976-86. 2008
    ..These data support a role for histamine in the effects of MA on the developing brain...
  61. ncbi request reprint Effects of sex on object recognition and spatial navigation in humans
    Angela M Rizk-Jackson
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
    Behav Brain Res 173:181-90. 2006
    ..These tests might be useful to compare assessments of object recognition and spatial learning and memory in humans and animal models...
  62. pmc NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity
    ALISON O'MAHONY
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94141, USA
    Mol Cell Biol 26:7283-98. 2006
    ..These findings suggest that NF-kappaB/Rel transcription factors act as pivotal regulators of activity-dependent inhibitory and excitatory neuronal function regulating synaptic plasticity and memory...
  63. pmc Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
    Jorge J Palop
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, CA 94141, USA
    Proc Natl Acad Sci U S A 100:9572-7. 2003
    ....
  64. ncbi request reprint Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein
    Kishorchandra Gohil
    Center for Comparative Respiratory and Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 35:1343-54. 2003
    ..The repression of specific genes that determine synaptic plasticity and neuronal development may account for suppressed electrophysiological activities of cortex and impaired behavior in Ttpa(-/-) mice...
  65. ncbi request reprint Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function
    Claudio Mastronardi
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 26:13167-79. 2006
    ....
  66. pmc Loss of AKAP150 perturbs distinct neuronal processes in mice
    Brian J Tunquist
    Howard Hughes Medical Institute, Oregon Health and Science University, 3181 South West Sam Jackson Park Road, Portland, Oregon 97239, USA
    Proc Natl Acad Sci U S A 105:12557-62. 2008
    ..These studies argue that distinct AKAP150-enzyme complexes regulate context-dependent neuronal signaling events in vivo...
  67. doi request reprint Isoform-dependent effects of apoE on doublecortin-positive cells and microtubule-associated protein 2 immunoreactivity following (137)Cs irradiation
    Laura Villasana
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Radiat Environ Biophys 49:421-6. 2010
    ..Together, these data indicate that brains of apoE3 mice respond differently to (137)Cs irradiation than those of apoE2 or apoE4 mice...
  68. ncbi request reprint Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice
    Luke Esposito
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Neurosci 26:5167-79. 2006
    ..Whereas reductions in Sod2 would be expected to trigger or exacerbate neuronal and vascular pathology in AD, increasing Sod2 activity might be of therapeutic benefit...
  69. pmc Mouse behavioural analysis in systems biology
    Peter Van Meer
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biochem J 389:593-610. 2005
    ..Finally, common behavioural tests used to assess brain function are reviewed, and it is illustrated how behavioural tests are used to increase our understanding of the role of histaminergic neurotransmission in brain function...
  70. ncbi request reprint Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor
    Seema Bhatnagar
    Department of Psychology and the Neuroscience Program, Box 1109, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
    Physiol Behav 81:545-55. 2004
    ..Together, these data suggest that the 5-HT-3A receptor does not have a unitary role in the regulation of anxiety- and fear-related behaviors but has a potentially substantial role in the regulation of HPA activity...
  71. ncbi request reprint Novel object recognition in Apoe(-/-) mice improved by neonatal implantation of wild-type multipotential stromal cells
    Alexandra Peister
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Exp Neurol 201:266-9. 2006
    ..These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases...
  72. ncbi request reprint Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation
    Lora K Heisler
    Department of Clinical Biochemistry, Addenbrooke s Hospital and the University of Cambridge, Cambridge CB2 2QR, United Kingdom
    J Neurosci 27:6956-64. 2007
    ....
  73. pmc Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase Cepsilon
    Clyde W Hodge
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, Emeryville, California 94608, USA
    J Clin Invest 110:1003-10. 2002
    ..The findings also suggest PKCepsilon as a possible therapeutic target for development of anxiolytics...
  74. ncbi request reprint The presence of apoE4, not the absence of apoE3, contributes to AD pathology
    Bruce Teter
    UCLA SFVP MC151 and VA 6LAHS, Sepulveda, CA 91343, USA
    J Alzheimers Dis 4:155-63. 2002

Research Grants10

  1. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2010
    ..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..
  2. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2009
    ..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..
  3. The Role of mGluR8 in Anxiety
    Jacob Raber; Fiscal Year: 2007
    ..Elucidating the role of mGluR8 in anxiety and assessing the potential of pharmacological mGluR8 stimulation to reduce anxiety might be especially valuable for patients with anxiety disorders resistant to treatment with benzodiazepine. ..
  4. Androgens and apoE4 induced cognitive impairments
    Jacob Raber; Fiscal Year: 2005
    ....