Jonathan Purnell

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interven
    Jonathan Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Circulation 127:180-7. 2013
  2. doi request reprint Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans
    J Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Diabetes Obes Metab 13:229-34. 2011
  3. pmc Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss
    Jonathan Q Purnell
    Oregon Health and Science Univ, Div of Endocrinology, Diabetes, and Clinical Nutrition, Center for the Study of Weight Regulation, L481, 3181 SW Sam Jackson Park, Portland, OR 97239, USA
    Am J Physiol Endocrinol Metab 296:E351-7. 2009
  4. ncbi request reprint Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity
    J Q Purnell
    Department of Medicine, Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, OR, USA
    Int J Obes (Lond) 31:385-9. 2007
  5. ncbi request reprint Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    Treat Endocrinol 2:33-47. 2003
  6. ncbi request reprint Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women
    Jonathan Q Purnell
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 89:281-7. 2004
  7. ncbi request reprint Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:5747-52. 2003
  8. pmc Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes 52:2623-9. 2003
  9. ncbi request reprint Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia
    J Q Purnell
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Arterioscler Thromb Vasc Biol 21:567-72. 2001
  10. ncbi request reprint Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002

Research Grants

  1. CORTISOL, CENTRAL OBESITY, AND INSULIN RESISTANCE
    Jonathan Purnell; Fiscal Year: 2003
  2. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
  3. Structure and Regulation of Ghrelin in Obesity
    Jonathan Purnell; Fiscal Year: 2009
  4. Hypothalamic fMRI response to nutrients
    Jonathan Purnell; Fiscal Year: 2007
  5. Regulation of Cortisol Metabolism and Fat Patterning
    Jonathan Purnell; Fiscal Year: 2007
  6. Structure and Regulation of Ghrelin in Obesity
    Jonathan Purnell; Fiscal Year: 2007
  7. Sex steroid, HPA regulation, and fat patterning
    Jonathan Purnell; Fiscal Year: 2003
  8. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010

Detail Information

Publications30

  1. doi request reprint The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interven
    Jonathan Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Circulation 127:180-7. 2013
    ..The purpose of this study was to determine whether excessive weight gain with diabetes mellitus therapy of type 1 diabetes mellitus is prospectively associated with atherosclerotic disease...
  2. doi request reprint Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans
    J Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Diabetes Obes Metab 13:229-34. 2011
    ..We therefore sought to determine if the brain response differed to glucose vs. fructose in humans independently of the ingestive process...
  3. pmc Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss
    Jonathan Q Purnell
    Oregon Health and Science Univ, Div of Endocrinology, Diabetes, and Clinical Nutrition, Center for the Study of Weight Regulation, L481, 3181 SW Sam Jackson Park, Portland, OR 97239, USA
    Am J Physiol Endocrinol Metab 296:E351-7. 2009
    ....
  4. ncbi request reprint Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity
    J Q Purnell
    Department of Medicine, Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, OR, USA
    Int J Obes (Lond) 31:385-9. 2007
    ..To determine which parameters of body composition or metabolism best correlate with changes in 24 h ghrelin levels following weight loss...
  5. ncbi request reprint Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    Treat Endocrinol 2:33-47. 2003
    ....
  6. ncbi request reprint Association of 24-hour cortisol production rates, cortisol-binding globulin, and plasma-free cortisol levels with body composition, leptin levels, and aging in adult men and women
    Jonathan Q Purnell
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 89:281-7. 2004
    ..This increase in hypothalamic-pituitary-adrenal axis activity may play a role in the alterations in body composition and central fat distribution in men vs. women and with aging...
  7. ncbi request reprint Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:5747-52. 2003
    ..Our data are consistent with the hypotheses that insulin may negatively regulate ghrelin and that high-density lipoprotein may be a carrier particle for circulating ghrelin...
  8. pmc Relationship of family history of type 2 diabetes, hypoglycemia, and autoantibodies to weight gain and lipids with intensive and conventional therapy in the Diabetes Control and Complications Trial
    Jonathan Q Purnell
    Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon 97201, USA
    Diabetes 52:2623-9. 2003
    ..These data support the hypothesis that increased weight gain with intensive therapy might be explained, in part, by genetic traits...
  9. ncbi request reprint Relationship of insulin sensitivity and ApoB levels to intra-abdominal fat in subjects with familial combined hyperlipidemia
    J Q Purnell
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, WA, USA
    Arterioscler Thromb Vasc Biol 21:567-72. 2001
    ....
  10. ncbi request reprint Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002
    ..Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion...
  11. ncbi request reprint A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations
    David S Weigle
    University of Washington School of Medicine, Seattle, WA, USA
    Am J Clin Nutr 82:41-8. 2005
    ..Ad libitum, low-carbohydrate diets decrease caloric intake and cause weight loss. It is unclear whether these effects are due to the reduced carbohydrate content of such diets or to their associated increase in protein intake...
  12. ncbi request reprint Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet
    David S Weigle
    University of Washington School of Medicine, Veterans Affairs Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98104, USA
    J Clin Endocrinol Metab 88:1577-86. 2003
    ..Fat restriction avoids the increase in ghrelin levels caused by dietary energy restriction...
  13. ncbi request reprint Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome
    Andrea M Haqq
    Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:3573-6. 2003
    ..Further investigation is warranted to determine whether long-term octreotide treatment causes sustained ghrelin suppression, changes eating behavior, and induces weight loss in this population...
  14. ncbi request reprint Ghrelin in chronic kidney disease: too much or too little?
    Robert H Mak
    Department of Pediatrics, Center for the Study of Weight Regulation, Oregon Health and Science University, Portland, Oregon, USA
    Perit Dial Int 27:51-5. 2007
  15. pmc Effects of higher dietary protein intake on energy balance and metabolic control in children with long-chain 3-hydroxy acyl-CoA dehydrogenase (LCHAD) or trifunctional protein (TFP) deficiency
    Melanie B Gillingham
    The Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Genet Metab 90:64-9. 2007
    ..Long-term studies are needed to determine whether higher protein diets will reduce the risk of overweight and obesity in children with LCHAD or TFP deficiency...
  16. ncbi request reprint Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome
    Andrea M Haqq
    Division of Endocrinology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:174-8. 2003
    ..Elevation of serum ghrelin levels to the degree documented in this study may play a role as an orexigenic factor driving the insatiable appetite and obesity found in PWS...
  17. pmc Plasma distribution and signaling activities of IGF-II precursors
    Alicia G Marks
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 152:922-30. 2011
    ..Thus, both IGF-II precursor forms are present in human plasma but do not preferentially activate the IR...
  18. ncbi request reprint PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity
    Susan J Murdoch
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1705-12. 2003
    ..71, P < 0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance...
  19. ncbi request reprint Changes in plasma amino Acid levels do not predict satiety and weight loss on diets with modified macronutrient composition
    Mikhail S Koren
    University of Washington School of Medicine, Seattle, Wash, USA
    Ann Nutr Metab 51:182-7. 2007
    ..We examined whether high-carbohydrate or high-protein diets induce satiety and weight loss by altering plasma concentrations of these amino acids...
  20. ncbi request reprint Elevated plasma ghrelin levels in Prader Willi syndrome
    David E Cummings
    Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center University of Washington, Seattle, Washington, USA
    Nat Med 8:643-4. 2002
  21. ncbi request reprint Köbberling type of familial partial lipodystrophy: an underrecognized syndrome
    Karen L Herbst
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 26:1819-24. 2003
    ..The latter disorder is associated with mutations in the LMNA gene. FPLD1 is thought to be rare. Here, we report 13 subjects with FPLD1, suggesting that this syndrome is more common than previously thought...
  22. ncbi request reprint Effects of transdermal estrogen on levels of lipids, lipase activity, and inflammatory markers in men with prostate cancer
    Jonathan Q Purnell
    Department of Medicine, Division of Endocrinology, Diabetes, and Clinical Nutrition, Oregon Health and Science University, Portland, OR 97239, USA
    J Lipid Res 47:349-55. 2006
    ..Compared with ADT, short-term TDE therapy of prostate cancer improves lipid levels without deterioration of CVD-associated inflammatory markers and may, on longer-term follow-up, improve CVD and mortality rates...
  23. ncbi request reprint Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome
    Andrea M Haqq
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Endocrinol Metab 88:2206-12. 2003
    ..GH intervention improved body composition and REE and may contribute to better sleep quality and pulmonary function. GH administration did not impact fasting ghrelin concentration...
  24. ncbi request reprint Plasma C-reactive protein concentration is not affected by isocaloric dietary fat reduction
    Mikhail S Koren
    University of Washington School of Medicine, Seattle, Washington, USA
    Nutrition 22:444-8. 2006
    ..However, it remains unclear whether dietary fat has an effect independent from weight change on markers of inflammation...
  25. pmc Exchanging carbohydrate or protein for fat improves lipid-related cardiovascular risk profile in overweight men and women when consumed ad libitum
    Mario Kratz
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Investig Med 58:711-9. 2010
    ..The impact of low-fat diets on the plasma lipoprotein profile is incompletely understood...
  26. pmc LDL composition in E2/2 subjects and LDL distribution by Apo E genotype in type 1 diabetes
    Susan J Murdoch
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, United States
    Atherosclerosis 192:138-47. 2007
    ..The apo E isoform also has a significant effect on LDL concentration in both homozygotes and heterozygotes...
  27. pmc Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  28. ncbi request reprint Nutrition principles and recommendations in diabetes
    Marion J Franz
    Diabetes Care 27:S36-46. 2004
  29. ncbi request reprint Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Nutrition Concepts by Franz, Inc, Minneapolis, Minnesota 55439, USA
    Diabetes Care 25:148-98. 2002
  30. ncbi request reprint Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications
    Marion J Franz
    Diabetes Care 26:S51-61. 2003

Research Grants12

  1. CORTISOL, CENTRAL OBESITY, AND INSULIN RESISTANCE
    Jonathan Purnell; Fiscal Year: 2003
    ....
  2. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
  3. Structure and Regulation of Ghrelin in Obesity
    Jonathan Purnell; Fiscal Year: 2009
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
  4. Hypothalamic fMRI response to nutrients
    Jonathan Purnell; Fiscal Year: 2007
    ..Lay Description: This study will use functional MRI scanning to explore how the brain is affected by sugar and fat. These studies will help us to better understand why changes in the diet might lead to weight gain or loss. ..
  5. Regulation of Cortisol Metabolism and Fat Patterning
    Jonathan Purnell; Fiscal Year: 2007
    ..abstract_text> ..
  6. Structure and Regulation of Ghrelin in Obesity
    Jonathan Purnell; Fiscal Year: 2007
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
  7. Sex steroid, HPA regulation, and fat patterning
    Jonathan Purnell; Fiscal Year: 2003
    ..abstract_text> ..
  8. Structure and Regulation of Ghrelin in Obesity
    Jonathan Q Purnell; Fiscal Year: 2010
    ..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..